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| 1 | Anti-inflammatory properties of the short-chain fatty acids acetate and propionate:A study with relevance to inflammatory bowel disease显示文摘AIM: To compare the anti-inflammatory properties of butyrate with two other SCFAs,namely acetate and propionate,which have less well-documented effects on inflammation. METHODS: The effect of SCFAs on cytokine release from human neutrophils was studied with ELISA. SCFA-dependent modulation of NF-κB reporter activity was assessed in the human colon adenocarcinoma cell line,Colo320DM. Finally,the effect of SCFAs on gene expression and cytokine release,measured with RT-PCR and ELISA,respectively,was studied in mouse colon organ cultures established from colitic mice. RESULTS: Acetate,propionate and butyrate at 30 mmol/L decreased LPS-stimulated TNFα release from neutrophils,without affecting IL-8 protein release. All SCFAs dose dependently inhibited NF-κB reporter activity in Colo320DM cells. Propionate dose-dependently suppressed IL-6 mRNA and protein release from colon organ cultures and comparative studies revealed that propionate and butyrate at 30 mmol/L caused a strong inhibition of immune-related gene expression,whereas acetate was less effective. A similar inhibition was achieved with the proteasome inhibitor MG-132,but not the p38 MAPK inhibitor SB203580. All SCFAs decreased IL-6 protein release from organ cultures. CONCLUSION: In the present study propionate and butyrate were equipotent,whereas acetate was less effective,at suppressing NF-κB reporter activity,immune-related gene expression and cytokine release in vitro. Our findings suggest that propionate and acetate,in addition to butyrate,could be useful in the treatment of inflammatory disorders,including IBD. | Sofia Tedelind Fredrik Westberg Martin Kjerrulf Alexander Vidal | 2007 | World Journal of Gastroenterology2007，13，20： | 81 |
| 2 | 自然保护区、恢复力和动态景观显示文摘在这个日益被人类活动所改变的世界里,保护生物多样性对于维持有恢复力的生态系统和确保生态系统产品的可持续流动以及对社会的服务是至关重要的。但是,现有的自然保护区和国家公园不大可能结合生态系统的长期和大尺度的动态。因此,保护策略必须包括大面积的人类利用经营的土地。为了能使生态系统在大规模的自然和人为干扰之后得以重组,以生态存储形式出现的空间恢复力是必备的前提。生态存储包括那些能使生态系统得以重组的物种、相互作用和结构,它的组成部分可能出现在干扰斑块中,也可能出现在周围的景观中。现有的静态自然保护区应该由动态自然保护区加以补充,例如生态休闲地和动态演替保护区,这些都是在景观尺度上模拟自然干扰状况,进行生态系统经营的组成部分。 | Janne Bengtsson Per Angelstam Thomas Elmqvist Urban Emanuelsson Carl Folke Margareta Ihse Fredrik Moberg Magnus Nystrm 王胜 | 2003 | AMBIO-人类环境杂志2003，32，6： | 11 |
| 3 | Intracellular distribution of amyloid beta peptide and its relationship to the lysosomal system显示文摘Background:Amyloid beta peptide(Aβ)is the main component of extraneuronal senile plaques typical of Alzheimer’s disease(AD)brains.Although Aβis produced by normal neurons,it is shown to accumulate in large amounts within neuronal lysosomes in AD.We have recently shown that under normal conditions the majority of Aβis localized extralysosomally,while oxidative stress significantly increases intralysosomal Aβcontent through activation of macroautophagy.It is also suggested that impaired Aβsecretion and resulting intraneuronal increase of Aβcan contribute to AD pathology.However,it is not clear how Aβis distributed inside normal neurons,and how this distribution is effected when Aβsecretion is inhibited.Methods:Using retinoic acid differentiated neuroblastoma cells and neonatal rat cortical neurons,we studied intracellular distribution of Aβby double immunofluorescence microscopy for Aβ40 or Aβ42 and different organelle markers.In addition,we analysed the effect of tetanus toxin-induced exocytosis inhibition on the intracellular distribution of Aβ.Results:Under normal conditions,Aβwas found in the small cytoplasmic granules in both neurites and perikarya.Only minor portion of Aβwas colocalized with trans-Golgi network,Golgi-derived vesicles,early and late endosomes,lysosomes,and synaptic vesicles,while the majority of Aβgranules were not colocalized with any of these structures.Furthermore,treatment of cells with tetanus toxin significantly increased the amount of intracellular Aβin both perikarya and neurites.Finally,we found that tetanus toxin increased the levels of intralysosomal Aβalthough the majority of Aβstill remained extralysosomally.Conclusion:Our results indicate that most Aβis not localized to Golgi-related structures,endosomes,lysosomes secretory vesicles or other organelles,while the suppression of Aβsecretion increases intracellular intra-and extralysosomal Aβ. | Lin Zheng Angel Cedazo-Minguez Martin Hallbeck Fredrik Jerhammar Jan Marcusson Alexei Terman | 2012 | Translational Neurodegeneration2012，1，1： | 10 |
| 4 | Cholesterol metabolism in cholestatic liver disease and liver transplantation:From molecular mechanisms to clinical implications显示文摘The aim of this review is to enlighten the critical roles that the liver plays in cholesterol metabolism. Liver transplantation can serve as gene therapy or a source of gene transmission in certain conditions that affect cholesterol metabolism, such as low-density-lipoprotein(LDL) receptor gene mutations that are associated with familial hypercholesterolemia. On the other hand, cholestatic liver disease often alters cholesterol metabolism. Cholestasis can lead to formation of lipoprotein X(Lp-X), which is frequently mistaken for LDL on routine clinical tests. In contrast to LDL, Lp-X is non-atherogenic, and failure to differentiate between the two can interfere with cardiovascular risk assessment, potentially leading to prescription of futile lipid-lowering therapy. Statins do not effectively lower Lp-X levels, and cholestasis may lead to accumulation of toxic levels of statins. Moreover, severe cholestasis results in poor micellar formation, which reduces cholesterol absorption, potentially impairing the cholesterol-lowering effect of ezetimibe. Apolipoprotein B-100 measurement can help distinguish between atherogenic and non-atherogenic hypercholesterolemia. Furthermore, routine serum cholesterol measurements alone cannot reflect cholesterol absorption and synthesis. Measurements of serum non-cholesterol sterol biomarkers- such as cholesterol precursor sterols, plant sterols, and cholestanol- may help with the comprehensive assessment of cholesterol metabolism. An adequate cholesterol supply is essential for liver-regenerative capacity. Low preoperative and perioperative serum cholesterol levels seem to predict mortality in liver cirrhosis and after liver transplantation. Thus, accurate lipid profile evaluation is highly important in liver disease and after liver transplantation. | Katriina Nemes Fredrik Aberg Helena Gylling Helena Isoniemi | 2016 | World Journal of Hepatology2016，8，22： | 6 |
| 5 | Effects of spatial variation in cohesion over the concrete-rock interface on dam sliding stability显示文摘The limit equilibrium method(LEM) is widely used for sliding stability evaluation of concrete gravity dams.Failure is then commonly assumed to occur along the entire sliding surface simultaneously.However,the brittle behaviour of bonded concrete-rock contacts,in combination with the varying stress over the interface,implies that the failure of bonded dam-foundation interfaces occurs progressively.In addition,the spatial variation in cohesion may introduce weak spots where failure can be initiated.Nonetheless,the combined effect of brittle failure and spatial variation in cohesion on the overall shear strength of the interface has not been studied previously.In this paper,numerical analyses are used to investigate the effect of brittle failure in combination with spatial variation in cohesion that is taken into account by random fields with different correlation lengths.The study concludes that a possible existence of weak spots along the interface has to be considered since it significantly reduces the overall shear strength of the interface,and implications for doing so are discussed. | Alexandra Krounis Fredrik Johansson Stefan Larsson | 2015 | Journal of Rock Mechanics and Geotechnical Engineering2015，7，6： | 4 |
| 6 | Direct generation of linearly polarized photon emission with designated orientations from site-controlled InGaN quantum dots显示文摘Semiconductor quantum dots(QDs)have been demonstrated viable for efficient light emission applications,in particular for the emission of single photons on demand.However,the preparation of QDs emitting photons with predefined and deterministic polarization vectors has proven arduous.Access to linearly polarized photons is essential for various applications.In this report,a novel concept to directly generate linearly-polarized photons is presented.This concept is based on InGaN QDs grown on top of elongated GaN hexagonal pyramids,by which the predefined elongation determines the polarization vectors of the emitted photons from the QDs.This growth scheme should allow fabrication of ultracompact arrays of photon emitters,with a controlled polarization direction for each individual emitter. | Anders Lundskog Chih-Wei Hsu K Fredrik Karlsson Supaluck Amloy Daniel Nilsson Urban Forsberg Per Olof Holtz Erik Janzen | 2014 | Light(Science & Applications)2014，3，1： | 4 |
| 7 | Manufacture and characterization of graphene membranes with suspended silicon proof masses for MEMS and NEMS applications显示文摘Graphene’s unparalleled strength,chemical stability,ultimate surface-to-volume ratio and excellent electronic properties make it an ideal candidate as a material for membranes in micro-and nanoelectromechanical systems(MEMS and NEMS).However,the integration of graphene into MEMS or NEMS devices and suspended structures such as proof masses on graphene membranes raises several technological challenges,including collapse and rupture of the graphene.We have developed a robust route for realizing membranes made of double-layer CVD graphene and suspending large silicon proof masses on membranes with high yields.We have demonstrated the manufacture of square graphene membranes with side lengths from 7µm to 110µm,and suspended proof masses consisting of solid silicon cubes that are from 5µm×5µm×16.4µm to 100µm×100µm×16.4µm in size.Our approach is compatible with wafer-scale MEMS and semiconductor manufacturing technologies,and the manufacturing yields of the graphene membranes with suspended proof masses were>90%,with>70%of the graphene membranes having>90%graphene area without visible defects.The measured resonance frequencies of the realized structures ranged from tens to hundreds of kHz,with quality factors ranging from 63 to 148.The graphene membranes with suspended proof masses were extremely robust,and were able to withstand indentation forces from an atomic force microscope(AFM)tip of up to~7000nN.The proposed approach for the reliable and large-scale manufacture of graphene membranes with suspended proof masses will enable the development and study of innovative NEMS devices with new functionalities and improved performances. | Xuge Fan Anderson D.Smith Fredrik Forsberg Stefan Wagner Stephan Schroder Sayedeh Shirin Afyouni Akbari Andreas C.Fischer Luis Guillermo Villanueva Mikael Ostling Max C.Lemme Frank Niklaus | 2020 | Microsystems & Nanoengineering2020，6，1： | 4 |
| 8 | Cerebral venous thrombosis and heparin-induced thrombocytopenia in an 18-year old male with severe ulcerative colitis显示文摘The risk of thromboembolism is increased in inflammatory bowel disease and its symptoms may be overlooked. Furthermore, its treatment can be complex and is not without complications. We describe a case of an adolescent boy who developed a cerebral sinus venous thrombosis during a relapse of his ulcerative colitis and who, while on treatment with heparin, developed heparin-induced thrombocytopenia (HIT). The treatment was then switched to fondaparinux, a synthetic and selective inhibitor of activated factor . | Gudrun Scheving Thorsteinsson Maria Magnussson Lena M Hallberg Nils Gunnar Wahlgren Fredrik Lindgren Petter Malmborg Thomas H Casswall | 2008 | World Journal of Gastroenterology2008，14，28： | 4 |
| 9 | EVAPS蒸发系统的能源和环境解决方案显示文摘介绍了欧洲某家工厂采用9效蒸发系统后,能源和环境绩效都得到了提高。还介绍了另外一家工厂采用LCC分析得出的解决方案,改善了工厂的环境绩效和能源效率。 | Fredrik Anngen Randy Stern Anders Wernqvist | 2008 | 中华纸业2008，29，23： | 4 |
| 10 | microRNAs in colon cancer: A roadmap for discovery显示文摘 | Simona Rossi Antonio Fabio Di Narzo Pieter Mestdagh Bart Jacobs Fredrik T. Bosman Bengt Gustavsson Bernard Majoie Arnaud Roth Jo Vandesompele Isidore Rigoutsos Mauro Delorenzi Sabine Tejpar | 2012 | FEBS Letters2012，，19： | 3 |
| 11 | 铁钼法制备甲醛技术的优势探讨显示文摘从甲醛浓度、残留甲醇和甲酸含量、质量参数一致性、余热利用等方面,介绍了用于人造板胶黏剂工业的铁钼法甲醛制备技术。 | Fredrik Rietz 张华民 | 2016 | 林产工业2016，0，1： | 3 |
| 12 | Efficacy and safety of granulocyte, monocyte/macrophage adsorptive in pediatric ulcerative colitis显示文摘AIM: To investigate efficacy and safety for granulocyte, monocyte apheresis in a population of pediatric patients with ulcerative colitis.METHODS: The ADAPT study was a prospective, openlabel, multicenter study in pediatric patients with moderate, active ulcerative colitis with pediatric ulcerative colitis activity index(PUCAI) of 35-64. Patients received one weekly apheresis with Adacolumn granulocyte, monocyte/macrophage adsorptive(GMA) apheresis over 5 consecutive weeks, optionally followed by up to 3 additional apheresis treatments over 3 consecutive weeks. The primary endpoint was the change in mean PUCAI between baseline and week 12; the secondary endpoint was improvement in PUCAI categorized as(Significant Improvement, PUCAI decrease of ≥ 35), Moderate Improvement(PUCAI decrease of 20 < 35), Small Improvement(PUCAI decrease of 10 < 20) or No change(PUCAI decrease of < 10). RESULTS: Twenty-five patients(mean age 13.5 years; mean weight 47.7 kg) were enrolled. In the intention-to-treat set(ITT), the mean value for PUCAI improvement was 22.3 [95%CI: 12.9-31.6; n = 21]. In the per-protocol(PP) set, the mean improvement was 36.3 [95%CI: 31.4-41.1; n = 8]. Significant Improvement was recorded for 9 out of 20 patients(45%); 5 out of 20 patients(25%) had Moderate Improvement and one patient(5%) had No Change in PUCAI score at week 12. In the PP set, six out of eight patients(75%) showed Significant Improvement; and in two out of eight patients(25%) Moderate Improvement was recorded. The endoscopic activity index(EAI) decreased by 3 points on average. Seven(7) out of 21(33%) patients in ITT and 4 out of 8(50%) patients in PP have used steroids during the clinical investigation. The mean steroid dosage for these patients in the ITT set decreased from a mean 12.4 mg to 10 mg daily on average from Baseline to week 12.CONCLUSION: Adacolumn; GMA apheresis treatment was effective in pediatric patients with moderate active Ulcerative Colitis. No new safety signals were reported. The present data contribute to considering GMA apheresis as a therapeutic option in pediatric patients having failed first line therapy. | Tarja Ruuska Peter Küster Lena Grahnquist Fredrik Lindgren Anne Vibeke Wewer | 2016 | World Journal of Gastroenterology2016，22，17： | 3 |
| 13 | 人造板胶黏剂工业中铁钼法甲醛制备技术的优势探讨显示文摘从甲醛浓度、甲醇残留量、甲酸含量、质量稳定性、余热利用等方面,介绍了用于人造板胶黏剂工业的铁钼法甲醛制备技术。 | Fredrik Rietz 张华民 | 2016 | 中国人造板2016，23，3： | 3 |
| 14 | Minamata Convention on Mercury: Chinese progress and perspectives显示文摘Mercury(Hg)is a global threat to human and environmental health[1].To address this global issue,the Minamata Convention on Mercury(MC)was agreed upon by 128 countries on 19January 2013.China officially ratified the MC in August 2016.As the largest emit- | Yan Lin Shuxiao Wang Eirik Hovland Steindal Hua Zhang Huan Zhong Yindong Tong Zuguang Wang Hans Fredrik Veiteberg Braaten Qingru Wu ThorjФrn Larssen | 2017 | National Science Review2017，4，5： | 3 |
| 15 | Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist显示文摘 | Sama I. Sayin Annika Wahlstr?m Jenny Felin Sirkku J?ntti Hanns-Ulrich Marschall Krister Bamberg Bo Angelin Tuulia Hy?tyl?inen Matej Ore?i? Fredrik B?ckhed | 2013 | Cell Metabolism2013，，2： | 3 |
| 16 | Detection of Circulating Pancreas Epithelial Cells in Patients with Pancreatic Cystic Lesions显示文摘 | Andrew D. Rhim Fredrik I. Thege Steven M. Santana Timothy B. Lannin Trisha N. Saha Shannon Tsai Lara R. Maggs Michael L. Kochman Gregory G. Ginsberg John G. Lieb Vinay Chandrasekhara Jeffrey A. Drebin Nuzhat Ahmad Yu- Xiao Yang Brian J. Kirby Ben Z. Stang | 2013 | Gastroenterology2013，，： | 3 |
| 17 | Complications From Inflammatory Bowel Disease During Pregnancy and Delivery显示文摘 | Gabriella Br?ms Fredrik Granath Marie Linder Olof Stephansson Maria Elmberg Helle Kieler | 2012 | Clinical Gastroenterology and Hepatology2012，，11： | 2 |
| 18 | 优于黑箱模型的海洋生态系统模型方法:利用GIS研究沿海生态系统碳通量显示文摘海洋生态系统碳通量研究常用方法包括盆地尺度黑箱模型和高分辨率的三维模型,都强调生态系统中的浮游部分。这些方法适用于海洋研究,但应用于沿海生态系统时会出现相当多的问题,这是因为某些生态位尺度的不同而且底栖生物是该生态系统功能的主导群体。此外,三维模型需要大量的建模工作。该项目基于大量样地调查,应用高分辨率(20m×20m)GIS数据网格对(瑞典波罗的海)Laxemar地区的海岸生态系统进行了研究。该模型在核废料埋藏点安全评估工程背景下发展起来,对假想的从计划中的埋藏点中释放的放射性核素的去向加以估计。该评估项目不仅需要深入了解该地生态系统动态,而且需要定量描述系统中物质的储量和通量。通过数据网格建立对生物量的空间分布、初级生产量和净生态系统产量(NEP)等碳收支状况的描述,从而对该地区碳源和碳汇进行定位。结果表明,在盆地内生态系统特征有较大变异;大尺度上,内部盆地为净生产,而外部盆地为净呼吸,甚至包括浅海底栖植物群落。内部盆地区域的底栖过程较之平流过程对碳通量有较大或类似的影响,而外部盆地则相反。预期放射性核素遵循环境中有机物循环路线,这些研究结果切实增强了我们描述和预测它们在生态系统中去向的能力。 | Erik Wijnbladh Bror Fredrik Jnsson Linda Kumblad 马泽清 | 2006 | AMBIO-人类环境杂志2006，35，8： | 2 |
| 19 | Chinese character recognition by the auto recognition system显示文摘 | Jens Hacker Fredrik Engelhardt | 1995 | IEEE International Conference on Neural Networks1995，5，： | 2 |
| 20 | Identification of influential spreaders in complex networks显示文摘 | Kitsak Maksim Gallos Lazaros K Havlin Shlomo Liljeros Fredrik Muchnik Lev Stanley H Eugene Makse Hernán A | 2010 | Nature Physics2010，，11： | 2 |
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