|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 血管内超声去肾交感神经术治疗高血压:一项多中心,国际,单盲,随机,假手术对照试验显示文摘早期研究表明,基于射频的去肾交感神经术可降低中度高血压患者的血压。研究者研究了在没有使用抗高血压药物的情况下,使用血管内超声去。肾交感神经术是否会降低高血压患者的动态血压。 | 刘青 叶鹏 Azizi M Schmieder RE Mahfoud F Weber MA Daemen J Davies J Basile J Kirtane AJ Wang Y Lobo MD Saxena M Feyz L Rader F Lurz P Sayer J Sapoval M Levy T Sanghvi K Abraham J Sharp ASP Fisher NDL Bloch MJ Reeve-Stoffer H Coleman L Mullin C Mauri L | 2018 | 中华高血压杂志2018，26，10： | 27 |
| 2 | Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial显示文摘 | Roger Stupp Monika E Hegi Warren P Mason Martin J van den Bent Martin JB Taphoorn Robert C Janzer Samuel K Ludwin Anouk Allgeier Barbara Fisher Karl Belanger Peter Hau Alba A Brandes Johanna Gijtenbeek Christine Marosi Charles J Vecht Karima Mokhtari Piet | 2009 | Lancet Oncology2009，，5： | 4 |
| 3 | 维生素D对内皮功能的影响:一项随机、双盲、安慰剂对照试验显示文摘在非高血压人群中,低水平的25羟基维生素D[25-hydroxyvitamin D,25(OH)D]已证实与高血压风险增加有关,且维生素D缺乏与内皮功能障碍相关。然而,非高血压人群补充维生素D对内皮细胞功能的影响尚未得到验证。方法: | Borgi L McMullan C Wohlhueter A Curhan GC Fisher ND Forman JP 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，10： | 4 |
| 4 | 高热致胚胎发育毒性机理的研究——热休克蛋白合成显示文摘按Kimmel实验条件热暴露孕10天大鼠。暴露后2小时取胚胎用^(35)S—蛋氨酸标记,SDS—PAGE蛋白分析,可见70和90KilodaltonKD热休克蛋白合成增加。70KD HSP合成用Westernblot分析又进一步得到证实。离体培养胚胎热暴露后,用同样方法分析蛋白,证实70和90KD HSPs合成增加。结果与Kimmel骨骼畸形和胚胎体节融合发生率相符合。本结果为German提出的环境致畸机理假说提供了依据。 | 芦春林 C A Kimmel G L Kimmel D J Heredia B R Fisher N T Brown | 1993 | 北京医科大学学报1993，25，6： | 4 |
| 5 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 6 | Chromodomain-helicase-DNA binding protein 5, 7 and pronecrotic mixed lineage kinase domain-like protein serve as potential prognostic biomarkers in patients with resected pancreatic adenocarcinomas显示文摘Pancreatic cancer is one of the deadliest cancers with a very poor prognosis. Recently, there has been a significant increase in research directed towards identifying potential biomarkers that can be used to diagnose and provide prognostic information for pancreatic cancer. These markers can be used clinically to optimize and personalize therapy for individual patients. In this review, we focused on 3 biomarkers involved in the DNA damage response pathway and the necroptosis pathway: Chromodomainhelicase-DNA binding protein 5, chromodomain-helicaseDNA binding protein 7, and mixed lineage kinase domain-like protein. The aim of this article is to review present literature provided for these biomarkers and current studies in which their effectiveness as prognostic biomarkers are analyzed in order to determine their future use as biomarkers in clinical medicine. Based on the data presented, these biomarkers warrant further investigation,and should be validated in future studies. | Crystal S Seldon Lauren E Colbert William A Hall Sarah B Fisher David S Yu Jerome C Landry | 2016 | World Journal of Gastrointestinal Oncology2016，8，4： | 2 |
| 7 | Tenecteplase Reperfusion therapy in Acute ischaemic Cerebrovascular Events-Ⅱ (TRACE Ⅱ): rationale and design显示文摘Background and purpose Tenecteplase(TNK)is a promising agent for treatment of acute ischaemic stroke(AIS).We hypothesised that recombinant human TNK tissue-type plasminogen activator(rhTNK-tPA)is non-inferior to rt-PA in achieving excellent functional outcome at 90 days,when administered within 4.5 hours of ischaemic stroke onset.Methods and design Tenecteplase Reperfusion therapy in Acute ischemic Cerebrovascular Events(TRACE)is a phase Ⅲ,multicentre,prospective,randomised,open-label,blinded-end point non-inferiority study.Patients eligible for intravenous thrombolysis therapy are randomised to rhTNK-tPA 0.25 mg/kg(single bolus)to a maximum of 25 mg or rt-PA 0.9 mg/kg(10%bolus+90%infusion/1 hour)to a maximum of 90 mg.Medications considered necessary for the patient’s health may be given at the discretion of the investigator during 90-day follow-up.Study outcomes The primary study outcome is excellent functional outcome defined as modified Rankin Scale(mRS)0–1 at 90 days.Secondary efficacy outcomes include favourable functional outcome defined as mRS≤2 at 90 days,ordinal distribution of mRS and major neurological improvement on the National Institutes of Health Stroke Scale.Safety outcomes are symptomatic intracranial haemorrhage within 36 hours and death from any cause.Discussion There is no completed registration study of TNK in AIS worldwide.TRACE Ⅱ strives to provide evidence for a new drug application for rhTNK-tPA in AIS within 4.5 hours through a well-designed and rigorously executed randomised trial in China. | Shuya Li Bruce C V Campbell Lee H Schwamm Marc Fisher Mark Parsons Hao Li Yuesong Pan Yongjun Wang | 2022 | Stroke & Vascular Neurology2022，7，1： | 2 |
| 8 | A controlled clinical trial of high -dose methylprednisolone in the treatment of severe sepsis and septic shock显示文摘 | Bone R C Fisher C J Clemmer T P | 1987 | N Engl J Med1987，317，： | 2 |
| 9 | Object reconstruction by incorporating geometric constraints in reverse engineering显示文摘 | Werghi N Fisher R Robertson C | 1999 | Computer-Aided Design1999，31，6： | 1 |
| 10 | Relation of cerebral vasospasm to subaraclmoid hemorrhage visualized by computerized to mographic scanning显示文摘 | FISHER C M KISTLER J P DAVIS J M | 1980 | Neurosurgery1980，6，： | 1 |
| 11 | Implantation and the placenta key pieces of the development puzzle 显示文摘 | CROSS J C WERB Z FISHER S J | 1994 | Science1994，5190，266： | 1 |
| 12 | Ten year results of a randomized clinical trial comparing radical mastectomy and total mastectomy with and without radiation 显示文摘 | Fisher B Redmond C Fish ER | 1985 | N Engl J Med1985，312，11： | 1 |
| 13 | Joint toque control by a direct feedback for industrial robots显示文摘 | LUH J Y S FISHER W D RICHARD P C P | 1995 | IEEE Trans on Aut Contl1995，64，20： | 1 |
| 14 | Petrology and Crystallization History of Multiphase Sulfide Droplets in a Mafic Dike from Uruguay:Implications for the Origin of Cu-Ni-PGE Sulfide Deposits显示文摘 | Prichard H M Hutchinson D Fisher P C | 2004 | Economic Geology2004，99，： | 1 |
| 15 | Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma,multicentric castleman's disease,and primary effusion lymphoma显示文摘 | Dupin N Fisher C Kellam P | 1999 | Prod Natl Acad Sci U S A1999，96，： | 1 |
| 16 | PEGylation of cytokines and other therapeutic proteins and peptides: the importance of biological optimization of coupling techniques 显示文摘 | Francis C E Fisher D Delgado C | 1998 | Int J Hematol1998，68，3： | 1 |
| 17 | A velocity-modified temperature for the plastic flow of metals 显示文摘 | MacGregor C W Fisher J C | 1946 | Journal of Applied Mechanics Transactions of the ASME1946，13，： | 1 |
| 18 | Phospholipid hydroperox- ides are substrates for non-selenium glutathione peroxidase 显示文摘 | Fisher AB Dodia C Manevich Y | 1999 | J Bi- ol Chem1999，274，21： | 1 |
| 19 | Atomic-scale investiga- tion of defects, dopants, and lithium transport in the LiFePO4 oli- vine-type battery material 显示文摘 | Islam M S Driscoll D J Fisher C A J | 2005 | Chem Mater2005，17，： | 1 |
| 20 | Proboscis lateralis: a rare craniofaeial anomaly, reconstruction, and long-term evaluation 显示文摘 | David LR Sanger C Fisher D | 2008 | J Craniofae Surg2008，19，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员