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| 1 | Insulin sensitizers in treatment of nonalcoholic fatty liver disease:Systematic review显示文摘AIM: To summarize the evidence available for the clinical effectiveness of insulin sensitizers in the treatment of nonalcoholic fatty liver disease (NAFLD) systematically. METHODS: Relevant articles were located using computer-assisted searches of Medline (1966-March 2006), EMBASE (1988-March 2006), CINAHL (1982-March 2003), Educational Resource Information Center (1966-March 2006), Library, Information Science & Technology Abstracts (1967-March 2006), Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects (1994-2006), dissertations in ProQuest and FirstSearch databases. Manual searches were made in the abstracts from meetings of the American Gastroenterological Association (1999-2006), and the American Association for the Study of Liver Diseases (2003-2005). Studies were retrieved using the following selection criteria: (1) clinical trials using insulin sensitizers in subjects with NAFLD, (2) adult patients, (3) published as full manuscripts or abstracts, and (4) English, Spanish, German, and French languages only. Data were abstracted independently by two reviewers following standardized procedures. A face-to- face comparison of data was conducted to ensure the completeness and reliability of the abstraction process. RESULTS: Nine studies were included, six using metformin and three using thiazolidinediones. Only two studies were placebo-controlled trials. The mediansample size for all studies was 18 subjects. In the placebo-controlled trials, metformin improved insulin resistance markers and liver function tests, but not histological scores. In the single-arm trials, metformin and thiazolidinediones improved insulin resistance markers and liver function tests, and beneficial histological changes were reported. There is limited high-quality information available from which to draw categorical conclusions about the clinical use of insulin sensitizers in NAFLD.CONCLUSION: Current information indicates that the use of insulin sensitizers in NAFLD improves insulin resistance and liver function. Histological changes must be corroborated in randomized controlled trials. | Norberto C Chavez-Tapia Tonatiuh Barrientos-Gutierrez Felix I Tellez-ávila Francisco Sánchez-ávila Maria Antonieta Montao-Reyes Misael Uribe | 2006 | World Journal of Gastroenterology2006，12，48： | 11 |
| 2 | PPIs are not associated with a lower incidence of portal-hypertension-related bleeding in cirrhosis显示文摘AIM:To determine if proton pump inhibitor use in cirrhotic patients with endoscopic findings of portal hypertension is associated with a lower frequency of gastrointestinal bleeding.METHODS:Patients with cirrhosis and endoscopic findings related to portal hypertension,receiving or not receiving proton pump inhibitor (PPI) therapy,were included retrospectively.We assigned patients to two groups:group 1 patients underwent PPI therapy and group 2 patients did not undergo PPI therapy.RESULTS:One hundred and five patients with a median age of 58 (26-87) years were included,57 (54.3%) of which were women.Esophageal varices were found in 82 (78%) patients,portal hypertensive gastropathy in 72 (68.6%) patients,and gastric varices in 15 (14.3%) patients.PPI therapy was used in 45.5% of patients (n=48).Seventeen (16.1%) patients presented with upper gastrointestinal bleeding;in 14/17 (82.3%) patients,bleeding was secondary to esophageal varices,and in 3/17 patients bleeding was attributed to portal hypertensive gastropathy.Bleeding related to portal hypertension according to PPI therapy occurred in 18.7% (n=9) of group 1 and in 14% (n=8) of group 2 (odds ratio:0.83,95% confidence interval:0.5-1.3,P=0.51).CONCLUSION:Portal hypertension bleeding is not associated with PPI use.These findings do not support the prescription of PPIs in patients with chronic liver disease with no currently accepted indication. | Mauricio Garcia-Saenz-de-Sicilia Francisco Sanchez-Avila Norberto C Chavez-Tapia Gustavo Lopez-Arce Sandra Garcia-Osogobio Roberto Ruiz-Cordero Felix I Tellez-Avila | 2010 | World Journal of Gastroenterology2010，16，46： | 6 |
| 3 | Prevalence of metabolic syndrome, obesity and diabetes type 2 in cryptogenic cirrhosis显示文摘AIM: To evaluate the prevalence of metabolic syndrome (MS), obesity and type 2 diabetes mellitus (T2DM) in a group of Mexican Mestizo patients with cryptogenic cirrhosis (CC) and to compare this group with patients with cirrhosis secondary to other causes (disease controls). METHODS: Patients with CC, diagnosed between January, 1990 and April, 2005, were included in a retrospective study. Patients with cirrhosis caused by chronic hepatitis C, alcohol abuse or autoimmune hepatitis (AIH) served as disease controls. RESULTS: A total of 134 patients with CC were analyzed. Disease controls consisted of 81 patients with chronic hepatitis C, 33 with alcohol abuse and 20 with AIH. The median age of patients with CC was 57 years (range, 16-87); 83 (61.9%) patients were female; 53 (39.6%) were Child A, 65 (48.5%) Child B, and 16 (11.9%) were Child C cirrhosis. The prevalence of MS (29.1% vs 6%; P < 0.001), obesity (16.4% vs 8.2%; P = 0.04) and T2DM (40% vs 22.4%; P = 0.013) was higher in CC patients than in disease controls. There were no differences in sex, age or liver function tests between the two groups. CONCLUSION: The prevalence of MS, obesityand T2DM were higher in patients with CC than in patients with cirrhosis secondary to others causes. Our findings support the hypothesis that non-alcoholic steatohepatitis (NASH) plays an under-recognized role in CC. | Felix I Tellez-Avila Francisco Sanchez-Avila Mauricio García-Saenz-de-Sicilia Norberto C Chavez-Tapia Ada M Franco-Guzman Gustavo Lopez-Arce Eduardo Cerda-Contreras Misael Uribe | 2008 | World Journal of Gastroenterology2008，14，30： | 6 |
| 4 | Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation显示文摘BACKGROUND Arachidyl amido cholanoic acid(Aramchol)is a potent downregulator of hepatic stearoyl-CoA desaturase 1(SCD1)protein expression that reduces liver triglycerides and fibrosis in animal models of steatohepatitis.In a phase IIb clinical trial in patients with nonalcoholic steatohepatitis(NASH),52 wk of treatment with Aramchol reduced blood levels of glycated hemoglobin A1c,an indicator of glycemic control.AIM To assess lipid and glucose metabolism in mouse hepatocytes and in a NASH mouse model[induced with a 0.1%methionine and choline deficient diet(0.1MCD)]after treatment with Aramchol.METHODS Isolated primary mouse hepatocytes were incubated with 20μmol/L Aramchol or vehicle for 48 h.Subsequently,analyses were performed including Western blot,proteomics by mass spectrometry,and fluxomic analysis with 13C-uniformly labeled glucose.For the in vivo part of the study,male C57BL/6J mice were randomly fed a control or 0.1MCD for 4 wk and received 1 or 5 mg/kg/d Aramchol or vehicle by intragastric gavage for the last 2 wk.Liver metabolomics were assessed using ultra-high-performance liquid chromatography-time of flight-MS for the determination of glucose metabolism-related metabolites.RESULTS Combination of proteomics and Western blot analyses showed increased AMPK activity while the activity of nutrient sensor mTORC1 was decreased by Aramchol in hepatocytes.This translated into changes in the content of their downstream targets including proteins involved in fatty acid(FA)synthesis and oxidation[PACCα/β(S79),SCD1,CPT1A/B,HADHA,and HADHB],oxidative phosphorylation(NDUFA9,NDUFB11,NDUFS1,NDUFV1,ETFDH,and UQCRC2),tricarboxylic acid(TCA)cycle(MDH2,SUCLA2,and SUCLG2),and ribosome(P-p70S6K[T389]and P-S6[S235/S236]).Flux experiments with 13Cuniformely labeled glucose showed that TCA cycle cataplerosis was reduced by Aramchol in hepatocytes,as indicated by the increase in the number of rounds that malate remained in the TCA cycle.Finally,liver metabolomic analysis showed that glucose homeostasis was improved by Aramchol in 0.1MCD fed mice in a dose-dependent manner,showing normalization of glucose,G6P,F6P,UDP-glucose,and Rbl5P/Xyl5P.CONCLUSION Aramchol exerts its effect on glucose and lipid metabolism in NASH through activation of AMPK and inhibition of mTORC1,which in turn activate FAβ-oxidation and oxidative phosphorylation. | David Fernández-Ramos Fernando Lopitz-Otsoa Laura Delacruz-Villar Jon Bilbao Martina Pagano Laura Mosca Maider Bizkarguenaga Marina Serrano-Macia Mikel Azkargorta Marta Iruarrizaga-Lejarreta Jesús Sot Darya Tsvirkun Sebastiaan Martijn van Liempd Felix M Goni Cristina Alonso María Luz Martínez-Chantar Felix Elortza Liat Hayardeny Shelly C Lu JoséM Mato | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 5 | Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12显示文摘 | Birgit Oppmann Robin Lesley Bianca Blom Jackie C Timans Yuming Xu Brisdell Hunte Felix Vega Nancy Yu Jing Wang Komal Singh Francesca Zonin Elena Vaisberg Tatyana Churakova Man-ru Liu Daniel Gorman Janet Wagner Sandra Zurawski Yong-Jun Liu John S Abrams Ke | 2000 | Immunity2000，，5： | 2 |
| 6 | Simultaneous quantification of arachidonic acid metabolites in cultured tumor cells using high-performance liquid chromatography/electrospray ionization tandem mass spectrometry显示文摘 | Kempen E C Yang P Felix E | 2001 | Anal Biochem2001，297，2： | 1 |
| 7 | Variant angina associated with bitter orange in a dietary supplement显示文摘 | Gange C A Madias C Felix Gretzik E M | 2006 | Mayo Clinic Proc2006，81，： | 1 |
| 8 | Latent heat thermal energy storage using cylindrical capsule: Numerical and experimental investigations 显示文摘 | A Felix Regin S C Solanki J S Saini | 2006 | Renewable Energy2006，31，13： | 1 |
| 9 | Environmental impact and management of phosphogypsum 显示文摘 | Hanan T Mohamed C Felix A L | 2009 | Journal of Environmental Man- agement2009，90，8： | 1 |
| 10 | Global Supplier Selection: A Fuzzy-AHP Approach显示文摘 | Felix T S C Kumar N Tiwari M K | 2008 | International Journal ofProductionResearch2008，46，14： | 1 |
| 11 | Assessment of the Urodynamic diagnosis in patients with urinary incontinence associated with normal pressure hydrocephalus 显示文摘 | Felix C Jose LG Jose AP | 2015 | Neurourol Urodyn2015，34，： | 1 |
| 12 | Clinical heterogeneity in autoimmune acute liver failure显示文摘AIM: To describe the outcome and prognosis in a cohort of patients with acute liver failure due to autoimmune hepatitis without liver transplantation. METHODS: A retrospective trial was conducted in 11 patients with acute liver failure due to autoimmune hepatitis who attended the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran. Demographic, biochemical and severity indexes, and treatment and outcome were assessed. RESULTS: Among the 11 patients, with a median age of 31 years, 72% had inflammatory response syndrome, and six patients received corticosteroids. The mortality rate within four weeks was 56%, and the one-year survival was 27%. In the survivors, severity indexes were lower and 83% received corticosteroids. CONCLUSION: We observed a relatively high survival rate in patients with acute liver failure due to autoimmune hepatitis. This survival rate could be influenced by severity of the disease and/or use of corticosteroids. | Norberto C Chavez-Tapia Julio Martinez-Salgado Julio Granados Misael Uribe Felix I Tellez-Avila | 2007 | World Journal of Gastroenterology2007，13，12： | 1 |
| 13 | Preoperative assessment of deep myometrial and cervical invasion in endometrial carcinoma:comparison ofmagnetic resonance imaging and histopathologic evaluation显示文摘 | Vasconcelos C Felix A Cunha TM | 2007 | J Obstet Gynaecol2007，27，8： | 1 |
| 14 | In-line process condition monitoring expert system for injection molding显示文摘 | Felix T s Chan Henry C W Lau Bing Jiang | 2000 | Journal of Materials Processing Technology2000，101，： | 1 |
| 15 | Peripheral osteoma of the mandibular condyle显示文摘 | J C M A Mancini M Woltmann V B Felix | 2005 | Journal of the Chinese Medical Association2005，34，1： | 1 |
| 16 | Panhandle PCR:a technical advance to amplify MLL genomic translocation breakpoints显示文摘 | FELIX C A JONES D H | 1998 | Leukemia1998，12，6： | 1 |
| 17 | Fluorine containing beta-cyclodextrin:a new class of amphiphilic carriers显示文摘 | Granger C E Felix C P Parrot-Lopez H P | 2000 | Tetrahedron Letters2000，41，48： | 1 |
| 18 | The effect of distance from light source on light intensity from curing lights 显示文摘 | Felix C A Price R B | 2003 | J Adhes Dent2003，5，4： | 1 |
| 19 | JOE : A mobile, inverted pendulum显示文摘 | Felix G Aldo D A Silvio C | 2002 | IEEE Transaction on Industrial Electronics2002，49，1： | 1 |
| 20 | The solubility of calcium zincate (CaZn2(OH)6 · 2H2O)显示文摘 | Felix Ziegler Annette C Johnson | 2001 | Cement and Concrete Research2001，31，： | 1 |
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