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| 1 | Colorectal liver metastases: Current management and future perspectives显示文摘The liver is the commonest site of metastatic disease for patients with colorectal cancer,with at least 25%developing colorectal liver metastases(CRLM)during the course of their illness.The management of CRLM has evolved into a complex field requiring input from experienced members of a multi-disciplinary team involving radiology(cross sectional,nuclear medicine and interventional),Oncology,Liver surgery,Colorectal surgery,and Histopathology.Patient management is based on assessment of sophisticated clinical,radiological and biomarker information.Despite incomplete evidence in this very heterogeneous patient group,maximising resection of CRLM using all available techniques remains a key objective and provides the best chance of long-term survival and cure.To this end,liver resection is maximised by the use of downsizing chemotherapy,optimisation of liver remnant by portal vein embolization,associating liver partition and portal vein ligation for staged hepatectomy,and combining resection with ablation,in the context of improvements in the functional assessment of the future remnant liver.Liver resection may safely be carried out laparoscopically or open,and synchronously with,or before,colorectal surgery in selected patients.For unresectable patients,treatment options including systemic chemotherapy,targeted biological agents,intraarterial infusion or bead delivered chemotherapy,tumour ablation,stereotactic radiotherapy,and selective internal radiotherapy contribute to improve survival and may convert initially unresectable patients to operability.Currently evolving areas include biomarker characterisation of tumours,the development of novel systemic agents targeting specific oncogenic pathways,and the potential reemergence of radical surgical options such as liver transplantation. | Jack Martin Angelica Petrillo Elizabeth C Smyth Nadeem Shaida Samir Khwaja HK Cheow Adam Duckworth Paula Heister Raaj Praseedom Asif Jah Anita Balakrishnan Simon Harper Siong Liau Vasilis Kosmoliaptsis Emmanuel Huguet | 2020 | World Journal of Clinical Oncology2020，11，10： | 5 |
| 2 | Clinical profile of diabetes at diagnosis among children and adolescents at an endocrine clinic in Ghana显示文摘AIM To determine the clinical features of diabetes in children and adolescents in Ghana.METHODS Retrospective review of clinical features of all children and adolescents with new-onset diabetes seen at the paediatric endocrinology clinic of Komfo Anokye Teaching Hospital in Kumasi, from February 2012 to Auguest 2016. RESULTS One hundred and six subjects presented with diabetes. Ninety(84.9%) were diagnosed by clinical features and family history as type 1, and 16(15.1%) type 2. For type 1 subjects, age range at diagnosis was 0.9-19.9 year(y), peak age of onset 12-13 year, and 3.3% were < 5 year, 21.1% 5-< 10 year, 45.6% 10-< 15 year and 30.0% 15-< 20 year. Seventy-one point one percent were female. Common clinical features were polyuria(100%), polydipsia(98.9%), and weight loss(82.2%). Mean BMI SD was -0.54, range -3.84 to 2.47. 60.0% presented in diabetic ketoacidosis(DKA). Nine had infections at onset(skin, abscess, leg ulcer). Mean± SD HbA 1c at diagnosis was 12.7% ± 1.9%(115±21 mmol/mol). Four have since died: Hypoglycaemia(2), recurrent DKA(1), osteosarcoma(1). Two other type 1 cases died of DKA at presentation in emergency before being seen by the paediatric endocrinologist. Crude mortality rate including these 2 cases was 32.2/1000 patient years. Type 2 cases were 81% female, age of onset 9-19 year. Mean BMI SD was 1.49, range -0.87 to 2.61. Forty-three point eight percent presented in DKA. All type 2 cases had acanthosis nigricans. Overall, 9.8% did not have home refrigeration, most using clay pot evaporative cooling for insulin storage. CONCLUSION Type 1 occurs with a female preponderance and high DKA rates. Type 2 also occurs. Typology based on clinical features is difficult. Community and professional awareness is warranted. | Emmanuel Ameyaw Serwah B Asafo-Agyei Sumithira Thavapalan Angela C Middlehurst Graham D Ogle | 2017 | World Journal of Diabetes2017，8，9： | 2 |
| 3 | Modeling Erbium - Doped Fiber Amplifiers显示文摘 | Randy Giles C Emmanuel Desurvire | 1991 | Journal of Lightwave Technology1991，9，2： | 2 |
| 4 | Early dynamic transcriptomic changes during preoperative radiotherapy in patients with rectal cancer: A feasibility study显示文摘AIM: To develop novel biomarkers of rectal radiotherapy, we measured gene expression profiles on biopsies taken before and during preoperative radiotherapy. METHODS: Six patients presenting with a locally advanced rectal cancer (T>T2, N0/Nx, M0) eligible for preoperative radiotherapy (45 Gy in 25 fractions) were selected in a pilot study. Six tumor and 3 normal tissues biopsies were taken before and during radiotherapy,after a dose of 7.2 Gy at a median time of 1 h following irradiation (0:27-2:12). Tumor or normal tissue purity was assessed by a pathologist prior to RNA extraction. Mean RNA content was 23 μg/biopsy (14-37) before radiotherapy and 22.7 μg/biopsy (12-35) during radiotherapy. After RNA amplification, biopsies were analysed with 54K HG-U133A Plus 2.0 Affymetrix expression micro-arrays. Data were normalized according to MAS5 algorithm. A gene expression ratio was calculated as: (gene expression during radiotherapy-gene expression before radiotherapy)/gene expression before radiotherapy. Were selected genes that showed a ratio higher than ± 0.5 in all 6 patients. RESULTS: Microarray analysis showed that preoperative radiotherapy significantly up-regulated 31 genes and down-regulated 6 genes. According to the Gene Ontology project classification, these genes are involved in protein metabolism (ADAMDEC1 ; AKAP7 ; CAPN5 ; CLIC5 ; CPE ; CREB3L1 ; NEDD4L ; RAB27A), ion transport (AKAP7 ; ATP2A3 ; CCL28 ; CLIC5 ; F2RL2 ; NEDD4L ; SLC6A8), transcription (AKAP7 ; CREB3L1 ; ISX ; PAB-PC1L ; TXNIP), signal transduction (CAPN5 ; F2RL2 ; RA- B27A ; TNFRSF11A), cell adhesion (ADAMDEC1 ; PXDN ; SPON1 ; S100A2), immune response (CCL28 ; PXDN ; TNFRSF11A) and apoptosis (ITM2C ; PDCD4 ; PVT1). Up-regulation of 3 genes (CCL28 ; CLIC5 ; PDCD4) was detected by 2 different probes and up-regulation of 2 genes (RAB27A ; TXNIP) by 3 probes. CONCLUSION: Micro-arrays can efficiently assess early transcriptomic changes during preoperative radiotherapy for rectal cancer, and may help better understand tumor radioresistance. | Stephane Supiot Wilfried Gouraud Loc Campion Pascal Jezéquel Bruno Buecher Josiane Charrier Marie-Francoise Heymann Marc-Andre Mahé Emmanuel Rio Michel Chérel | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 5 | Ultrasonographic diagnosis of hepatic fibrosis or cirrhosis显示文摘 | Christophe Aubé Frédéric Oberti Nouri Korali Marc-Antoine Namour Didier Loisel Jean-Yves Tanguy Emmanuelle Valsesia Christophe Pilette Marie Christine Rousselet Pierre Bedossa Hervé Rifflet Moussa Y Ma?ga Dominique Penneau-Fontbonne Christine Caron Paul C | 1999 | Journal of Hepatology1999，，3： | 2 |
| 6 | Visual censuses of tropical fish aggregations on artificial reefs : slate versus video recording techniques 显示文摘 | Emmanuel T Pascale C Karine P | 2005 | Journal of Experimental Marine Biology and Ecology2005，315，： | 1 |
| 7 | A novel ligin on poplar trees with a reduced caffeicacid/5-hydroxyferulic acid O-methyl-transferase activity显示文摘 | Janvan D Marie B Emmanuelle C | 1995 | Plant Journal1995，8，6： | 1 |
| 8 | Study of 17 β-estradiol-5-benzoate, 17 α-methyltestosterone and medroxyprogesterone acetate fixation in bovine hair显示文摘 | LAURIANE R EMMANUELLE B NORA C | 2005 | Anal Chim Acta2005，532，2： | 1 |
| 9 | Amiodarone reduces transmural heterogeneity of repolarization in the human heart显示文摘 | Emmanuel D Gilles L Flavien C | 1998 | JACC1998，32，： | 1 |
| 10 | Aluminium, titanium boride, and nitride films sputter-deposited from muhicomponent alloy targets studied by XPS显示文摘 | Emmanuel C Onyiriuka | 1993 | Appl Spectrosc1993，47，1： | 1 |
| 11 | Stated and reported route diversion behavior: implications of benefits of advanced traveler information systems 显示文摘 | Asad K Adib K Emmanuel L C | 1994 | Transportation Research Record1994，1464，： | 1 |
| 12 | Multi-institutional validation of a symptom based classification for renal cell carcinoma 显示文摘 | JEAN-JACQUES P EMMANUELLE L LUCA C | 2004 | J Urol2004，172，： | 1 |
| 13 | The composition of octopus renal fluid I Inorganic constitution显示文摘 | Emmanuel C F Martin A W | 1956 | Z vergl Physiol1956，39，： | 1 |
| 14 | Benign par-oxysmal positional vertigo : 10-year experience in treating592 patients with cannaiith repositioning procedure 显示文摘 | Emmanuel P Theognosia C Minas T | 2005 | Laryngoscope2005，115，9： | 1 |
| 15 | Peritoneal dialysis in acute kidney injury: lessons learned and applied 显示文摘 | Emmanuel A B Rajasekara C | 2011 | Seminars in Dialysis2011，24，2： | 1 |
| 16 | Fast Discrete Curvelet Transforms 显示文摘 | Emmanuel C Laurent D David D | 2005 | Multiscale Modeling & Simulation(S 1540-3459)2005，5，3： | 1 |
| 17 | Performance Measurement in Blind Audio Source Separateion 显示文摘 | EMMANUEL VINCENT R GRIBONVAL C FEVOTTE | 2006 | IEEE Transactions on Audio Speech and Language Processing2006，14，4： | 1 |
| 18 | Mapping wound-response genes involved in post-harvest physiological deterio-ration(PPD)of cassava(Manihot esculenta Crantz)显示文摘 | DIEGO F C KIM R EMMANUEL O | 2002 | Euphytica2002，128，： | 1 |
| 19 | Hydration mechanisms and swelling behavior of Na-Magadiite显示文摘 | Céline Eypert-Blaison Emmanuel Sauzéat Manuel Pelletier | 2001 | Chem Mater2001，13，： | 1 |
| 20 | Dual Src and Abl inhibitors target wild type Abl and the AblT315I Imatinib-resistant mutant with different mechanisms显示文摘 | Emmanuele C Marco R Samantha Z | 2010 | Bioorg Med Chem2010，18，11： | 1 |
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