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| 1 | Chemotherapy and its evolving role in the management of advanced prostate cancer显示文摘当查尔斯·哈金斯首先在管理这些病人描述了外科的阉割的角色时,先进前列腺癌症作为自从 1940 年代,对雄激素剥夺应答被认出了。然而,雄激素剥夺仅仅为绝大多数人导致短暂疾病控制,与那些尽管有,进行阉割作为有阉割抵抗的前列腺癌症(CRPC ) 标记的睾丸激素层次。直到 2004,为这些病人的治疗学的竞技场仍然保持停滞,没有代理人在 CRPC 背景显示出幸存获得。二份里程碑出版物由提供 ‘ 改变了前列腺癌症治疗风景; level-1 evidence’那基于 docetaxel 的化疗在全面幸存(OS ) 导致了延伸。这被 cabazitaxel 的赞同根据与 docetaxel 在病人 pretreated 表明它的功效的阶段 III 数据在 2010 跟随。更最近,很多个下一代的指导雄激素的代理人(例如 abiraterone 和 enzalutamide ) 也被显示了与 CRPC 在人导致一个幸存好处。与可得到的那么多新治疗选择,很多个问题留下。这些包括:怎么最好与这些更新的神经质的代理人定序化疗,在 taxanes 和指导雄激素的代理人之间的抗力移转的临床的含意并且它病人的子集可以从化疗的早使用有益于大多数。这评论将在当前的时代在先进前列腺癌症的管理提供化疗的演变角色的概述。 | Michael T Schweizer Emmanuel S Antonarakis | 2014 | Asian Journal of Andrology2014，16，3： | 6 |
| 2 | Review of the malaria epidemiology and trends in Zambia显示文摘A comprehensive desk review of malaria trends was conducted between 2000-2010 in Zambia to study malaria epidemiology and trends to guide strategies and approaches for effective malaria control.This review considered data from the National Health Information Management System,Malaria Surveys and Programme Review reports and analyzed malaria in-patient cases and deaths in relation to intervention coverage for all ages.Data showed three distinct epidemiological strata after a notable malaria reduction(66%)in in-patient cases and deaths,particularly between 2000-2008.These changes occurred following the(re-)introduction and expansion of indoor residual spraying up to 90%coverage,scale-up of coverage of long-lasting insecticidetreated nets in household from 50%to 70%,and artemisin-based combination therapy nationwide.However,malaria cases and deaths re-surged,increasing in 2009-2010 in the northern-eastern parts of Zambia.Delays in the disbursement of funds affected the implementation of interventions,which resulted in resurgence of cases and deaths.In spite of a decline in malaria disease burden over the past decade in Zambia,a reversal in impact is notable in the year 2009-2010,signifying that control gains are fragile and must be sustained toeliminate malaria. | Freddie Masaninga Emmanuel Chanda Pascalina Chanda-Kapata Busiku Hamainza Hieronymo T Masendu Mulakwa Kamuliwo Wambinji Kapelwa John Chimumbwa John Govere Mac Otten Ibrahima Soce Fall Olusegun Babaniyi | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，2： | 2 |
| 3 | Human intestinal parasitism,potable water availability and methods of sewage disposal among nomadic Fulanis in Kuraje rural settlement of Zamfara state显示文摘Objective:To ascertain the level of intestinal parasites vis-a-vis the quality of housing and water supply,and sanitary conditions among the people of Kuraje village in Zamfara state. Methods:The study was cross sectional in nature.Individual households were selected using systematic random sampling methods and pre-tested questionnaires were administered to all the members of each household.Stool samples were collected and processed using standard laboratory procedures.Housing conditions,sources of water and sanitary conditions of the households were also inspected.Results were analysed using Epi Info 2006 model.Results: The prevalence of intestinal parasites was 67.0%(347/519).72.3%(251/347),17.0%(59/347),and 10.7%(37/347) had one,two and three or more parasites,respectively.The associated factors with intestinal parasites were poor housing and sanitary conditions,lack of potable water and illiteracy.The commonest parasites encountered were hookworm(22.0%),Ascaris lumbricoides (18.5%),and Strongyloides stercoralis(15.6%) while the least common was Enterobius vermicularis (1.6%).Others were Giardia lamblia(5.7%),Hymenolepsis nana(5.0%),Trichuris trichiura(8.8%), Entamoeba histolytica(14.4%) and Schistosoma mansoni(8.4%).Conclusions:The infection rate of intestinal parasites in Kuraje village is high.More efforts should be intensified towards improvement in sanitary and housing standards,supply of potable water and institution of a more comprehensive literacy programme for the people of the community. | Godwin T Jombo James G Damen Hauwa Safiyanu Friday Odey Emmanuel M Mbaawuaga | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，6： | 2 |
| 4 | Visual censuses of tropical fish aggregations on artificial reefs : slate versus video recording techniques 显示文摘 | Emmanuel T Pascale C Karine P | 2005 | Journal of Experimental Marine Biology and Ecology2005，315，： | 1 |
| 5 | Three-dimensional finite volume computation of viscoelastic fluid encapsulation by phase-field modeling显示文摘 | Domenico Borzacchiello Emmanuel Leriche Beno?t Blottière Jacques Guillet | 2012 | Journal of Non-Newtonian Fluid Mechanics2012，，： | 1 |
| 6 | FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer:A randomized GERCOR study显示文摘 | Christophe T Thierry A Emmanuel A | 2004 | Clin on Co2004，22，2： | 1 |
| 7 | Benign par-oxysmal positional vertigo : 10-year experience in treating592 patients with cannaiith repositioning procedure 显示文摘 | Emmanuel P Theognosia C Minas T | 2005 | Laryngoscope2005，115，9： | 1 |
| 8 | Prucalopride, a systemic enterokinetic, for the treatment of constipation 显示文摘 | Emmanuel A Roy A Nicholls T | 2002 | Aliment Pharmacol Ther2002，16，7： | 1 |
| 9 | Decreased expression of Toll-like receptor-4 and MD-2correlates with intestinal epithelial cell protection againstdysregulated proinflammatory gene expression in responseto bacterial,lipopolysaccharide 显示文摘 | Maria T Abreu Puja Vora Emmanuelle Faure | 2001 | J Exp Med2001，167，3： | 1 |
| 10 | A wildfire model for the estimation of the temperature rise of an overhead line conductor显示文摘 | Emmanuel I K Panagiotis T T John S K | 2010 | IEEE Transactions on Power Delivery~2010，25，2： | 1 |
| 11 | Lovastatin stimulates human vascular smooth muscle cellexpression of bone morphogenetic protein-2,a potent inhibitor oflow-density lipoprotein-stimulated cell growth 显示文摘 | EMMANUELE L ORTMANN J DOERFLINGER T | 2003 | Biochemicaland biophysical research communications2003，302，1： | 1 |
| 12 | Anti-TNF-a therapies:the next generation 显示文摘 | MICHAEL A P FRANCES R B EMMANUEL A T | 2003 | Nat Rev Drug Discov2003，2，9： | 1 |
| 13 | Pillared graphene: A new 3-D network nanostructure for enhanced hydrogen storage显示文摘 | Georgios K D Emmanuel T George E F | 2008 | Nano Lett2008，8，10： | 1 |
| 14 | New chemical tools for investigating human mitotic kinesin Eg5显示文摘 | Emmanuel K Salvatore D Bernd T | 2007 | Bioorganic & Medicinal ChemistD2007，15，： | 1 |
| 15 | Outcome and Cost Analysis of Sacral Nerve Modulation for Treating Urinary and/or Fecal Incontinence显示文摘 | Anne-Marie Leroi Xavier Lenne Beno?t Dervaux Emmanuel Chartier-Kastler Brigitte Mauroy Lo?c Le Normand Philippe Grise Jean-Luc Faucheron Yann Parc Paul-Antoine Lehur Fran?ois Mion Henri Damon Xavier Barth Albert Leriche Christian Saussine Laurent Guy Fran | 2011 | Annals of Surgery2011，，4： | 1 |
| 16 | Compatibilizing Poly( vinylidene fluoride)/Nylon-6 Blends with Nanoclay显示文摘 | Loan T V Emmanuel P G | 2007 | Macro molecules2007，40，23： | 1 |
| 17 | Protein adsorption on nanocrystalline Ti02 films, an immobilization strategy for bioanalytical devices 显示文摘 | Emmanuel T Durrent J R | 1998 | Anal Chem1998，70，： | 1 |
| 18 | Fractal approach for signal processing and application to the diagnosis of cavitation显示文摘 | PATRICE S EMMANUEL L T | 2000 | Mechanical Systems and Signal Processing2000，14，3： | 1 |
| 19 | Immobilisafion and bioelectrochemistry of proteins on nanoporous TiO2 and ZnO films 显示文摘 | Emmanuel T Anthony E G C Brian O' Regan | 2001 | J Electroanal Chem2001，517，： | 1 |
| 20 | Immobilisation and bioelectrochemistry of proteins on nanoporous TiO2 and ZnO films 显示文摘 | Emmanuel T Anthony E G C | 2001 | J Electroanal Chem2001，517，12： | 1 |
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