| 5 | Social-epigeneticmediators for racial disparities in pulmonary impairment among childhood cancer survivors显示文摘Dear Editor Previous research found that childhood cancer survivors of African ancestry have significantly higher morbidity and mortality than those of European ancestry[1].However,after adjusting for socio-economic factors,the magnitudes of racial health disparities are either substantially decreased or become statistically non-significant[1],suggesting that social and economic determinants may contribute to racial health disparities.Recently,we conducted epigenome-wide association studies(EWAS)for three key social determinants of health(SDOHs),namely,personal educational attainment,personal income,and neighborhood deprivation among survivors of childhood cancer,where 130 epigenome-wide significant SDOH-CpG associationswere identified among European ancestry survivors,and 25 of which were also validated in African ancestry survivors[2].Notably,many SDOH-associated CpG sites are also associated with tobacco use. | Nan Song Qian Dong Cheng Chen Qian Li Heather Mulder Emily Plyler John Easton Emily Walker Scott Olson Geoffrey Neale Kevin RKrull Deo Kumar Srivastava Kirsten K.Ness Jinghui Zhang Melissa M.Hudson Leslie L.Robison I-Chan Huang Zhaoming Wang | 2023 | Cancer Communications2023，43，2： | 0 |
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