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| 1 | LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity显示文摘Den dritic cells(DCs)play a pivotal role in priming adaptive immunity.However,the in volveme nt of DCs in con trolling excessive and deleterious T cell responses remains poorly defined.Moreover,the metabolic dependenee and regulation of DC function are unclear.Here we show that LKB1 signaling in DCs functions as a brake to restrain excessive tumor-promoting regulatory T cell(Treg)and Th17 cell responses,thereby promoting protective anti-tumor immunity and maintaining proper immune homeostasis.LKB1 deficiency results in dysregulated metabolism and mTOR activation of DCs.Loss of LKB1 also leads to aberrant DC maturation and production of cytokines and immunoregulatory molecules.Blocking mTOR signaling in LKB1-deficient DCs partially rectifies the abno rmal phe no types of DC activation and Treg expansio n,whereas unc on trolled Th17 resp on ses depend upon IL-6-STAT3 signaling.By coordi nating metabolic and immune quiesce nee of DCs,LKB1 acts as a crucial signali ng hub in DCs to enforce protective anti-tumor immunity and normal immune homeostasis. | Yanyan Wang Xingrong Du Jun Wei Lingyun Long Haiyan Tan Cliff Guy Yogesh Dhungana Chenxi Qian Geoffrey Neale Yang-Xin Fu Jiyang Yu Junmin Peng Hongbo Chi | 2019 | Cell Research2019，29，5： | 3 |
| 2 | A multi-center prospective cohort study of benign breast diseaseand risk of subsequent breast cancer显示文摘 | Geoffrey CKabat Joan GJones Neal Olson | 2010 | Cancer Causes Control2010，21，23： | 1 |
| 3 | Transgenic switchgrass ( Panicum virgatum L.) biomass is increased by overexpression of switchgrass sucrose synthase ( PvSUS1 )显示文摘 | Charleson R. Poovaiah Mitra Mazarei Stephen R. Decker Geoffrey B. Turner Robert W. Sykes Mark F. Davis C. Neal Stewart | 2015 | Biotechnology Journal2015，，4： | 1 |
| 4 | A multi-center prospective cohort study of benign breast disease and risk of subsequent breast cancer显示文摘 | Geoffrey C Kabat Joan G Jones Neal Olson | 2010 | Cancer Causes Control2010，21，14： | 1 |
| 5 | Seasonal intermittent preventive treatment with artesunate and sulfadoxine-pyrimethamine for prevention of malaria in Senegalese children: a randomised, placebo-controlled, double-blind trial显示文摘 | Badara Cissé Cheikh Sokhna Denis Boulanger Jacqueline Milet El Hadj Ba Keshena Richardson Rachel Hallett Colin Sutherland Kirsten Simondon Fran?ois Simondon Neal Alexander Oumar Gaye Geoffrey Targett Jo Lines Brian Greenwood Jean-Fran?ois Trape | 2006 | The Lancet2006，，9511： | 1 |
| 6 | Social-epigeneticmediators for racial disparities in pulmonary impairment among childhood cancer survivors显示文摘Dear Editor Previous research found that childhood cancer survivors of African ancestry have significantly higher morbidity and mortality than those of European ancestry[1].However,after adjusting for socio-economic factors,the magnitudes of racial health disparities are either substantially decreased or become statistically non-significant[1],suggesting that social and economic determinants may contribute to racial health disparities.Recently,we conducted epigenome-wide association studies(EWAS)for three key social determinants of health(SDOHs),namely,personal educational attainment,personal income,and neighborhood deprivation among survivors of childhood cancer,where 130 epigenome-wide significant SDOH-CpG associationswere identified among European ancestry survivors,and 25 of which were also validated in African ancestry survivors[2].Notably,many SDOH-associated CpG sites are also associated with tobacco use. | Nan Song Qian Dong Cheng Chen Qian Li Heather Mulder Emily Plyler John Easton Emily Walker Scott Olson Geoffrey Neale Kevin RKrull Deo Kumar Srivastava Kirsten K.Ness Jinghui Zhang Melissa M.Hudson Leslie L.Robison I-Chan Huang Zhaoming Wang | 2023 | Cancer Communications2023，43，2： | 0 |
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