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| 1 | 卒中存活者体力活动和锻炼建议:美国心脏协会/美国卒中协会针对医疗专业人员的声明显示文摘目的这份科学声明为卒中存活者的体力活动和锻炼建议提供了一份证据纵览。证据提示,卒中存活者会经历体力下降(physical deconditioning)并导致久坐的生活方式。因此,本更新版科学声明旨在为医务人员提供全面的指导,使其更好地理解体力活动的益处,并为卒中存活者各个恢复阶段的锻炼方案提供推荐意见。方法写作组成员由美国心脏协会(American Heart Association,AHA)卒中委员会的科学声明监督委员会和AHA手稿监督委员会任命。作者利用系统文献综述,参考公开发表的临床和流行病学研究、发病率和死亡率报告、临床与公共卫生指南、权威声明、个人文件以及专家意见,对现有的证据进行总结并指出目前的知识空白。结果卒中后体力活动不足非常普遍。大量证据明确支持对卒中存活者进行运动训练,包括有氧运动和力量训练。运动训练能改善功能能力、日常生活活动的执行能力以及生活质量,同时降低随后的心血管事件风险。卒中存活者的体力活动目标和锻炼方案需个体化制定以最大限度地增高长期依从性。结论写作组给出的推荐是,体力活动和锻炼方案应融入卒中存活者的治疗。卒中存活者体力活动的推动应强调低到中等强度的有氧活动、增强肌肉力量、减少久坐的生活方式以及对卒中二级预防的危险因素管理。 | Sandra A. Billinger Ross Arena Julie Bemhardt Janice J. Eng Barry A. Franklin Cheryl Mortag Johnson Marilyn MacKay-Lyons Richard F. Macko Gillian E. Mead Elliot J. Roth Marianne Shaughnessy Ada Tang 孙新亭 张通 | 2014 | 国际脑血管病杂志2014，22，10： | 80 |
| 2 | Ultrafast epitaxial growth of metre-sized single-crystal graphene on industrial Cu foil显示文摘A foundation of the modern technology that uses single-crystal silicon has been the growth of highquality single-crystal Si ingots with diameters up to 12 inches or larger. For many applications of graphene, large-area high-quality(ideally of single-crystal) material will be enabling. Since the first growth on copper foil a decade ago, inch-sized single-crystal graphene has been achieved. We present here the growth, in 20 min, of a graphene film of(5 ×50) cm^2 dimension with >99% ultra-highly oriented grains.This growth was achieved by:(1) synthesis of metre-sized single-crystal Cu(1 1 1) foil as substrate;(2)epitaxial growth of graphene islands on the Cu(1 1 1) surface;(3) seamless merging of such graphene islands into a graphene film with high single crystallinity and(4) the ultrafast growth of graphene film.These achievements were realized by a temperature-gradient-driven annealing technique to produce single-crystal Cu(1 1 1) from industrial polycrystalline Cu foil and the marvellous effects of a continuous oxygen supply from an adjacent oxide. The as-synthesized graphene film, with very few misoriented grains(if any), has a mobility up to ~23,000 cm^2 V^(-1)s^(-1)at 4 K and room temperature sheet resistance of ~230 Ω/□. It is very likely that this approach can be scaled up to achieve exceptionally large and high-quality graphene films with single crystallinity, and thus realize various industrial-level applications at a low cost. | Xiaozhi Xu Zhihong Zhang Jichen Dong Ding Yi Jingjing Niu Muhong Wu Li Lin Rongkang Yin Mingqiang Li Jingyuan Zhou Shaoxin Wang Junliang Sun Xiaojie Duan Peng Gao Ying Jiang Xiaosong Wu Hailin Peng Rodney S. Ruoff Zhongfan Liu Dapeng Yu Enge Wang Feng Ding Kaihui Liu | 2017 | Science Bulletin2017，62，15： | 40 |
| 3 | Nitric oxide synthase and heme oxygenase expressions in human liver cirrhosis显示文摘瞄准:门静脉高血压是肝肝硬化的普通复杂并发症。肝内压力能以几个方法被提高。从内脏的内脏影响脉管系统, vasoconstrictors 的增加和增加的循环进门静脉系统的反常建筑学都可以作出贡献。因而内长的血管扩张药也许能减轻高血压。我们因此试图调查内长的血管扩张药的层次,氮的氧化物(没有) 并且通过氮的氧化物 synthase (NOS ) 的表示的一氧化碳(公司) 并且他我氧合酶(惊讶) 。方法:肝脏硬化症(n=20 ) 并且非肝脏硬化症(n=20 ) 肝从经历了外科的病人被获得。NOS 的各种各样的 isoforms 的 mRNA 和蛋白质表情并且惊讶用竞争 PCR,西方的污点和免疫组织化学被检验。结果:当内皮 NOS (eNOS ) 在硬变肝是起来调整的时,在可诱导的 NOS (i NOS ) 或神经元 NOS (nNOS ) 表情没有重要变化。附随地, caveolin-1, eNOS 的一个确定的下面管理者,是起来调整的。可诱导的 HO-1 和组成的 HO-2 被发现在不同本地化在硬变肝虽然显示出增加的表示。结论:NOS 表示力量的差别由于他们在在肝硬化的病理维持肝动态平衡或参与的不同角色。在高血压的肝以内的纯粹的应力可以导致 eNOS 的增加的表示。接着, caveolin-1 也被增加。这是否对进一步的肝硬化用作一个防御机理或是肝硬化的后果,是还未知的。HO-1 和 HO-2 的提高的表示建议公司可以微弱地作为血管扩张药虽然在它的角色补偿。它是可能的那个公司并且不在肝以内有平行或协调的功能并且可以在门静脉高血压的病理生理学反对地工作。 | Beatrice J Goh Bee Tee Tan Wei Min Hon Kang Hoe Lee Hoon Eng Khoo | 2006 | World Journal of Gastroenterology2006，12，4： | 19 |
| 4 | 一种社交网络虚假信息传播控制方法显示文摘针对社交网络中日渐泛滥的虚假信息,提出了一种社交网络虚假信息传播控制方法Fidic,针对社交网络中虚假信息传播时途经的用户序列,该方法基于PageRank的思想并结合用户传播虚假信息时的指向关系来对用户进行评级,用户的评级越高表明其在虚假信息传播过程中起到的作用越大.该方法通过控制高评级用户的传播行为从而缩小虚假信息传播的覆盖面,最终达到遏制甚至消除虚假信息传播的目的.实验证明该方法既可以获得较高的精度,而且方便可行,具有较高实用价值. | 王永刚 蔡飞志 Eng Keong Lua 胡建斌 陈钟 | 2012 | 计算机研究与发展2012，49，S2： | 18 |
| 5 | Construction and Co-expression of Grass Carp Reovirus VP6 Protein and Enhanced Green Fluorescence Protein in the Insect Cells显示文摘Grass carp reovirus(GCRV),a disaster agent to aquatic animals,belongs to Genus Aquareovirus of family Reoviridea.Sequence analysis revealed GCRV genome segment 8(s8) was 1 296 bp nucleotides in length encoding an inner capsid protein VP6 of about 43kDa.To obtain in vitro non-fusion expression of a GCRV VP6 protein containing a molecular of fluorescence reporter,the recombinant baculovirus,which contained the GCRVs8 and eGFP(enhanced green fluorescence protein) genes,was constructed by using the Bac-to-Bac insect expression system.In this study,the whole GCRVs8 and eGFP genes,amplified by PCR,were constructed into a pFastBacDual vector under polyhedron(PH) and p10 promoters,respectively.The constructed dual recombinant plasmid(pFbDGCRVs8/eGFP) was transformed into DH10Bac cells to obtain recombinant Bacmid(AcGCRVs8/eGFP) by transposition.Finally,the recombinant bacluovirus(vAcGCRVs8/eGFP) was obtained from transfected Sf9 insect cells.The green fluorescence that was expressed by transfected Sf9 cells was initially observed 3 days post transfection,and gradually enhanced and extended around 5 days culture in P1(Passage1) stock.The stable high level expression of recombinant protein was observed in P2 and subsequent passage budding virus(BV) stock.Additionally,PCR amplification from P1 and amplified P2 BV stock further confirmed the validity of the dual-recombinant baculovirus.Our results provide a foundation for expression and assembly of the GCRV structural protein in vitro. | Qin FANG Eng Khuan Seng Wen DAI Lan-lan ZHANG | 2007 | 中国病毒学2007，22，5： | 13 |
| 6 | Poor performance of the modified early warning score for predicting mortality in critically ill patients presenting to an emergency department显示文摘BACKGROUND:This study was undertaken to validate the use of the modified early warning score(MEWS) as a predictor of patient mortality and intensive care unit(ICU)/ high dependency(HD)admission in an Asian population.METHODS:The MEWS was applied to a retrospective cohort of 1 024 critically ill patients presenting to a large Asian tertiary emergency department(ED) between November 2006 and December2007.Individual MEWS was calculated based on vital signs parameters on arrival at ED.Outcomes of mortality and ICU/HD admission were obtained from hospital records.The ability of the composite MEWS and its individual components to predict mortality within 30 days from ED visit was assessed.Sensitivity,specificity,positive and negative predictive values were derived and compared with values from other cohorts.A MEWS of ≥4 was chosen as the cut-off value for poor prognosis based on previous studies.RESULTS:A total of 311(30.4%) critically ill patients were presented with a MEWS ≥4.Their mean age was 61.4 years(SD 18.1) with a male to female ratio of 1.10.Of the 311 patients,53(17%)died within 30 days,64(20.6%) were admitted to ICU and 86(27.7%) were admitted to HD.The area under the receiver operating characteristic curve was 0.71 with a sensitivity of 53.0%and a specificity of 72.1%in addition to a positive predictive value(PPV) of 17.0%and a negative predictive value(NPV)of 93.4%(MEWS cut-off of ≥4) for predicting mortality.CONCLUSION:The composite MEWS did not perform well in predicting poor patient outcomes for critically ill patients presenting to an ED. | Le Onn Ho Huihua Li Nur Shahidah Zhi Xiong Koh Papia Sultana Marcus Eng Hock Ong | 2013 | World Journal of Emergency Medicine2013，4，4： | 12 |
| 7 | Nonlinear Dynamics and Stability of Neural Networks with Delay-Time显示文摘In this paper we study the dynamic properties and stabilities of neural networks with delay-time (which includes the time-varying case) by differential inequalities and Lyapunov function approaches. The criteria of connective stability, robust stability, Lyapunov stability, asymptotic atability, exponential stability and Lagrange stability of neural networks with delay-time are established, and the results obtained are very useful for the design, implementation and application of adaptive learning neural networks. | L. C. Jiao, member, IEEE, and Zheng Bao, Senior member, IEEECenter for Neural Networks and Institute of Elec. Eng, Xidian University, Xian 710071, China | 1992 | Journal of Systems Engineering and Electronics1992，3，2： | 11 |
| 8 | Male sexual dysfunction in Asia显示文摘性总是是在亚洲社会的一个禁忌题目。在过去几年,然而,人的性健康的领域里的了解改善了,并且对性健康研究的兴趣最近增加了。在亚洲的可勃起的机能障碍,性腺机能减退和早泄的传染病学和流行在韦斯特是类似的。然而,几个问题对亚洲男性特定,包括文化和信仰,了解,依从和传统 / 补足的药的可获得性。在亚洲,性药仍然在它的幼年期,并且从政府,相关社会,医生和媒介的一个一致努力被要求推进性药到护理的最前线。 | Christopher CK Ho Praveen Singam Goh Eng Hong Zulkifli Md Zainuddin | 2011 | Asian Journal of Andrology2011，13，4： | 10 |
| 9 | 对称和非对称型摩擦耗能连接的抗震性能与设计方法研究现状显示文摘该文综述了对称和非对称型摩擦耗能连接40多年以来的发展历史和研究现状。摩擦耗能连接可用于结构的减震耗能,通过合理设计可实现地震作用下带摩擦耗能连接结构的低损伤,提高结构的韧性。研发滞回性能稳定、重复性好的摩擦耗能连接是相关研究的主要目标之一。该文从微观和宏观两个方面介绍了金属滑移面之间的摩擦磨损机理,从摩擦磨损的角度讨论了不同摩擦片材料对摩擦连接减震性能的影响。描述了螺栓预紧力大小对摩擦连接减震性能的影响,也总结了摩擦连接的抗腐蚀和抗火性能。阐述了摩擦耗能连接在钢结构支撑、梁柱节点和柱脚节点的应用,并介绍了相关节点的设计方法。对此类连接的关键技术进行了总结,并对该技术的后续研究进行了展望。 | Kim Eng Chouery 樊奎 贾良玖 | 2021 | 工程力学2021，38，5： | 10 |
| 10 | 日粮中添加桑叶粉对扬州鹅饲料利用率及生长和屠宰性能的影响显示文摘在扬州鹅的基础饲料中分别添加0%、2%、4%、6%和8%5种不同质量分数的桑叶粉,分析添食桑叶粉对扬州鹅饲料利用率以及鹅生长性能、生理生化指标和屠宰性能的影响。结果显示,随着桑叶粉添加量的增加,饲料中的干物质、粗灰分、粗蛋白、粗纤维、粗脂肪、钙、磷以及能量利用率均呈现下降趋势;与对照组相比,饲粮中添加6%和8%桑叶粉可显著降低扬州鹅的平均日增体质量(P<005),提高仔鹅的料重比;添加2%桑叶粉可在一定程度上增加胸肌厚度,但添加量达到4%时又有所下降;饲料中添加桑叶粉能降低扬州鹅血液中的总胆固醇和甘油三酯含量以及碱性磷酸酶活性;随着桑叶粉添加量的增加,仔鹅半净膛率有所下降,肝脏质量减小,腹脂率下降。综合上述试验结果,确定扬州鹅日粮中的最佳桑叶粉添加量为4%。 | 赵卫国 孙梦琦 侯启瑞 杨海明 黄先智 方荣俊 Eng Andres Diaz Veiga 李龙 | 2019 | 蚕业科学2019，45，3： | 8 |
| 11 | Comparison of peripapillary retinal nerve fiber layer thickness between myopia severity groups and controls显示文摘AIM: To compare the peripapillary retinal nerve fiber layer(RNFL) thickness measured via optical coherence tomography(OCT) between different groups of myopia severity and controls. METHODS: This was a prospective cross-sectional study. All subjects underwent a full ophthalmic examination, refraction, visual field analysis and A-scan biometry. Myopic patients were classified as low myopia(LM) [spherical equivalent(SE) from greater than-0.5 D, up to-3.0 D], moderate myopia(MM; SE greater than-3.0 D, up to-6.0 D) and high myopia(HM; SE greater than-6.0 D). The control group consisted of emmetropic(EM) patients(SE from +0.5 D to-0.5 D). A Zeiss Cirrus HD-OCT machine was used to measure the peripapillary RNFL thickness of both eyes of each subject. The mean peripapillary RNFL thickness between groups was compared using both analysis of variance and analysis of covariance.RESULTS: A total of 403 eyes of 403 subjects were included in this study. The mean age was 31.48±10.23 y. There were 180(44.7%) eyes with EM, 124(30.8%) with LM, 73(18.1%) with MM and 26(6.5%) with HM. All groups of myopia severity had a thinner average RNFL than the EM group, but after controlling for gender, age, and axial eye length, only the HM group differed significantly from the EM group(P=0.017). Likewise, the superior, inferior and nasal RNFL was thinner in all myopia groups compared to controls, but after controlling for confounders, only the inferior quadrant RNFL was significantly thinner in the HM group, when compared to the EM group(P=0.017). CONCLUSION: The average and inferior quadrant RNFL is thinner in highly myopic eyes compared to emmetropic eyes. Refractive status must be taken into consideration when interpreting the OCT of myopic patients, as RNFL thickness varies with the degree of myopia. | Evelyn Li Min Tai Jiunn Loong Ling Eng Hui Gan Hussein Adil Wan-Hiram Wan-Hazabbah | 2018 | International Journal of Ophthalmology(English edition)2018，11，2： | 7 |
| 12 | Link between colorectal cancer and polymorphisms in the uridine-diphosphoglucuronosyltransferase 1A7and 1A1 genes显示文摘AIM: To investigate the relationship between single nucleotide polymorphisms in the uridine-diphosphoglucuronosyltransferase (UGT) UGT1A7 and UGT1A1 genes and patients suffering from colorectal cancer (CRC). METHODS: A case-control study was designed in order to investigate the genotypes of the UG71A7 and UGT1A1 genes, which were identified by the polymerase chain reaction-restriction fragment length polymorphism (RFLP) method, for 268 CRC patients and 441 healthy controls. RESULTS: The results of simple logistical regressions revealed odds ratios (ORs) of 1.97 (P<0.001), 1.91 (P<0.001), and 2.03 (P<0.00L) for patients who carried the UGT1A7*1/*3 genotype, UGT1A7*3 allele, andvariant-211 UGT1A1 allele. The interaction of UGT1A7*3allele and variant-211 LGT1A1 allele produced an additiveeffect on the risk for the development of CRC [observed OR (2.34) greater than expected OR (1.59)]. For the 268patients, the results of simple logistical regressions indicated that the OR of developing metastases was 4.90 (P<0.001) and 4.89 (P<0.001) for the individuals possessing UGT1A7*3 allele and variant-211 UGT1A1 allele, respectively. The results of multivariate logistical regressions confirmed these findings (OR = 2.51, P= 0.01;and OR = 2.71, P = 0.01, respectively). The interactionof these two variants resulted in an additive effect on the risk for metastases amongst patients [observed OR (6.83) greater than expected OR (4.56)].CONCLUSION: In conclusion, carriage of the UGT1A7*3allele, as well as variant-211 UGT1A1 allele represents a risk factor for the development of, and a determinant for, metastases associated with CRC patients. | Kung-Sheng Tang Hui-Fen Chiu Hong-Hwa Chen Hock-Liew Eng Chia-Jung Tsai Hsiu-Chen Teng Ching-Shan Huang | 2005 | World Journal of Gastroenterology2005，11，21： | 7 |
| 13 | 外源过氧化氢处理对采后荔枝褐变及活性氧代谢的影响显示文摘【目的】研究外源过氧化氢(H_(2)O_(2))处理对采后荔枝褐变及活性氧代谢的影响,为荔枝采后保鲜提供途径,以期提高果实的贮藏品质。【方法】以清水处理为对照(CK),采用不同浓度(1、5和10 mmol/L)的外源H_(2)O_(2)浸泡荔枝3 min,在4℃下冷藏放置,每隔3 d取样一次,进行失重率、褐变指数、丙二醛(MDA)含量、细胞膜透性、内源H_(2)O_(2)含量、超氧阴离子(O_(2)-)产生速率、多酚氧化酶(PPO)活性和超氧化物歧化酶(SOD)活性等生理指标的测定。【结果】不同浓度的外源H_(2)O_(2)处理对采后荔枝会产生不同的贮藏效果。以5 mmol/L外源H_(2)O_(2)处理保鲜效果最佳,明显降低果皮中MDA含量、内源H_(2)O_(2)含量和PPO活性,并提高SOD活性,减缓O_(2)-产生速率。至贮藏末期(12 d),经5 mmol/L外源H_(2)O_(2)处理的采后荔枝SOD活性较CK显著提高31.41%(P<0.05,下同),MDA含量、PPO活性、O_(2)-产生速率和内源H_(2)O_(2)含量较CK分别降低44.72%、38.72%、22.63%和13.75%,其失重率、褐变指数和相对电导率最低。1 mmol/L外源H_(2)O_(2)处理效果稍逊于5 mmol/L外源H_(2)O_(2)处理,而经10 mmol/L外源H_(2)O_(2)处理显著提高采后荔枝的MDA和内源H_(2)O_(2)含量,加速采后果实衰老。【结论】采用5 mmol/L外源H_(2)O_(2)处理可调节采后荔枝的活性氧代谢而延缓其衰老进程,为H_(2)O_(2)应用于采后荔枝保鲜提供理论支撑。 | 潘家丽 覃子倚 李静 Khoo Hock Eng 董新红 | 2022 | 南方农业学报2022，53，5： | 6 |
| 14 | Prehospital system delay in patients with ST-segment elevation myocardial infarction in Singapore显示文摘BACKGROUND: Timely reperfusion in ST-segment elevation myocardial infarction(STEMI)improves outcomes. System delay is that between first medical contact and reperfusion therapy,comprising prehospital and hospital components. This study aimed to characterize prehospital system delay in Singapore.METHODS: A retrospective chart review was performed for 462 consecutive STEMI patients presenting to a tertiary hospital from December 2006 to April 2008. Patients with cardiac arrest secondarily presented were excluded. For those who received emergency medical services(EMS),ambulance records were reviewed. Time intervals in the hospital were collected prospectively. The patients were divided into two equal groups of high/low prehospital system delay using visual binning technique.RESULTS: Of 462 patients, 76 received EMS and 52 of the 76 patients were analyzed. The median system delay was 125.5 minutes and the median prehospital system delay was 33.5minutes(interquartile range [IQR]=27.0, 42.0). Delay between call-received-by-ambulance and ambulance-dispatched was 2.48 minutes(IQR=1.47, 16.55); between ambulance-dispatch and arrival-at-patient-location was 8.07 minutes(IQR=1.30, 22.13); between arrival-at- and departurefrom-patient-location was 13.12 minutes(IQR=3.12, 32.2); and between leaving-patient-location to ED-registration was 9.90 minutes(IQR=1.62, 32.92). Comparing patients with prehospital system delay of less than 35.5 minutes versus more showed that the median delay between ambulancedispatch and arrival-at-patient-location was shorter(5.75 vs. 9.37 minutes, P<0.01). The median delay between arrival-at-patient-location and leaving-patient-location was also shorter(10.78 vs.14.37 minutes, P<0.01).CONCLUSION: Prehospital system delay in our patients was suboptimal. This is the first attempt at characterizing prehospital system delay in Singapore and forms the basis for improving efficiency of STEMI care. | Andrew Fu Wah Ho Pin Pin Pek Stephanie Fook-Chong Ting Hway Wong Yih Yng Ng Aaron Sung Lung Wong Marcus Eng Hock Ong | 2015 | World Journal of Emergency Medicine2015，6，4： | 6 |
| 15 | Upper gastrointestinal carcinoid tumors incidentally found by endoscopic examinations显示文摘AIM: This study shares Asian clinical experiences of carcinoid tumors that originated in the upper gastrointestinal tract.METHODS: From May 1987 to June 2002, we had found only 13 cases of histologically confirmed carcinoid tumors in the upper gastrointestinal tract by endoscopic examinations. There were eight males and five females.The mean age was 53.16±20.51 years that ranged from 26 to 82 years. Each of their clinical presentations,locations, tumor morphology, and size and the treatment outcome were analyzed and discussed.RESULTS: One patient had a polypoid lesion at the lower esophagus, nine were stomach lesions and three located at the duodenum. All patients with polypoid and submucosal tumor types were of small size (<1.7 cm) and all patients survived after simple excision or polypectomy.Four of the five patients in tumor mass forms died and the tumors were more than 2.0 cm in size.CONCLUSION: Carcinoid tumors rarely originated from the upper gastrointestinal tract and are usually found accidentally after endoscopic study. Bigger size (more than 2 cm) tumor masses may indicate a more severe disease and poor prognosis. | Tsung-Hui Hu Chung-Mou Kuo King-Wah Chiu Chung-Huang Kuo Keng-Liang Wu Yeh-Pin Chou Sheng-Nan Lu Shue-Shian Chiou Chi-Sin Changchien Hock-Liew Eng | 2005 | World Journal of Gastroenterology2005，11，44： | 5 |
| 16 | 卒中治疗专业学术圆桌会议临床前推荐更新版显示文摘首份卒中治疗专业学术圆桌会议(Stroke Yherapy Academic Industry Roundtable,STAIR)推荐于1999年出版,旨在提高潜在的急性卒中治疗方法的临床前研究质量。虽然这些推荐意见被认为是合理的,但并未得到严格的遵循和验证。为了更好地向临床转化,有关候选急性卒中疗法的临床前试验的质量和广度已取得实质性进展。更新后的STAIR临床前推荐进一步强调了最初提出的建议,即通过适当的生理学监测在多种动物物种中采用组织学和功能结局来确定可重复的剂量反应和时间窗。更新后的STAIR推荐意见包括:高质量科学研究的基本原则应消除随机和评价偏倚,预先确定纳入和排除标准,计算合适的效能和样本量,并公开潜在的利益冲突。应在年轻的健康雄性动物中进行初步评价之后,在雌性、高龄动物和伴有合并症(如高血压、糖尿病和高胆固醇血症)的动物中做进一步研究。此外还要在动物实验中应用临床相关生物学标志物。尽管只有通过临床试验产生基于此的有效疗法之后才能证实该推荐意见的有效性,但遵循这些推荐有望提高成功的机会。 | Marc Fisher Giora Feuerstein David W. Howells Patricia D. Hum Thomas A. Kent Sean I. Savitz Eng H. Lo 吕志宿(译) 罗本燕(译) | 2009 | 国际脑血管病杂志2009，17，8： | 5 |
| 17 | 白塞病相关自身抗原Kinectin的表达型cDNA文库筛选与鉴定显示文摘目的研究白塞病患者血循环中的自身抗体及其针对的细胞内靶抗原。方法应用免疫印迹-化学发光法对39例白塞病患者血清进行初步研究,以含有高滴度抗体的患者血清作为“探针”免疫筛选表达型!ZAP噬菌体cDNA文库并鉴定候选克隆,通过真核转录、翻译以及免疫沉淀实验分析阳性克隆表达产物的抗原性。结果文库筛选获得6个独立候选克隆,均为人Kinectin部分全长cDNA,以其中最大克隆的基因表达产物为抗原基质的免疫沉淀研究显示,23.1%(9/39)的白塞病患者血清呈阳性反应,正常人以及系统性红斑狼疮、干燥综合征患者对照阴性。结论Kinectin是白塞病相关自身靶抗原;抗Kinectin抗体与白塞病免疫发病机制的关系值得深入探索,抗体可能对疾病具有潜在血清学诊断价值。 | 陆瑜 叶萍 陈顺乐 顾越英 Eng M.Tan Edward KL Chan | 2005 | 中华风湿病学杂志2005，9，10： | 5 |
| 18 | A review of silicon-based wafer bonding processes,an approach to realize the monolithic integration of Si-CMOS and III-V-on-Si wafers显示文摘The heterogeneous integration of III-V devices with Si-CMOS on a common Si platform has shown great promise in the new generations of electrical and optical systems for novel applications,such as HEMT or LED with integrated control circuitry.For heterogeneous integration,direct wafer bonding(DWB)techniques can overcome the materials and thermal mismatch issues by directly bonding dissimilar materials systems and device structures together.In addition,DWB can perform at wafer-level,which eases the requirements for integration alignment and increases the scalability for volume production.In this paper,a brief review of the different bonding technologies is discussed.After that,three main DWB techniques of single-,double-and multi-bonding are presented with the demonstrations of various heterogeneous integration applications.Meanwhile,the integration challenges,such as micro-defects,surface roughness and bonding yield are discussed in detail. | Shuyu Bao Yue Wang Khaw Lina Li Zhang Bing Wang Wardhana Aji Sasangka Kenneth Eng Kian Lee Soo Jin Chua Jurgen Michel Eugene Fitzgerald Chuan Seng Tan Kwang Hong Lee | 2021 | Journal of Semiconductors2021，42，2： | 5 |
| 19 | Anemia and iron deficiency in gastrointestinal and liver conditions显示文摘Iron deficiency anemia(IDA) is associated with a number of pathological gastrointestinal conditions other than inflammatory bowel disease, and also with liver disorders. Different factors such as chronic bleeding, malabsorption and inflammation may contribute to IDA. Although patients with symptoms of anemia are frequently referred to gastroenterologists, the approach to diagnosis and selection of treatment as well as follow-up measures is not standardized and suboptimal. Iron deficiency, even without anemia, can substantially impact physical and cognitive function and reduce quality of life. Therefore, regular iron status assessment and awareness of the clinical consequences of impaired iron status are critical. While the range of options for treatment of IDA is increasing due to the availability of effective and well-tolerated parenteral iron preparations, a comprehensive overview of IDA and its therapy in patients with gastrointestinal conditions is currently lacking. Furthermore, definitions and assessment of iron status lack harmonization and there is a paucity of expert guidelines on this topic. This review summarizes current thinking concerning IDA as a common co-morbidity in specific gastrointestinal and liver disorders, and thus encourages a more unified treatment approach to anemia and iron deficiency, while offering gastroenterologists guidance on treatment options for IDA in everyday clinical practice. | Jürgen Stein Susan Connor Garth Virgin David Eng Hui Ong Lisandro Pereyra | 2016 | World Journal of Gastroenterology2016，22，35： | 5 |
| 20 | Interventional radiology in living donor liver transplant显示文摘The shortage of deceased donor liver grafts led to the use of living donor liver transplant(LDLT).Patients who un-dergo LDLT have a higher risk of complications than those who undergo deceased donor liver transplantation(LT).Interventional radiology has acquired a key role in every LT program by treating the majority of vascular and nonvascular post-transplant complications,improving graft and patient survival and avoiding,in the majority of cases,surgical revision and/or re-transplant.The aim of this paper is to review indications,diagnostic modalities,technical considerations,achievements and potential complications of interventional radiology procedures after LDLT. | Yu-Fan Cheng Hsin-You Ou Chun-Yen Yu Leo Leung-Chit Tsang Tung-Liang Huang Tai-Yi Chen Hsien-Wen Hsu Allan M Concerjero Chih-Chi Wang Shih-Ho Wang Tsan-Shiun Lin Yueh-Wei Liu Chee-Chien Yong Yu-Hung Lin Chih-Che Lin King-Wah Chiu Bruno Jawan Hock-Liew Eng Chao-Long Chen | 2014 | World Journal of Gastroenterology2014，20，20： | 5 |
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