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| 1 | Long-term aspirin pretreatment in the prevention of cerulein-induced acute pancreatitis in rats显示文摘AIM:To investigate the effects of long term pretreatment with low-,medium-and high-dose aspirin(acetylsalicylic acid,ASA) on a model of acute pancreatitis(AP) induced in rats.METHODS:Forty male Wistar rats were used.Three experimental groups,each consisting of eight animals,received low-(5 mg/kg per day),medium-(150 mg/kg per day) and high-dose(350 mg/kg per day) ASA in supplemented pellet chow for 100 d.Eight animals,serving as the AP-control group,and another eight,serving as reference value(RV) group,were fed with standard pellet chow for the same period.After pretreatment,AP was induced in the experimental animals by intraperitoneal administration of cerulein(2 × 50 μg/kg),while the RV group received saline in the same way.Twelve hours after the second injection,the animals were sacrificed.Pancreatic tissue and plasma samples were collected.One part of the collected pancreatic tissues was used for histopathological evaluation,and the remaining portion was homogenized.Cytokine levels [tumor necrosis factor,interleukin(IL)1β,IL-6],hemogram parameters,biochemical parameters(amylase and lipase),nuclear factor-κB,aspirin triggered lipoxins and parameters related to the antioxidant system(malondialdehyde,nitric oxide,hemeoxygenase-1,catalase and superoxide dismutase) were measured.RESULTS:Cerulein administration induced mild pancreatitis,characterized by interstitial edema(total histopathological score of 5.88 ± 0.44vs 0.25 ± 0.16,P < 0.001).Subsequent pancreatic tissue damage resulted in an increase in amylase(2829.71 ± 772.48 vs 984.57 ± 49.22 U/L,P = 0.001) and lipase(110.14 ± 75.84 U/L vs 4.71 ± 0.78 U/L,P < 0.001) in plasma,and leucocytes(6.89 ± 0.48 vs 4.36 ± 0.23,P = 0.001) in peripheral blood.Cytokines,IL-1β(18.81 ± 2.55 pg/μg vs 6.65 ± 0.24 pg/μg,P = 0.002) and IL-6(14.62 ± 1.98 pg/μg vs 9.09 ± 1.36 pg/μg,P = 0.04) in pancreatic tissue also increased.Aspirin pretreatment reduced the increase in the aforementioned parameters to a certain degree and partially improved the histopathological alterations caused by cerulein.No evidence of side effects related to chronic ASA administration(e.g.,inflammation or bleeding) was observed in the gastrointestinal tract in macroscopic and histopathological examination.CONCLUSION:Long term ASA pretreatment could prevent and/or ameliorate certain hematological,serological and histological alterations caused by ceruleininduced AP. | Ibrahim Akyazi Evren Eraslan Ahmet Gülubuk Elif Ergül Ekiz Zeynep L rakli Damla Haktanir Deniz Aktaran Bala Mete zkurt Erdal Matur Mukaddes zcan | 2013 | World Journal of Gastroenterology2013，19，19： | 5 |
| 2 | Effect of 1%brinzolamide and 0.5%timolol fixed combination on intraocular pressure after cataract surgery with phacoemulsification显示文摘AIM:To evaluate the effect of brinzolamide-timolol fixed combination on intraocular pressure(IOP)after cataract surgery.METHODS:The study included 92 eyes of 87 patients who underwent cataract surgery and intraocular lens implantation.Patients scheduled for phacoemulsification were assigned to 1 of 2 groups.The treatment group received 1 drop of brinzolamide-timolol fixed combination immediately after surgery,and the control group received no treatment.The IOP was measured preoperatively and at 2h and 24h postoperatively.RESULTS:The mean IOP change was lower in the treatment group than in the control group at 2h postoperatively.The difference between the mean IOP values of the two groups at 2h postoperatively was found to be statistically significant.Twenty-four hours after the surgery,the mean IOP change was still higher in the control group when compared to the treatment group.CONCLUSION:The fixed combination brinzolamidetimolol can effectively reduce IOP after cataract surgery. | Kemal rnek Nesrin Byktortop Nurgl rnek Reyhan Ogurel Inci Elif Erbahceci Zafer Onaran | 2013 | International Journal of Ophthalmology(English edition)2013，6，6： | 2 |
| 3 | Serum levelsof C-reactive protein and uric acid in patients withcardiac syndrome X显示文摘 | Eroglu S Elif Sade L Yildirir A | 2009 | Acta Cardiol2009，64，2： | 1 |
| 4 | 含季铵盐的芳酰腙配体的铜(Ⅱ)配合物的合成和表征:体外DNA键合和核酸酶活性显示文摘制备了2个新的含有N,N,N-三甲基丙烷-1-铵基团和N,N,N-三甲基戊烷-1-铵基团的苯乙酮-(4-羟基苯腙)配体:(E)-3-(4-(1-(2-(4-hydroxybenzoyl)hydrazono)ethyl)phenoxy)-N,N,N-trimethylpropan-1-ammonium perchlorate(H2L1)和(E)-3-(4-(1-(2-(4-hy-droxybenzoyl)hydrazono)ethyl)phenoxy)-N,N,N-trimethylpentane-1-ammonium perchlorate(H2L2)。以这2个配体分别合成了2个新的铜配合物:[Cu(HL1)2]和[Cu(HL2)2],研究了这些配体和配合物的DNA结合和切割活性,还研究了DNA切割的机理以及化合物浓度对DNA切割反应的影响。紫外-可见光谱结果表明,所有化合物均优先通过主沟结合模式与DNA结合,在甲基绿(主要的沟结合剂)的存在下切割DNA的活性受到抑制的结果也支持这一结论。电泳研究的结果则表明,化合物在存在或不存在氧化剂(H2O2)的情况下均对质粒DNA表现出显著的切割活性,活性主要取决于化合物的浓度。化合物通过水解途径裂解pBR322 DNA,在存在不同自由基清除剂情况下的DNA裂解实验也支持这一结论。 | EdaŞengül Elif Cansu Gökçe Topkaya Tolga Göktürk Ramazan Gup | 2020 | 无机化学学报2020，36，7： | 1 |
| 5 | Hypoxia Imaging of Uterine Cervix Carcinoma With 18F-FETNIM PET/CT显示文摘 | Laetitia Vercellino David Groheux Anne Thoury Marc Delord Marie-Hélène Schlageter Yann Delpech Emmanuelle Barré Valérie Baruch-Hennequin Perrine Tylski Laurence Homyrda Francine Walker Emmanuel Barranger Elif Hindié | 2012 | Clinical Nuclear Medicine2012，，11： | 1 |
| 6 | Gingival levels of monocyte chemoattractant protein-1 (MCP-1) in diabetes mellitus and periodontitis: an experimental study in rats显示文摘 | Elif Eser Sakall?o?lu Bülent Ayas Müge Lütfio?lu Gonca ?ayir Kele? G?khan A??kg?z Erhan F?ratl? | 2008 | Clinical Oral Investigations2008，，1： | 1 |
| 7 | Gingival levels of monocyte chemoattractant protein-1 (MCP-1) in diabetes mellitus and periodontitis: an experimental study in rats显示文摘 | Elif Eser Sakall?o?lu Bülent Ayas Müge Lütfio?lu Gonca ?ayir Kele? G?khan A??kg?z Erhan F?ratl? | 2008 | Clinical Oral Investigations2008，，1： | 1 |
| 8 | Gingival levels of monocyte chemoattractant protein-1 (MCP-1) in diabetes mellitus and periodontitis: an experimental study in rats显示文摘 | Elif Eser Sakall?o?lu Bülent Ayas Müge Lütfio?lu Gonca ?ayir Kele? G?khan A??kg?z Erhan F?ratl? | 2008 | Clinical Oral Investigations2008，，1： | 1 |
| 9 | Long term supplier selection u- sing a combined fuzzy MCDM approach: A case study for a tele- communication company 显示文摘 | SEMIH O SELIN S K ELIF L | 2009 | Expert Systems with Application2009，36，2： | 1 |
| 10 | Significance of Serum and Ascitic Fluid C-Reactive Protein in Differential Diagnosis of Benign and Malignant Ascites显示文摘 | Ilhami Yuksel Fatih Karaahmet Yusuf Coskun Serta K?l?ncalp Mevlut Hamamci Hakan Akinci Yusuf Ustun Zahide Simsek Elife Erarslan Sahin Coban | 2014 | Digestive Diseases and Sciences2014，，10： | 1 |
| 11 | Increased Pulse Wave Velocity and Carotid Intima-Media Thickness in Patients with Ulcerative Colitis显示文摘 | Remzi Adnan Akdo?an Murtaza Emre Durako?lugil Sinan Altan Kocaman Yüksel ?i?ek Tu?ba Durako?lugil Elif Ergül Halil Rak?c? | 2013 | Digestive Diseases and Sciences2013，，8： | 1 |
| 12 | Autoimmune complications and clinical outcomes of herpes simplex encephalitis in children: A case series显示文摘Objective:To report the neurologic prognosis and autoimmune complications of 16 cases of childhood herpes simplex virus encephalitis.Methods:The study was conducted atŞanlıurfa Training and Research Hospital,Turkey from June 2017 to August 2019.The study included 16 pediatric patients aged between 6 months and 17 years(median age 77.7 months)who were diagnosed with herpes simplex virus type 1 encephalitis by pediatric infectious disease and pediatric neurology clinics.Patients were followed using patient records,and interviews at the pediatric neurology clinic or via the telephone.Clinical and demographic data,received therapies,neurologic prognosis and complications were evaluated.Results:Patients with and without autoimmune encephalitis were compared in terms of age,sex,symptom duration before treatment,initial cerebrospinal fluid protein,glucose,red blood count and white blood count but no significant difference was found.Autoimmune complications were seen in four patients.N-methyl-D-aspartate encephalitis was observed in three patients and choreoathetosis was seen in one patient.The average follow-up period was 48.3 months.Twenty-five percent of the patients were receiving multiple antiepileptic drug(AED)treatment,43.8%were receiving single AED treatment and 31.3%were not receiving AED treatment at the end of the follow-up.Motor disability was observed in 12.5%and drug-resistant epilepsy was observed in 6.3%who had autoimmune complications.Conclusions:Seizures and movement disorders were controlled with immunotherapy and autoantibodies should be studied routinely.Treatment should be started early upon recognition of autoimmune complications through follow-up by measuring autoantibody levels and clinical examination results.Effective prevention and curative treatment modalities are needed to avoid herpes simplex virus encephalitis complications. | Gül Demet KayaÖzçora Elif Söbü Türkan UygurŞahin Enes Salı Gonca Bektaş | 2023 | Asian Pacific Journal of Tropical Medicine2023，16，5： | 0 |
| 13 | Antimicrobial activity against periodontopathogenic bacteria,antioxidant and cytotoxic effects of various extracts from endemic Thermopsis turcica显示文摘Objective:To investigate the in vitro antimicrobial potential of Thermopsis turcica Kit Tan,Vural&Kckdk against periodoutopathogenie bacteria,its antioxidant activity and cytotoxic effect on various cancer cell lines.Methods:In vitro antimicrobial activities of elhanol.methanol,ethyl acetate(ElAc,n-hexane and water extracts of Thermopsis turcica herb against periodontopathogenic bacteria,Aggregatibacter actinnmycelemconilans ATCC 29523 and Porphyromonas gingivalis ATCC 33277 were tested by agar well diffusion,minimum inhibitory concentration(MIC)and minimal bactericidal concentration(MBC),Antioxidant properties of the extracts were evaluatod by 1,1-diphenyl-2-picryl-hydrazyl radical scavenging activity and p-carotene bleaching methods.Amounts of phenolic contents of the extracts were also analysed by using the Folin-Ciocalteu reagent.Additionally,cytotoxic activity of the extracts on androgcn-insensilivc prostate cancer,androgen—sensitive prostate cancer,chronic myelogenous leukemia and acute promyelocytic leukemia bunian cancer cell lines were determined by 3-4,5-dimelhylthiazol-2-yh-2,5-diphenyltclrazolium bromide assay.Human gingival fibroblast cells were used as a control.Results:Our data showed that ELAc extract had the highest antimicrobial effect on Aggregatibacter actinomycetemitans(MIC:1.562 mg/ml_MHC:3.124 mg/ml.)and Porph yromonas gingiralis(MIC:0.781 mg/mL,MBC:1.562 mg/mL).In antioxidant assays.ElAc extract exhibited also the highest radical scavenging activity[IC_(50)=(30.0±0.3)μg/ml.]and the highest inhibition[(74.35±0.30)%]|against lineloic acide oxidation.The amount of phenolic content of it was also the highest[(l62.5±l.2)μg/mg gallic acid].In cytotoxic assay,only etbanol[IC_(50)=(80.00±1.21)μg/ml.]and EtAc extract[IC_(50)=(70.0±0.9)μg/ml]were toxic on acute promyeloeytic leukemia cells at 20—100μg/mL.P<0.05>.However,no toxic effect was observed on human gingival fibroblast cells.Cunclusions:According to our findings,owing to its antioxidant and cytotoxic potential,EtAc exlrael might include anticancer agents for acute promyelocytic leukemia. | Elif Burcu Bali Leyla Acik Glin Akca Meral Sarper Mualla Pinar Eli Ferit Avcu Mecit Vural | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，7： | 0 |
| 14 | Clinical characteristics and outcomes of nosocomial COVID-19 in Turkey:A retrospective multicenter study显示文摘Objective:To identify the clinical characteristics and outcomes of hospital-acquired SARS-CoV-2 infection during the vaccination period nationwide in Turkey.Methods:COVID-19 patients followed in the pandemic services across Turkey between January 1,2021,and March 31,2022 were investigated retrospectively.Nosocomial COVID-19 was defined as a patient neither diagnosed with COVID-19 nor suspected COVID-19 at the hospital admission and was confirmed COVID-19≥5 days after hospital admission.The primary outcome of this study was in-hospital mortality;demographic features and vaccination status was compared between survivors and non-survivors.Results:During the study period,15573 COVID-19 patients were followed in 18 centers and 543(3.5%)patients were nosocomial COVID-19.Most patients with nosocomial COVID-19(80.4%)were transferred from medical wards.162(29.8%)of the patients with nosocomial COVID-19 admitted to the intensive care unit due to disease severity and 138(25.4%)of the patients died during hospital stay.Advanced age(≥65 years)and number of comorbid diseases(≥2)was found to be associated with mortality in nosocomial COVID-19(OR 1.74,95%CI 1.11-2.74 and OR 1.60,95%CI 1.02-2.56,respectively).Vaccination was associated with survival in nosocomial COVID-19(OR 0.25,95%CI 0.16-0.38).Conclusions:Patients with nosocomial COVID-19 had increased admission to intensive care units and higher mortality rate.Vaccination can decrease the in-hospital mortality rate. | Süleyman Yıldırım Celalettin Yılmaz Gülru Polat Serap Argun Baris İlknur Başyiğit İlknur Kaya Ceyda Anar Mihriban Bozkurt HüsnüBaykal Hulya Dirol Gamzenur Ozbey Emine Ozsari Emel Cireli Ali KadriÇırak Dursun Tatar Mine Gayaf Selen Karaoglanoglu Yener Aydin Atilla Eroglu Yıldız Olçar Berna Botan Yıldırım Bengül Gürsoy Deniz Demir Yılmaz Elif Yelda Ozgun Niksarlioglu Ramazan Eren Ayşegül Tomruk Erdem Müge Meltem Tor Fusun Fakili MustafaÇolak Merve Erçelik Ali Tabaru Özlem Ediboglu | 2023 | Asian Pacific Journal of Tropical Medicine2023，16，8： | 0 |
| 15 | Potential of fungal thermostable alpha amylase enzyme isolated from Hot springs of Central Anatolia(Turkey)in wheat bread quality显示文摘Many industrial processes may quickly proceed with biotechnological and enzymatic support.Functional and production facilitator properties of enzymes have provided variable advantages for industry.Therefore,enzyme utilization has become inevitable for industry and supplied financial advantages in case of the high energy requirement process.In the study,the amylase enzymes were isolated from thermal spring sources,and the effect on bread quality was examined.Firstly,fungal amylases were isolated from thermal spring sources(29-98◦C)in various places around Turkey.After determining the functional properties of amylase enzymes,the most active enzyme was used in bread production to examine their effect on bread quality.The maximum alpha-amylase activity(38.6 U/mg)has been detected in Aspergillus niger G 2-1 isolate.When compared with the commercially available one,native alpha-amylase increased the bread volume.A significant difference(p<0.01)was found in the color properties and size of the bread between microbial produced in this study and commercially produced alpha-amylase.Five ppm alpha-amylase addition showed the optimum bread properties for dough processing. | Arzu Unal Asiye Seis Subasi Semra Malkoc Ijlal Ocak SElif Korcan Elif Yetilmezer Seyhun Yurdugül Hülya Yaman Turgay Sanal Alaettin Keceli | 2022 | Food Bioscience2022，45，1： | 0 |
| 16 | An international guideline with six personalised titration schedules for preventing myocarditis and pneumonia associated with clozapine显示文摘White blood cell(WBC)monitoring has reduced clozapinetreated patient deaths associated with agranulocytosis to a rarity.However,clozapine protocols and package inserts worldwide provide no instructions for preventing myocarditis or pneumonia during clozapine titrations.Prescribers worldwide are largely unaware of that.Meanwhile,as they worry about agranulocytosis,their clozapine-treated patients are at risk of dying from pneumonia or myocarditis.Consequently,an international guideline with 104 authors from 50 countries/regions was recently published to provide personalised clozapine titration schedules for adult inpatients.This forum article reviews pneumonia and myocarditis occurring during clozapine titration,as well as the three most innovative aspects of this new guideline:(1)personalised titration,(2)C reactive protein(CRP)measures,and(3)dose predictions based on blood levels.Clozapine metabolism is influenced by 3 levels of complexity:(1)ancestry groups,(2)sex-smoking subgroups,and(3)presence/absence of poor metabolizer status.These 3 groups of variables should determine the maintenance dose and speed of clozapine titration;they are summarised in a table in the full-text.The international clozapine titration guideline recommends measuring CRP levels simultaneously with WBC,at baseline and weekly at least for the first 4 weeks of titration,the highest risk period for clozapine-induced myocarditis. | Jose de Leon Can-Jun Ruan Georgios Schoretsanitis Christopher Rohde Elif Anıl Yağcıoğlu Trino Baptista Oleg O Kirilochev Carlos De las Cuevas Christoph U Correll | 2022 | General Psychiatry2022，35，3： | 0 |
| 17 | Dynamics and cytokinic regulation of immune cell infiltration in genetically engineered mouse models of pancreatic cancer dictate the sensitivity to immunotherapy显示文摘Dear Editor,Targeting the immune compartment in pancreatic duc-tal adenocarcinoma(PDAC)holds promise for prognostic improvement,yet our knowledge on the spatial and tem-poral dynamics and the molecular modulators of the PDAC-associated immunophenotype is scarce. | Okan Safak Shenghan Wang Carmen Mota Reyes Ibrahim Halil Gürcinar Sergey Tokalov Nedim Can Cevik Kivanc Görgülü Bengi Su Yilmaz Emre Erdogan Linhan Ye Qiaolin Li Elif Arik Sever SamedÖzer Güldal Süyen Helmut Friess Güralp Onur Ceyhan Rouzanna Istvanffy Hana Algül Ihsan Ekin Demir | 2024 | Cancer Communications2024，44，1： | 0 |
| 18 | Evaluation of proximal tubule functions in children with COVID‑19:a prospective analytical study显示文摘Background There are limited numbers of studies focusing on renal efects of coronavirus disease 2019(COVID-19)infection and proximal tubular dysfunction in children with COVID-19 infections.The purpose of this study was to evaluate the functions of the proximal tubule in hospitalized children with confrmed acute COVID-19.Methods The children who were hospitalized for confrmed COVID-19 were included in this prospective descriptive analysis.The presence of at least two of the following four abnormalities was used to diagnose proximal tubule injury:abnormal tubular reabsorption of phosphate,normoglycemic glycosuria,hyperuricosuria,and proteinuria.Results A total of 115 patients were included in the study.About a third of the individuals had elevated blood creatinine levels or proteinuria.In addition,abnormal renal tubular phosphate loss measured by renal tubular phosphate loss was found in 10(8.7%)patients,as was hyperuricosuria in 28.6%.As a result,total proximal tubular dysfunction was found in 24(20.9%)patients.Conclusions One in every fve children with acute COVID-19 infections had proximal tubular dysfunction,according to our data.Although,the rate of proximal tubular dysfunction was lower than in adults,it should be noted.The recovery of proximal tubular function in children with COVID-19 should be followed. | Fatma Devrim Elif Böncüoğlu Elif Kıymet ŞahikaŞahinkaya Ela Cem Mine Düzgöl Aybüke Akaslan Kara KamileÖtiken Arıkan AslıKantar Ebru Yılmaz Nida Dinçel Nuri Bayram İlker Devrim | 2022 | World Journal of Pediatrics2022，18，9： | 0 |
| 19 | Development of gluten-free tarhana formulations:Part II.Utilization of legume composite flours and baker’s yeast显示文摘Many gluten-free foods are prepared from starch-rich ingredients with low protein and fiber content,resulting in poor nutritional and functional quality.In this study,five different composite legume flours which are prepared from different levels of chickpea,lentil,common bean,soybean and lupin flours were used at 75%level in gluten-free tarhana formulations to improve nutritional quality.Also,effect of baker’s yeast(Saccharomyces cerevisiae)at different levels(2.5%and 5.0%)on physicochemical and sensory attributes of the samples containing composite flours was investigated.The inclusion of composite flours(75%)resulted in lower L^(*) and hue values in tarhana than gluten-free sample without composite flour.The viscosity of tarhana soup containing“25%chickpea+50%lentil”composite flour(F2)was similar to traditional wheat tarhana soup(p>0.05).The utilization of composite flours containing“50%chickpea+25%lentil”(F1),F2,and“25%chickpea+25%lentil+25%common bean”(F3)in tarhana revealed comparable oil absorption capacity to wheat tarhana.Besides,pH and foaming capacity values of the samples containing composite flours were greater than wheat tarhana and gluten-free tarhana without composite flour.The addition of composite flours elicited markedly higher ash,protein,fat,and mineral content.While phytic acid concentration of tarhana enhanced with the incorporation of composite flour,the use of 5.0%yeast considerably decreased phytic acid content and enriched ash,protein,total phenolic content,Ca,Cu,K,Mg,and P concentrations of tarhana in comparison with tarhana containing 2.5%yeast.The inclusion of F1,F2,and F3 elicited acceptable sensory scores in tarhana.It was concluded that gluten-free tarhana prepared from legume composite flours(especially F1,F2,and F3)+5.0%yeast could offer a nutritious and acceptable alternative for gluten-free diet with greater protein and mineral contents.Based on the findings,further studies may evaluate the use of hydrocolloids to improve the technological and sensory properties of functional tarhana formulations developed in this study. | Hatice Kılıç Keskin Nermin Bilgiçli Elif Yaver | 2022 | Food Bioscience2022，47，3： | 0 |
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