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| 1 | Nigella sativa relieves the deleterious effects of ischemia reperfusion injury on liver显示文摘AIM: To determine whether Nigella sativa prevents hepatic ischemia-reperfusion injury to the liver. METHODS: Thirty rats were divided into three groups as sham (Group 1), control (Group 2), and Nigella sati-va (NS) treatment group (Group 3). All rats underwent hepatic ischemia for 45 min followed by 60 min period of reperfusion. Rats were intraperitoneally infused with only 0.9% saline solution in group 2. Rats in group 3 received NS (0.2 mL/kg) intraperitoneally, before isch-emia and before reperfusion. Blood samples and liver tissues were harvested from the rats, and then the rats were sacrifi ced. Serum aspartate aminotransfera-se (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels were determined. Total antioxidant capacity (TAC), catalase (CAT), total oxida-tive status (TOS), oxidative stress index (OSI) and my-eloperoxidase (MPO) in hepatic tissue were measured. Also liver tissue histopathology was evaluated by light microscopy. RESULTS: The levels of liver enzymes in group 3 weresignifi cantly lower than those in the group 2. TAC in liver tissue was significantly higher in group 3 than in group 2. TOS, OSI and MPO in hepatic tissue were signifi cantly lower in group 3 than the group 2. Histo-logical tissue damage was milder in the NS treatment group than that in the control group. CONCLUSION: Our results suggest that Nigella sa-tiva treatment protects the rat liver against to hepatic ischemia-reperfusion injury. | Fahrettin Yildiz Sacit Coban Alpaslan Terzi Mustafa Ates Nurten Aksoy Hale Cakir Ali Riza Ocak Muharrem Bitiren | 2008 | World Journal of Gastroenterology2008，14，33： | 8 |
| 2 | Infection control in severely burned patients显示文摘In the last two decades, much progress has been made in the control of burn wound infection and nasocomial infections(NI) in severely burned patients. The continiually changing epidemiology is partially related to greater understanding of and improved techniques for burn patient management as well as effective hospital infection control measures. With the advent of antimicrobial chemotherapeutic agents, infection of the wound site is now not as common as, for example, urinary and blood stream infections. Universal application of early excision of burned tissues has made a substantial improvement in the control of wound-related infections in burns. Additionally, the development of new technologies in wound care have helped to decrease morbidity and mortality in severe burn victims. Many examples can be given of the successful control of wound infection, such as the application of an appropriate antibiotic solution to invasive wound infection sites with simultaneous vacuum-assisted closure, optimal preservation of viable tissues with waterjet debridement systems, edema and exudate controlling dressings impregnated with Ag(Silvercel, Aquacell-Ag). The burned patient is at high risk for NI. Invasive interventions including intravenous and urinary chateterization, and entubation pose a further risk of NIs. The use of newly designed antimicrobial impregnated chateters or silicone devices may help thecontrol of infection in these immunocomprimised patients. Strict infection control practices(physical isolation in a private room, use of gloves and gowns during patient contact) and appropriate empirical antimicrobial therapy guided by laboratory surveillance culture as well as routine microbial burn wound culture are essential to help reduce the incidance of infections due to antibiotic resistant microorganisms. | Yusuf Kenan Coban | 2012 | World Journal of Critical Care Medicine2012，1，4： | 6 |
| 3 | Rhabdomyolysis, compartment syndrome and thermal injury显示文摘Rhabdomyolysis(RML) after electrical burns and crush injuries is a well-known clinical entity, but its occurrence following thermal injury has not gained so much attention. Capillary leak syndrome and following polycompartmental syndrome are devastating end results of major thermal injuries. In the current review, polycompartment syndrome within the clinical picture of systemic oedema and its relationship to RML is discussed along with its management and prevention. | Yusuf Kenan Coban | 2014 | World Journal of Critical Care Medicine2014，3，1： | 2 |
| 4 | Eosinophilic gastroenteritis associated with allergic asthma and atopic eczema显示文摘 | Bora Aktas Sahin Coban Akif Altmbas Omer Basar | 2014 | Chinese Medical Journal2014，，1： | 2 |
| 5 | Subthreshold micropulse laser versus intravitreal anti-VEGF for diabetic macular edema patients with relatively better visual acuity显示文摘AIM:To compare the effects of yellow(577 nm)subthreshold micropulse laser(SML)and intravitreal(IV)anti-vascular endothelial growth factor(VEGF)treatment in patients with diabetic macular edema(DME)with relatively better visual acuity[best corrected visual acuity(BCVA)≤0.15 log MAR].METHODS:The medical records of 76 eyes of 47 patients underwent IV(0.5 mg)anti-VEGF injection or SML for the DME with relatively better BCVA were reviewed.The IV group received three consecutive monthly IV anti-VEGF injections,then were retreated as needed.The laser treatment group was treated at baseline and 3 mo,and then retreated at 6 and 9 mo if needed.All participants were followed up for one year.The mean BCVA and mean central macular thickness(CMT)values changes over the follow-up were evaluated.RESULTS:Twenty-four and 23 patients were assigned to the SML and IV subgroups,respectively.The mean number of treatments was 3.64±0.76 in SML group and 5.85±1.38 in IV group(P<0.05).The subgroups were similar with regard to the mean BCVA score at baseline and at the 1st and 3rd months,but the score of SML group was better than that of IV group at the 6th,9th,and 12th months(P<0.05).The decrease in the mean CMT values from baseline values was higher in SML group at the 6th,9th,and 12th months(P<0.05).CONCLUSION:Yellow SML treatment is superior to IV anti-VEGF injection in DME patients with relatively better BCVA for increasing visual acuity and decreasing CMT at 6,9,and 12 mo.SML can be a good alternative first-line therapy for DME with BCVA≤0.15 log MAR. | Sezen Akkaya Banu Acιkalιn Yusuf Emre Dogan Fatih Coban | 2020 | International Journal of Ophthalmology(English edition)2020，13，10： | 2 |
| 6 | Resection and primary anastomosis with or without modified blow-hole colostomy for sigmoid volvulus显示文摘AIM: To evaluate the efficacy of resection and primary anastomosis (RPA) and RPA with modified blow-hole colostomy for sigmoid volvulus. METHODS: From March 2000 to September 2007, 77 patients with acute sigmoid volvulus were treated. A total of 47 patients underwent RPA or RPA with modified blow-hole colostomy. Twenty-five patients received RPA (Group A), and the remaining 22 patients had RPA with modified blow-hole colostomy (Group B). The clinical course and postoperative complications of the two groups were compared. RESULTS: The mean hospital stay, wound infection and mortality did not differ significantly between the groups. Superficial wound infection rate was higher in group A (32% vs 9.1%). Anastomotic leakage was observed only in group A, with a rate of 6.3%. The difference was numerically impressive but was statistically not significant. CONCLUSION: RPA with modified blow-hole colostomy provides satisfactory results. It is easy to perform and may become a method of choice in patients with sigmoid volvulus. Further studies are required to further establish its role in the treatment of sigmoid volvulus. | Sacid Coban Mehmet Yilmaz Alpaslan Terzi Fahrettin Yildiz Dincer Ozgor Cengiz Ara Saim Yologlu Vedat Kirimlioglu | 2008 | World Journal of Gastroenterology2008，14，36： | 2 |
| 7 | Iron deficiency anemia in the olderly:prevalence and endoscopic evaluation of the gastrointestinal tract in outpatients显示文摘 | Coban E Timuracaoclu A Meric M | 2003 | Acta Hawmatol2003，110，： | 1 |
| 8 | Repeated administration of synthetic oligodeoxynucleotides expressing CpG motifs provides long-term protection against bacterial infection 显示文摘 | Klinman D M Conover J Coban C | 1999 | Infection and Immunity1999，67，11： | 1 |
| 9 | Primary T-lymphoma of the breast with bilateral involvement,unusual presentation显示文摘 | Kebudi A Coban A Yetkin G | | 0，，147： | 1 |
| 10 | Particulate adjuvant and innate immunity: Past achievements, present findings, and future prospects显示文摘 | Kuroda E Coban C Ishii K J | 2013 | International Reviews of Immunology2013，32，2： | 1 |
| 11 | Serum IL-18 is increased at early postburn period in moderately burned patients显示文摘 | Coban YK Aral M | 2006 | Media-tots lnflamm2006，2006，16： | 1 |
| 12 | Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin 显示文摘 | Coban C Ishii KJ Kawai T | 2005 | J Exp Med2005，201，1： | 1 |
| 13 | Effect of iron deficiency anemia on the levels ofiaemoglobin Ale in nondiabeticpatients 显示文摘 | CobanE OzdoganM TimuragaogluA | 2004 | Acta Haematol2004，112，3： | 1 |
| 14 | Spontaneous intestina perforation due to non-Hodgkin's lymphoma:evaluation o eight cases显示文摘 | Ara C Coban S Kayaalp C | 2007 | Dig Dis Sci2007，52，8： | 1 |
| 15 | Analgesia in preterm newborns: the comparative effects of sucrose and glucose 显示文摘 | Okan F Coban A Ince Z | 2007 | Eur J Pediatr2007，166，10： | 1 |
| 16 | Thermal conductivity of particle filled polyethylene composite materials显示文摘 | Kumlutas D Tavmana I H Coban M T | 2003 | Composites Science and Technology2003，63，1： | 1 |
| 17 | The effect of rosuvastatin treatment on the mean platelet volume in patients with uncontrolled primarydyslipidemia with hypolipidemic diet treatment显示文摘 | Coban E Afacan B | 2008 | Platelets2008，19，2： | 1 |
| 18 | Pathological role of Tolllike receptor signaling in cerebral malaria显示文摘 | Coban C Ishii K J Uematsu S | 2007 | International Immunology2007，19，1： | 1 |
| 19 | Co-existence of acute appendicitis and inflammatory myofibroblastic tumor of the small intestine:A case report显示文摘 | Unver N Coban G Onaran O I | 2015 | Ann Med Surg(Lond)2015，4，3： | 1 |
| 20 | Body mass index,cholecystitis,cholelithiasis,pancreatitis and imaging of common bile duct stones显示文摘 | Coban G Yildirim E Gokturk S | 2014 | Am J Med Sci2014，347，5： | 1 |
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