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| 1 | Utility of magnetic resonance imaging in anorectal disease显示文摘Imaging of both benign and malignant anorectal diseases has traditionally posed a challenge to clinicians, and as a result history and physical exam have been relied on heavily. CT scanning and endorectal ultrasound have become popular in assessment of anatomy and staging of tumors, but have limitations. Magnetic resonance imaging (MRI) has the capability to fill in the gaps left open by more conventional imaging modalities and continues to be promising as the definitive imaging technique in the pelvis, especially with advancement of emerging technologies in this field. A comprehensive review of this topic has been undertaken. Anorectal disease is divided into three broad categories: cancer, fistula/abscess, and pelvic floor disorders. A review of the literature is performed to evaluate the use of MRI and other imaging modalities in these three areas. Preoperative imaging is useful in the evaluation of all three areas of anorectal disease. MRI is an effective tool in delineating anatomy and, when correlating with the specific clinical scenario, is an effective adjunct in clinical decision-making in order to optimize outcome. MRI continues to be a promising and novel approach to imaging various afflictions of the anorectum and the pelvic floor. Its role is more well-established in some areas than in others, and there are still signif icant limitations. As technology advances, MRI will shed more light on a complex anatomical area. | Loren Berman Gary M Israel Shirley M McCarthy Jeffrey C Weinreb Walter E Longo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes - Association analyses in 9,518 subjects显示文摘 | Owen, KR Groves, CJ Hanson, RL Knowler, WC Shuldiner, AR Elbein, SC Mitchell, BD Froguel,P Ng, MCY Chan, JC Jia, WP Deloukas, P Hitman, GA Walker, M Frayling, TM Hattersley, AT Zeggini, E McCarthy, MI | 2007 | 中国生物学文摘2007，21，11： | 2 |
| 3 | Sustainable urban development — the public health dimension显示文摘Public health in England developed during the first half of the nineteenth century with concern for sanitation in urban areas. Since that time environment, behaviour, social relationships, health services and genetic constitution are all recognized to contribute to health and disease in populations. Sustainable development is now of global concern, and its foundations—economy, environment and society—are similar to the determinants of health. However, while improved environment will have an important contribution to health, the broader social objectives are also needed to avoid the downward cycle of inequality and cultural deterioration that has occurred in some western cities. Epidemiological studies at University College London are particularly concerned with these social dimensions, and research opportunities exist for collaboration with environmental sciences in a number of areas, including intersectoral work, societies in social transition, collaboration with business, and research within through the European Union. | Mark McCarthy Department of Public Health and Epidemiology, University College London, 1 19 Torrington Place, London WC1E 6EA, United Kingdom. E mail: m.mccarthy@ucl.ac.uk | 1999 | Journal of Environmental Sciences1999，11，3： | 2 |
| 4 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 5 | Insulin-like growth factor ( IGF ) signalling is required for early dorso- anterior development of the zebrafish embryo 显示文摘 | Eivers E McCarthy K Glynn C | 2004 | Int J Dev Biol2004，48，10： | 1 |
| 6 | A cost, profit, and efficiency analysis of performing carpal tunnel surgery in the operating room versus the clinic setting in the United States显示文摘 | Chatterjee A McCarthy J E Montagne S A | 2011 | Ann Plast Surg2011，66，3： | 1 |
| 7 | Acid mine drainage arising from gold mining activity in Johannesburg,South Africa and environs显示文摘 | Naicker K Cukrowska E McCarthy T S | 2003 | Environmental Pollution2003，22，1： | 1 |
| 8 | Structural basisfor the activation of innate pattern recognition receptor RIG- I by viral RNA显示文摘 | Kowalinski E Lunardi T McCarthy A A | 2011 | Cell2011，147，20： | 1 |
| 9 | Electrospun silk material systems for wound healing显示文摘 | S E Wharram X Zhang D L Kaplan S P McCarthy | | 0，，： | 1 |
| 10 | Purification of secretory immunoglobulin A from milk of the brushtail possum (Trichosurus vulpecula)显示文摘 | Doolin E E Midwinter R G McCarthy A R | 2001 | NZ Vet J2001，49，5： | 1 |
| 11 | Effects of basic figbroblast growth factor on bone format i on in vitro 显示文摘 | Canalis E Centrella M Mccarthy T | 1988 | J Clin Invest1988，81，： | 1 |
| 12 | Insulin-like growth factor (IGF) signaling is required for early dorso-anterior development of the zebrafish embryo 显示文摘 | Eivers E McCarthy K Glynn C | 2004 | Int J Dev Biol2004，48，10： | 1 |
| 13 | Isolation of growth factors from adult bovine bone显示文摘 | Canalis E McCarthy T Centrella M | 1988 | Calcif Tissue Int1988，43，： | 1 |
| 14 | TCF7L2 : the biggest story in diabetes genetics since HLA显示文摘 | Zeggini E McCarthy MI | 2007 | Diabetologia2007，50，1： | 1 |
| 15 | An antibody- and synthetic peptide-defined rubella virus E1 glycoprotein neutraliza- tiondomain显示文摘 | Wolinsky J S Sukholutsky E Moore W T Lovett A McCarthy M Adame B | 1993 | J Virol1993，67，2： | 1 |
| 16 | Outcome of laparoscopic ventral mesh rectopexy for external rectal prolapsed显示文摘 | Randall J Smyth E McCarthy K | 2014 | Colorectal Dis2014，16，11： | 1 |
| 17 | Current concepts review:transforming growth factor beta and remodeling of bone 显示文摘 | Centrella M Mccarthy TL Canalls E | 1991 | J Bone Joint Surg Am1991，73，9： | 1 |
| 18 | Structural basis for the activation of innate immune pattern recognition receptor RIG-I by double-stranded RNA显示文摘 | Kowalinski E Lunardi T McCarthy A A | 2011 | Cell2011，147，2： | 1 |
| 19 | Genome-wide association studies in type2 diabetes显示文摘 | McCarthy MI Zeqqini E | 2009 | Curr Diab Rep2009，9，2： | 1 |
| 20 | AT2 receptors:functional relevance in cardiovascular disease显示文摘 | Jones E S Vinh A McCarthy C A | 2008 | Pharmacol Ther2008，120，3： | 1 |
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