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| 1 | 子宫肌瘤栓塞失败的分析显示文摘Objective: To assess the outcomes of patients who underwent uterine fibroid embolization (UFE) and to evaluate factors associated with failure of UFE. Design: Retrospective study. Setting: University teaching hospital. Patient(s): Two hundred thirty-three consecutive patients who underwent UFE from November 1997 to February 2004. Intervention(s): Uterine fibroid embolizations were performed by three interventional radiologists using 355-500-μpolyvinyl alcohol particles. Main Outcome Measure(s): Hysterectomy rate, myomectomy rate, and repeat UFE rate. Result(s): With a mean follow-up of 13 months, a total of 22 patients underwent surgery after UFE (9.4%); 16 had hysterectomies (6.9%), and 6 had myomectomies (2.6%). This included 3 patients who underwent repeat UFE and subsequently required surgical intervention. The mean (±SEM) time interval between UFE and subsequent treatment was 12.5 ±2.0 months. Among patients who required surgery, 13 (59.1%) presented with recurrent menorrhagia, and 5 (22.7%) complained of persistent abdominal pain. Histopathologic examination revelead concomitant findings of adenomyosis in 25%of hysterectomy specimens. Patients who failed UFE were more likely to have had a previous myomectomy (13%vs 2.4%) and significant reduction in the uterine size 6 months after UFE (57.1%vs 25.2%). Conclusion(s): The overall failure rate of UFE is 9.4%. Failure is mainly due to persistent menorrhagia and abdominal pain. Shrinkage of the uterus after UFE does not necessarily correlate with long-term success of UFE. | Huang J.Y.J. Kafy S. Dugas A. T. Tulandi 李跃萍 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，0，4： | 2 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | Incidence and determinants of cigarette smoking initiation in young adults显示文摘 | Jennifer L. O’Loughlin Erika N. Dugas Erin K. O’Loughlin Igor Karp Marie-Pierre Sylvestre | 2013 | Journal of Adolescent Health2013，，： | 2 |
| 4 | Use of simplex-latticedesign techniques to determineoptimum distribution of fertilizers between times of their of their application 显示文摘 | DUGA G G | 1992 | Fertilizer Research1992，31，： | 1 |
| 5 | Analysis of Flt3 length mutations in 1003 patients with acute myeloid leukemia:correlation to cytogenetics,FAB subtype,and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease显示文摘 | Schnittger S Schoch C Dugas M | 2002 | Blood2002，100，： | 1 |
| 6 | Minimizing dilutional coagulopathy in exanguinating hemorrhage:A computer simulation显示文摘 | Hirshberg A Dugas M Banez E | 2003 | J Trauma2003，54，3： | 1 |
| 7 | Baseline serum levels of mast cell tryptase are raised in hemodialysis patients and associated with severity of pruritus显示文摘 | Dugas-Breit S Schopf P Dugas M | 2005 | J Dtsch Dermatol Ges2005，3，5： | 1 |
| 8 | Molecular detection of early - stage laryngopharyngeal squamous cell carcinomas 显示文摘 | Temam S Benard J Dugas C | 2005 | Clin Cancer Res2005，11，7： | 1 |
| 9 | Molecular genetics of quantitative fibrinogen disorders 显示文摘 | Asselta R Spena S Duga S | 2007 | Cardiovasc Hematol Agents Med Chem2007，5，2： | 1 |
| 10 | Pheochromocytoma and pregnancy: a case report and review of anesthetic management显示文摘 | Dugas G Fuller J Singh S | 2004 | Can J Anaesth2004，51，2： | 1 |
| 11 | Generalized anxiety disorder publications: Where do we stand a decade later?显示文摘 | Dugas M J Anderson K G Deschenes S S | 2010 | J Anxiety Disord2010，24，7： | 1 |
| 12 | Crystalline MnO2as possible alternatives to amorphous compounds in electrochemical supercapacitors显示文摘 | BROUSSE T TOUPIN M DUGAS R | 2006 | Journal of the Electrochemical Society2006，153，12： | 1 |
| 13 | Sucrose induction of Arobidopsis miR398 represses two Cu/Zn superoxide dismutases显示文摘 | Dugas D V Bartel B | 2008 | Plant Mol Biol2008，67，： | 1 |
| 14 | The molecular basis of quantitative fibrinogen disorders显示文摘 | Asselta R Duga S Tenchini ML | 2006 | J Thromb Haemost2006，4，10： | 1 |
| 15 | Qualification of parallel kinematics machines in high-speed milling on free form surfaces显示文摘 | MyriamTerrier Amaud Dugas | 2004 | International Journal of Machine Tools &Manufaeture2004，，44： | 1 |
| 16 | Impact of LDL carotenoid and α-tocopherol content on LDL oxidation by endothelial cells in culture显示文摘 | Dugas T R Morel D W Harrison E H | 1998 | J Lipid Res1998，39，5： | 1 |
| 17 | Missense mutations in the human beta fibrinogen gene cause congenital afibrinogenemia by impairing fibrinogen secretion 显示文摘 | DUGA S ASSELTA R SANTAGOSTINO E | 2000 | Blood2000，95，4： | 1 |
| 18 | T-cell receptor excision circles:a novel prognostic parameter for the outcome of transplantation in multiple myeloma patients显示文摘 | LANTHALER A J DUGAS M | 2003 | British J Haematol2003，122，5： | 1 |
| 19 | Dietary supplementation with β-carotene, but not with lycopene,inhibits endothelial cell-mediated oxidation of low-density lipoprotein显示文摘 | Dugas T R Morel D W Harrison E H | 1999 | Free Radic Biol Med1999，26，910： | 1 |
| 20 | Absorption and Desorption Rates of Carbon Dioxide With Monoethanolamine and Piper- azine 显示文摘 | Dugas R Rochelle G T | 2009 | Energy Procedia2009，1，11： | 1 |
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