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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Analysis of Flt3 length mutations in 1003 patients with acute myeloid leukemia:correlation to cytogenetics,FAB subtype,and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease显示文摘 | Schnittger S Schoch C Dugas M | 2002 | Blood2002，100，： | 1 |
| 3 | Minimizing dilutional coagulopathy in exanguinating hemorrhage:A computer simulation显示文摘 | Hirshberg A Dugas M Banez E | 2003 | J Trauma2003，54，3： | 1 |
| 4 | Baseline serum levels of mast cell tryptase are raised in hemodialysis patients and associated with severity of pruritus显示文摘 | Dugas-Breit S Schopf P Dugas M | 2005 | J Dtsch Dermatol Ges2005，3，5： | 1 |
| 5 | Generalized anxiety disorder publications: Where do we stand a decade later?显示文摘 | Dugas M J Anderson K G Deschenes S S | 2010 | J Anxiety Disord2010，24，7： | 1 |
| 6 | Crystalline MnO2as possible alternatives to amorphous compounds in electrochemical supercapacitors显示文摘 | BROUSSE T TOUPIN M DUGAS R | 2006 | Journal of the Electrochemical Society2006，153，12： | 1 |
| 7 | T-cell receptor excision circles:a novel prognostic parameter for the outcome of transplantation in multiple myeloma patients显示文摘 | LANTHALER A J DUGAS M | 2003 | British J Haematol2003，122，5： | 1 |
| 8 | Analysis of FLT3 Length Mutation in 1003 Patients with Acute Mydloid Leukemia:Correction to Cytogenetics, FAB SUBTYPE, and Prognosis in the AMLCG Study and Usefulness as a Market for the Detection of Minimal Residual Disease显示文摘 | Schniuger S Schoch C Dugas M | 2002 | Blood2002，100，1： | 1 |
| 9 | Minimizing dilutional ooagulopathy in exsanguinating hemorrhage: a computer simulation显示文摘 | Dugas M Banez EI | 2003 | J Trauma2003，54，3： | 1 |
| 10 | Carbon dioxide fluxes over bermudagrass, native prairie and sorghum显示文摘 | Dugas W A Heuer M L Mayeux H S | 1999 | A gricultural and Forest Meteorology1999，93，： | 1 |
| 11 | Analy- sis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB sub- type,and prognosis in the AMLCG study and usefulness as amarker for the detection of minimal residual disease 显示文摘 | SCHNITTGER S SCHOCH C DUGAS M | 2002 | Blood2002，100，： | 1 |
| 12 | Crystalline MnO2 as possible alternatives to amorphous compounds in electrochemical supercapacitors 显示文摘 | BROUSSE T TOUPIN M DUGAS R | 2006 | Electrochem Soc2006，，153： | 1 |
| 13 | Analysis of FLT3length mutations in 1003 patients with acute myeloid leukemia:correlation to cytogenetics,FAB subtype,and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease显示文摘 | Schnittger S Schoch C Dugas M | 2002 | Blood2002，100，1： | 1 |
| 14 | Baseline serumlevels of mast cell tryptase are raised in hemodialysis patientsand associated with severity of pruritus显示文摘 | Dugas Breit S Schopf P Duages M | 2005 | J Dtsch DermatolGes2005，3，： | 1 |
| 15 | Baseline serum levels of mast cell tryptase are raised in Hemodialysis patients and associated with severity of pruritus显示文摘 | Dugas-Breit S Schopf P Dugas M | 2005 | J Dtsch Dermatol Ges2005，3，5： | 1 |
| 16 | Stem flow and porometer measurements of transpiration from honey mesquitr显示文摘 | ANSLEY R J DUGAS W A HEUER M L | 1994 | J Ecp Bot1994，45，6： | 1 |
| 17 | Synthesis of 7-dehydro-choles- terol through a palladium catalyzed selective homoan- nular conjugated diene formation 显示文摘 | Dugas D Brunel J M | 2006 | J Mol Catal A Chem2006，253，： | 1 |
| 18 | Generalized anxiety disorder publications: Where do we stand a decade later? 显示文摘 | Dugas M J Anderson K G Deschenes S S | 2010 | J Anxiety Disord2010，24，7： | 1 |
| 19 | Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease显示文摘 | Schnittger S Schoch C Dugas M | 2002 | Blood2002，100，1： | 1 |
| 20 | The molecular basis of quantitative fibrinogen disorders显示文摘 | ASSELTA R DUGA S TENCHINI M L | 2006 | J Thromb Haemost2006，4，10： | 1 |
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