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| 1 | Live cell screening platform identifies PPAR6 as a regulator of cardiomyocyte proliferation and cardiac repair显示文摘Zebrafish 能高效地通过 cardiomyocyte 增长改革他们的心。相反,哺乳动物的 cardiomyocytes 站立即在出生以后增殖,限制出生后的哺乳动物的心的再生能力。因此,如果出生后的 cardiomyocyte 增长的内长的潜力能被提高,它能为心失败病人提供有希望的未来治疗。这里,我们开始系统地识别触发出生后的 cardiomyocyte 增长的小分子。由屏蔽为估计房间周期阶段利用一个基于 Fucci 的系统的化学复合图书馆,我们作为出生后的 cardiomyocyte 增长的 inducer 识别了 carbacyclin。在 vitro, carbacyclin 经由 peroxisome 导致了新生、成年的 mononuclear 老鼠 cardiomyocytes 的增长激活 proliferator 的受体(PPAR )/PDK1/p308Akt/GSK3/-catenin 小径。PPAR 的抑制在 zebrafish 心新生期间减少了 cardiomyocyte 增长。尤其是,象有在在老鼠的心肌的梗塞以后的 PPAR 收缩筋的治疗一样的组成地活跃的 PPAR 的可诱导的 cardiomyocyte 特定的 overexpression 在 cardiomyocytes 导致了房间周期前进,减少了结疤,并且改进了心脏的功能。一起,我们建立了屏蔽系统和礼品的 cardiomyocyte 增长有为心脏的病理的治疗的诺言的一个新 drugable 目标由 cardiomyocyte 损失引起了。 | Ajit Magadum Yishu Ding Lan He Teayoun Kim Mohankrishna Dalvoy Vasudevarao Qinqiang Long Kevin Yang Nadeera Wickramasinghe Harsha V Renikunta Nicole Dubois Gilbert Weidinger Qinglin Yang Felix B Engel | 2017 | Cell Research2017，27，8： | 6 |
| 2 | Preparation of stable micropatterns of gold on cell-adhesion-resistant hydrogels assisted by a hetero-bifunctional macromonomer linker显示文摘Surface patterning is very useful in biomaterial studies, yet it is not easy to prepare a micropattern with cell-adhesion contrast that is stable in a wet environment. Recently, a platform technique of transfer photolithography was invented to fabricate stable metal microarrays on the surface of a cell-adhesion resistant and mechanically biomimetic poly(ethylene glycol) hydrogel; the linker is the key chemical in such a transfer strategy. This article reports the design and synthesis of a hetero-bifunctional macromonomer linker with a thiol group at one end and an acryloyl group at the other end. The bifunctional linker was characterized by GPC and 1H NMR, and the average number of thiol groups in the bifunctional linker was detected by Ellman's reagent. The regent stability under wet conditions was also confirmed by the model reactants. The resultant micropatterned surfaces are meaningful for future studies of cell behaviors on mechanically biomimetic matrixes. | SUN JianGuo GRAETER Stefan V TANG Jian HUANG JingHuan LIU Peng LAI YuXiao YU Lin MAJER Günter SPATZ Joachim P DING JianDong | 2014 | Science China Chemistry2014，57，4： | 2 |
| 3 | Efficient focusing of hard X-rays generated by femtosecond laser driven plasma显示文摘 | TOMOV I V CHEN J DING X | 2004 | Chemical Physics Letters2004，389，： | 1 |
| 4 | Antibody binding to neuronal surface in Sydenham chorea, but not in PANDAS or Tourette syndrome 显示文摘 | Brilot F Merheb V Ding A | 2011 | Neu- rology2011，17，4： | 1 |
| 5 | Serum levels of vitamin D,sunlight exposure,and knee cartilage loss in older adults:the Tasmanian older adult cohort study显示文摘 | Ding C Cicuttini F Parameswaran V | | 0，，： | 1 |
| 6 | Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3receptors显示文摘 | Souslova V Cesare P Ding Y | 2000 | Nature2000，407，6807： | 1 |
| 7 | A vector approach for the analysis and synthesis of directional modulation transmitters显示文摘 | DING Y FUSCO V F | 2014 | Antennasand Propagation IEEE Transactions on2014，62，1： | 1 |
| 8 | 20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension 显示文摘 | Ding Y Wu CC Gareia V | 2013 | Am J Physiol Renal Physiol2013，305，5： | 1 |
| 9 | A Computational Study of Glutathione and Its Fragments:N-Acetylcisteinylglycine and -glutamylmethylamide 显示文摘 | Ding V Z Y Dawson S S H Lau L W Y | 2011 | Chem Phys Lett2011，507，： | 1 |
| 10 | Transcranial Doppler ultrasoundfor screening cerebral small vessel disease: a community study 显示文摘 | Mok V Ding D Fu J | 2012 | Stroke2012，43，10： | 1 |
| 11 | Catalytic Superefitieal Water Oxidation: Phenol Conversion and Product Selectivity显示文摘 | Ding Z Aki S N V K Abraham M A | 1995 | Environmental Science & Technology1995，29，11： | 1 |
| 12 | 查看详情显示文摘 | Song S D Zou X L Giruzzi G Xiao W W Ding X T Ding B J Ségui J L Elbèze D Clairet F Fenzi C Aniel T Artaud J F Basiuk V Bouquey F Magne R Corbel E the Tore Supra Team | | 0，，： | 1 |
| 13 | Fourier Rotman lens enabled directional modulation transmitter显示文摘 | DING Y ZHANG Y FUSCO V | 2015 | International Journalof Antennas and Propagation2015，，： | 1 |
| 14 | 显示文摘 | LaBella V P Emery C Ding Z | 2001 | Appl Phys Lett2001，19，79： | 1 |
| 15 | Enhancement of neural synchrony by time delay显示文摘 | Dhamala M Jirsa V K Ding M | 2004 | Phys Rev Lett2004，92，： | 1 |
| 16 | Angiotensin II sustains brain inflammation in mice via TGF-[Beta]显示文摘 | Lanz Tobias V Ding Zhaoqing Ho Peggy P Luo Jian Agrawal Ankur N Srinagesh Hrishikesh Axtell Robert Zhang Hui Platten Michael Wyss-Coray Tony Steinman Lawrence | 2010 | Journal of Clinical Investigation2010，，8： | 1 |
| 17 | Application of the Karhunen–Loeve transform temporal image filter to reduce noise in real-time cardiac cine MRI显示文摘 | Yu Ding Yiu-Cho Chung Subha V Raman Orlando P Simonetti | 2009 | Physics in Medicine and Biology2009，，12： | 1 |
| 18 | Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors 显示文摘 | Souslova V Cesare E Ding Y | 2000 | Nature2000，407，： | 1 |
| 19 | Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors显示文摘 | Souslova V Cesare P Ding Y | 2000 | Nature2000，407，6807： | 1 |
| 20 | The contribution of a satellite market to price discovery: Evidence from the Singapore exchange显示文摘 | Covrig V Ding D Low B S | 2004 | Journal of Futures Markets2004，24，10： | 1 |
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