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| 1 | 近红外光促脂质体释药及光热治疗显示文摘以牛血清蛋白(BSA)为模板制备金纳米簇(AuNCs),透析至中性,原位组装香豆素6(C6)载药脂质体,形成纳米簇杂化脂质体体系Lips/C6@AuNCs.实验结果表明:体系稳定性增强,保持AuNCs良好的光热转化效率,在808nm激光源照射下,药物释放速率加快,具有光促释药的效果,细胞实验证实AuNCs良好的生物相容性,光热治疗与化学治疗效果显著.通过静电自组织,表面进一步分别修饰靶向分子叶酸(FA)、谷胱甘肽(GSH)和魔芋葡甘露聚糖(KGM),可以进一步实现肿瘤微环境响应、靶向释药和长循环释放等效果,有望实现化学治疗、光热治疗等协同治疗的脂质体肿瘤治疗体系. | 龚玲俐 刘含 陆爽 王慧敏 范於菟 陈永盛 杨昌英 | 2020 | 三峡大学学报(自然科学版)2020，42，6： | 1 |
| 2 | Multiple genotyping based on multiplex PCR and microarray显示文摘The genetic variability has obtained more and more attention in the process of diagnosis and treatment of tumors.Herein,we have described a multiple genotyping method based on magnetic enrichmentmultiplex PCR(MEM-PCR) and microarray technology.Monodisperse magnetic beads were fabricated and modified with streptavidin.Four loci on two genes(M235T and A-6G loci on AGT gene,A1298 C and C677 T loci on MTHFR gene) were selected to study single nucleotide polymorphisms(SNP).Target sequences of these SNP loci were amplified using Cy3-labeled primers through multiplex PCR in one tube after the templates were enriched and purified by functional magnetic beads(MB).Four pairs of NH_2-labeled probes,corresponding to each locus,were fixed on CHO-modified glass slide by covalent binding.Hybridization between target sequences and probes was performed under suitable conditions.The spotting locations on microarray and the ratio of fluorescence intensity,produced by different loci,were used to distinguish the SNP genotypes.Finally,three of gastric cancer samples were collected and genotyping analysis for these four SNP loci was carried out successfully simultaneously by this method. | Xian-Bo Mou Zeeshan Ali Bo Li Tao-Tao Li Huan Yi Hong-Ming Dong Nong-Yue He Yan Deng Xin Zeng | 2016 | Chinese Chemical Letters2016，27，11： | 0 |
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