|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Brain stem cells as the cell of origin in glioma显示文摘Glioma incidence rates in the United States are near 20000 new cases per year, with a median survival time of 14.6 mo for high-grade gliomas due to limited therapeutic options. The origins of these tumors and their many subtypes remain a matter of investigation. Evidence from mouse models of glioma and human clinical data have provided clues about the cell types and initiating oncogenic mutations that drive gliomagenesis, a topic we review here. There has been mixed evidence as to whether or not the cells of origin are neural stem cells, progenitor cells or differentiated progeny. Many of the existing murine models target cell populations defined by lineage-specific promoters or employ lineagetracing methods to track the potential cells of origin. Our ability to target specific cell populations will likely increase concurrently with the knowledge gleaned from an understanding of neurogenesis in the adult brain. The cell of origin is one variable in tumorigenesis, as oncogenes or tumor suppressor genes may differentially transform the neuroglial cell types. Knowledge of key driver mutations and susceptible cell types will allow us to understand cancer biology from a developmental standpoint and enable early interventional strategies and biomarker discovery. | Aram S Modrek N Sumru Bayin Dimitris G Placantonakis | 2014 | World Journal of Stem Cells2014，6，1： | 12 |
| 2 | 一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. | Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P | 2014 | 中华神经外科疾病研究杂志2014，13，5： | 6 |
| 3 | Sensitivity analysis of a star optical network based on mutually coupled semiconductor lasers显示文摘 | Michail B Apostolos A Dimitris S | 2012 | Journal of Lightwave Technology2012，30，16： | 1 |
| 4 | Study of pumped storage schemes to support high RES penetration in the electric pwer system of Greece显示文摘 | John S Anagnostopoulos Dimitris E Papantonis | 2012 | Energy2012，45，： | 1 |
| 5 | Nonlinear coupled mechanics and initial bucking of comosite plates with piezoelectric actuators and sensors显示文摘 | Dimitris Varelis Dimitris A S | 2002 | Smart Material and Structure (S0964-1726)2002，11，3： | 1 |
| 6 | The thickness and volume ofLLETZ specimens can predict the relative risk of pregnancy -related morbidity 显示文摘 | Khalid S Dimitriou E Conroy R | 2012 | BJOG2012，119，6： | 1 |
| 7 | MicroRNA fingerprinting of CLL patients with chromosome 17p deletion identify a miR-21 score that stratifies early survival显示文摘 | Rossi S Shimizu M Barbarotto E Nicoloso MS Dimitri F Sampath D | | 0，，： | 1 |
| 8 | Analysis of the bubbling effect in synchronized networks with semiconductor laser显示文摘 | Michail B Apostolos A Dimitris S | 2013 | IEEE Photonics Technology Letters2013，25，9： | 1 |
| 9 | Cure kinetics of epoxy amine resins used in the restoration of works of art from glass or ceramic显示文摘 | EVRIKLEIA G K DIMITRIS IRINI SA IRINI D S | | 0，，42： | 1 |
| 10 | Adaptive algorithms to track the Parafac decomposition of a third-order ten- sor显示文摘 | Dimitri N Nicholas D S | 2009 | IEEE Transactions2009，57，6： | 1 |
| 11 | Isothermal and nonisothermal crystallization kinetics of poly (propylene terephthalate)显示文摘 | Dimitris S A George Z P George P K | 2004 | J Polym Sci Part B:Polym Phys 20042004，3784，： | 1 |
| 12 | Nitrogen-cen- tered activators of peroxide- reinforced oxygen delignification 显示文摘 | Dimitris S Argropoulos Miro Suchy Leonid Akim | 2004 | Ind Eng Chem Res2004，43，： | 1 |
| 13 | Incorporating Illumination Constraints in Deformable Models for Shape from Shading and Light Direction Estimation显示文摘 | Dimitris S Dimitris M | 2003 | IEEE Transactions on Pattern Analysis and Machine Intelligence2003，25，2： | 1 |
| 14 | Mast cell-dependent B and T lymphocyte activation is mediated by the secretion of immunologically active exosomes显示文摘 | Dimitris S Sophie Le P Ire'ne V | 2001 | The Journal of Immunology2001，166，2： | 1 |
| 15 | The contribution of scenic beauty indicators in estimating environmental welfare measures: a case study显示文摘 | Ioanna F Dimitris S | 2004 | Social Indicators Research2004，65，： | 1 |
| 16 | Diversity, Activity, and Abundance of Sulfate-Reducing Bacteria in Saline and Hypersaline Soda Lakes显示文摘 | Mirjam F Dimitry Y S Bait L | 2007 | Appl Environ Microbiol2007，73，7： | 1 |
| 17 | Reaction of haem containing proteins and enzymes with hydroperoxides: the radical view显示文摘 | DIMITRI A S | 2005 | Biochimica et Biophysica Acta2005，1707，： | 1 |
| 18 | Regeneration of periodontal tissues : combinations of barrier memb-ranes and grafting materials-biologi- cal foundation and preclinical evidence : a systematic review 显示文摘 | Anton S Dimitris N Frank S | 2008 | J Clin Periodontol2008，35，8： | 1 |
| 19 | The effects of rosuvastatin alone or in combination with fenofibrate or omega 3 fatty acids on inflammation and oxidative stress in patients with mixed dyslipidemia显示文摘 | Aris P Agouridis Vasilis Tsimihodimos Theodosios D Filippatos Andromachi A Dimitriou Costantinos C Tellis Moses S Elisaf Dimitri P Mikhailidis Alexandros D Tselepis | 2011 | Expert Opinion on Pharmacotherapy2011，，17： | 1 |
| 20 | Specificity of short interfering RNA determined through gene expression signatures显示文摘 | Dimitri S Leigh F Aparna S | 2003 | Proc Natl Acad Sci USA2003，100，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员