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| 1 | Staining for p53 and Ki-67 increases the sensitivity of EUS-FNA to detect pancreatic malignancy显示文摘AIM:To investigate whether tumor marker staining can improve the sensitivity of endoscopic ultrasound-guided fine needle aspiration(EUS-FNA)to diagnose pancreatic malignancy. METHODS:Patients who underwent EUS-FNA were retrospectively identified.Each EUS-FNA specimen was evaluated by routine cytology and stained for tumor markers p53,Ki-67,carcinoembryonic antigen(CEA) and CA19-9.Sensitivity,specificity,positive and negative predictive values(PPV and NPV),and positive and negative likelihood ratios(PLR and NLR)were calculated in order to evaluate the performance of each test to detect malignancy. RESULTS:Sixty-one specimens had complete sets of stains,yielding 49 and 12 specimens from pancreatic adenocarcinomas and benign pancreatic lesions due to pancreatitis,respectively.Cytology alone had sensitivity and specificity of 41%and 100%to detect malignancy, respectively.In 46%of the specimens,routine cytology alone was deemed indeterminate.The addition of either p53 or Ki-67 increased the sensitivity to 51%and 53%,respectively,with perfect specificity,PPV and PLR (100%,100%and infinite).Both stains in combination increased the sensitivity to 57%.While additional staining with CEA and CA19-9 further increased the sensitivity to 86%,the specificity,PPV and PLR were significantly reduced(at minimum 42%,84%and 1,respectively).Markers in all combinations performed poorly as a negative test(NPV 26%to 47%,and NLR 0.27 and 0.70).CONCLUSION:Immunohistochemical staining for p53 and Ki-67 can improve the sensitivity of EUS-FNA to diagnose pancreatic adenocarcinoma. | Alexander W Jahng Sonya Reicher David Chung Donna Varela Rahul Chhablani Anil Dev Binh Pham Jose Nieto Rose J Venegas Samuel W French Bruce E Stabile Viktor E Eysselein | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，11： | 3 |
| 2 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 3 | Methotrexate treatment for scarcoid associated panuveitis 显示文摘 | DEV S MCCALLUM R M JAFFE G J | 1999 | Ophthalmology1999，106，1： | 1 |
| 4 | Osteoblast minerali- zation with composite nanofibrous substrate for bone tissue regenerati- on 显示文摘 | Venugopal J R Cfiri Dev V R Senthilram T | 2011 | Cell Biol Int2011，35，1： | 1 |
| 5 | The Effects of Customer and Competitor Orientations on Performance in Global Markets : a Contingency Analysis 显示文摘 | ZHOU K Z BROWN J R DEV C S | 2007 | Journal of International Business Studies2007，38，： | 1 |
| 6 | New methods of calculating metabolic rate with special reference to protein metabolism显示文摘 | WEIR J B deV | 1949 | J Physiol1949，109，13： | 1 |
| 7 | o'-eonvergence in the presence of spatial effects 显示文摘 | REY S J DEV B | 2006 | Papers in Regional Science2006，，2： | 1 |
| 8 | PICK1 interacts with and regulates PKC phosphorylation of mGLUR7显示文摘 | Dev K K Nakajima Y Kitano J | 2000 | J Neurosci2000，20，19： | 1 |
| 9 | Secondary structure of llS globulin in aqueous solution 显示文摘 | Dev S B Keller J T Rha C K | 1988 | Biochim Biophys Acta1988，9，： | 1 |
| 10 | Retinopathy progression and visual outcomes after phacocmulsification in patients with diabetes mellitus显示文摘 | Borrillo J L Mittra R A Dev S | 1999 | Trans Am Ophthalmol Soc1999，97，43： | 1 |
| 11 | Rapid,futile K+ cycling and pool-size dynamics define low-affinity potassium transport in barley显示文摘 | MARK W S DEV T B HERBERT J K | 2006 | Plant Physiol2006，141，： | 1 |
| 12 | Using influence strategies to reduce marketing channel opportunism: The moderating effect of relational norms 显示文摘 | Brown J R Grzeskowiak S Dev C S | 2009 | Mar- keting Letters2009，20，2： | 1 |
| 13 | Enhancement of therapeutic drug and DNA delivery into cells by electroporation显示文摘 | Rabussay D Dev N B Fewell J | 2003 | J Phys D Appl Phys2003，36，1： | 1 |
| 14 | Managing Marketing Chan- nel Opportunism: The Efficacy of Ahernative Governance Mechanisms 显示文摘 | BROWN J R DEV C S LEE D | 2000 | Journal of Marketing2000，64，2： | 1 |
| 15 | σ-convergence in the presence of spatial effects显示文摘 | Rey S J Dev B | 2006 | Papers in Regional Science2006，85，2： | 1 |
| 16 | Problem-based learning in clinical practice facilitating critical thinking显示文摘 | J NURSES STAFF DEV | 2000 | A Price and B Price2000，16，6： | 1 |
| 17 | Image quality and artifacts in coronary CT angiography with dual-source CT: initial experience 显示文摘 | Dev D Lee C J Ohba M | 2008 | J Cardiovasc Computed Tomogr2008，2，2： | 1 |
| 18 | Hybrid LEDs basedon ZnO-nanowire arrays显示文摘 | El-Shaer A Dev A Richters J | 2010 | Phys Status Solidi (B)2010，247，6： | 1 |
| 19 | Market orientation, competitive advantage, and performance : A demand- based perspective 显示文摘 | Zhou K Z Brown J R Dev C S | 2009 | Journal of Business Re- search2009，62，11： | 1 |
| 20 | An unusual case of heart failure due to Plasmodium vivaxinfection with a favorable outcome显示文摘 | Dev N Gadpayle AK Sankar J | 2014 | Rev Soc Bras Med Trop2014，47，5： | 1 |
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