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| 1 | Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review显示文摘Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP.Molecular characterization revealed overexpression in MRP1(80%), MGMT(79%), TOP2A(75), RRM1(42%),TOPO1(42%), PTEN(45%), CMET(40%), and C-KIT(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease. | Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford J Whatcott Zoran Gatalica Michael T Barrett Derek Cridebring Daniel D Von Hoff | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 6 |
| 2 | Radiographic assessment of leg alignment and grading of knee osteoarthritis:A critical review显示文摘Knee osteoarthritis(OA) is a progressive joint disease hallmarked by cartilage and bone breakdown and associated with changes to all of the tissues in the joint,ultimately causing pain,stiffness,deformity and disability in many people.Radiographs are commonly used for the clinical assessment of knee OA incidence and progression,and to assess for risk factors.One risk factor for the incidence and progression of knee OA is malalignment of the lower extremities(LE).The hipknee-ankle(HKA) angle,assessed from a full-length LE radiograph,is ideally used to assess LE alignment.Careful attention to LE positioning is necessary to obtain the most accurate measurement of the HKA angle.Since full-length LE radiographs are not always available,the femoral shaft-tibial shaft(FS-TS) angle may be calculated from a knee radiograph instead.However,the FS-TS angle is more variable than the HKA angle and it should be used with caution.Knee radiographs are used to assess the severity of knee OA and its progression.There are three types of ordinal grading scales for knee OA:global,composite and individual feature scales.Each grade on a global scale describes one or more features of knee OA.The entire description must be met for a specific grade to be assigned.The KellgrenLawrence scale is the most commonly-used global scale.Composite scales grade several features of knee OA individually and sum the grades to create a total score.One example is the compartmental grading scale for knee OA.Composite scales can respond to change in a variety of presentations of knee OA.Individual feature scales assess one or more OA features individually and do not calculate a total score.They are most often used to monitor change in one OA feature,commonly joint space narrowing.The most commonly-used individual feature scale is the OA Research Society International atlas.Each type of scale has its advantages;however,composite scales may offer greater content validity.Responsiveness to change is unknown for most scales and deserves further evaluation. | Lisa Sheehy T Derek V Cooke | 2015 | World Journal of Rheumatology2015，5，2： | 2 |
| 3 | Time saving technology succeeds for fairfield underpass显示文摘 | DEREK T | 2004 | Concrete2004，38，9： | 1 |
| 4 | From Rumors to Facts, and Facts to Rumors: The Role of Certainty Decay in Consumer Communications 显示文摘 | Dubois D Derek D R Zakary L T | 2011 | Journal of Marketing Research2011，48，6： | 1 |
| 5 | Approximate conditional mean particle filtering for linear/nonlinear dynamic state space models显示文摘 | Derek Yee Reilly Kirubarajan J P Punithakumar T K | 2008 | Signal Processing2008，56，12： | 1 |
| 6 | Perceptual-Cognitive Expertise in Sport: A Meta-Analysis 显示文摘 | DEREK T Y WILLIAMS M A CHRISTOPHER M | 2007 | Journal of Sport & Exercise Psychology2007，，29： | 1 |
| 7 | Occupational exposures in healthcare workers in University Hospital Dubrava--10 year follow-up study显示文摘 | Serdar T Derek L Unic'A | 2013 | Cent Eur J Public Health2013，21，3： | 1 |
| 8 | Tracking with vir- tual slides: a tool to study diagnostic error in histopathol- ogy显示文摘 | Darren T Chee H L Derek M | 2009 | Histopathology2009，55，1： | 1 |
| 9 | Recent developments in adjuvants for vaccines against infectious diseases显示文摘 | Derek T Mackichan ML Singh M | 2001 | Biomol Eng2001，18，： | 1 |
| 10 | Time saving technology succeeds for fairfield underpass显示文摘 | Derek T | 2004 | Concrete2004，38，9： | 1 |
| 11 | Application of the equilibriumplanformconcept to natural beaches in Northern Ireland显示文摘 | Derek W T Jackson J Andrew G C | | 0，，： | 1 |
| 12 | Occupational exposures in healthcare workers in University Hospital Dubrava 10 year follow-up study显示文摘 | Serdar T Derek L Uni A | 2013 | Cent Eur J Public Health2013，21，3： | 1 |
| 13 | The trouble with chain marketing 显示文摘 | Derek T | 1998 | Hospitality Management1998，，17： | 1 |
| 14 | High bandwidth fast steering mirror显示文摘 | Francisc M T Derek J E Timothy R H | 2005 | Proc SPIE2005，5877，： | 1 |
| 15 | Protocol com- position logic(PCL)显示文摘 | Datta A Derek A Mitchell T C | 2007 | Electronic Notes in Theoret- ical Computer Science (ENTCS)2007，172，： | 1 |
| 16 | Mediation analysis in social psychology:current practices and new recommendations显示文摘 | Derek D R Kristopher J P Zakary L T | 2011 | Social and Personality Psychology Compass2011，5，6： | 1 |
| 17 | An efficient synthesis of ( - ) - dodecahydro - 3a,6,6,9a - tetramethylnaphtho uran from ( - ) - selareol 显示文摘 | DEREK H R SHYAMA1 I P DENNIS K T | 1994 | Tetrahedron Letters1994，35，32： | 1 |
| 18 | Validation of Companion Diagnostic for Detection of Mutations in Codons 12 and 13 of the KRAS Gene in Patients with Metastatic Colorectal Cancer: Analysis of the NCIC CTG CO.17 Trial显示文摘 | Harbison Christopher T Horak Christine E Ledeine Jean-Marie Mukhopadhyay Pralay Malone Daniel P O’Callaghan Chris Jonker Derek J Karapetis Christos S Khambata-Ford Shirin Gustafson Nancy Trifan Ovidiu C Chang Shao-Chun Ravetto Paul Green Geo | 2013 | Archives of Pathology & Laboratory Medicine2013，，6： | 1 |
| 19 | Preconditioning andArrhythmias显示文摘 | PETER T DEREK M Y HON | 2002 | Circulation2002，106，： | 1 |
| 20 | Occupational exposures in healthcare workers in University Hospital Dubrava--10year follow-up study显示文摘 | Serdar T Derek L Uni A | 2013 | Cent Eur J Public Health2013，21，3： | 1 |
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