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| 1 | MRI动态增强扫描对脊柱结核和脊柱转移瘤的鉴别诊断价值显示文摘目的探讨MR T1WI动态增强成像半定量和定量分析对脊柱结核和脊柱转移瘤的鉴别诊断价值,提高术前影像诊断准确性。资料与方法对24例脊柱结核和22例脊柱转移瘤进行MR T1WI动态增强扫描,对图像后处理分析得到的时间-信号强度曲线、上升期病变信号强度增幅、最大上升线性斜率及应用双室药物代谢动力学分析获得的血管通透性常数(Ktrans)和转运常数(kep)进行比较。结果 24例脊柱结核患者中,仅1例(4.2%)呈速降型曲线,12例(50.0%)呈平台型,11例(45.8%)呈持续增强型;22例脊柱转移瘤中,12例(54.5%)呈速降型曲线,7例(31.8%)呈平台型曲线,3例(13.6%)呈持续增强型曲线。脊柱结核组和脊柱转移瘤组信号强度增幅[(198±81)%与(165±60)%]、时间-信号强度曲线最大上升线性斜率[(100±55)%与(111±41)%]和Ktrans[(0.077±0.036)/min与(0.077±0.028)/min]差异均无统计学意义(t=1.56、0.76、0,P>0.05)。脊柱结核组kep明显低于转移瘤组[(0.270±0.015)/min与(0.490±0.023)/min,t=38.74,P<0.001]。结论MR T1WI动态增强成像可以为表现不典型、常规MRI检查不易鉴别的脊柱结核和脊柱转移瘤的鉴别诊断提供一定的参考。 | 郎宁 苏敏英 Hon J.Yu 袁慧书 | 2015 | 中国医学影像学杂志2015，23，5： | 48 |
| 2 | 基于LUCC的城市生态安全研究进展显示文摘近代工业革命以来特别是二战以后,世界范围内城市化发展迅速,受城市化驱动的土地利用/覆盖变化(Land use/cover change,LUCC)及其环境影响越来越突出,不仅对城市生态安全产生了危胁,甚至在区域和全球尺度上影响生态系统的结构与功能,成为当今地球生态系统平衡与人类社会可持续发展的研究热点。尽管LUCC与城市生态安全态势有密切联系,然而目前研究中对土地利用变化的驱动机制较为侧重,涉及LUCC对城市生态安全影响的研究文献仍很缺乏。从城市生态安全的概念辨析入手,评述了国内外LUCC与城市生态安全响应研究的进展,将相关研究分为两个阶段:即定性和(半)定量研究阶段。指出了现有研究在理论体系与研究方法在指导实践中的不足之处,即:(1)基于LUCC城市尺度的生态安全研究的理论体系尚不成熟,目前的研究多未结合研究区域LUCC的动态特征对城市生态安全状态进行评价,因而也难以应用于指导城市生态建设实践;(2)目前的城市土地利用的生态影响实例研究中仍很缺乏采用数学模型、地理信息系统(GIS)、环境影响评价(EIA)、生态风险评价技术(ERA)及政策仿真等手段进行动态化的、多场景(Multi-Scenarios)模拟分析的综合运用,也缺乏对这些研究方法在实践中的应用的比较研究;(3)缺乏从土地利用动态监测、驱动力机制、生态响应等方面进行区域生态安全演变及调控的综合研究,现实指导意义有限。在上述工作的基础上,探讨了此研究领域未来的发展方向,即:(1)实现不同研究尺度的紧密结合;(2)多种研究方法的集成运用;(3)基于多学科知识体系的评价方法与指标体系的明细化与合理化。 | 张浩 马蔚纯 HO Hon Hing | 2007 | 生态学报2007，27，5： | 36 |
| 3 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 4 | Toward Cloud Computing QoS Architecture:Analysis of Cloud Systems and Cloud Services显示文摘Cloud can be defined as a new computing paradigm that provides scalable, on-demand, and virtualized resources for users. In this style of computing, users can access a shared pool of computing resources which are provisioned with minimal management efforts of users. Yet there are some obstacles and concerns about the use of clouds. Guaranteeing quality of service(Qo S) by service providers can be regarded as one of the main concerns for companies tending to use it. Service provisioning in clouds is based on service level agreements representing a contract negotiated between users and providers. According to this contract, if a provider cannot satisfy its agreed application requirements, it should pay penalties as compensation. In this paper, we intend to carry out a comprehensive survey on the models proposed in literature with respect to the implementation principles to address the QoS guarantee issue. | Mohammad Hossein Ghahramani MengChu Zhou Chi Tin Hon | 2017 | IEEE/CAA Journal of Automatica Sinica2017，4，1： | 19 |
| 5 | Nitric oxide synthase and heme oxygenase expressions in human liver cirrhosis显示文摘瞄准:门静脉高血压是肝肝硬化的普通复杂并发症。肝内压力能以几个方法被提高。从内脏的内脏影响脉管系统, vasoconstrictors 的增加和增加的循环进门静脉系统的反常建筑学都可以作出贡献。因而内长的血管扩张药也许能减轻高血压。我们因此试图调查内长的血管扩张药的层次,氮的氧化物(没有) 并且通过氮的氧化物 synthase (NOS ) 的表示的一氧化碳(公司) 并且他我氧合酶(惊讶) 。方法:肝脏硬化症(n=20 ) 并且非肝脏硬化症(n=20 ) 肝从经历了外科的病人被获得。NOS 的各种各样的 isoforms 的 mRNA 和蛋白质表情并且惊讶用竞争 PCR,西方的污点和免疫组织化学被检验。结果:当内皮 NOS (eNOS ) 在硬变肝是起来调整的时,在可诱导的 NOS (i NOS ) 或神经元 NOS (nNOS ) 表情没有重要变化。附随地, caveolin-1, eNOS 的一个确定的下面管理者,是起来调整的。可诱导的 HO-1 和组成的 HO-2 被发现在不同本地化在硬变肝虽然显示出增加的表示。结论:NOS 表示力量的差别由于他们在在肝硬化的病理维持肝动态平衡或参与的不同角色。在高血压的肝以内的纯粹的应力可以导致 eNOS 的增加的表示。接着, caveolin-1 也被增加。这是否对进一步的肝硬化用作一个防御机理或是肝硬化的后果,是还未知的。HO-1 和 HO-2 的提高的表示建议公司可以微弱地作为血管扩张药虽然在它的角色补偿。它是可能的那个公司并且不在肝以内有平行或协调的功能并且可以在门静脉高血压的病理生理学反对地工作。 | Beatrice J Goh Bee Tee Tan Wei Min Hon Kang Hoe Lee Hoon Eng Khoo | 2006 | World Journal of Gastroenterology2006，12，4： | 19 |
| 6 | Robotic surgery for rectal cancer: A systematic review of current practice显示文摘AIM: To give a comprehensive review of current litera-ture on robotic rectal cancer surgery.METHODS: A systematic review of current literature via PubMed and Embase search engines was per-formed to identify relevant articles from january 2007 to november 2013. The keywords used were: 'robotic surgery', 'surgical robotics', 'laparoscopic computer-assisted surgery', 'colectomy' and 'rectal resection'. RESULTS: After the initial screen of 380 articles, 20 pa-pers were selected for review. A total of 1062 patients(male 64.0%) with a mean age of 61.1 years and body mass index of 24.9 kg/m2 were included in the review.Out of 1062 robotic-assisted operations, 831(78.2%) anterior and low anterior resections, 132(12.4%) in-tersphincteric resection with coloanal anastomosis, 98(9.3%) abdominoperineal resections and 1(0.1%) Hart-mann's operation were included in the review. Robotic rectal surgery was associated with longer operative time but with comparable oncological results and anastomotic leak rate when compared with laparoscopic rectal surgery. CONCLUSION: Robotic colorectal surgery has con-tinued to evolve to its current state with promising re-sults; feasible surgical option with low conversion rate and comparable short-term oncological results. The challenges faced with robotic surgery are for more high quality studies to justify its cost. | Tony Wing Chung Mak Janet Fung Yee Lee Kaori Futaba Sophie Sok Fei Hon Dennis Kwok Yu Ngo Simon Siu Man Ng | 2014 | World Journal of Gastrointestinal Oncology2014，6，6： | 16 |
| 7 | Telerobotic-assisted laparoscopic abdominoperineal resection for low rectal cancer: Report of the first case in Hong Kong and China with an updated literature review显示文摘Telerobotic surgery is the most advanced development in the field of minimally invasive surgery. The da Vinci surgical system, which is currently the most widely used telerobotic device, was approved by the Food and Drug Administration of the United States of America for clinical use in all abdominal operations in July 2000. The first da Vinci surgical system in China was installed in November 2005 at our institution. We herein report the first telerobotic-assisted laparoscopic abdominoperineal resection using the 3-arm da Vinci surgical system for low rectal cancer in Hong Kong and China, which was performed in August 2006. The operative time and blood loss were 240 min and 200 mL, respectively. There was no complication, and the patient was discharged on postoperative day five. An updated review of published literature on telerobotic-assisted colorectal surgery is included in this report, with special emphasis on its advantages and limitations. | Simon Siu-Man Ng Janet Fung-Yee Lee Raymond Ying-Chang Yiu Jimmy Chak-Man Li Sophie Sok-Fei Hon | 2007 | World Journal of Gastroenterology2007，13，17： | 12 |
| 8 | T1ρ/T2 mapping and histopathology of degenerative cartilage in advanced knee osteoarthritis显示文摘AIM To investigate whether normal thickness cartilage in osteoarthritic knees demonstrate depletion of proteoglycan or collagen content compared to healthy knees.METHODS Magnetic resonance(MR) images were acquired from5 subjects scheduled for total knee arthroplasty(TKA)(mean age 70 years) and 20 young healthy control subjects without knee pain(mean age 28.9 years). MR images of T1ρ mapping, T2 mapping, and fat suppressed proton-density weighted sequences were obtained.Following TKA each condyle was divided into 4 parts(distal medial, posterior medial, distal lateral, posterior lateral) for cartilage analysis. Twenty specimens(bone and cartilage blocks) were examined. For each joint,the degree and extent of cartilage destruction was determined using the Osteoarthritis Research Society International cartilage histopathology assessment system.In magnetic resonance imaging(MRI) analysis, 2 readers performed cartilage segmentation for T1ρ/T2 values and cartilage thickness measurement.RESULTS Eleven areas in MRI including normal or near normal cartilage thickness were selected. The corresponding histopathological sections demonstrated mild to moderate osteoarthritis(OA). There was no significant difference in cartilage thickness in MRI between control and advanced OA samples [medial distal condyle, P = 0.461;medial posterior condyle(MPC), P = 0.352; lateral distal condyle, P = 0.654; lateral posterior condyle, P = 0.550],suggesting arthritic specimens were morphologically similar to normal or early staged degenerative cartilage.Cartilage T2 and T1ρ values from the MPC were significantly higher among the patients with advanced OA(P= 0.043). For remaining condylar samples there was no statistical difference in T2 and T1ρ values between cases and controls but there was a trend towards higher values in advanced OA patients. CONCLUSION Though cartilage is morphologically normal or near normal, degenerative changes exist in advanced OA patients. These changes can be detected with T2 and T1ρ MRI techniques. | Benjamin S Kester Philip M Carpenter Hon J Yu Taiki Nozaki Yasuhito Kaneko Hiroshi Yoshioka Ran Schwarzkopf | 2017 | World Journal of Orthopedics2017，8，4： | 12 |
| 9 | MR动态增强对于中轴骨脊索瘤和骨巨细胞瘤的鉴别诊断价值的初步研究显示文摘目的探讨MR T1WI动态增强成像半定量和定量分析对中轴骨脊索瘤和骨巨细胞瘤鉴别诊断的价值。资料与方法收集2008年6月—2013年10月于北京大学第三医院放射科进行MR T1WI动态增强扫描并经病理证实的中轴骨13例脊索瘤和17例骨巨细胞瘤患者,对两者后处理分析得到的信号强度-时间曲线类型及应用双室药物代谢动力学分析获得的转运常数(K^(trans))和速率常数(k_(ep))进行统计学分析。结果 13例脊索瘤中,9例(69.2%)为持续上升型,4例(30.8%)为平台型;17例骨巨细胞瘤患者中,11例(64.7%)为速升速降型曲线,6例(35.3%)为平台型曲线。骨巨细胞瘤Ktrans明显高于脊索瘤K^(trans)[(0.1247±0.0747)/min比(0.0603±0.0411)/min,P<0.01];骨巨细胞瘤的k_(ep)明显高于脊索瘤的k_(ep)[(0.6629±0.2272)/min比(0.1736±0.1184)/min,P<0.01]。以K^(trans)为0.0777/min作为诊断骨巨细胞瘤的阈值时,其诊断的敏感度、特异度分别为89.5%、76.9%;以k_(ep)为0.4339/min作为诊断骨巨细胞瘤的阈值时,其诊断的敏感度、特异度分别为94.7%、100.0%。ROC分析K^(trans)诊断骨巨细胞瘤的曲线下面积为0.826,k_(ep)诊断骨巨细胞瘤的曲线下面积为0.980。结论MR T1WI动态增强成像可以为常规影像学诊断困难的中轴骨脊索瘤和骨巨细胞瘤的鉴别诊断提供一定的参考。 | 郎宁 苏敏英 Hon J.Yu 袁慧书 | 2016 | 中国医学影像学杂志2016，24，8： | 11 |
| 10 | Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy显示文摘Conventional immunohistochemistry(IHC)is a widely used diagnostic technique in tissue pathology.However,this technique is associated with a number of limitations,including high inter-observer variability and the capacity to label only one marker per tissue section.This review details various highly multiplexed techniques that have emerged to circumvent these constraints,allowing simultaneous detection of multiple markers on a single tissue section and the comprehensive study of cell composition,cellular functional and cell-cell interactions.Among these techniques,multiplex Immunohistochemistry/Immunofluorescence(mIHC/IF)has emerged to be particularly promising.mIHC/IF provides high-throughput multiplex staining and standardized quantitative analysis for highly reproducible,efficient and cost-effective tissue studies.This technique has immediate potential for translational research and clinical practice,particularly in the era of cancer immunotherapy. | Wei Chang Colin Tan Sanjna Nilesh Nerurkar Hai Yun Cai Harry Ho Man Ng Duoduo Wu Yu Ting Felicia Wee Jeffrey Chun Tatt Lim Joe Yeong Tony Kiat Hon Lim | 2020 | Cancer Communications2020，40，4： | 11 |
| 11 | 动态增强磁共振成像在肺癌脊柱转移判别诊断中的应用显示文摘目的探讨动态增强磁共振成像(DCE-MRI)在肺癌脊柱转移判别诊断中的应用价值。资料与方法对61例脊柱转移癌患者行DCE-MRI,对扫描获得的图像进行后处理,获得信号强度-时间曲线、曲线上升期信号强度增幅(Peak SE%)、曲线最大上升线性斜率(Max Wash-in SE%)、曲线下降斜率(Wash-out SE%)等半定量参数,应用双室药物代谢动力学分析获得容积转运常数(K^(trans))和速率常数(K_(ep))等定量参数。应用CHAID法建立决策树模型,确定最佳分类参数,并识别最优分割。结果 61例脊柱转移癌患者的DCE-MRI扫描参数中Wash-out SE%、K_(ep)在肺癌与其他肿瘤脊柱转移之间差异有统计学意义(P<0.01),而Peak SE%、Max Wash-in SE%、K^(trans)在两者之间差异无统计学意义(P>0.05);当Wash-out SE%>-660.6%且Max Wash-in SE%>98.0%时约94.7%的患者原发灶可能来源于肺;使用本研究建立的决策树进行判别时,10-折交叉验证显示其错误率为(29.5±5.8)%。结论采用DCE-MRI半定量及定量分析参数进行肺癌脊柱转移的判别诊断具有可行性,可以为脊柱转移癌的来源鉴别及临床治疗提供参考依据。 | 郎宁 苏敏英 张恩龙 Hon J.Yu 袁慧书 | 2017 | 中国医学影像学杂志2017，25，9： | 10 |
| 12 | Cyclic ADP-ribose and NAADP:fraternal twin messengers for calcium signaling显示文摘The concept advanced by Berridge and colleagues that intracellular Ca2+-stores can be mobilized in an agonist-dependent and messenger(IP3)-mediated manner has put Ca 2+-mobilization at the center stage of signal transduction mechanisms.During the late 1980s,we showed that Ca2+-stores can be mobilized by two other messengers unrelated to inositol trisphosphate(IP 3) and identified them as cyclic ADP-ribose(cADPR),a novel cyclic nucleotide from NAD,and nicotinic acid adenine dinucleotide phosphate(NAADP),a linear metabolite of NADP.Their messenger functions have now been documented in a wide range of systems spanning three biological kingdoms.Accumulated evidence indicates that the target of cADPR is the ryanodine receptor in the sarco/endoplasmic reticulum,while that of NAADP is the two pore channel in endolysosomes. As cADPR and NAADP are structurally and functionally distinct,it is remarkable that they are synthesized by the same enzyme.They are thus fraternal twin messengers.We first identified the Aplysia ADP-ribosyl cyclase as one such enzyme and,through homology,found its mammalian homolog,CD38.Gene knockout in mice confirms the important roles of CD38 in diverse physiological functions from insulin secretion,susceptibility to bacterial infection,to social behavior of mice through modulating neuronal oxytocin secretion.We have elucidated the catalytic mechanisms of the Aplysia cyclase and CD38 to atomic resolution by crystallography and site-directed mutagenesis.This article gives a historical account of the cADPR/NAADP/CD38-signaling pathway and describes current efforts in elucidating the structure and function of its components. | Hon Cheung LEE | 2011 | Science China(Life Sciences)2011，54，8： | 9 |
| 13 | NOD2 和 TLR2 ligands 由在遗传性过敏症的像皮炎的皮肤发炎与真皮的成纤维细胞交往触发 basophils 和嗜曙红血球的激活显示文摘有遗传性过敏症的皮炎(广告) 的病人的皮肤由葡萄球菌 aureus 为殖民有唯一的倾向(S。aureus ) ,它贡献发炎和广告的冷酷的预后。尽管位于 S 下面的机制。不清楚的、最近的研究在在 S 调整煽动性的回答为模式识别受体发现了一个枢轴的角色的广告遗体的导致 aureus 的恶化。aureus 感染。在现在的学习,我们使用了像广告的皮肤发炎的一个典型老鼠模型并且发现了那 S。联系 aureus 的核苷酸绑定 oligomerization 包含域的蛋白质 2 (NOD2 ) 并且像使用费的受体 2 (TLR2 ) ligands 加重了像广告的症状,它进一步被败坏由在里面 basophils 和嗜曙红血球的 vivo 扩大。随后的组织学的分析表明真皮的成纤维细胞在像广告的皮肤损害是弥漫的。有 basophils 和嗜曙红血球的人的真皮的成纤维细胞的合作文化在真皮的成纤维细胞上导致了对 NOD2/TLR2 ligands 和细胞间的粘附 molecule-1 的提高的表示的精力旺盛的 cytokine/chemokine 回答。Basophils 和嗜曙红血球为在合作文化的广告相关的 cytokine/chemokine 表示主要负责。直接细胞间的接触为在 basophils 和真皮的成纤维细胞之间的串音是必要的,当可溶的调停人是足够的调停时嗜曙红血球成纤维细胞相互作用。而且,细胞内部的 p38 激活 mitogen 的蛋白质 kinase,细胞外的调整信号的 kinase,和表明小径的原子 factor-kappa B 为在广告相关的发炎的 basophils,嗜曙红血球,和真皮的成纤维细胞的 NOD2/TLR2 调停 ligand 的激活是必要的。这研究通过天生的有免疫力的房间的激活提供广告的 NOD2/TLR2-mediated 恶化的证据因此使一条新奇机械学的小径由清楚些哪个 S。aureus 贡献广告的 pathophysiology。 | Delong Jiao Chun-Kwok Wong Huai-Na Qiu Jie Dong Zhe Cai Man Chu Kam-Lun Hon Miranda Sin-Man Tsang Christopher Wai-Kei Lam | 2016 | Cellular & Molecular Immunology2016，13，4： | 8 |
| 14 | 中国基层医疗二型糖尿病人中阳痿的普遍性,相互关联,患者态度和寻求治疗的行为显示文摘本研究探讨在基层医疗二型糖尿病人中,阳痿的普遍性、相互关联、患者态度和寻求治疗的行为。我们将一份结构性匿名自填问卷发放到十所普通科门诊诊所进行横断性调查。在603位参与者(91%回应率)中,以国际勃起功能指数(iief)作定义之阳痿的普遍性为79.1%。多数参与者患轻度阳痿(28.9%),随后为轻至中度阳痿(27.9%)、中度阳痿(13.4%)及严重阳痿(9%)。接近55%的阳痿患者并不自觉患有此症。少于10%的患者曾寻求医生治疗,76.1%的参与者表示若被确诊为阳痿,会期望得到医生治理。他们认为最重要的医生治理是临床评估(41.7%),其次是治理潜在因素(37.8%)、转介专科医生(27.5%)、教育(23.9%)、处方磷酸二酯酶5型抑制剂(16.9%),及转介辅导服务(6.7%)。与诊断阳痿最密切关联的因素是自觉患有阳痿(OR=90.49(20.00—409.48,P〈0.001))、以及较年长的组别(OR=1.043(1.011-1.076,P=0.008))。总体而言,阳痿在二型糖尿病人中非常普遍。其中大部分病人如患上阳痿都希望得到医生救治,但只有少数会真正提出此要求。建议医护人员使用结构性问卷筛选二型糖尿病人中的阳痿患者,有助于找出未被诊断的阳痿个案。 | Wai Hon Lo Sau Nga Fu Carlos King Ho Wong Ee San Chen | 2014 | Asian Journal of Andrology2014，16，5： | 8 |
| 15 | 脊柱病变动态对比增强MRI药物代谢动力学分析血流曲线选择的初步研究显示文摘目的研究脊柱病变动态对比增强MRI(DCE-MRI)药物代谢动力学分析中不同动脉输入函数的应用,并探讨其选择方案。资料与方法对2008年6月—2013年12月北京大学第三医院放射科行DCE-MRI检查的62例脊柱病变患者进行回顾性分析,其中包括骨髓瘤(n=9)、转移瘤(n=22)、淋巴瘤(n=7)及结核(n=24)。分别计算MR T1WI动态增强扫描信号强度-时间曲线的信号强度增幅、最大上升线性斜率和曲线下降期斜率。使用Tofts双室药物代谢动力学分析方法对曲线进行拟合,拟合过程中分别使用慢速、中速、快速血流曲线,获得血管通透性常数(K^(trans))和转运常数(k_(ep))。将3种流速药物代谢动力学获得的K^(trans)、k_(ep)和动态增强曲线参数进行相关性分析。结果 K^(trans)(fast)与造影剂流入相关,K^(trans)(fast)与K^(trans)(medium)的相关系数>与K^(trans)(slow)的相关系数(0.94比0.85,P<0.05);k_(ep)(fast)与造影剂洗脱相关,与曲线下降期斜率具有较强的相关性(r=0.94),k_(ep)(fast)与k_(ep)(medium)的相关系数>与k_(ep)(slow)的相关系数(0.94比0.64,P<0.05)。结论对于4 min左右的脊柱病变动态增强的药物代谢动力学分析,快速和中速曲线拟合所得K^(trans)和k_(ep)相对于慢速血流曲线具有更强的相关性,提示在今后的研究工作中可根据不同临床要求选择适宜的曲线。 | 郎宁 苏敏英 Hon J.Yu 袁慧书 | 2016 | 中国医学影像学杂志2016，24，7： | 7 |
| 16 | Chromosome 1q21 amplification and oncogenes in hepatocellular carcinoma显示文摘Hepatocellular 癌(HCC ) 在之中人的恶意最致命。在人的 multistep hepatocarcinogenesis 期间, genomic 获得在 proto-oncogenes 的激活代表重要机制。在许多情形,激活 oncogenes 为癌症治疗学作为预示的标记和目标两个都保持临床的含意。染色体 1q 拷贝的获得是在 HCC 的最经常检测的改变之一, 1q21 是最经常的最小的放大区域(3 月) 。更好的理解生理并且在 1q21 amplicon 以内的目标基因的 pathophysiological 角色将显著地在 HCC 致病改进我们的知识,并且可以导致忍受 1q21 的扩大的 HCC 的一个更有效的管理。如此的知识为 HCC 治疗为新治疗学的策略的发展有长期的含意。我们的研究组和其它,在 HCC 集中了于象 JTB, CKS1B,和 CHD1L 那样的 1q21 目标基因的鉴定和描述前进。在这评论,我们将在 1q21 amplicon 以内总结已知的目标基因的当前的科学知识, CHD1L 的精确 oncogenic 机制将详细被讨论。 | Leilei CHEN Tim Hon Man CHAN Xin-yuan GUAN | 2010 | Acta Pharmacologica Sinica2010，31，9： | 6 |
| 17 | Rapid testing methods for food contaminants and toxicants显示文摘Food safety is one of the major concerns in every country regardless of the economic and social development. The frequent occurrence of food scandals in the world has led the Chinese government to implement several strategies to fortify the food supply system to a high food safety standard. This relies heavily on laboratory testing services but conventional methods for detection of food contaminants and toxicants are limited by sophisticated sample preparation procedures,long analysis time,large instruments and professional personnel to meet the increasing demands. In this review,we have incorporated most of the current and potential rapid detection methods for many notorious food contaminants and toxicants including microbial agents,toxic ions,pesticides,veterinary drugs and preservatives,as well as detection of genetically modified food genes and adulterated edible oil. Development of rapid,accurate,easy-to-use and affordable testing methods could urge food handlers and the public to actively screen for food contaminants and toxicants instead of passively relying on monitoring by the government examination facility. This review also provides several recommendations including how to encourage the public to engage in the food safety management system and provide optimal education and financial assistance that may improve the current Chinese food safety control system. | Jiachi Chiou Arthur Ho Hon Leung Hang Wai Lee Wing-tak Wong | 2015 | Journal of Integrative Agriculture2015，14，11： | 6 |
| 18 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 19 | Quality of life after laparoscopic vs open sphincter-preserving resection for rectal cancer显示文摘AIM: To compare quality of life (QoL) outcomes in Chinese patients after curative laparoscopic vs open surgery for rectal cancer. METHODS: Eligible Chinese patients with rectal cancer undergoing curative laparoscopic or open sphincterpreserving resection between July 2006 and July 2008 were enrolled in this prospective study. The QoL outcomes were assessed longitudinally using the validated Chinese versions of the European Organization for Research and Treatment of Cancer QLQ-C30 and QLQCR38 questionnaires before surgery and at 4, 8, and 12 mo after surgery. The QoL scores at the different time points were compared between the laparoscopic and open groups. A higher score on a functional scale indicated better functioning, whereas a higher score on a symptom scale indicated a higher degree of symptoms.RESULTS: Seventy-four patients (49 laparoscopic and 25 open) were enrolled. The two groups of patients were comparable in terms of sociodemographic data, types of surgery, tumor staging, and baseline mean QoL scores. There was no significant decrease from baseline in global QoL for the laparoscopic group at different time points, whereas the global QoL was worse compared to baseline beginning at 4 mo but returned to baseline by 12 mo for the open group (P = 0.019, Friedman test). Compared to the open group, the laparoscopic group had significantly better physical (89.9±1.4 vs 79.2±3.7, P = 0.016), role (85.0±3.4 vs 63.3±6.9, P = 0.005), and cognitive (73.5±3.4 vs 50.7±6.2, P = 0.002) functioning at 8 mo, fewer micturition problems at 4-8 mo (4 mo: 32.3±4.7 vs 54.7±7.1, P = 0.011; 8 mo: 22.8±4.0 vs 40.7±6.9, P = 0.020), and fewer male sexual problems from 8 mo onward (20.0±8.5 vs 76.7±14.5, P = 0.013). At 12 mo after surgery, no significant differences were observed in any functional or symptom scale between the two groups, with the exception of male sexual problems, which remained worse in the open group (29.2±11.3 vs 80.0±9.7, P = 0.026). CONCLUSION: Laparoscopic sphincter-preserving resection for rectal cancer is associated with better preservation of QoL and fewer male sexual problems when compared with open surgery in Chinese patients. These findings, however, should be interpreted with caution because of the small sample size of the study. | Simon Siu-Man Ng Wing-Wa Leung Cherry Yee-Ni Wong Sophie Sok-Fei Hon Tony Wing-Chung Mak Dennis KwokYu Ngo Janet Fung-Yee Lee | 2013 | World Journal of Gastroenterology2013，19，29： | 6 |
| 20 | Incidence and Phenotype of Inflammatory Bowel Disease Based on Results From the Asia-Pacific Crohn’s and Colitis Epidemiology Study显示文摘 | Siew C. Ng Whitney Tang Jessica Y. Ching May Wong Chung Mo Chow A.J. Hui T.C. Wong Vincent K. Leung Steve W. Tsang Hon Ho Yu Mo Fong Li Ka Kei Ng Michael A. Kamm Corrie Studd Sally Bell Rupert Leong H. Janaka de Silva Anuradhani Kasturiratne M.N.F. Mufeen | 2013 | Gastroenterology2013，，1： | 6 |
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