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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Visualizing large-scale high-dimensional data via hierarchical embedding of KNN graphs显示文摘Visualizing intrinsic structures of high-dimensional data is an essential task in data analysis.Over the past decades,a large number of methods have been proposed.Among all solutions,one promising way for enabling effective visual exploration is to construct a k-nearest neighbor(KNN)graph and visualize the graph in a low-dimensional space.Yet,state-of-the-art methods such as the LargeVis still suffer from two main problems when applied to large-scale data:(1)they may produce unappealing visualizations due to the non-convexity of the cost function;(2)visualizing the KNN graph is still time-consuming.In this work,we propose a novel visualization algorithm that leverages a multilevel representation to achieve a high-quality graph layout and employs a cluster-based approximation scheme to accelerate the KNN graph layout.Experiments on various large-scale datasets indicate that our approach achieves a speedup by a factor of five for KNN graph visualization compared to LargeVis and yields aesthetically pleasing visualization results. | Haiyang Zhu Minfeng Zhu Yingchaojie Feng Deng Cai Yuanzhe Hu Shilong Wu Xiangyang Wu Wei Chen | 2021 | Visual Informatics2021，5，2： | 2 |
| 3 | Modelling Australian Domestic and International Inbound Travel:a Spatiale temporal Approach显示文摘 | Minfeng Deng George Athanasopoulos | 2011 | Tourism Management2011，，32： | 1 |
| 4 | Modelling Australian domestic and international inboundtravel:a spatial temporal approach显示文摘 | Minfeng Deng George Athanasopoulos | 2011 | Tourism Management2011，，32： | 1 |
| 5 | Modelling Australian domestic and international inbound travel: a spatial temporal ap- proach 显示文摘 | Minfeng Deng George Athanasopoulos | 2011 | Tourism Management2011，，32： | 1 |
| 6 | Modeling Australian domestic and international inbound travel : A spatial-temporal approach 显示文摘 | Minfeng Deng George Athanasopoulos | 2011 | Tourism Management2011，32，5： | 1 |
| 7 | Modeling Australian domestic and international inbound travel:A spatial-temporal approach显示文摘 | Deng Minfeng Athanasopoulos G | 2011 | Tourism Management2011，32，5： | 1 |
| 8 | Targeting FAPα-positive lymph node metastatic tumor cells suppresses colorectal cancer metastasis显示文摘Lymphatic metastasis is the main metastatic route for colorectal cancer, which increases the risk of cancer recurrence and distant metastasis. The properties of the lymph node metastatic colorectal cancer(LNM-CRC) cells are poorly understood, and effective therapies are still lacking. Here, we found that hypoxia-induced fibroblast activation protein alpha(FAPα) expression in LNM-CRC cells. Gain-or loss-function experiments demonstrated that FAPα enhanced tumor cell migration, invasion, epithelial-mesenchymal transition, stemness, and lymphangiogenesis via activation of the STAT3 pathway. In addition, FAPα in tumor cells induced extracellular matrix remodeling and established an immunosuppressive environment via recruiting regulatory T cells, to promote colorectal cancer lymph node metastasis(CRCLNM). Z-GP-DAVLBH, a FAPα-activated prodrug, inhibited CRCLNM by targeting FAPα-positive LNM-CRC cells. Our study highlights the role of FAPα in tumor cells in CRCLNM and provides a potential therapeutic target and promising strategy for CRCLNM. | Shuran Fan Ming Qi Qi Qi Qun Miao Lijuan Deng Jinghua Pan Shenghui Qiu Jiashuai He Maohua Huang Xiaobo Li Jie Huang Jiapeng Lin Wenyu Lyu Weiqing Deng Yingyin He Xuesong Liu Lvfen Gao Dongmei Zhang Wencai Ye Minfeng Chen | 2024 | Acta Pharmaceutica Sinica B2024，14，2： | 0 |
| 9 | The Northern End of the Xiannvshan Fault at the Three Gorges Area显示文摘The Xiannvshan fault zone, lying along the western margin of the Huangling anticline, is one of the most important fault zones in the Three Gorges reservoir area. The fault experienced strong activity during the Cenozoic Era. The question of whether the fault zone goes through the Yangtze River has been one of the key problems faced in previous studies as it has a significant influence upon the assessment of geological hazards and earthquake stability in the reservoir area. Based on tectonic and geomorphic observations along the fault zone between the Baixianchi village in Changyang county and Huangkou village in Zigui town, together with the comparisons between the geology in Guizhou and Quyuan town in the north bank of the Yangtze River and the Xiannvshan fault zone, it is suggested that the north end of this fault zone is located around Huangkou village and does not go through the Yangtze rivers northward. The evidence is as follows: ① On the basis of field data collection, it is found that the Xiannvshan Fault zone, which stretches 80km, underwent thrust movement in the Cenozoic period, resulting in ravines and fault scarps, topographically. Whereas, on the northern bank of the Yangtze River, faults are rarely found, and most of the faults are developed in the Jurassic strata,without topographical effects. Therefore, the Xiannvshan Fault zone has not stretched to the north bank of the Yangtze River. ② The fault gouge and tectonite zone were found developed on the Xiannvshan Fault zone at Baixianchi village, but only a tectonite zone was found at Zhouping village. There are also some branch faults close to the northern end of the fault zone. So, the activity of the fault zone weakened from south to north in Cenozoic. The fault zone extends northward and dies out at Huangkou. It doesn't stretch forward any longer as indicated by continuous strata, sparse joints, and small folds, etc. | Bi Minfeng Chu Quanzhi Deng Zhihui Pan Bo Zhang Changhou Zhou Qing | 2012 | Earthquake Research in China2012，26，4： | 0 |
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