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| 1 | Pain sensation in pancreatic diseases is not uniform: The different facets of pancreatic pain显示文摘AIM: To systematically characterize specific pain patterns in the most frequent pancreatic diseases.METHODS: Pain in patients with chronic pancreatitis(n = 314), pancreatic cancer(n = 469), and other pancreatic tumors(n = 249) including mucinous(n = 20) and serous cystadenoma(n = 31), invasive(n = 37) and non-invasive intraductal papillary mucinous neoplasia(IPMN; n = 48), low stage(n = 18) and high stage neuroendocrine neoplasia(n = 44), and ampullary cancer(n = 51) was registered and correlated with clinicopathological data. Survival times were estimated by the Kaplan-Meier method. Patients alive at the follow-up time were censored. Survival curves were compared statistically using the log-rank test.RESULTS: Forty-nine point one percent of pancreatic cancer patients revealed no pain, whereas in chronic pancreatitis only 18.3% were pain free. In contrary, moderate/severe pain was registered in 15.1% in pancreatic cancer patients that was increased in chronic pancreatitis with up to 34.2%. Serous cystadenoma was asymptomatic in most cases(58.1%), whereas 78.9% of all mucinous cystadenoma patients suffered pain. In neuroendocrine neoplasia pain was not a key clinical symptom since 64% of low stage neuroendocrine neoplasia and 59% of high stage neuroendocrine neoplasia patients were pain free. Cancer localization in the pancreatic body and patients with malignant pancreatic neoplasms were associated with more severe pain. Tumor grading and stage did not show any impact on pain. Only in pancreatic cancer, pain was directly associated with impaired survival.CONCLUSION: Pancreatic pain depicts different patterns of abdominal pain sensation according to the respective pancreatic disorder and does not allow a unification of the term pancreatic pain. | Jan G D'Haese Mark Hartel Ihsan Ekin Demir Ulf Hinz Frank Bergmann Markus W Büchler Helmut Friess Güralp O Ceyhan | 2014 | World Journal of Gastroenterology2014，20，27： | 8 |
| 2 | 老年男性勃起功能及迟发性性腺功能减退症状与下尿路症状严重性的关系显示文摘本文旨在研究土耳其爱琴海地区的老年男性下尿路症状(LUTSs)、勃起功能障碍(ED)和有症状的迟发性性腺功能减退症(SLOH)三者间的关系。符合以下标准的500名男性患者被纳入该研究:40周岁以上;过去6个月内有稳定的性关系;在六个泌尿外科诊所之一进行过就诊登记。每位患者均行血清PSA、睾酮水平及尿流率的检测,并填写国际前列腺症状评分和生活质量评分(IPSS-QoL)量表、国际勃起功能指数(IIEF)问卷和老年男性症状(AMS)量表。在所有的研究对象中,23.9%的患者有轻度LUTSs,53.3%有中度LUTSS,22.8%有重度LUTSS。每组间总睾酮水平无明显差异。除此之外,69.6%的病人患有ED,且ED的发生率与LUTS严重性呈正相关。71.2%的患者出现SLOH(AMS〉27),且IPSS评分越高,严重的性腺功能减退症状的发生率也越高。相关性分析显示以上三种问卷分数之间有显著关联。总之,LUTS严重性是ED和SLOH的非年龄依赖性危险因素,LUTS严重性和SLOH症状之间似乎有显著的相关性,但还需要从病因学和生物学角度进行深入阐明。 | Ozan Bozkurt Deniz Bolat Omer Demir Oktay Ucer Ali Sahin Burak Ozcift Abdulkadir Pekta Tahir Turan Bilal H Gümü Ertan Cans Ahmet Bolukbasi Haluk Erol Adil Esenx | 2013 | Asian Journal of Andrology2013，15，6： | 4 |
| 3 | Laryngopharyngeal reflux and Helicobacter pylori显示文摘Laryngopharyngeal reflux(LPR) occurs when gastric contents pass the upper esophageal sphincter, causing symptoms such as hoarseness, sore throat, coughing, excess throat mucus, and globus. The pattern of reflux is different in LPR and gastroesophageal reflux. LPR usually occurs during the daytime in the upright position whereas gastroesophageal reflux disease more often occurs in the supine position at night-time or during sleep. Ambulatory 24-h double pH-probe monitoring is the gold standard diagnostic tool for LPR. Acid suppression with proton pump inhibitor on a long-term basis is the mainstay of treatment. Helicobacter pylori(H. pylori) is found in many sites including laryngeal mucosa and interarytenoid region. In this paper, we aim to present the relationship between LPR and H. pylori and review the current literature. | Taner Yllmaz Münir Demir Bajin Rlza nder Günayd?n Serdar zer Tevfik Szen | 2014 | World Journal of Gastroenterology2014，20，27： | 4 |
| 4 | Precontoured buttress plate vs reconstruction plate for acetabulum posterior wall fractures: A biomechanical study显示文摘BACKGROUND The purpose of open reduction and internal fixation of acetabulum posterior wall fractures is to restore anatomical structure and stability of the hip joint, in order to start weight bearing as soon as possible and prevent hip arthrosis; restoration of the anatomy should preserve function of the joint as well. Although 'special shaped precontoured plates' have been developed in recent years for surgical treatment of this region, studies comparing the traditional plates with the newly designed precontoured plates are lacking.AIM To evaluate the biomechanical properties of precontoured anatomic buttress and conventional curved reconstruction plates(CCRPs) for posterior wall acetabulum fracture treatment.METHODS Twelve pelvis models were created for testing plate treatment of fracture in the posterior wall of the acetabulum. These 12 pelvis models were used to create 24 hemipelvis models(experimental) by cutting from the sagittal plane and passing over the center of gravity, after which the posterior wall acetabular fractures(of similar type and size) were created. In these experimental models, the right acetabulum was fixed with a 5-hole CCRP, while the left was fixed with a precontoured anatomic buttress plate(PABP). Samples were placed through thetest device and were subjected to static load testing, with a constant testing velocity of 2 mm/min until the load reached 2.3 kN or the acetabular fixation failed. Dynamic tests were also performed with sinusoidal wave load, with a maximal load of 2.3 kN and a load ratio of 0.1.RESULTS The average stiffness values were 460.83 ± 95.47 N/mm for the PABP and 291.99± 118.58 N/mm for the 5-hole CCRP. The precontoured anatomic acetabulum buttress plates had significantly higher rigidity than the CCRPs(P = 0.022). There was a statistically significant difference between the unloaded and 2.3 kN-loaded values of AL(posterosuperior fracture line vertical to the ground surface) and CL(posteroinferior fracture line vertical to the ground surface) parameters for both the PABPs and the 5-hole CCRPs(P = 0.036 and P = 0.045, respectively).According to the static tests, the amount of total displacement was significantly less in the PABPs than in the CCRPs. Comparative analysis of the displacement in the BL(posterior wall fracture line horizontal to the ground) parameter yielded no statistically significant differences between the PABP and the 5-hole CCRPs(P= 0.261).CONCLUSION PABP provides more stable fixation in acetabulum posterior wall fractures than5-hole CCRP, allowing for proximal or distal fracture line screw application without reshaping. | Güray Altun Gürsel Saka Teyfik Demir Fatma Kübra Erbay Elibol Mehmet Or?un Polat | 2019 | World Journal of Orthopedics2019，10，5： | 3 |
| 5 | Nerve Growth Factor and Artemin Are Paracrine Mediators of Pancreatic Neuropathy in Pancreatic Adenocarcinoma显示文摘 | Güralp O. Ceyhan Karl-Herbert Sch?fer Annika G. Kerscher Ulrich Rauch Ihsan Ekin Demir Mustafa Kadihasanoglu Carolin B?hm Michael W. Müller Markus W. Büchler Nathalia A. Giese Mert Erkan Helmut Friess | 2010 | Annals of Surgery2010，，5： | 2 |
| 6 | Neural invasion in pancreatic cancer: A mutual tropism between neurons and cancer cells显示文摘 | Güralp O. Ceyhan Ihsan Ekin Demir Burak Altintas Ulrich Rauch Gerald Thiel Michael W. Müller Nathalia A. Giese Helmut Friess Karl-Herbert Sch?fer | 2008 | Biochemical and Biophysical Research Communications2008，，3： | 2 |
| 7 | Pancreatic Enzyme Replacement Therapy in Patients With Exocrine Pancreatic Insufficiency Due to Chronic Pancreatitis: A 1-Year Disease Management Study on Symptom Control and Quality of Life显示文摘 | Jan G. D’Haese Güralp O. Ceyhan Ihsan Ekin Demir Peter Layer Waldemar Uhl Matthias L?hr Reinhard Rychlik Konstantinos Pirilis York Z?llner Birgit Gradl Douglas Foerster Julia M?bius Friederike Henniges Helmut Friess | 2014 | Pancreas2014，，： | 2 |
| 8 | Comparison of the treatment performances of blast furnace slag-based and gravel-based vertical flow wetlands operated identically for domestic wastewater treatment in Turkey 显示文摘 | Korkusuz E A Beklioglu M Demirer G N | 2005 | Ecol Eng2005，24，3： | 1 |
| 9 | Relevance of nutritional route and intercellular adhesion molecule - 1 in patients with acute renal failure and its prognostic implications 显示文摘 | Sezer MT Demir M Gungor G | 2008 | J Ren Nutr2008，18，3： | 1 |
| 10 | Effects of basic fibroblast growth factor and phenytoin on healing of abdominal wal fascia and colonic anastomoses显示文摘 | Günes HV Demirer S Aydinuraz K | | 0，，03： | 1 |
| 11 | Effect of hematocrit on blood pressure via hyperviscosity显示文摘 | Cinar Y Demir G Cinar A B | | 0，，07： | 1 |
| 12 | Comparison of dexmedetomidine and three differrrent doses of midazolam in preoperative sedation显示文摘 | Eren G Cukurova Z Demir G | | 0，，03： | 1 |
| 13 | A comparative analysis of several vehicle emission models for road freight transportation显示文摘 | Demir E Bekta? T Laporte G | 2011 | Transportation Research Part D: Transport and Environment2011，6，5： | 1 |
| 14 | Treatment options in painful chronic pancreatitis: a systematic review显示文摘 | Jan G. D’Haese Güralp O. Ceyhan Ihsan Ekin Demir Elke Tieftrunk Helmut Friess | 2014 | HPB2014，，6： | 1 |
| 15 | Effect of hematocrit on blood pressure via hyperviscosity显示文摘 | ??nar Y Demir G Pac M | 1999 | American journal of hypertension1999，12，7： | 1 |
| 16 | Biogas production potential from cotton wastes显示文摘 | sci A Demirer G N | 2007 | Renewable Energy2007，32，： | 1 |
| 17 | Serum levels of leptin and homoeysteine in women with polyeystie ovary syndrome and its relationship to endocrine, clinical and metabolic parameters 显示文摘 | Atamer A Demir B Bayhan G | 2008 | J Int Med Res2008，36，： | 1 |
| 18 | High plasma D-dimer level is associated with decreased survival in patients with lung cancer 显示文摘 | Altiay G Ciftci A Demir M | 2007 | Clin Oncol (R Coll Radiol)2007，19，7： | 1 |
| 19 | Two -phase anaerobic digestion of unscreened dairy manure 显示文摘 | G N Demirer S Chen | 2005 | Process Biochemistry2005，，11： | 1 |
| 20 | Assessment of urban air quality in Is-tanbul using fuzzy synthetic evaluation 显示文摘 | Onkal-Engin G Demir I Hiz H | 2004 | Atmospheric Environment2004，38，： | 1 |
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