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| 1 | Pain sensation in pancreatic diseases is not uniform: The different facets of pancreatic pain显示文摘AIM: To systematically characterize specific pain patterns in the most frequent pancreatic diseases.METHODS: Pain in patients with chronic pancreatitis(n = 314), pancreatic cancer(n = 469), and other pancreatic tumors(n = 249) including mucinous(n = 20) and serous cystadenoma(n = 31), invasive(n = 37) and non-invasive intraductal papillary mucinous neoplasia(IPMN; n = 48), low stage(n = 18) and high stage neuroendocrine neoplasia(n = 44), and ampullary cancer(n = 51) was registered and correlated with clinicopathological data. Survival times were estimated by the Kaplan-Meier method. Patients alive at the follow-up time were censored. Survival curves were compared statistically using the log-rank test.RESULTS: Forty-nine point one percent of pancreatic cancer patients revealed no pain, whereas in chronic pancreatitis only 18.3% were pain free. In contrary, moderate/severe pain was registered in 15.1% in pancreatic cancer patients that was increased in chronic pancreatitis with up to 34.2%. Serous cystadenoma was asymptomatic in most cases(58.1%), whereas 78.9% of all mucinous cystadenoma patients suffered pain. In neuroendocrine neoplasia pain was not a key clinical symptom since 64% of low stage neuroendocrine neoplasia and 59% of high stage neuroendocrine neoplasia patients were pain free. Cancer localization in the pancreatic body and patients with malignant pancreatic neoplasms were associated with more severe pain. Tumor grading and stage did not show any impact on pain. Only in pancreatic cancer, pain was directly associated with impaired survival.CONCLUSION: Pancreatic pain depicts different patterns of abdominal pain sensation according to the respective pancreatic disorder and does not allow a unification of the term pancreatic pain. | Jan G D'Haese Mark Hartel Ihsan Ekin Demir Ulf Hinz Frank Bergmann Markus W Büchler Helmut Friess Güralp O Ceyhan | 2014 | World Journal of Gastroenterology2014，20，27： | 8 |
| 2 | Nerve Growth Factor and Artemin Are Paracrine Mediators of Pancreatic Neuropathy in Pancreatic Adenocarcinoma显示文摘 | Güralp O. Ceyhan Karl-Herbert Sch?fer Annika G. Kerscher Ulrich Rauch Ihsan Ekin Demir Mustafa Kadihasanoglu Carolin B?hm Michael W. Müller Markus W. Büchler Nathalia A. Giese Mert Erkan Helmut Friess | 2010 | Annals of Surgery2010，，5： | 2 |
| 3 | Effects of amniotic membrane transplantation and mitomycin C on wound healing in experimental glaucoma surgery显示文摘 | Demir T Turgut B Akyol N | 2002 | Ophthalmologica2002，216，6： | 1 |
| 4 | Effect of hematocrit on blood pressure via hyperviscosity显示文摘 | Cinar Y Demir G Cinar A B | | 0，，07： | 1 |
| 5 | lqyperspectral image classification using rele- vance vector machines 显示文摘 | DEMIR B ERTURK S | 2007 | IEEE Geoscience and Remote Sen- sin9 Letters2007，4，4： | 1 |
| 6 | Expression of vasodilator-stimulated phosphoprotein in human placenta:possible implications in trophoblast invasion 显示文摘 | Kayisli U A Selam B Demir R | 2002 | Molecular Human Reproduction2002，8，1： | 1 |
| 7 | An investigation of mechanical and metallurgical properties of explosive welded aluminum-dual phase steel显示文摘 | Acarer M Demir B | 2008 | Materials Letters2008，62，25： | 1 |
| 8 | Tumor angiogenesis in predicting the survival of patients with stage I lung cancer显示文摘 | Medetoglu B Gunluoglu MZ Demir A | | 0，，05： | 1 |
| 9 | The effect of standard posterolateralversus muscle-sparing thoracotomy on multiple parameters显示文摘 | Akcali Y Demir H Tezcan B | 2003 | AnnThorac Surg2003，76，： | 1 |
| 10 | Comparison of the effects of intravitreal bevacizumab and triamcinolone acetonide in the treatment of macular edema secondary to central retinal vein occlusion 显示文摘 | Demir M Dirim B Acar Z | 2014 | Indian J Ophthalmol2014，62，： | 1 |
| 11 | Hyperspectral image classification using relevance vector machines显示文摘 | Demir B Erturk S | 2007 | IEEE Geoscience and Remote Sensing Letters2007，4，4： | 1 |
| 12 | Clustering spatial networks for aggregate query processing: a hypergraph approach显示文摘 | Demir E Aykanat C Cambazoglu B | 2008 | Information Systems2008，33，1： | 1 |
| 13 | Comparison of the effectiveness of reboxetine versus fluoxetine in patients with atypical depression : a single - blind, randomized clinical trial显示文摘 | Tanner E Demir EY Cosar B | 2006 | Adv Ther2006，23，6： | 1 |
| 14 | Serum levels of leptinand homocysteine in women with polycystic ovarysyndrome and its relationship to endocrine, clinical andmetabolic parameters显示文摘 | Atamer A Demir B Bayhan | 2008 | J Int Med Res2008，36，1： | 1 |
| 15 | Effect of raloxifene and atorvastatin in atherosclerotic process in ovariectomized rats显示文摘 | Cetinkaya Demir B Uyar Y Ozbilgin K | 2013 | J Obstet Gynaecol Res2013，39，1： | 1 |
| 16 | Simulating uz ban growth driven by transportation networks : A ease study of the Istan- bul third bridge 显示文摘 | Ayazli I E Kilic F Lauf S Demir H Kleinschmit B | 2015 | Land Use Policy2015，49，： | 1 |
| 17 | Single stage treatment of complete dislocation of radil head and forearm deformity us- ing osteogenesis in pacdiatric patiengs having multiple carti-laginous exostosis显示文摘 | Demir B Garsu S Ozturk K | 2011 | Arch Orthop Trauma Surg2011，，： | 1 |
| 18 | Immunohistocheraistry of matrixanetalloproteinase(MMP) ,their substrates and their inhibitors(TIMP) during trophoblast invasion in human placenta显示文摘 | Huppertz B Kertschanska S Demir AR | 1998 | Cell Tissue Res1998，291，1： | 1 |
| 19 | Serum levels of leptin and homoeysteine in women with polyeystie ovary syndrome and its relationship to endocrine, clinical and metabolic parameters 显示文摘 | Atamer A Demir B Bayhan G | 2008 | J Int Med Res2008，36，： | 1 |
| 20 | The effects of rosiglitazone treatment on the fibrinolytic system in patients with type 2 diabetes mellitus显示文摘 | Guldiken S Turgut B Demir M | 2006 | Clin Applied Thrombosis/Hemostasis2006，12，： | 1 |
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