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| 1 | Role of autophagy in prion protein-induced neurodegenerative diseases显示文摘Prion 疾病,由海绵状的退化和错误褶层的累积描绘了并且在中央神经系统聚集了 PrPSc,是致命的 neurodegenerative 和人和动物的传染混乱之一。在更早的研究,在神经原的 autophagy 液泡经常在象 Alzheimer 的家那样的 neurodegenerative 疾病被观察, Parkinson 是,并且亨廷顿是象 prion 疾病一样的疾病。Autophagy 是几个细胞质的部件(蛋白质或细胞器) 被在一个 double-membrane-bound 泡扣押的一个高度保存的 homeostatic 过程称为的 autophagosome 并且与 lysosome 在他们的熔化之上降级了。在基础生理的层次的细胞间的自我消化的小径为维持纸巾和机关的健康地位是不可缺少的。在 prion 感染的情况下,增加证据显示 autophagy 把消除病理学的 PrPSc 的一个关键能力在神经原以内积累了。相反,在影响神经原的 autophagy 机能障碍可以贡献海绵状的变化的形成。在这评论,我们在 neurodegenerative 混乱关于哺乳动物的 autophagy 的效果总结了最近的调查结果,特别地在 prion 疾病。我们也总结了一些小分子的治疗学的潜力(例如锂, rapamycin, Sirtuin 1 和 resveratrol ) 在大脑上减轻如此的疾病的目标工作。而且,我们讨论了 autophagy 的争论角色,它是否调停 neuronal 毒性或在 neurodegenerative 混乱服务保护的功能。 | Hao Yao Deming Zhao Sher Hayat Khan Lifeng Yang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，6： | 65 |
| 2 | Subcellular localization of the stripe disease-specific protein encoded by rice stripe virus (RSV) in its vector,the small brown planthopper,Laodel-phax striatellus显示文摘The stripe disease-specific protein (SP) encoded by the rice stripe virus (RSV) was successfully used as a localization signal of the virus in its vector, the small brown lanthopper, Laodelphax striatellus Fallen. Immunogold particles in large numbers were detected in various parts of the viruliferous females: the ovum, surface of chorion, the mid-gut lumen, and the columnar cells. Whereas there was noneof these particles in the non-viruliferous females and males, and testis of viruliferous males. Endosymbionts (mycetocytes) were abundant, harboring ovaries of both viruliferous and non-viruliferous females, but none in the testis of males. The results provided us with the direct proof that RSV is a ciruculative and propagative plant virus and it was transovarially transmitted alongside with endosymbionts of its vector. Therefore, we deem it a nice lead for future studies on the mechanism of RSV transmission and functioning of its viral proteins. | WU Aizhong ZHAO Yan QU Zhicai SHEN Daleng PAN Chongguang SU Deming | 2001 | Chinese Science Bulletin2001，46，21： | 23 |
| 3 | Observation and analysis of near-surface atmospheric aerosol optical properties in urban Beijing显示文摘Year-round measurements of the mass concentration and optical properties of fine aerosols(PM_(2.5)) from June 2009 to May 2010 at an urban site in Beijing were analyzed.The annual mean values of the PM_(2.5) mass concentration,absorption coefficient(Ab),scattering coefficient(Sc) and single scattering albedo(SSA)at 525 nm were 67±66μg/m^3,64 ±62 Mm^(-1),360 ±405 Mm^(-1) and 0.82 ±0.09,respectively.The bulk mass absorption efficiency and scattering efficiency of the PM_(2.5) at 525 nm were 0.78 m^2/g and 5.55 m^2/g,respectively.The Ab and Sc showed a similar diurnal variation with a maximum at night and a minimum in the afternoon,whereas SSA displayed an opposite diurnal pattern.Significant increases in the Ab and Sc were observed in pollution episodes caused by the accumulation of pollutants from both local and regional sources under unfavorable weather conditions.Aerosol loadings in dust events increased by several times in the spring,which had limited effects on the Ab and Sc due to the low absorption and scattering efficiency of dust particles.The frequency of haze days was the highest in autumn because of the high aerosol absorption and scattering under unfavorable weather conditions.The daily PM_(2.5)concentration should be controlled to a level lower than 64 μg/m^3 to prevent the occurrence of haze days according to its exponentially decreased relationship with visibility. | Junshan Jing Yunfei Wu Jun Tao Huizheng Che Xiangao Xia Xiaochun Zhang Peng Yan Deming Zhao Leiming Zhang | 2015 | Particuology2015，13，1： | 16 |
| 4 | Genesis of the Wulong gold deposit,Liaoning Province,NE China:Constrains from noble gases,radiogenic and stable isotope studies显示文摘TheWulong lode deposit contains over 80 tonnes of gold with an average grade of 5.35 g/t.It is one of the largest deposits in Dandong City,Liaoning Province in northeast China.Previous studies on the deposit focused on its geological characteristics,geochemistry,fluid inclusions,and the timing of gold mineralization.However,controversy remains regarding the origin of the ore-forming fluids and metals,and the genesis of the gold deposit.This paper presents zircon UePb and pyrite RbeSr ages and S,Pb,He,and Ar isotopic results along with quartz H and O isotopic data for all litho-units associated with the deposit.Laser ablation inductively coupled mass spectrometry measurements yielded zircon UePb dates for samples of pre-mineralization rocks like granite porphyry dike,the Sanguliu granodiorite,fine-grained diorite,and syn-mineralization diorite,as well as post-mineralization dolerite,and lamprophyre;their emplacement ages are 1261 Ma,1241 Ma,1231 Ma,1201 Ma,1192 Ma,and 1152 Ma,respectively.The pyrite RbeSr isochron age is 1191 Ma,indicating that both magmatism and mineralization occurred during the Early Cretaceous.The d18OH2O values of ore-forming hydrothermal fluids from the quartzepolymetallic sulfide vein stage vary from 4.8&to 6.5&,and the dDV-SMOW values are between67.7&and75.9&,indicating that the ore-forming fluids were primarily magmatic.The noble gas isotope compositions of fluid inclusions hosted in pyrite suggest that the ore-forming fluids were dominantly derived from crustal sources with minor mantle input.Sulfur isotopic values of pyrite vary between 0.2&and 3.5&,suggesting that S was derived from a homogeneous magmatic source or possibly from fluids derived from the crust.The Pb isotopic compositions of sulfides(207Pb/204Pb?15.51 e15.71,206Pb/204Pb?17.35e18.75,208Pb/204Pb?38.27e40.03)indicate that the Pb of the Wulong gold deposit is a mixture of crust and mantle components.Geochronological and geochemical data,together with the regional geological history,indicate that Early Cretaceous magmatism and mineralization of the Wulong gold deposit occurred during the rollback of the subducting Paleo-Pacific Plate,which resulted in lithospheric thinning and the destruction of the North China Craton(NCC),which indicates that the deposit is of magmaticehydrothermal origin. | Peng Zhang Linlin Kou Yan Zhao Zhongwei Bi Deming Sha Renping Han Zhumin Li | 2020 | Geoscience Frontiers2020，11，2： | 13 |
| 5 | Polarization-maintaining few mode fiber composed of a central circular-hole and an elliptical-ring core显示文摘We propose a novel waveguide design of polarization-maintaining few mode fiber(PM-FMF) supporting ≥10non-degenerate modes, utilizing a central circular air hole and a circumjacent elliptical-ring core. The structure endows a new degree of freedom to adjust the birefringence of all the guided modes, including the fundamental polarization mode. Numerical simulations demonstrate that, by optimizing the air hole and elliptical-ring core,a PM-FMF supporting 10 distinctive polarization modes has been achieved, and the effective index difference Δn_(eff) between the adjacent guided modes could be kept larger than 1.32 × 10^(-4) over the whole C +L band. The proposed fiber structure can flexibly tailored to support an even larger number of modes in PM-FMF(14-mode PM-FMF has been demonstrated as an example), which can be readily applicable to a scalable mode division multiplexing system. | JIAJIA ZHAO MING TANG KYUNGHWAN OH ZHENHUA FENG CAN ZHAO RUOLIN LIAO SONGNIAN FU PERRY PING SHUM DEMING LIU | 2017 | Photonics Research2017，5，3： | 9 |
| 6 | Testing the ability of RIEMS2.0 to simulate multi-year precipitation and air temperature in China显示文摘RIEMS2.0 (Regional Integrated Environment Modeling System, Version 2.0) is now being developed starting from RIEMS1.0 by the Key Laboratory of Regional Climate Environment Research for Temperate East Asia, Institute of Atmospheric Physics, Chinese Academy of Sciences, China. In order to test RIEMS2.0’s ability to simulate long-term climate and its changes, as well as provide a basis for further development and applications, we compare simulated precipitation and air temperature from 1980 to 2007 (simulation duration from Jan. 1, 1979 to Dec. 31, 2007) under different cumulus parameterization schemes with the observed data. The results show that RIEMS2.0 can reproduce the spatial distribution of precipitation and air temperature, but that the model overestimates precipitation with the rainfall center moving northwestward and underestimates air temperature for annual simulations. Annual and interannual variations in precipitation and air temperature for different climate subregions are well captured by the model. Further analysis of summer and winter simulations shows that precipitation is overestimated, except for the Jianghuai-Jiangnan subregions in the winter, and the air temperature bias in the summer is weaker than in the winter. There are larger biases for precipitation and air temperature in semiarid subregions. Anomalies in precipitation and air temperature are also well captured by the model. Although a similar distribution can be found between observed data and simulated results under different cumulus parameterization schemes, these show differences in intensity and location. In sum, RIEMS2.0 shows good stability and does well in simulating the long-term climate and its changes in China. | ZHAO DeMing FU CongBin YAN XiaoDong | 2009 | Chinese Science Bulletin2009，54，17： | 4 |
| 7 | Decipher the mechanisms of rabbit's low susceptibility to prion infection显示文摘兔子有低危险性到 prion 感染。从到 prion 疾病的不同危险性的动物种类的 prion 蛋白质(PrP ) 上的研究在兔子 prion 蛋白质(RaPrPC ) 识别了关键氨基酸残余,特定的主题,和特殊特征贡献兔子 PrPC 和低危险性的稳定性到 prion 感染。然而,没有证据,证明兔子对 prion 疾病完全抵抗。兔子 prion 能通过蛋白质错误褶层在 vitro 被产生,这被报导了周期的扩大并且证明了传染、能递送。这里,我们在与 prion 感染的与兔子的低危险性的关系在兔子特定的 PrP 结构和特征上考察了研究。 | Zhen Yuan Deming Zhao Lifeng Yang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，11： | 4 |
| 8 | Molecular mechanisms of neurodegeneration mediated by dysfunctional subcellular organelles in transmissible spongiform encephalopathies显示文摘能递送的海绵状的 encephalopathies 包括 synaptic 损坏,树枝状的萎缩, vacuolization,和 microglial 激活与传播和 pathophysiology 的完全新奇的机制指一组传染 neurodegenerative 疾病。广泛的 neuronal 损失是长期的大脑恶化和 prion 疾病的致命的结果的主要原因。作为病理学的改变的最后的结果, neuronal 死亡是所有 prion 疾病的一个突出的特征。为 prion 疾病负责的机制很好没被理解。neuronal 损坏的分子的基础的更全面的理解为为能递送的海绵状的 encephalopathies 和分享类似的特征的另外的 neurodegenerative 疾病的有效治疗的发展是必要的。这里,我们考察 mitochondrial 机能障碍和 endoplasmic 蜂窝胃的分子的机制调停压力的 neuronal 死亡,哪个戏在 prion 疾病的 pathogenisis 的关键角色。 | Zhiqi Song Deming Zhao Lifeng Yang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，6： | 3 |
| 9 | Recent advances in interlayer and separator engineering for lithium-sulfur batteries显示文摘Lithium-sulfur(Li-S)batteries have great potential in next-generation energy storage due to its high theoretical specific capacity and energy density.However,there are several challenges to the practical application of Li-S batteries including the growth of lithium dendrites and the shuttle effect of polysulfide.Introducing interlayeres(freestanding or coated on the separator)is an effective approach to reduce these obstacles and improve the electrochemical performance of Li-S batteries.In this review,we briefly summarize the interlayer materials and structures modified on both cathodic and anodic sides including(ⅰ)carbon-based materials,(ⅱ)polymers,(ⅲ)inorganic metal compounds,(iv)metal-organic frameworks,as well as(v)the novel separators in recent years.We also systematically address the fabrication processes,assembling methods,and functions of interlayers for enhancing the performance of Li-S batteries.Furthermore,the prospects and outlooks of the future development of advanced interlayers and separators are also presented. | Deming Zhu Tao Long Bin Xu Yixin Zhao Haitao Hong Ruijie Liu Fancheng Meng Jiehua Liu | 2021 | Journal of Energy Chemistry2021，30，6： | 2 |
| 10 | Vibration Deformation Monitoring of Offshore Wind Turbines Based on GBIR显示文摘In view of the disadvantages of vibration safety monitoring technology for offshore wind turbines,a new method is proposed to obtain deformation information of towering and dynamic targets in real-time by the ground-based interferometric ra-dar(GBIR).First,the working principle and unique advantages of the GBIR system are introduced.Second,the offshore wind turbines in Rongcheng,Shandong Province are selected as the monitoring objects for vibration safety monitoring,and the GPRI-II portable radar interferometer is used for the health diagnosis of these wind turbines.Finally,the interpretation method and key processing flow of data acquisition are described in detail.This experiment shows that the GBIR system can accurately identify the millimeter-scale vibration deformation of offshore wind turbines and can quickly obtain overall time series deformation images of the target bodies,which demonstrate the high-precision deformation monitoring ability of the GBIR technology.The accuracy meets the requirements of wind turbine vibration monitoring,and the method is an effective spatial deformation monitoring means for high-rise and dynamic targets.This study is beneficial for the further enrichment and improvement of the technical system of wind turbine vibration safety monitoring in China.It also provides data and technical support for offshore power engineering management and control,health diagnosis,and disaster prevention and mitigation. | MA Deming LI Yongsheng LIU Yanxiong CAI Jianwei ZHAO Rui | 2021 | Journal of Ocean University of China2021，20，3： | 2 |
| 11 | Regulation of proteasomes in prion disease显示文摘prion 疾病的特点是错误褶层蛋白质 PrP 对 neuronal 房间有毒的 Sc , 。proteasome 系统为快速、精确、及时的降级 ofproteins 负责并且在细胞的蛋白质质量控制起一个重要作用。增加的证据在 prion 疾病显示损害 activityof proteasomes。积累的 PrP Sc 能直接或间接地影响 proteasome 活动。错误褶层蛋白质可以影响 20S proteasome 的 19S regulatoryparticle,或 translational 以后修正的集会和活动,它可以不利地影响蛋白质降级 activityof proteasomes。在这评论,我们在 prionand 有关 proteasomes 的可能的规定总结了最近的调查结果另外的 neurodegenerative 疾病。proteasome 系统可以由改变它的结构提高它的降级活动,并且当 neuronal 房间服从于应力时,这项活动能被相关女伴也增加。当 proteasomesystem 被禁止时,经由 autophagy 的蛋白质总数的降级可以作为一个补偿系统增加。它是 possiblethat 平衡在 vivo 在 proteasome 和 autophagy 之间存在;当一个人被损害时,其它的活动可以增加维持动态平衡。然而,更多的研究是需要的 toelucidate 在 proteasome 系统和 autophagy 之间的关系。 | Ting Zhu Sher Hayat Khan Deming Zhao Lifeng Yang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，7： | 2 |
| 12 | Ecological Effects of Remote Smallsand Descending on Urban Area:Deduced from the 'Mud - Snow' in Changchun City显示文摘A serious sandstorm occurred in North China from April 5 to April 7, 2000, while the remote smallsand decending took place in even larger area to the far northeast China. In Chanchun city, smallsand descending with snow provides the best samples to conduct a quantitative research on the possible impacts of city - ecology. In the 253km2 urban district area of Changchun city, smallsands accumulated up to more than 3000t on April 7, according to the calculation of four 'mud - snow' samples. After naturally melting in room temperature, two samples are taken to do quarantine of 'invasion bacteria'. As a preliminary result, the individual amount of bacterium in 1 ml sample water is up to 8. 9 x 104 or 1. 05 x 105, and it is estimated that there are 640 million 'invasion bacterium' individuals in one square meter. This study proves that other than the obvious environmental effects of sandstorm, the urban micro - ecosystem is very possible under threat by the 'invasion bacterium' accompanied by remote descending smallsand. | Wu Donghui Hu Ke Wang Yun Yang Deming Zhao Wei Chen Shan | 2000 | Global Geology2000，5，2： | 2 |
| 13 | Interaction between misfolded PrP and the ubiquitin-proteasome system in prion-mediated neurodegeneration显示文摘Prion 疾病与细胞的 prion 蛋白质(PrPC ) 的 conformational 变换被联系到病理学的表 isoforms (PrPSc ) ,它是在理解以外的传染代理人。增加的证据显示 PrPsc 的功能的未知有毒的获得位于 neuronal 死亡下面。相反地,充分证据显示那细胞的 prion 蛋白质可能由调停是直接细胞毒素的独立于 prion 复制的 -sheet-rich conformers 的毒害神经的发信号。而且,象 PrPSc 和淀粉的蛋白质那样的 -sheet-rich isoform 的共有的财产成为解释蛋白质错误褶层疾病的一般病理学的机制的制轮楔。ubiquitin-proteasome 系统(不间断电源) 的机能障碍在各种各样的蛋白质错误褶层疾病被含有。然而,这个缺陷的机制在许多情况中仍然保持未知。在 prion 疾病,感染 prion 的老鼠大脑增加了 ubiquitin 的层次结合,它与减少的 proteasome 相关工作。PrPC 和 PrPSc 在 proteasome 抑制以后在房间积累,它导致增加的房间死亡。在 20S 核心粒子和 PrP isoforms 之间的一个直接相互作用被表明。这里,我们考察错误褶层 PrP 和不间断电源的能力影响对方,它可能贡献调停 prion 的 neurodegeneration 的病理学的特征。 | Zhu Lin Deming Zhao Lifeng Yang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，6： | 2 |
| 14 | Cellular prion protein released on exosomes from macrophages binds to Hsp70显示文摘Prion 疾病是传染、致命的 neurodegenerative 混乱。变换成 prion 蛋白质(PrPSc ) 的错误褶层 isoform 的细胞的 prion 蛋白质(PrPC ) 为 prion 疾病感染负责。免疫系统在从圆周便于 prion 感染的传播到中央神经系统起一个重要作用。巨噬细胞被认为与 PrPSc 的交通和复制联系了。那么,在巨噬细胞理解 PrPC trafficking 是重要的为 PrPSc 探索运输机制。这里,我们从 Ana-1 巨噬细胞房间线的文化媒介孤立 exosomes 并且由西方的弄污, immunoelectron 显微镜学,和 co-immunoprecipitation 在分泌 exosomes 由 exosomes 和和 Hsp70 的 PrPC 的相互作用调查了 PrPC trafficked。结果证明从巨噬细胞的文化媒介的孤立的泡被 exosomes 和讨厌的人 PrPC 描绘。并且 PrPC 在细胞内部的环境两个都跳了到 Hsp70 并且分泌了 exosomes。相反, PrPC 没与 exosomes, Tag101 和 Flotillin-1 的标记蛋白质有相互作用。这些结果建议在细胞外的空间在场的 PrPC 可能是通过从巨噬细胞的分泌 exosomes 的 externalized,并且 Hsp70 可以在经由分泌 exosomes 释放的 PrPC 的过程起作用。 | Guihua Wang Xiangmei Zhou Yu Bai Zhongqiu Zhang Deming Zhao | 2010 | Acta Biochimica et Biophysica Sinica2010，42，5： | 2 |
| 15 | PP2 and piceatannol inhibit PrP106-126-induced iNOS activation mediated by CD36 in BV2 microglia显示文摘Prion 疾病是人和动物的一组能递送的致命的 neurodegenerative 混乱,包括牛的海绵状的 encephalopathy, scrapie,和 CreutzfeldtJakob 疾病。Microglia,中央神经系统的居民巨噬细胞,对病理学的织物改变精致地敏感,改变他们的形态学和显型采用一个所谓的激活的状态并且执行免疫学的响应 pathophysiological 大脑侮辱工作。尽管最近的调查结果提供了珍贵卓见进角色 microglia,在在 prion 观察的 proinflammatory 事件玩,为这些回答的开始负责的细胞内部的发信号分子尚待被阐明。看起来 microglial 激活包含 PrP106126 绑定和象 CD36 和 integrins 那样的房间表面免疫者和粘附分子的激活与象 Fyn 那样的 Src 家庭酷氨酸 kinases 的随后的招募, Lyn,和 Syk kinases。在现在的学习,我们证明 CD36 涉及导致 PrP106126 的 microglial 激活并且 PP2 和 piceatannol (照片) 能废除毒害神经的 prion 在 microglia 的导致肽的可诱导的氮的氧化物 synthase 激活。这些调查结果作为 Src 家庭 kinase Fyn 和涉及毒害神经的 prion peptidesmicroglia 相互作用的酷氨酸 kinase Syk 禁止者揭开 PP2 和照片的一个以前未被认出的角色,因此提供新卓见进由毒害神经的 prion 肽位于 microglia 的激活下面的机制。 | Siming Zhang Lifeng Yang Mohammed Kouadir Rongrong Tan Yun Lu Jiaxin Chang Binrui Xu Xiaomin Yin Xiangmei Zhou Deming Zhao | 2013 | Acta Biochimica et Biophysica Sinica2013，45，9： | 2 |
| 16 | Investigation of the transport and fate of Pb, Cd, Cr(VI) and As(V) in soil zones derived from moderately contaminated farmland in Northeast, China显示文摘 | Xingmin Zhao Deming Dong Xiuyi Hua Shuofei Dong | 2009 | Journal of Hazardous Materials2009，，： | 1 |
| 17 | A Fuzzy Programming Approach for Supply Chain Network Design显示文摘 | Xiaoyu Ji Xiande Zhao Deming Zhou | 2007 | International Journal of Uncertainty Fuzziness and Knowledge-Based Systems2007，15，4： | 1 |
| 18 | Quantification of prio n gene expression in brain and peripheral organs of golden hamster by real-time RT-PCR显示文摘 | Ning Zhanyong Zhao Deming Liu Hongxiang | 2005 | Animal Biotechnology2005，16，： | 1 |
| 19 | Absorption of ammonia on tantalum hydroxide synthesized by a hydrofluoric acid method显示文摘 | Zhao Deming Jiang Heng Gong Hong Su Tingting | 2011 | Transition Metal Chemistry2011，36，1： | 1 |
| 20 | Yield Effect of Chemical and Soil Nitrogen on the Mid-season and Ratooning Hybrid Rice显示文摘Using hybrid rice Yixiang1577 as the material,the mid-season and ratooning hybrid rice yield variation was studied in Southern Sichuan at different levels of nitrogen fertilizer. The results showed that rice yield by using N fertilizer increased to the most signifi cant level than no fertilizer ones,and the mid-season rice and rice yield by using more N fertilizer increased to the signif icant level than less fertilizer ones. The rice yield by using no fertilizer ones increased to the most signif icant level than some used fertilizer,and the ratooning rice and rice yield by using more N fertilizer decreased to the most signifi cant level than less fertilizer ones. The rice yield by using some fertilizer increased to the most signif icant level than no fertilizer ones for mid-season+rationing rice and rice yield by using some fertilizer had no obvious differences at different nitrogen levels. Therefore,application of fertilizer can improve yield of mid-season rice and mid-season+rationing rice. Soil test results showed that nutrient contents in rice fi eld in South Sichuan were very rich in nitrogen,which could provide more adequate crop growth potential soil nitrogen nutrition. The crops with a deep root system had stronger ability of utilization on soil nitrogen. Therefore,the ratooning rice used no or little N fertilizer had a high yield performance because they made full use of soil nitrogen with deep root system. | BAO Lingfeng LINT Gang ZHAO Deming LI Yunwu HE Bin | 2009 | Journal of Northeast Agricultural University(English Edition)2009，16，3： | 1 |
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