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| 1 | Role of autophagy in prion protein-induced neurodegenerative diseases显示文摘Prion 疾病,由海绵状的退化和错误褶层的累积描绘了并且在中央神经系统聚集了 PrPSc,是致命的 neurodegenerative 和人和动物的传染混乱之一。在更早的研究,在神经原的 autophagy 液泡经常在象 Alzheimer 的家那样的 neurodegenerative 疾病被观察, Parkinson 是,并且亨廷顿是象 prion 疾病一样的疾病。Autophagy 是几个细胞质的部件(蛋白质或细胞器) 被在一个 double-membrane-bound 泡扣押的一个高度保存的 homeostatic 过程称为的 autophagosome 并且与 lysosome 在他们的熔化之上降级了。在基础生理的层次的细胞间的自我消化的小径为维持纸巾和机关的健康地位是不可缺少的。在 prion 感染的情况下,增加证据显示 autophagy 把消除病理学的 PrPSc 的一个关键能力在神经原以内积累了。相反,在影响神经原的 autophagy 机能障碍可以贡献海绵状的变化的形成。在这评论,我们在 neurodegenerative 混乱关于哺乳动物的 autophagy 的效果总结了最近的调查结果,特别地在 prion 疾病。我们也总结了一些小分子的治疗学的潜力(例如锂, rapamycin, Sirtuin 1 和 resveratrol ) 在大脑上减轻如此的疾病的目标工作。而且,我们讨论了 autophagy 的争论角色,它是否调停 neuronal 毒性或在 neurodegenerative 混乱服务保护的功能。 | Hao Yao Deming Zhao Sher Hayat Khan Lifeng Yang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，6： | 65 |
| 2 | Soil Erosion Changes over the Past Five Decades in the Red Soil Region of Southern China显示文摘This paper reports the dynamic changes of soil and water loss in the red soil region of Southern China since the 1950s. The red soil region covers eight provinces: Jiangxi, Zhejiang, Fujian, Anhui, Hubei, Hunan, Guangdong and Hainan. From the 1950s to 1986, the annual rate of soil erosion increased by 3.4%. From 1986 to 1996 and from 1996 to 2000, the annual rates of soil erosion decreased by 2.0% and 0.32%, respectively. Field surveys showed that from 2000 to 2005, the area of soil and water loss decreased annually by 1.2%. This decrease was a result of large-scale erosion control activities across China. Although the eroded soil has been restored, the restoration process is very slow and full restoration will take a long time. Our report suggests that controlling soil and water loss is a challenging task, and additional measures must be taken to effectively control the soil erosion in the red soil region. | LIANG Yin LI Decheng LU Xixi YANG Xuan PAN Xianzhang MU Huan SHI Deming ZHANG Bin | 2010 | Journal of Mountain Science2010，7，1： | 18 |
| 3 | Characteristics and tectonic setting of volcanic rocks in Early Cretaceous Baiyingaolao Formation of Keyouzhongqi area,Inner Mongolia显示文摘The authors studied zircon LA-ICP-MS U-Pb dating,the zircon Hf isotope and geochemistry of acidic volcanic rocks in Baiyingaolao Formation of Keyouzhongqi area,Inner Mongolia,and discussed the chronology,source region and tectonic setting of the volcanic rocks in the studied area. The clear oscillatory zoning of zircons indicates a typical magmatic origin,and the results of dating show that the volcanic rocks of Baiyingaolao Formation were formed in Early Cretaceous( 121. 5 ± 1. 0 Ma). The features of major and trace elements show that the rocks are alkali-rich,poor in calcium and magnesium with enrichment in LILEs like Th,U,K and Gd and depletion in HFSEs,e. g. Nb,Ta,Sr and Ti. The fact implies that they were the products of partial melting of the crust. εHf( t) =( +6.30--+9.06) and TDM2= 600--835 Ma,suggest the magma originated from partial melting of the young crust. Combined with the evolution of regional tectonic structure,the authors conclude that the acidic volcanic rocks of Baiyingaolao Formation may be formed under the extensional environment related to the subduction of Paleo-Pacific Plate. | KONG Yuanming MA Rui HE Zhonghua YANG Deming WU Qing WANG Yang | 2014 | Global Geology2014，17，2： | 8 |
| 4 | Variation of Antarctic seal population in response to human activities in the 20th century显示文摘A sediment core was collected from the Fildes Peninsula of Antarctica, which contained numerous seal hairs and was identified to be seal excrement deposition. By analyzing its total organic carbon (TOC) and concentrations of bio-elements, the seal population changes of the past century were reconstructed. The variation of seal population in the last century on the Fildes Peninsula is primarily controlled by human activities. The sealing industry in the early 20th century caused the dramatic decline of seal popula-tion. The protection of the Antarctic seals since the 1960s and the reduced seal's competition with whales for prey resources due to whaling lead to the recovery of seal population and make the high level of the seal population sustainable. | YANG QiChao SUN LiGuang KONG DeMing HUANG Tao WANG YuHong | 2010 | Chinese Science Bulletin2010，55，11： | 7 |
| 5 | X-BAND CIRCULARLY POLARIZED RECTENNAS FOR MICROWAVE POWER TRANSMISSION APPLICATIONS显示文摘Circularly polarized rectennas operating at X-band are studied in this paper. The quasi-square patches fed by aperture coupling are used as the circularly polarized receiving antennas, which are easily matched and integrated with the circuits of rectennas. The double-layer structure not only minimizes the size of the rectennas but also decreases the effects of the circuits on the an- tenna. The receiving elements have broader bandwidth and higher gain than the single-layer patches. Two rectennas operating at 10GHz are designed, fabricated and measured. The voltage of 3.86V on a load of 200? is measured and a high RF-DC conversion efficiency of 75% is obtained at 9.98GHz. It is convenient for this kind of rectennas to form large arrays for high power applications. | Yang Xuexia Xu Junshu Xu Deming Xu Changlong | 2008 | Journal of Electronics(China)2008，25，3： | 7 |
| 6 | Allele-aware chromosome-scale assembly of the allopolyploid genome of hexaploid Ma bamboo(Dendrocalamus latiflorus Munro)显示文摘Dendrocalamus latiflorus Munro is a woody clumping bamboo with rapid shoot growth.Both genetic transformation and clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)gene editing techniques are available for D.latiflorus,enabling reverse genetic approaches.Thus,D.latiflorus has the potential to be a model bamboo species.However,the genome sequence of D.latiflorus has remained unreported due to its polyploidy and large genome size.Here,we sequenced the D.latiflorus genome and assembled it into three allele-aware subgenomes(AABBCC),representingthe largest genome of a major bamboo species.We assembled 70 allelic chromosomes(2,737 Mb)for hexaploid D.latiflorus using both singlemolecule sequencing from the Pacific Biosciences(Pac Bio)Sequel platform and chromosome conformation capture sequencing(Hi-C).Repetitive sequences comprised 52.65%of the D.latiflorus genome.We annotated 135231 protein-coding genes in the genome based on transcriptomes from eight different tissues.Transcriptome sequencing using RNA-Seq and Pac Bio singlemolecule real-time long-read isoform sequencing revealed highly differential alternative splicing(AS)between non-abortive and abortive shoots,suggesting that AS regulates the abortion rate of bamboo shoots.This high-quality hexaploid genome and comprehensive strand-specific transcriptome datasets for this Poaceae family member will pave the way for bamboo research using D.latiflorus as a model species. | Yushan Zheng Deming Yang Jundong Rong Liguang Chen Qiang Zhu Tianyou He Lingyan Chen Jing Ye Lili Fan Yubang Gao Hangxiao Zhang Lianfeng Gu | 2022 | Journal of Integrative Plant Biology2022，64，3： | 6 |
| 7 | Political connections, media monitoring and long-term loans显示文摘We analyze data on Chinese non-state-listed firms and find that it is easier for firms with political connections to obtain long-term loans with extended debt maturities than it is for firms without political connections. Our investigation indicates that this phenomenon is significantly less common with increased media monitoring. Houston et al.(2011) find strong evidence that the state ownership of media is associated with higher levels of bank corruption in China, but our study shows that, to a certain extent, media monitoring can curb corruption. | Deming Yang Zhengfei Lu Danglun Luo | 2014 | China Journal of Accounting Research2014，，3： | 4 |
| 8 | Decipher the mechanisms of rabbit's low susceptibility to prion infection显示文摘兔子有低危险性到 prion 感染。从到 prion 疾病的不同危险性的动物种类的 prion 蛋白质(PrP ) 上的研究在兔子 prion 蛋白质(RaPrPC ) 识别了关键氨基酸残余,特定的主题,和特殊特征贡献兔子 PrPC 和低危险性的稳定性到 prion 感染。然而,没有证据,证明兔子对 prion 疾病完全抵抗。兔子 prion 能通过蛋白质错误褶层在 vitro 被产生,这被报导了周期的扩大并且证明了传染、能递送。这里,我们在与 prion 感染的与兔子的低危险性的关系在兔子特定的 PrP 结构和特征上考察了研究。 | Zhen Yuan Deming Zhao Lifeng Yang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，11： | 4 |
| 9 | An Efficient ECDSA-Based Signature Scheme for Wireless Networks显示文摘Wired equivalent security is difficult to provide in wireless networks due to high dynamics, wireless link vulnerability, and decentralization. The Elliptic Curve Digital Signature Algorithm(ECDSA) has been applied to wireless networks because of its low computational cost and short key size, which reduces the overheads in a wireless environment. This study improves the ECDSA scheme by reducing its time complexity. The significant advantage of the algorithm is that our new scheme needs not to calculate modular inverse operation in the phases of signature generation and signature verification. Such an improvement makes the proposed scheme more efficient and secure. | XU Zhong DAI Guanzhong YANG Deming | 2006 | Wuhan University Journal of Natural Sciences2006，11，6： | 4 |
| 10 | Effects of the Nozzle Design on the Properties of Plasma Jet and Formation of YSZ Coatings under Low Pressure Conditions显示文摘How to control the quality of the coatings has become a major problem during the plasma spraying. Because nozzle contour has a great influence on the characteristic of the plasma jet, two kinds of plasma torches equipped with a standard cylindrical nozzle and a converging-diverging nozzle are designed for low pressure plasma spraying(LPPS) and very low pressure plasma spraying(VLPPS). Yttria stabilized zirconia(YSZ) coatings are obtained in the reducing pressure environment. The properties of the plasma jet without or with powder injection are analyzed by optical emission spectroscopy, and the electron temperature is calculated based on the ratio of the relative intensity of two ArⅠspectral lines. The results show that some of the YSZ powder can be vaporized in the low pressure enlarged plasma jet, and the long anode nozzle may improve the characteristics of the plasma jet. The coatings deposited by LPPS are mainly composed of the equiaxed grains and while the unmelted powder particles and large scalar pores appear in the coatings made by VLPPS. The long anode nozzle could improve the melting of the powders and deposition efficiency, and enhance the coatings' hardness. At the same time, the long anode nozzle could lead to a decrease in the overspray phenomenon. Through the comparison of the two different size's nozzle, the long anode is much more suitable for making the YSZ coatings. | SUN Chengqi GAO Yang YANG Deming FU Yingqing | 2016 | Chinese Journal of Mechanical Engineering2016，29，5： | 3 |
| 11 | Evaluation of dolomite reservoirs in the Longwangmiao Formation,Lower Cambrian in Northern Sichuan basin,China显示文摘With the extended petroleum exploration of the carbonate reservoir in the Longwangmiao Formation,Lower Cambrian in Sichuan basin,looking for a new favorable exploration area is the primary task in current exploration.This paper focusing on the dolomite reservoir in the Longwangmiao Formation in the Northern Sichuan basin,will evaluate the reservoir conditions,including reservoir lithology,reservoir spaces,physical properties and other basic characteristics.Combined with sedimentary environment study and diagenesis analysis,the genetic mechanism of Longwangmiao reservoir in study area will be discussed.It indicates that the reservoir rocks of Longwangmiao Formation in the study area are composed of dolarenite and crystalline dolomite,and the main reservoir spaces are intergranular dissolved pores,intragranular dissolved pores and intercrystalline dissolved pores.However,most of dissolved pores have been filled with bitumen,which lead to the reservoir properties very poor,both the porosity and permeability are worse than that of central Sichuan basin,so the reservoir in the Longwangmiao Formation in the Northern Sichuan basin is low-porosity and low-permeability reservoir.During the Early Cambrian Longwangmiao period,the study was near the old-land,and the energy of sea water was not enough to deposit many grain shoals,which cause the sediments are small with lots of quartz and muds.Moreover,because lacking of large scale karstification in the late diagenesis,there isn't much dissolved pores and vugs develop in the Longwangmiao Formation.Some Intergranular dissolved pores and intercrystalline dissolved pores formed by the early atmosphere water dissolved exist as some reservoir spaces,but most of them have been filled with bitumen,which was residual when the ancient oil reservoir transformed.Above factors cause the Longwangmiao Formation in the Northern Sichuan basin become not a very favorable reservoir in Sichuan basin. | Xuefei Yang Yaping Wang Xingzhi Wang Deming Zeng Longbo Xu Zisang Huang | 2017 | Petroleum2017，3，4： | 3 |
| 12 | Molecular mechanisms of neurodegeneration mediated by dysfunctional subcellular organelles in transmissible spongiform encephalopathies显示文摘能递送的海绵状的 encephalopathies 包括 synaptic 损坏,树枝状的萎缩, vacuolization,和 microglial 激活与传播和 pathophysiology 的完全新奇的机制指一组传染 neurodegenerative 疾病。广泛的 neuronal 损失是长期的大脑恶化和 prion 疾病的致命的结果的主要原因。作为病理学的改变的最后的结果, neuronal 死亡是所有 prion 疾病的一个突出的特征。为 prion 疾病负责的机制很好没被理解。neuronal 损坏的分子的基础的更全面的理解为为能递送的海绵状的 encephalopathies 和分享类似的特征的另外的 neurodegenerative 疾病的有效治疗的发展是必要的。这里,我们考察 mitochondrial 机能障碍和 endoplasmic 蜂窝胃的分子的机制调停压力的 neuronal 死亡,哪个戏在 prion 疾病的 pathogenisis 的关键角色。 | Zhiqi Song Deming Zhao Lifeng Yang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，6： | 3 |
| 13 | Regulation of proteasomes in prion disease显示文摘prion 疾病的特点是错误褶层蛋白质 PrP 对 neuronal 房间有毒的 Sc , 。proteasome 系统为快速、精确、及时的降级 ofproteins 负责并且在细胞的蛋白质质量控制起一个重要作用。增加的证据在 prion 疾病显示损害 activityof proteasomes。积累的 PrP Sc 能直接或间接地影响 proteasome 活动。错误褶层蛋白质可以影响 20S proteasome 的 19S regulatoryparticle,或 translational 以后修正的集会和活动,它可以不利地影响蛋白质降级 activityof proteasomes。在这评论,我们在 prionand 有关 proteasomes 的可能的规定总结了最近的调查结果另外的 neurodegenerative 疾病。proteasome 系统可以由改变它的结构提高它的降级活动,并且当 neuronal 房间服从于应力时,这项活动能被相关女伴也增加。当 proteasomesystem 被禁止时,经由 autophagy 的蛋白质总数的降级可以作为一个补偿系统增加。它是 possiblethat 平衡在 vivo 在 proteasome 和 autophagy 之间存在;当一个人被损害时,其它的活动可以增加维持动态平衡。然而,更多的研究是需要的 toelucidate 在 proteasome 系统和 autophagy 之间的关系。 | Ting Zhu Sher Hayat Khan Deming Zhao Lifeng Yang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，7： | 2 |
| 14 | A direct real-time polymerase chain reaction assay for rapid high-throughput detection of highly pathogenic North American porcine reproductive and respiratory syndrome virus in China without RNA purification显示文摘Background:Porcine reproductive and respiratory syndrome virus(PRRSV),and particularly its highly pathogenic genotype(HP-PRRSV),have caused massive economic losses to the global swine industry.Results:To rapidly identify HP-PRRSV,we developed a direct real-time reverse transcription polymerase chain reaction method(dRT-PCR) that could detect the virus from serum specimen without the need of RNA purification.Our dRT-PCR assay can be completed in 1.5 h from when a sample is received to obtaining a result.Additionally,the sensitivity of dRT-PCR matched that of conventional reverse transcription PCR(cRT-PCR) that used purified RNA.The lowest detection limit of HP-PRRSV was 6.3 TCID_(50) using dRT-PCR.We applied dRT-PCR assay to 144 field samples and the results showed strong consistency with those obtained by cRT-PCR.Moreover,the dRT-PCR method was able to tolerate 5-20%(v/v) serum.Conclusions:Our dRT-PCR assay allows for easier,faster,more cost-effective and higher throughput detection of HP-PRRSV compared with cRT-PCR methods.To the best of our knowledge,this is the first report to describe a real-time RT-PCR assay capable of detecting PRRSV in crude serum samples without the requirement for purifying RNA.We believe our approach has a great potential for application to other RNA viruses. | Kang Kang Keli Yang Jiasheng Zhong Yongxiang Tian Limin Zhang Jianxin Zhai Li Zhang Changxu Song Christine Yuan Gou Jun Luo Deming Gou | 2015 | Journal of Animal Science and Biotechnology2015，6，1： | 2 |
| 15 | ANALYSIS OF SOIL EROSION CHARACTERISTICS AND SEDIMENT SOURCES FOR THE YANTZE THREE GORGES REGION显示文摘In this paper the researches made in 1981-1990 have identified that the annual soil loss in the Three Gorges region is 157 million t. and the annual incoming sediment load of the Three Gorges reservoir is 40 million t. Soil erosion increases with the destruction of vegetative cover and its subsequent evolution. The annual amounts of sediment erosion for forest land, shrub land, grassland and farmland make up respectively 6.19%, 10.76%, 23.05% and 60% of the total erosion of the Three Gorges region; the quantities of incoming sediment load to the Yangtze River from the above four types of land account for 5.95%, 12.42%, 35.46% and 46.1 % of the total amount of sediment transported to the reservoir. The farmland of offers the main source of sediment. Gravitational erosion produces more bed loads, which will present serious threat to the Three Gorges Project if entering the reservoir. Resettlement of people to the upper parts of the mountainous areas for agricultural production will increase the sediment yield of the Three Gorges region by 10-20 million t and increase the incoming sediment of the Yangtze River by 50-60 million t. Consequently, it is necessary to make a realistic assessment of the soil erosion in the Three Gorges region. | SHI Deming, YANG Yansheng, LU Xixi, and LIANG Ying (Nanjing Institute of Soil Science,Chinese Academy of Sciences) | 1992 | International Journal of Sediment Research1992，7，2： | 2 |
| 16 | Ecological Effects of Remote Smallsand Descending on Urban Area:Deduced from the 'Mud - Snow' in Changchun City显示文摘A serious sandstorm occurred in North China from April 5 to April 7, 2000, while the remote smallsand decending took place in even larger area to the far northeast China. In Chanchun city, smallsand descending with snow provides the best samples to conduct a quantitative research on the possible impacts of city - ecology. In the 253km2 urban district area of Changchun city, smallsands accumulated up to more than 3000t on April 7, according to the calculation of four 'mud - snow' samples. After naturally melting in room temperature, two samples are taken to do quarantine of 'invasion bacteria'. As a preliminary result, the individual amount of bacterium in 1 ml sample water is up to 8. 9 x 104 or 1. 05 x 105, and it is estimated that there are 640 million 'invasion bacterium' individuals in one square meter. This study proves that other than the obvious environmental effects of sandstorm, the urban micro - ecosystem is very possible under threat by the 'invasion bacterium' accompanied by remote descending smallsand. | Wu Donghui Hu Ke Wang Yun Yang Deming Zhao Wei Chen Shan | 2000 | Global Geology2000，5，2： | 2 |
| 17 | Interaction between misfolded PrP and the ubiquitin-proteasome system in prion-mediated neurodegeneration显示文摘Prion 疾病与细胞的 prion 蛋白质(PrPC ) 的 conformational 变换被联系到病理学的表 isoforms (PrPSc ) ,它是在理解以外的传染代理人。增加的证据显示 PrPsc 的功能的未知有毒的获得位于 neuronal 死亡下面。相反地,充分证据显示那细胞的 prion 蛋白质可能由调停是直接细胞毒素的独立于 prion 复制的 -sheet-rich conformers 的毒害神经的发信号。而且,象 PrPSc 和淀粉的蛋白质那样的 -sheet-rich isoform 的共有的财产成为解释蛋白质错误褶层疾病的一般病理学的机制的制轮楔。ubiquitin-proteasome 系统(不间断电源) 的机能障碍在各种各样的蛋白质错误褶层疾病被含有。然而,这个缺陷的机制在许多情况中仍然保持未知。在 prion 疾病,感染 prion 的老鼠大脑增加了 ubiquitin 的层次结合,它与减少的 proteasome 相关工作。PrPC 和 PrPSc 在 proteasome 抑制以后在房间积累,它导致增加的房间死亡。在 20S 核心粒子和 PrP isoforms 之间的一个直接相互作用被表明。这里,我们考察错误褶层 PrP 和不间断电源的能力影响对方,它可能贡献调停 prion 的 neurodegeneration 的病理学的特征。 | Zhu Lin Deming Zhao Lifeng Yang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，6： | 2 |
| 18 | An improved Tet-on system in micro RNA overexpression and CRISPR/Cas9-mediated gene editing显示文摘Background: Tetracycline(Tet)-regulated expression system has become a widely applied tool to control gene activity. This study aimed to improve the Tet-on system with superior regulatory characteristics.Results: By comprehensively comparing factors of transactivators, Tet-responsive elements(TREs), orientations of induced expression cassette, and promoters controlling the transactivator, we developed an optimal Tet-on system with enhanced inducible efficiency and lower leakiness. With the system, we successfully performed effective inducible and reversible expression of micro RNA, and presented a more precise and easily reproducible fine-tuning for confirming the target of a mi RNA. Finally, the system was applied in CRISPR/Cas9-mediated knockout of nuclear factor of activated T cells-5(NFAT5), a protective transcription factor in cellular osmoregulation.Conclusions: This study established an improved Tet-on system for powerful and stringent gene regulation in functional genetic studies. | Kang Kang Lian Huang Qing Li Xiaoyun Liao Quanjin Dang Yi Yang Jun Luo Yan Zeng Li Li Deming Gou | 2019 | Journal of Animal Science and Biotechnology2019，10，4： | 2 |
| 19 | Overfitting effect of artificial neural network based nonlinear equalizer: from mathematical origin to transmission evolution显示文摘Overfitting effect of artificial neural network(ANN)based nonlinear equalizer(NLE)leads to a trap of bit error ratio(BER)overestimation in optical fiber communication system,especially when the performance is evaluated by the commonly-used pseudo-random binary sequence(PRBS).First,we mathematically investigate the PRBS generation and Gray code mapping rules,in comparison with the use of Mersenne Twister random sequence(MTRS).Under the condition of a symbol erasure channel,we identify that ANN can recognize both the PRBS generation and symbol mapping rules,by increasing the weights of NLE at specific positions,whereas the MTRS is currently safe owing to the limited input length of current ANN based NLE.Then,we design four channel models of fiber optical transmission to experimentally examine various impairments on the evolution of overfitting effect.When both the additive white Gaussian noise(AWGN)channel and the bandwidth limited channel are considered,the mitigation of overfitting becomes possible by the use of pruned PRBS(P-PRBS)training set with removing the generation and mapping rules determined input symbols.However,as for both the chromatic dispersion(CD)uncompensated channel and the CD managed channel,the overfitting effect becomes serious,because both CD and fiber nonlinearity induced inter-symbol interference(ISI)is beneficial for ANN to identify the PRBS symbol rules.Finally,possible solutions to mitigate the overfitting effect are summarized. | Zheng YANG Fan GAO Songnian FU Ming TANG Deming LIU | 2020 | Science China(Information Sciences)2020，63，6： | 2 |
| 20 | PP2 and piceatannol inhibit PrP106-126-induced iNOS activation mediated by CD36 in BV2 microglia显示文摘Prion 疾病是人和动物的一组能递送的致命的 neurodegenerative 混乱,包括牛的海绵状的 encephalopathy, scrapie,和 CreutzfeldtJakob 疾病。Microglia,中央神经系统的居民巨噬细胞,对病理学的织物改变精致地敏感,改变他们的形态学和显型采用一个所谓的激活的状态并且执行免疫学的响应 pathophysiological 大脑侮辱工作。尽管最近的调查结果提供了珍贵卓见进角色 microglia,在在 prion 观察的 proinflammatory 事件玩,为这些回答的开始负责的细胞内部的发信号分子尚待被阐明。看起来 microglial 激活包含 PrP106126 绑定和象 CD36 和 integrins 那样的房间表面免疫者和粘附分子的激活与象 Fyn 那样的 Src 家庭酷氨酸 kinases 的随后的招募, Lyn,和 Syk kinases。在现在的学习,我们证明 CD36 涉及导致 PrP106126 的 microglial 激活并且 PP2 和 piceatannol (照片) 能废除毒害神经的 prion 在 microglia 的导致肽的可诱导的氮的氧化物 synthase 激活。这些调查结果作为 Src 家庭 kinase Fyn 和涉及毒害神经的 prion peptidesmicroglia 相互作用的酷氨酸 kinase Syk 禁止者揭开 PP2 和照片的一个以前未被认出的角色,因此提供新卓见进由毒害神经的 prion 肽位于 microglia 的激活下面的机制。 | Siming Zhang Lifeng Yang Mohammed Kouadir Rongrong Tan Yun Lu Jiaxin Chang Binrui Xu Xiaomin Yin Xiangmei Zhou Deming Zhao | 2013 | Acta Biochimica et Biophysica Sinica2013，45，9： | 2 |
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