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| 1 | Transplantation of stem cell-derived astrocytes for the treatment of amyotrophic lateral sclerosis and spinal cord injury显示文摘Neglected for years, astrocytes are now recognized to fulfill and support many, if not all, homeostatic functionsof the healthy central nervous system(CNS). During neurodegenerative diseases such as amyotrophic lateral sclerosis(ALS) and spinal cord injury(SCI), astrocytes in the vicinity of degenerating areas undergo both morphological and functional changes that might compromise their intrinsic properties. Evidence from human and animal studies show that deficient astrocyte functions or loss-of-astrocytes largely contribute to increased susceptibility to cell death for neurons, oligodendrocytes and axons during ALS and SCI disease progression. Despite exciting advances in experimental CNS repair, most of current approaches that are translated into clinical trials focus on the replacement or support of spinal neurons through stem cell transplantation, while none focus on the specific replacement of astroglial populations. Knowing the important functions carried out by astrocytes in the CNS, astrocyte replacement-based therapies might be a promising approach to alleviate overall astrocyte dysfunction, deliver neurotrophic support to degenerating spinal tissue and stimulate endogenous CNS repair abilities. Enclosed in this review, we gathered experimental evidence that argue in favor of astrocyte transplantation during ALS and SCI. Based on their intrinsic properties and according to the cell type transplanted, astrocyte precursors or stem cell-derived astrocytes promote axonal growth, support mechanisms and cells involved in myelination, are able to modulate the host immune response, deliver neurotrophic factors and provide protective molecules against oxidative or excitotoxic insults, amongst many possible benefits. Embryonic or adult stem cells can even be genetically engineered in order to deliver missing gene products and therefore maximize the chance of neuroprotection and functional recovery. However, before broad clinical translation, further preclinical data on safety, reliability and therapeutic efficiency should be collected. Although several technical challenges need to be overcome, we discuss the major hurdles that have already been met or solved by targeting the astrocyte populationin experimental ALS and SCI models and we discuss avenues for future directions based on latest molecular findings regarding astrocyte biology. | Charles Nicaise Dinko Mitrecic Aditi Falnikar Angelo C Lepore | 2015 | World Journal of Stem Cells2015，7，2： | 13 |
| 2 | Randomized con- trolled trial of sevoflurane for intubation in neonates显示文摘 | HASSID S NICAISE C MICHEL F | 2007 | Paediatric Anaesthesia2007，，： | 1 |
| 3 | Choledochal cysts:comparison of findings at MR cholangiopancreatography and endo,opic retrograde cholangiopancreatography in eight patients显示文摘 | Matos C Nicaise N Deviere J | 1998 | Radiology1998，209，2： | 1 |
| 4 | Ultrasonographic evaluation of cervical length in pregnancies complicated by preterm premature rupture of membranes显示文摘 | Gire C Faggianelli P Nicaise C | 2002 | Ultrasound Obstet Gynecol2002，19，6： | 1 |
| 5 | Distribution, differentiat- ion, and survival of intravenously administered neural stem ce- lls in a rat model of amyotrophic lateral sclerosis显示文摘 | Mitrecic D Nicaise C Gajovic S | 2010 | Cell Transp- lant2010，19，5： | 1 |
| 6 | Induction of FOXP3-expressing regulatory CD4pos T cells by human mature autologous dendritic cells显示文摘 | Verhasseh V Vosters O Beuneu C Nicaise C Stordeur P Goldman M | 2004 | Eur J Immunol2004，34，： | 1 |
| 7 | Osteosarcoma cell-calcium signaling through tissue factor-factor Ⅶa complex and factor Xa显示文摘 | Daubie V De Decker R Nicaise C | 2007 | FEBS lett2007，581，14： | 1 |
| 8 | CCR5 deficiency exacerbates T-cell-mediated hepatitis in mice 显示文摘 | Moreno C Gustot T Nicaise C | 2005 | Hepology2005，42，4： | 1 |
| 9 | Comparison of GLUT1, GLUT2,GLUT4 and SGLT1 mRNA expression in the salivary glands and six other organs of control, streptozotocin-induced and Goto-Kakizaki diabetic rats显示文摘 | JURYSTA C NICAISE C GIROIX M H et aI | 2013 | Cell Physiol Biochem2013，31，1： | 1 |
| 10 | Second generation anti - eyclic citrullinated peptide ( anti - CCP2 ) antibodies can replace other anti - filaggrin anti- bodies and improve rheumatoid arthritis diagnosis 显示文摘 | GROOTENBOER MIGNOT S NICAISE ROLAND P DELAUNAY C | 2004 | Scand J Rheumatol2004，33，4： | 1 |
| 11 | Second generation anti -cyclic citrullinated pepeide(anti -CCP2)antibodies can replace other anti -filaggrin antibodies and improve rheumatoid arthritis diagnosis显示文摘 | F -Mignot S Nicaise Roland P Delaunay C | 2004 | Scand J Rheumatol2004，33，： | 1 |
| 12 | Neural progenitors derived from human induced pluripotent stem dells survive and differentiate upon transplantation into a rat model of amyotrophic lateral sclerosis 显示文摘 | POPESCU I R NICAISE C LIU S | 2013 | Stem cells translational medicine2013，2，3： | 1 |
| 13 | Bacillus licheniformis septicemia in a very-low-birth-weight neonate: a case report 显示文摘 | Lepine A Michel F Nicaise C | 2009 | Infection2009，37，2： | 1 |
| 14 | Choledochal cysts: comparison of fi ndings at MR cholangiopancreatography and endoscopic retrograde cholangiopancrea tography in eight patients显示文摘 | Matos C Nicaise N Deviere J | 1998 | Radiology1998，209，2： | 1 |
| 15 | Overexpression of the Astrocyte Gluta- mate Transporter GLT1 Exacerbates Phrenic Motor Neuron Degenera- tion, Diaphragm Compromise, and Forelimb Motor Dysfunction follow- ing Cervical Contusion Spinal Cord Injury 显示文摘 | Li K Nicaise C Sannie D | 2014 | J Neurosci2014，34，22： | 1 |
| 16 | The intestinal imcroflora regulates cytokine production positively in spleen-derived macrophages but negatively in bone marrow-derived macrophages显示文摘 | Nicaise P Gleizes A Sandre C | 1999 | Eur Cytokine Netw1999，10，： | 1 |
| 17 | Sec- ond generation anti - eyclic citrullinated peptide( anti - CCP2 ) an- tibodies can replace other anti - filaggrin anti - bodies and improve rheumatoid arthritis diagnosis 显示文摘 | Grootenboer Mignot S Nicaise Roland P Delau - Nay C | 2004 | Scand JRheumatol2004，33，4： | 1 |
| 18 | Second generation anti - cyclic citrullinated peptide ( anti - CCP2 )antibodies can replace other anti filaggrin antibodies and improve rheumatoid arthritis diagnosis显示文摘 | Grootenboer - Mignot S Nicaise - Roland P Delaunay C | 2004 | Scand J Rheumatol2004，33，4： | 1 |
| 19 | Airway humidification with a heat and moisture exchanger in mechani- cally ventilated neonate :a preliminary evalution 显示文摘 | Fassaaatal M Michel F Thomachot L Nicaise C | 2007 | Intensive Care Med2007，33，2： | 1 |
| 20 | Potential involve ment of the IL-33-ST2 axis in the pathogenesis of pri mary Sjogren's syndrome显示文摘 | Awada A Nicaise C Ena S | 2014 | Annals of the Rheumatic Diseases2014，73，6： | 1 |
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