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| 1 | Management of digestive bleeding related to portal hypertension in cirrhotic patients:A French multicenter cross-sectional practice survey显示文摘AIM: To investigate the conformity of management practices of gastrointestinal hemorrhage in cirrhotic patients with relevant guidelines. METHODS: A questionnaire on the management of digestive bleeding was completed for all consecutive cirrhotic patients admitted to 31 French hospitals. RESULTS: One hundred and twenty-six bleeding events were recorded. It was the first bleeding episode in 79 patients (63%), of whom 40 (51%) had a prior diagnosis of cirrhosis and 25 (32%) had previously undergone an endoscopy. The bleeding episode was a recurrence in 46 patients (37%). The median time between onset and admission was 4 h, but exceeded 12 h in 42% of cases. There was an agreement between centers forearly vasoactive drug administration (87% of cases), association with ligation (42%) more often than sclerosis (21%) at initial endoscopy, and antibiotic prophylaxis (64%). By contrast, prescription of beta-blockade alone or in combination (0 to 100%, P = 0.003) for secondary prophylaxis and lactulose (26% to 86%, P = 0.04), differed among centers. CONCLUSION: In French hospitals, management of bleeding related to portal hypertension in cirrhotic patients is generally in keeping with the consensus. Broad variability still remains concerning beta-blockade use for secondary prophylaxis. Screening for esophageal varices, the use of antibiotic prophylaxis and patients information need to be improved. | Pierre Ingrand Jérme Gournay Pierre Bernard Frédéric Oberti Brigitte Bernard-Chabert Arnault Pauwels Philippe Renard Eric Bartoli Jean-Franois Cadranel Jean-Claude Barbare Isabelle Ingrand Michel Beauchant | 2006 | World Journal of Gastroenterology2006，12，48： | 4 |
| 2 | Better to be alone than in bad company:The antagonistic effect of cisplatin and crizotinib combination therapy in non-small cell lung cancer显示文摘AIM To investigate the potential benefit of combining the cMET inhibitor crizotinib and cisplatin we performed in vitro combination studies.METHODS We tested three different treatment schemes in four non-small cell lung cancer(NSCLC) cell lines with a different cMET/epidermal growth factor receptor genetic background by means of the sulforhodamine B assay and performed analysis with Calcusyn.RESULTS All treatment schemes showed an antagonistic effect in all cell lines,independent of the cMET status.Despite their different genetic backgrounds,all cell lines(EBC-1,HCC827,H1975 and LUDLU-1) showed antagonistic combination indexes ranging from 1.3-2.7.These results were independent of the treatment schedule.CONCLUSION These results discourage further efforts to combine cMET inhibition with cisplatin chemotherapy in NSCLC. | Nele Van Der Steen Christophe Deben Vanessa Deschoolmeester An Wouters Filip Lardon Christian Rolfo Paul Germonpré Elisa Giovannetti Godefridus J Peters Patrick Pauwels | 2016 | World Journal of Clinical Oncology2016，7，6： | 2 |
| 3 | Linking a Game Engine Environment to Architectural Information on the Semantic Web显示文摘 | Pieter Pauwels Ronald De Meyer Jan Van Campenhout | 2011 | Journal of Civil Engineering and Architecture2011，5，9： | 2 |
| 4 | A new karst-dwelling bent-toed gecko (Squamata: Gekkonidae Cyrtodactylus) from Xiangkhoang Province, northeastern Laos显示文摘We describe a new karst-dwelling Cyrtodactylus from Ban Thathom, Xiangkhoang Province, northeastern Laos. The new species can be distinguished from other congeners by having four dark dorsal bands between limb insertions, a discontinuous nuchal loop,10 precloacal pores in males or 10–12 precloacal pits(females) separated by a diastema from a series of enlarged femoral scales bearing 18 or 19 pores(male)or 8–10 pits(females) along each femur, 14–18 dorsal tubercle rows at midbody, no precloacal groove, 30–36 midbody scale rows across belly between ventrolateral skin folds, transversely enlarged subcaudal plates, and a maximal known snout-vent length of 75.5 mm. Our description brings to 22 the number of Cyrtodactylus species recorded from Laos. | Roman A. Nazarov Olivier S.G. Pauwels Evgeniy L. Konstantinov Anatoliy S. Chulisov Nikolai L. Orlov Nikolay A. Poyarkov, Jr. | 2018 | Zoological Research2018，39，3： | 2 |
| 5 | The inhaled Steroid Treatment as Regular Therapy in early asthma study: rational and design 显示文摘 | Pauwels RA Busse WW ByrnePM | 2001 | Control Clin Trials2001，2，4： | 1 |
| 6 | Short-term cigarette smoke exposure enhances allergic airway inflammation in mice 显示文摘 | Moerloose KB Pauwels RA Joos GF | 2005 | Am J Respir Crit Care Med2005，172，： | 1 |
| 7 | Burden and clinical features of chronic obstructive pulmonary disease(COPD)显示文摘 | Pauwels RA Rabe KF | 2004 | Lancet2004，364，： | 1 |
| 8 | Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary updated 2003显示文摘 | Fabbri L Pauwels RA Hard SS GOLD Scientific Committee | 2004 | COPD2004，1，1： | 1 |
| 9 | Effect of age on allergen induced structural airway changes in brown Norway rats显示文摘 | Palmans E Vanacker N J Pauwels R A | 2002 | Am J Respir Crit Care Med2002，165，： | 1 |
| 10 | In vitro volatile sulfiur compound production of oral bacteria in different culture media 显示文摘 | Quirynen M Van Eldere J Pauwels M | 1999 | Quintessence Int1999，30，5： | 1 |
| 11 | Combined salmeterol andfluticasone in the treatment of chronic obstructive pulmonary dis-ease :a Handonmizeid controlled trail显示文摘 | Calverley P Pauwels R Vestbo J | 2003 | Lancet2003，361，： | 1 |
| 12 | Effects of word-of-mouth versus traditional marketing: Findings from an internet social networking site 显示文摘 | Trusov M BucklinR E Pauwels K | 2009 | Journal of Marketing2009，73，5： | 1 |
| 13 | Improved survival after variceal bleeding in patients with cirrhosis over the past two decades显示文摘 | CARBONELL N PAUWELS A SERFATY L | 2004 | Hepatology2004，40，3： | 1 |
| 14 | Survival and response after peptide receptor radionuelide therapy with octreotide in patients with advanced gastroenteropancreatie neuroendocrine tumors显示文摘 | Valkema R Pauwels S Kvols LK | 2006 | Semin Nucl Med2006，36，2： | 1 |
| 15 | Comparison of polyacry-lonitrile(AN69) and polysulphone membrane hemofiltration in canine endotoxic shock显示文摘 | Rogiers P Zhang H Pauwels D | | 0，，04： | 1 |
| 16 | A chromosomal abnormality in hyaline vascular Castleman′s disease:evidence for clonal proliferation of dysplastic stromal cells显示文摘 | Pauwels P Dal Cin P Vlasveld LT | | 0，，06： | 1 |
| 17 | Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression through paracrine neuregulin 1/HER3 signalling显示文摘 | De Boeck A Pauwels P Hensen K | | 0，，： | 1 |
| 18 | The effect of endotoxin inhalation on airway responsiveness and cellular influx in rats显示文摘 | Kips JC Peleman RA | 1990 | Am Rev Respir Dis1990，141，： | 1 |
| 19 | Early intervention with budesonide in mild persistent asthma:a randomised,double-blind trial显示文摘 | Pauwels RA Pederson S Busse WW | 2003 | Lancet2003，361，： | 1 |
| 20 | Elevated MMP - 12 protein levels in induced sputum from patients with COPD 显示文摘 | Demedts I K Morel - Montero A Lebecque S Pacheco Y Cataldo D Joos G F Pauwels R A Brusselle G G | 2006 | Thorax2006，61，6： | 1 |
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