|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Non-linear buckling analysis of imperfect thin spherical pressure hull for manned submersible显示文摘Thin spherical pressure hulls are used as a human occupancy in deep water applications.DNV and other standards specify the imperfection allowed for pressure hulls.Numerical analyses are carried out to find the buckling pressure for both perfect and imperfect thin spherical pressure hulls,considering the geometric and material non-linearities.It is observed that there is a huge variation in the elastic and inelastic buckling pressure in perfect spherical pressure hulls.Moreover,if the manufacturing imperfections are considered in the inelastic numerical analysis,still there is a reduction in the buckling pressure.Design criteria,for deep water pressure hulls,is that both buckling pressure and yield pressure must be greater than the design pressure.In the elastic analysis,if t/D>0.006 buckling pressure is always greater than the yield pressure whereas in the inelastic analysis,the buckling pressure is falling below the yield pressure for all t/D ratios.Hence,inelastic numerical analysis with manufacturing imperfection has to considered in the design of deep water spherical pressure hulls of manned submersibles. | SB.Pranesh Deepak Kumar V.Anantha Subramanian D.Sathianarayanan GA.Ramadass | 2017 | Journal of Ocean Engineering and Science2017，2，4： | 4 |
| 2 | Phenotyping emphysema and airways disease: Clinical value of quantitative radiological techniques显示文摘The pathophysiology of chronic obstructive pulmonary disease(COPD) and Alpha one antitrypsin deficiency is increasingly recognised as complex such that lung function alone is insufficient for early detection, clinical categorisation and dictating management. Quantitative imaging techniques can detect disease earlier and more accurately, and provide an objective tool to help phenotype patients into predominant airways disease or emphysema. Computed tomography provides detailed information relating to structural and anatomical changes seen in COPD, and magnetic resonance imaging/nuclear imaging gives functional and regional information with regards to ventilation and perfusion. It is likely imaging will become part of routine clinical practice, and an understanding of the implications of the data is essential. This review discusses technical and clinical aspects of quantitative imaging in obstructive airways disease. | Diana Crossley Alice Turner Deepak Subramanian | 2017 | World Journal of Respirology2017，7，1： | 1 |
| 3 | Surface hydrolysis-mediated PEGylation of poly(N-isopropyl acrylamide)based nanogels显示文摘In this work,poly(N-isopropyl acrylamide-co-acrylamide)[P(NIPAAm-co-AAm)]nanogels were modified by hydrolysis above the lower critical solution temperature(LCST)to localize carboxylic acid functional groups at the surface(surface hydrolysis).PNIPAAm copolymerized with 15%and 20%nominal AAm in the feed were prepared and compared to equivalent hydrogels with acrylic acid.The effect and extent of surface hydrolysis was confirmed by potentiometric titration and zeta potential.These surface modified nanogels were then modified with primary amine functionalized PEG chains.Surface hydrolysis-mediated PEGylation had little effect on the swelling response of the nanogels,while also preventing adsorption of model proteins in physiological relevant conditions.While both 15%and 20%AAm gels both decreased protein adsorption,only the 20%AAm gels resulted in fully preventing protein adsorption.The results presented here point to surface hydrolysis as a new route to passivate nanogels for use in vivo. | Jonathan T.Peters Stanley Verghese Deepak Subramanian Nicholas A.Peppas | 2017 | Regenerative Biomaterials2017，4，5： | 1 |
| 4 | Inter and intra-ethnic differences in the distribution of the molecular variants of TPMT, UGT1A1 and MDR1 genes in the South Indian population显示文摘 | Gurusamy Umamaheswaran Dhakchinamoorthi Krishna Kumar Dhandapani Kayathiri Subramanian Rajan Deepak Gopal Shewade Steven Aibor Dkhar Sajjanavar Manjunath Prayaga Ushakiran Gangadharan Reneega Kukreti Ritushree Chandrasekaran Adithan | 2012 | Molecular Biology Reports2012，，5： | 1 |
| 5 | Fuzzy classification metrics for scanner assessment and vulnerability reporting显示文摘 | Peter Kok Keong Loh Deepak Subramanian | | IEEE Transactions on Info0，，： | 1 |
| 6 | 肺PET图像的定量分析:挑战和机遇显示文摘数百万人受呼吸系统疾病的影响,导致巨大的全球性健康困扰。由于目前对导致呼吸系统疾病发展和进展的潜在机制认识不足,治疗选择仍然有限。为克服此局限和理解相关分子变化,将无创影像技术如PET和SPECT用于探索生物标志物,其中18F-脱氧葡萄糖(FDG)PET显像的研究最多。由于肺内组织、气体、血液和水的构成比变异,定量分析肺的分子影像数据仍具挑战性。这些成分的比例随着肺部疾病的不同而不同,因此有不同的定量分析方法来显示这种变化,但迄今为止还没有开发出对数据标准化的方法。该文回顾了肺部疾病中18F-FDG PET定量分析方法的数据,聚焦于解释肺内成分变化的方法,解读衍生参数。分析的疾病包括急性呼吸窘迫综合征、慢性阻塞性肺疾病、肺间质性疾病如特发性肺纤维化。基于对既往文献、进行中的研究以及作者间讨论的回顾,作者提出了建议性的注意事项,以协助解读从这些方法及未来研究设计中衍生的参数。 | 陈聪霞(译) 李文婵(译) 郭悦(译) 姚稚明(审校者) Delphine L.Chen Joseph Cheriyan Edwin R.Chilvers Gourab Choudhury Christopher Coello Martin Connell Marie Fisk Ashley M.Groves Roger N.Gunn Beverley F.Holman Brian F.Hutton Sarah Lee William MacNee Divya Mohan David Parr Deepak Subramanian Ruth Tai-Singer Kris Thielemans Edwin J.R.van Beek Laurence Vass Jeremy W.Wellen Ian Wilkinson Frederick J.Wilson | 2019 | 中华核医学与分子影像杂志2019，39，11： | 0 |
| 7 | An inherent acceleratory effect of insulin on small intestinal transit and its pharmacological characterization in normal mice显示文摘瞄准:在小肠的运输上学习胰岛素的固有的效果并且在正常 mice.METHODS 探索各种各样的系统 / 机制的参与:在 2 microU/kg, 2 mU/kg, 2 U/kg 或车辆的剂量的胰岛素皮下地予四组一夜的 fasted 正常男性老鼠被以。血葡萄糖(BG ) 层次被测量在胰岛素管理前的 2 min 和在为小肠的运输的测量牺牲动物前的 2 min (坐) 。炭饭被管理(0.3 mL ) intragastrically,在胰岛素管理和动物以后的 20 min 在 20 min 以后被牺牲并且坐被决定。为涉及导致胰岛素的效果在上的各种各样的机制的探索坐,能生产重要加速的胰岛素的剂量没有改变 BG 层次,坐被决定。下列药,颠茄碱(1 mg/kg ) , clonidine (0.1 mg/kg ) , ondansetron (1 mg/kg ) , naloxone (5 mg/kg ) , verapamil (8 mg/kg ) 和 glibenclamide (10 mg/kg ) ,静脉内地被管理在胰岛素(2 microU/kg ) 的管理以前的 10 min。结果:胰岛素( 2 microU/kg 和 2 mU/kg )的更低的剂量生产了重要加速没有阴沉的血葡萄糖层次,从52.0%~70.7%和73.5%坐( P <
0.01 ),当胰岛素( 2 U/kg )的最高的剂量在血生产了秋天时,是的葡萄糖层次也与重要加速联系了坐( P <
0.01 )。在胰岛素(2 microU/kg ) 的预告的处理与颠茄碱组织以后,胰岛素能颠倒颠茄碱生产的 50% 抑制。在 clonidine-pretreated 组,胰岛素管理能仅仅颠倒 clonidine 生产的 37% 抑制和抑制坐与车辆 + 相比是重要的对待胰岛素的组,即从 74.7% ~ 27.7%(P <
0.01 ) 。在 ondansetron-pretreated 组,胰岛素管理能生产仅仅温和的加速坐(23.5%) 。在 naloxone-pretreated 组,胰岛素管理能显著地颠倒抑制坐当与 naloxone 相比本身组织时,由 naloxone 生产了,即从 32.3% ~ 53.9%(P <
0.01 ) 。在 verapamil-pretreated 组,胰岛素管理能仅仅部分颠倒抑制(65%) 。在 glibenclamide-pretreated 组,胰岛素管理生产了进一步的加速坐(12.2%) 。结论:胰岛素内在地拥有 acceleratory 效果在上坐在正常老鼠。肾上腺素能、胆碱能的系统能起一个重要作用。钙隧道和 opioidergic 系统能起一个支持的作用;另外,内长的胰岛素版本罐头的改进扩充外长地管理的胰岛素的效果在上坐。 | Murali Krishna Reddy Peddyreddy Steven Aibor Dkhar Subramanian Ramaswamy Amrithraj Theophilus Naveen Deepak Gopal Shewade | 2006 | World Journal of Gastroenterology2006，12，16： | 0 |
| 8 | 脑室注射催产素对大鼠胃和十二指肠溃疡的作用显示文摘INTRODUCTION Central neurons that synthesize oxytocin are locatedin the supraoptic(SON) and paraventricular nuclei(PVN) of the hypothalamus. Magnocellular neurons inboth nuclei project to the posterior pituitary gland, | Mohammed AS AD, Deepak Gopal SHEWADE, Kallasam KOUMARAVELOU, Benny K ABRAHAM, Sadashivam VASU, Subramanian RAMASWAMY (Department of Pharmacology, Jawaharlal Institute of Post-graduate Medical Education and Research, Pondicherry 605 006, India) | 2001 | Acta Pharmacologica Sinica2001，22，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员