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您的检索式：作者名="Jonathan T.Peters"
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| 1 | Surface hydrolysis-mediated PEGylation of poly(N-isopropyl acrylamide)based nanogels显示文摘In this work,poly(N-isopropyl acrylamide-co-acrylamide)[P(NIPAAm-co-AAm)]nanogels were modified by hydrolysis above the lower critical solution temperature(LCST)to localize carboxylic acid functional groups at the surface(surface hydrolysis).PNIPAAm copolymerized with 15%and 20%nominal AAm in the feed were prepared and compared to equivalent hydrogels with acrylic acid.The effect and extent of surface hydrolysis was confirmed by potentiometric titration and zeta potential.These surface modified nanogels were then modified with primary amine functionalized PEG chains.Surface hydrolysis-mediated PEGylation had little effect on the swelling response of the nanogels,while also preventing adsorption of model proteins in physiological relevant conditions.While both 15%and 20%AAm gels both decreased protein adsorption,only the 20%AAm gels resulted in fully preventing protein adsorption.The results presented here point to surface hydrolysis as a new route to passivate nanogels for use in vivo. | Jonathan T.Peters Stanley Verghese Deepak Subramanian Nicholas A.Peppas | 2017 | Regenerative Biomaterials2017，4，5： | 1 |
| 2 | Advanced biomedical hydrogels:molecular architecture and its impact on medical applications显示文摘Hydrogels are cross-linked polymeric networks swollen in water,physiological aqueous solutions or biological fluids.They are synthesized by a wide range of polymerization methods that allow for the introduction of linear and branched units with specific molecular characteristics.In addition,they can be tuned to exhibit desirable chemical characteristics including hydrophilicity or hydrophobicity.The synthesized hydrogels can be anionic,cationic,or amphiphilic and can contain multifunctional crosslinks,junctions or tie points.Beyond these characteristics,hydrogels exhibit compatibility with biological systems,and can be synthesized to render systems that swell or collapse in response to external stimuli.This versatility and compatibility have led to better understanding of how the hydrogel’s molecular architecture will affect their physicochemical,mechanical and biological properties.We present a critical summary of the main methods to synthesize hydrogels,which define their architecture,and advanced structural characteristics for macromolecular/biological applications. | Jonathan T.Peters Marissa E.Wechsler Nicholas A.Peppas | 2021 | Regenerative Biomaterials2021，8，6： | 0 |
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