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| 1 | Diagnosis of biliary strictures after liver transplantation:Which is the best tool?显示文摘AIM: To evaluate the diagnostic value of different indirect methods like biochemical parameters, ultrasound (US) analysis, CT-scan and MRI/MRCP in comparison with endoscopic retrograde cholangiography (ERC), for diagnosis of biliary complications after liver transplantation. METHODS: In 75 patients after liver transplantation, who received ERC due to suspected biliary complications, the result of the cholangiography was compared to the results of indirect imaging methods performed prior to ERC. The cholangiography showed no biliary stenosis (NoST) in 25 patients, AST in 27 and ITBL in 23 patients. RESULTS: Biliary congestion as a result of AST was detected with a sensitivity of 68.4% in US analysis (specificity 91%), of 71% in MRI (specificity 25%) and of 40% in CT (specificity 57.1%). In ITBL, biliary congestion was detected with a sensitivity of 58.8% in the US, 88.9%in MRI and of 83.3% in CT. However, as anastomotic or ischemic stenoses were the underlying cause of biliary congestion, the sensitivity of detection was very low. InMRI detected the dominant stenosis at a correct localization in 22% and CT in 10%, while US failed completely. The biochemical parameters, showed no significant difference in bilirubin (median 5.7; 4,1; 2.5 mg/dL), alkaline phosphatase (median 360; 339; 527 U/L) or gamma glutamyl transferase (median 277; 220; 239 U/L) levels between NoST, AST and ITBL.CONCLUSION: Our data confirm that indirect imaging methods to date cannot replace direct cholangiography for diagnosis of post transplant biliary stenoses. However MRI may have the potential to complement or precede imaging by cholangiography. Optimized MRCP-processing might further improve the diagnostic impact of this method. | Thomas Zoepf Evelyn J. Maldonado-Lopez Philip Hilgard Alexander Dech■ne Massimo Malago Christoph E. Broelsch Joerg Schlaak Guido Gerken | 2005 | World Journal of Gastroenterology2005，11，19： | 32 |
| 2 | Prospective observational multicenter study to define a diagnostic algorithm for biliary candidiasis显示文摘AIM:To develop an algorithm to improve the diagnosis and treatment of patients with biliary candidiasis.METHODS:We performed a prospective study of 127patients who underwent endoscopic retrograde cholangiopancreatography,for various biliary disorders,at 3 tertiary referral centers in Germany from July 2011through July 2012(ClinicalTrials.gov:NCT01109550).Bile,buccal,and stool samples were collected.When indicated,endoscopic transpapillary bile duct biopsies were performed to clarify the etiology of bile duct strictures and to prove invasive fungal infections.RESULTS:Candida species were detected in 38 of the 127 bile samples(29.9%).By multivariate analysis patients’age and previous endoscopic sphincterotomy were independent risk factors for biliary candidiasis(P<0.05).Patients with immunosuppression(P=0.058)and recent long-term antibiotic therapy(>7 d)(P=0.089)tend to be at risk for biliary candidiasis.One patient was negative in mycological culture of bile fluid but invasive biliary candidiasis was diagnosed histologically.Of Candida subspecies detected,36.7%were azole-resistant,such as C glabrata.Eight patients received anti-mycotic therapy,based on our algorithm.Of these,3 had cancer with biliary tract involvement,2had secondary sclerosing cholangitis,1 had retroperitoneal fibrosis,and 5 had septicemia.In all patients contamination was ruled out by smears of the endoscope channel.CONCLUSION:Gastroenterologists should be aware of frequent candida colonization in patients with cholangitis and biliary disorders.Our suggested algorithm facilitates the further clinical management. | Philipp Lenz Franziska Eckelskemper Thomas Erichsen Tim Lankisch Alexander Dechêne Gabriele Lubritz Frank Lenze Torsten Beyna Hansjorg Ullerich Andre Schmedt Dirk Domagk | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 3 | Endoscopic treatment of pediatric post‐transplant biliary complications is safe and effective显示文摘 | Alexander Dechêne Cathrin Kodde Simone Kathemann Jürgen Treckmann Elke Lainka Andreas Paul Guido Gerken Ariel E. Feldstein Peter F. Hoyer Ali Canbay | 2015 | Digestive Endoscopy2015，，4： | 2 |
| 4 | Optimized endoscopic treatment of ischemic-type biliary lesions after liver transplantation显示文摘 | Thomas Zoepf Evelyn J. Maldonado de Dechêne Alexander Dechêne Massimo Malágo Susanne Beckebaum Andreas Paul Guido Gerken Philip Hilgard | 2012 | Gastrointestinal Endoscopy2012，，3： | 2 |
| 5 | Remote-con- trolled magnetic pulmonary vein isolation using a new three-dimensional non-fluoroscopic navigation system: a single-centre prospective study 显示文摘 | Da Costa A Ben H'dech M Romeyer-Bouchard C | 2013 | Arch Cardiovasc Dis2013，106，89： | 1 |
| 6 | Mapping and assessing water use in a central Asian in-igation system by utilizing MODIS remote sensing products 显示文摘 | Conrad C Dech S W Hafeez M | 2007 | Irrigation and Drainage Systems2007，21，34： | 1 |
| 7 | Flunarizine is a highly potent inhibitor of cardiac hERG potassium current 显示文摘 | Trepakova E S Dech S J Salata J J | 2006 | J Cardiovasc Pharrnacol2006，47，2： | 1 |
| 8 | Urbanization between compactness and dispersion:designing a spatial model for measuring 2D binary settlement landscape configurations显示文摘Measuring spatial patterns is a crucial task in spatial sciences.Multiple indicators have been developed to measure patterns in a quantitative manner.However,most comparative studies rely on relative comparisons,limiting their explanatory power to specific case studies.Motivated by advancements in earth observation providing unprecedented resolutions of settlement patterns,this paper suggests a measurement technique for spatial patterns to overcome the limits of relative comparisons.We design a model spanning a feature space based on two metrics-largest patch index and number of patches.The feature space is defined as‘dispersion index’and covers the entire spectrum of possible two-dimensional binary(settlement)patterns.The model configuration allows for an unambiguous ranking of each possible pattern with respect to spatial dispersion.As spatial resolutions of input data as well as selected areas of interest influence measurement results,we test dependencies within the model.Beyond,common other spatial metrics are selected for testing whether they allow unambiguous rankings.For scenarios,we apply the model to artificially generated patterns representing all possible configurations as well as to real-world settlement classifications differing in growth dynamics and patterns. | Hannes Taubenbock Michael Wurm Christian GeiB Stefan Dech Stefan Siedentop | 2019 | International Journal of Digital Earth2019，12，6： | 1 |
| 9 | Acute liver failure is associated with elevated liver stiffness and hepatic stellate cell activation 显示文摘 | Deche ne A Sowa JP Gieseler RK | 2010 | Hepatology2010，52，3： | 1 |
| 10 | The relationship between precipitation anomalies and satellite-derived vegetation activity in Central Asia显示文摘 | Ursula Gessner Vahid Naeimi Igor Klein Claudia Kuenzer Doris Klein Stefan Dech | 2012 | Global and Planetary Change2012，，： | 1 |
| 11 | The influence of kidney transplantation on carnitine metabolism 显示文摘 | Kohse KP Dech E Rossle C | 1988 | Clin Nephrol1988，29，4： | 1 |
| 12 | Comparison of two remote sensing based models for regional net primary productivity estimation:a case study in semi-arid central Kazakhstan显示文摘 | EISFELDER C KUENZER C DECH S | 2013 | Selected Topics in Applied Earth Observations and Remote Sensing2013，6，4： | 1 |
| 13 | Large-area assessment of impervious surface based on integrated analysis of single-date Landsat-7 images and geospatial vector data显示文摘 | T. Esch V. Himmler G. Schorcht M. Thiel T. Wehrmann F. Bachofer C. Conrad M. Schmidt S. Dech | 2009 | Remote Sensing of Environment2009，，8： | 1 |
| 14 | Effects of dihydrotestosterone on cardiac inward rectifier K^+ current显示文摘 | CARNES CA DECH SJ | 2002 | Int J Androl2002，25，4： | 1 |
| 15 | A Multipathogen Bile Sample-based PCR Assay Can Guide Empirical Antimicrobial Strategies in Cholestatic Liver Diseases显示文摘Background and objectives:Polymerase chain reaction(PCR)techniques provide rapid detection of pathogens.This pilot study evaluated the diagnostic utility and clinical impact of multiplex real-time PCR(mRT-PCR,SeptiFast)vs.conventional microbial culture(CMC)in bile samples of patients with chronic cholestatic liver diseases(cCLDs),endoscopic retrograde cholangio-pancreatography(ERCP),and peri-interventional-antimicrobial-prophylaxis(pAP).Methods:We prospectively collected bile samples from 26 patients for microbiological analysis by CMC and mRT-PCR.Concordance of the results of both methods was determined by Krippendorff's alpha(α)for inter-rater reliability and the Jaccard index of similarity.Results:mRT-PCR_(bile)and CMC_(bile)results were concordant for only Candida albicans(α=0.8406;Jaccard index=0.8181).mRT-PCR_(bile)detected pathogens in 8/8 cases(100%),CMC_(bile)in 7/8(87.5%),and CMCblood in 5/8(62.5%)with clinical signs of infection.mRTPCR_(bile),CMC_(bile),and CMCblood had identical detection results in 3/8(37.5%)with clinical signs of infection(two Klebsiella spp.and one Enterococcus faecium).The total pathogen count was significantly higher with mRT-PCR_(bile)than with CMC_(bile)(62 vs.31;χ^(2)=30.031,p<0.001).However,pathogens detected by mRT-PCR_(bile)were more often susceptible to pAP according to the patient infection/colonization history(PI/CH)and surveillance data for antibiotic resistance in our clinic(DARC).Pathogens identified by mRT-PC_(Rbile)and resistant to pAP by PI/CH and DARC were likely to be clinically relevant.Conclusions:mRT-PCR in conjunction with CMCs for bile analysis increased diagnostic sensitivity and may benefit infection management in patients with cholestatic diseases.Implementation of mRT-PCR in a bile sample-based diagnostic routine can support more rapid and targeted use of antimicrobial agents in cCLD-patients undergoing ERCP and reduce the rate/length of unnecessary administration of broad-spectrum antibiotics. | Michael Jahn Mustafa KÖzçürümez Sebastian Dolff Hana Rohn Dominik Heider Alexander Dechêne Ali Canbay Peter M.Rath Antonios Katsounas | 2022 | Journal of Clinical and Translational Hepatology2022，10，5： | 1 |
| 16 | System continuity and energy distribution in laser-induced thermotherapy显示文摘 | Dech M Werk M Beck A | 2002 | Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr2002，176，： | 1 |
| 17 | Mapping and assessing water use in a Central Asian irrigation system by utilizing MODIS remote sensing Products显示文摘 | Conrad C Dech S W Hafeez M | 2007 | Irrigation and Drainage Systems2007，21，34： | 1 |
| 18 | Web-based stereoscopic visual- ization for the global anatomy classroom显示文摘 | Kaspar M Dech F Parsad NM | | Stud Health Technol In- form0，163，： | 1 |
| 19 | Derivation of temporal windows for accurate crop discrimination in heterogeneous croplands of Uzbekistan using multitemporal RapidEye images显示文摘 | Christopher Conrad Stefan Dech Olena Dubovyk Sebastian Fritsch Doris Klein Fabian L?w Gunther Schorcht Julian Zeidler | 2014 | Computers and Electronics in Agriculture2014，，： | 1 |
| 20 | Temporal segmentation of MODIS time series for improving crop classification in Central Asian irrigation systems显示文摘 | Christopher Conrad RenéR. Colditz Stefan Dech Doris Klein PaulL. G. Vlek | 2011 | International Journal of Remote Sensing2011，，23： | 1 |
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