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| 1 | Isolation and characteristics of autoreactive T cells specific to aggrecan G1 domain from rheumatoid arthritis patients显示文摘Our previous work showed that the cartilage proteoglycan aggrecan could induce an erosive polyarthritis and spondylitis in BALB/c mice and the GI globular domain of the aggrecan (GI) contained the arthritogenic region. To elucidate whether autoreactive T cells to G1 are expressed in rheumatoid arthritis patients, we analyzed the frequency of human G1-specific T cells in the peripheral blood of five rheumatoid arthritis patients and tried to establish G1-reactive T cell lines from these rheumatoid arthritis patients. The results showed that the G1-specific T cells in PBL were detectable at the range of 4.97 ±0.5 ×10-6 in peripheral blood lymphocytes. We have also generated 15 G1-specific T lymphocyte lines from these pateints with a standard split-well method. All these cells expressed fine specificity to human recombinant G1, but not to unrelated antigen. All the 15 lines expressed a panT cell marker and 13 of them selectively used the αβ T cell receptor. Two of them used rye T cell receptor. The 13 of these T cell lines was CD4 positive. One line expressed CD8. One line expressed both CD4 and CD8. Moreover, 14 out of 15 lines expressed the Th-1 cytokine profile, characterized by interferon-γpositivity and IL-4 negativity. No Th-2 type cell line was generated. These data provide strong evidence in favor of the presence of autoreactive T cells in the rheumatoid arthritis pateints. What is the mechanism(s) that these autoreactive T cells attack self-target and whether these G1-specific, Th-1 type T cell lines can induce arthritis in immune deficiency mice are currently under investigation. | LI NING LI DONG QING ZHANG KUANG YAN ZHOU ANNIE CARTMAN JEAN YVES LEROUX A ROBIN POOLE YI PING ZHANG ( Shanghai Institute of Immunology, Shanghai Second Medical University, Shanghai 200025, China)(Joint Diseases Laboratory, Shriners Hospital, Dep | 2000 | Cell Research2000，10，1： | 7 |
| 2 | Nutritional care in hospitalized patients with chronic liver disease显示文摘AIM: To evaluate the practice of nutritional assessment and management of hospitalised patients with cirrhosis and the impact of malnutrition on their clinical outcome.METHODS: This was a retrospective cohort study on patients with liver cirrhosis consecutively admitted to the Department of Gastroenterology and Hepatology at the Royal Adelaide Hospital over 24 mo. Details were gathered related to the patients' demographics, disease severity, nutritional status and assessment, biochemistry and clinical outcomes. Nutritional status was assessed by a dietician and determined by subjective global assessment. Estimated energy and protein requirements were calculated by Simple Ratio Method. Intake was estimated from dietary history and/or food charts, and represented as a percentage of estimated daily requirements. Median duration of follow up was 14.9(0-41.4) mo. RESULTS: Of the 231 cirrhotic patients(167 male, age: 56.3 ± 0.9 years, 9% Child-Pugh A, 42% ChildPugh B and 49% Child-Pugh C), 131(57%) had formal nutritional assessment during their admission and 74(56%) were judged to have malnutrition. In-hospitalcaloric(15.6 ± 1.2 kcal/kg vs 23.7 ± 2.3 kcal/kg, P = 0.0003) and protein intake(0.65 ± 0.06 g/kg vs 1.01 ± 0.07 g/kg, P = 0.0003) was significantly reduced in patients with malnutrition. Of the malnourished cohort, 12(16%) received enteral nutrition during hospitalisation and only 6(8%) received ongoing dietetic review and assessment following discharge from hospital. The overall mortality was 51%, and was higher in patients with malnutrition compared to those without(HR = 5.29, 95%CI: 2.31-12.1; P < 0.001). CONCLUSION: Malnutrition is common in hospitalised patients with cirrhosis and is associated with higher mortality. Formal nutritional assessment, however, is inadequate. This highlights the need for meticulous nutritional evaluation and management in these patients. | Dep K Huynh Shane P Selvanderan Hugh AJ Harley Richard H Holloway Nam Q Nguyen | 2015 | World Journal of Gastroenterology2015，21，45： | 6 |
| 3 | Sequence Stratigraphy and Relative Sea Level Changes in Sinian System of Yichang, Hubei Province显示文摘The study on outcrop sequence stratigraphy of the Sinian section in the Yangtze Gorges an important step in the comprehensive stratigraphy for the Sinian stratotype. In this paper, the base of the Nantuo tillite is selected as the bottom boundary of the Sinian, and the top of the Baimatuo Member of the Dengying Formation is taken as the top boundary. The Sinian lasted from 740 the to 570 Ma. According to the features of sequence boundary facies and the parasequence sets, two supersequences are recognized in the Sinian with six sequences. In this paper, the authors discuss the correlation of those sequences. On the basis of the subsidence rate and the thickness of decompressed deposits, the authors discuss the mechanism of tectonic and sedimentation of the Dengying Formation and the features of high-frequency rhythms as well as the 3rd-order sequences in the Yangtze Gorges. | Wang Ziqiang (Department of Geology and Mineral Resources, China University of Geosciences, Beijing 100083) Gao Linzhi (Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037) Zhang Linghua Jiang Ganqing Zhang Chuanheng Yin Yong (Dep | 1996 | Journal of Earth Science1996，15，1： | 2 |
| 4 | CENTERS OF SOME CUBIC SYSTEMS显示文摘We solve the l:-l resonant center problem for two cubic systems with complex coefficients. | Valery G. ROMANOVSKI (Center for Applied Math. and Theoretical Physics, University of Maribor, Krekova 2, SI-2000 Maribor, Slovenia) and (Belarusian State University of Informatics & Radioelectronics, P.Brovka 6 Minsk 220027 Belarus) Alexandru ■UB■ (Dep | 2001 | Annals of Differential Equations2001，17，4： | 2 |
| 5 | Interleukin - 1β promotes hypoxia - induced apoptosis of glioblastoma ceils by inhibiting hypoxia - inducible factor - 1 mediated adrenomedullin production 显示文摘 | Sun W Depping R Jelkmann W | 2014 | Cell Death Dis2014，5，： | 1 |
| 6 | Synthesis and characterization of cobalt modified LTL-type zeolite显示文摘 | Monthes Del Villa Dep | 2000 | Applied Catalysis2000，197，1： | 1 |
| 7 | A fast and elitist multi - objective genetic algorithm : NSGA - Ⅱ 显示文摘 | DEP K PRATAP A AGARWAL S | 2002 | IEEE Transactions on Evolutionary Computation2002，6，2： | 1 |
| 8 | Dei ning pathways显示文摘 | De Bleser L Dep reitere R De Waele K | 2006 | Nurs M2006，14，7： | 1 |
| 9 | Inorganic-organic proton conductors based on alkylsulfone functionalities and their patterning by photoinduced methods显示文摘 | Dep re L Kappcl J | 1998 | ElectrochimicaActa1998，43，： | 1 |
| 10 | A dominant-negative isoform of hypoxia-indueible factor-1 alpha specifically expressed in human testis显示文摘 | Depping R Hagele S Wagner KF | 2004 | Biol Reprod2004，71，1： | 1 |
| 11 | Pulsed neutron-based on-line coal analysis显示文摘 | Dep L Belbot M Vourvopoulos G | 1998 | J Radioanal Nucl Ch1998，234，1： | 1 |
| 12 | Tech-nique,indications,and results显示文摘 | Deramond H Dep riester C Galibert P Percutane-ous verte broplasty with polymethylmethacry late | 1998 | Radiol Clin North Am1998，36，3： | 1 |
| 13 | Nuclear-cytoplasmatic shuttling of proteins in control of cellular oxygen sensing显示文摘 | Depping R Jelkmann W Kosyna FK | 2015 | J Mol Med (Berl)2015，93，6： | 1 |
| 14 | AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias显示文摘 | Stephen M. Sykes Steven W. Lane Lars Bullinger Demetrios Kalaitzidis Rushdia Yusuf Borja Saez Francesca Ferraro Francois Mercier Harshabad Singh Kristina M. Brumme Sanket S. Acharya Claudia Sch?ll Zuzana Tothova Eyal C. Attar Stefan Fr?hling Ronald A. DeP | 2011 | Cell2011，，5： | 1 |
| 15 | Use of aspartate aminotransferase to platelet ratio to reduce the need for Fibro Scan in the evaluation of liver fibrosis显示文摘AIM To evaluate the performance of aspartate aminotransferase to platelet ratio(APRI) score against FibroS can in predicting the presence of fibrosis. METHODS Data of patients who concurrently had APRI score, Fibro Scan and liver biopsy to assess their hepatitis C virus(HCV) and hepatitis B virus(HBV) over 6 years were retrospectively reviewed and details of their disease characteristics and demographics were recorded. Advanced fibrosis was defined as ≥ F3. RESULTS Of the 3619 patients(47.5 ± 11.3 years, 97M:36F) who had Fibro Scans and APRI for HCV and HBV, 133 had concurrent liver biopsy. Advanced liver fibrosis was found in 27/133(20%, F3 = 21 and F4 = 6) patients. Although APRI score(P < 0.001, AUC = 0.83) and FibroS can(P < 0.001, AUC = 0.84) predicted the presence of advanced fibrosis, the sensitivities and specificities were only modest(APRI score: 51.9% sensitivity, 84.9% specificity; FibroS can: 63% sensitivity, 84% specificity). Whilst 13/27(48%) patients with advanced fibrosis had APRI ≤ 1.0, no patients with APRI ≤ 0.5 had advanced fibrosis, with100% sensitivity. The use of APRI ≤ 0.5 would avoid the need for FibroS can in 43% of patients. CONCLUSION APRI score and Fibro Scan performed equally well in predicting advanced fibrosis. A proposed APRI cutoff score of 0.5 could be used as a screening tool for FibroS can, as cut-off score of 1.0 will miss up to 48% of patients with advanced fibrosis. Further prospective validation studies are required to confirm this finding. | Stephanie Wong Dep Huynh Frank Zhang Nam Q Nguyen | 2017 | World Journal of Hepatology2017，9，17： | 1 |
| 16 | A dominant-negative isoform of hypoxia-inducible factor-1 alpha specifically expressed in human testis显示文摘 | Depping R Hagele S Wagner K F | 2004 | Biol Reprod2004，71，1： | 1 |
| 17 | A p38-p65 transcription complex induced by endothelin-1 mediates signal transduction in cancer cells显示文摘 | Von Brandenstein MG Ngum Abety A Depping R | 2008 | Biochim Biophys Acta2008，1783，： | 1 |
| 18 | Expression of the erythropoietin receptor in human heart显示文摘 | Depping R Kawakami K Ocker H | 2005 | J Tberac Cardiovasc Surg2005，130，3： | 1 |
| 19 | Vascular permeability factor/vascular endothelial growth factor,miscrovasular hyperpermeability and angiogenesis显示文摘 | Dvorak HF Brow LF Dep tmarM | 1995 | Am J Pathol1995，146，5： | 1 |
| 20 | Defining pathways显示文摘 | De Bleser L Dep reitere R De Waele K | 2006 | Nurs M2006，14，7： | 1 |
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