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| 1 | Does progesterone show neuroprotective effects on traumatic brain injury through increasing phosphorylation of Akt in the hippocampus?显示文摘There are currently no federally approved neuroprotective agents to treat traumatic brain injury. Progesterone, a hydrophobic steroid hormone, has been shown in recent studies to exhibit neuroprotective effects in controlled cortical impact rat models. Akt is a protein kinase known to play a role in cell signaling pathways that reduce edema, inflammation, apoptosis, and promote cell growth in the brain. This study aims to determine if progesterone modulates the phosphorylation of Akt via its threonine 308 phosphorylation site. Phosphorylation at the threonine 308 site is one of several sites responsible for activating Akt and enabling the protein kinase to carry out its neuroprotective effects. To assess the effects of progesterone on Akt phosphorylation, C57BL/6 mice were treated with progesterone(8 mg/kg) at 1(intraperitonally), 6, 24, and 48 hours(subcutaneously) post closed-skull traumatic brain injury. The hippocampus was harvested at 72 hours post injury and prepared for western blot analysis. Traumatic brain injury caused a significant decrease in Akt phosphorylation compared to sham operation. However, mice treated with progesterone following traumatic brain injury had an increase in phosphorylation of Akt compared to traumatic brain injury vehicle. Our findings suggest that progesterone is a viable treatment option for activating neuroprotective pathways after traumatic brain injury. | Richard Justin Garling Lora Talley Watts Shane Sprague Lauren Fletcher David F.Jimenez Murat Digicaylioglu | 2014 | Neural Regeneration Research2014，9，21： | 6 |
| 2 | rate of adverse events of gastroduodenal snare polypectomy for non-flat polyp is low: A prospective and multicenter study显示文摘AIM To evaluate the rate of adverse events(AEs) during consecutive gastric and duodenal polypectomies in several Spanish centers. METHODS Polypectomies of protruded gastric or duodenal polyps ≥ 5 mm using hot snare were prospectively included. Prophylactic measures of hemorrhage were allowed in predefined cases. AEs were defined and graded according to the lexicon recommended by the American Society for Gastrointestinal Endoscopy. Patients were followed for 48 h, one week and 1 mo after theprocedure. RESULTS308 patients were included and a single polypectomy was performed in 205. Only 36(11.7%) were on prior anticoagulant therapy. Mean polyp size was 15 ± 8.9 mm(5-60) and in 294 cases(95.4%) were located in the stomach. Hemorrhage prophylaxis was performed in 219(71.1%) patients. Nine patients presented AEs(2.9%), and 6 of them were bleeding(n = 6, 1.9%)(in 5 out of 6 AE, different types of endoscopic treatment were performed). Other 24 hemorrhagic episodes could be managed without any change in the outcome of the endoscopy and, consequently, were considered incidents. We did not find any independent risk factor of bleeding.CONCLUSION Gastroduodenal polypectomy using prophylactic measures has a rate of AEs small enough to consider this procedure a safe and effective method for polyp resection independently of the polyp size and location. | Henry Córdova Lidia Argüello Carme Loras Antonio Naranjo Rodríguez Faust Riu Pons Joan B Gornals David Nicolás-Pérez Xavier Andújar Murcia Luis Hernández Santos Santolaria Carles Leal Carles Pons Enrique Pérez-Cuadrado-Robles Orlando García-Bosch Michel Papo Berger José Luis Ulla Rocha Cristina Sánchez-Montes Gloria Fernández-Esparrach | 2017 | World Journal of Gastroenterology2017，23，47： | 3 |
| 3 | Global cardiovascular dis-ease prevention:A can to action for nursing Muhilevel policies 显示文摘 | Lora EB David RT sabine R | 2011 | European Journal of Cardiovascular Nursing2011，，： | 1 |
| 4 | CD44 in Cancer显示文摘 | David Naor Shlomo Nedvetzki Itshak Golan Lora Melnik Yoram Faitelson | 2002 | Critical Reviews in Clinical Laboratory Sciences2002，，6： | 1 |
| 5 | A systematic review and meta-analysis of studies using the STRATIFY tool for prediction of falls in hospital patients显示文摘 | David Oliver Alexandra Papatoannou Lora Giangregorio Lehana Thabane Katerina Reiagys Gary Foster | 2008 | Age and Ageing2008，37，： | 1 |
| 6 | Effects of uncertainty, transmission type, driver age and gender on brake reaction and movement time显示文摘 | Lora Warshawsky-Livne David Shinar | 2002 | Journal of Safety Research2002，33，1： | 1 |
| 7 | Expression levels of estrogen receptor beta in conjunction with aromatase predict survival in non-small cell lung cancer显示文摘 | Vei Mah Diana Marquez Mohammad Alavi Erin L. Maresh Li Zhang Nam Yoon Steve Horvath Lora Bagryanova Michael C. Fishbein David Chia Richard Pietras Lee Goodglick | 2011 | Lung Cancer2011，，2： | 1 |
| 8 | Genetically Determined Par- tial Complement C4 Deficiency States Are Not Independent Risk 显示文摘 | Lora Boteva David L Morris | 2012 | Factors for SLE in UK and Spanish Populations2012，90，3： | 1 |
| 9 | Octogenarian liver grafts:Is their use for transplant currently justified?显示文摘AIM To analyse the impact of octogenarian donors in liver transplantation.METHODS We present a retrospective single-center study, performed between November 1996 and March 2015, that comprises a sample of 153 liver transplants. Recipients were divided into two groups according to liver donor age: recipients of donors ≤ 65 years(group A; n = 102), and recipients of donors ≥ 80 years(group B; n = 51). A comparative analysis between the groups was performed. Quantitative variables were expressed as mean values and SD, and qualitative variables as percentages. Differences in properties between qualitative variables were assessed by χ2 test. Comparison of quantitative variables was made by t-test. Graft and patient survivals were estimated using the Kaplan-Meier method.RESULTS One, 3 and 5-year overall patient survival was 87.3%, 84% and 75.2%, respectively, in recipients of younger grafts vs 88.2%, 84.1% and 66.4%, respectively, in recipients of octogenarian grafts(P = 0.748). One, 3 and 5-year overall graft survival was 84.3%, 83.1% and 74.2%, respectively, in recipients of younger grafts vs 84.3%, 79.4% and 64.2%, respectively, in recipients of octogenarian grafts(P = 0.524). After excluding the patients with hepatitis C virus cirrhosis(16 in group A and 10 in group B), the 1, 3 and 5-year patient(P = 0.657) and graft(P = 0.419) survivals were practically the same in both groups. Multivariate Cox regression analysis demonstrated that overall patient survival was adversely affected by cerebrovascular donor death, hepatocarcinoma, and recipient preoperative bilirubin, and overall graft survival was adversely influenced by cerebrovascular donor death, and recipient preoperative bilirubin.CONCLUSION The standard criteria for utilization of octogenarian liver grafts are: normal gross appearance and consistency, normal or almost normal liver tests, hemodynamic stability with use of < 10 μg/kg per minute of vasopressors before procurement, intensive care unit stay < 3 d, CIT < 9 h, absence of atherosclerosis in the hepatic and gastroduodenal arteries, and no relevant histological alterations in the pre-transplant biopsy, such as fibrosis, hepatitis, cholestasis or macrosteatosis > 30%. | Carlos Jiménez-Romero Felix Cambra Oscar Caso Alejandro Manrique Jorge Calvo Alejandro Marcacuzco Paula Rioja David Lora Iago Justo | 2017 | World Journal of Gastroenterology2017，23，17： | 1 |
| 10 | Global cardiovascular disease prevention:A call to action for nursiing显示文摘 | Lora E Burke PMFF David R | 2011 | Journal of Cardiovascular Nursing2011，26，4： | 1 |
| 11 | Prevalence, Associated Factors, and Comorbid Conditions for Ménière’s Disease显示文摘 | Jessica S. Tyrrell David J. D. Whinney Obioha C. Ukoumunne Lora E. Fleming Nicholas J. Osborne | 2014 | Ear and Hearing2014，，4： | 1 |
| 12 | New and Emerging Weight Management Strategies for Busy Ambulatory Settings: A Scientific Statement From the American Heart Association: Endorsed by the Society of Behavioral Medicine显示文摘 | Goutham Rao Lora E. Burke Bonnie J. Spring Linda J. Ewing Melanie Turk Alice H. Lichtenstein Marc-Andre Cornier J. David Spence Michael Coons | 2011 | Circulation2011，，10： | 1 |
| 13 | Global cardiovascular dis-ease prevention:A call to action for nursing Multilevel policies显示文摘 | Lora EB David RT Sabine R | 2011 | European Journal of Cardiovascular Nursing2011，1419，： | 1 |
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