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| 1 | Selective serotonin reuptake inhibitors in the treatment of premature ejaculation显示文摘在早泄( PE )的处理关于 se lective 血清素举起禁止者( SSRI )考察并且估计然后在减轻 PE.Data 为 SSRI 的使用有关现状知识提供实际建议和可能的机制更改研究的目的用 Medline 采购原料,在减轻 PE 有关 SSRI 和他们的可能的机制的使用从1996年1月1日出版到2006年8月1日的 48 篇文章被发现并且 reviewed.Study selectio 然而,他们的效果是中等的,关于类型,剂量,协议和持续时间没有一个通用协议。作为 PE 的第一药方治疗, Dapoxetine 可以改变这种瓶颈状况。SSRI 被建议与终生的 PE 在年轻人被过去常,并且当 etiological 因素被移开,但是 PE 仍然存在时,获得了 PE。Phosphodiesterase 5 禁止者(PDE5 ) 被建议独自被采用或当 SSRI 没能对待与 SSRI 联系的 PE 或性机能障碍时,与 SSRI 结合了发生。基于每天把他们当作一个合适的时期在需求上服药的协议被建议第一被选。可能的机制包括增加的 serotonergic neurotransmission 和激活的 5-hydroxytryptamine 2C ( 5-HT2C )受体,然后交换射精的阀值到高水平,减少阴茎敏感和他们的自己 antidepression.Conclusion 完成当前的 SSRI 的功效在 PE 的处理是中等的,他们没被 FDA 同意了,进一步要评估的因此新的 SSRI 相似 dapoxetine 需要。 | WANG Wei-fu CHANG Le Suks Minhas David J Ralph | 2007 | Chinese Medical Journal2007，，11： | 14 |
| 2 | 水力压裂监测新方法显示文摘深入了解水力压裂裂缝的几何形态和延伸情况有助于改善低渗油气藏压裂增产作业效果,改善油气井产能并提高油气采收率。应用地震方法对水力压裂裂缝进行监测和描述已经有多年了,而新的地震硬件和处理技术的出现使得这类监测更加有效、可靠。 | Les Bennett Joeol Le Calvez David R. ( Rich ) Sarver Kevin Tanner W.S.(Scott)Birk George Waters Julian Drew Gw e nola Michaud Paolo Primiero Leo Eisner Rob Jones David Leslie Michael John Williams Jim Govenlock Richard C. ( Rick ) Klein Kazuhiko Tezuka | 2007 | 国外测井技术2007，22，4： | 7 |
| 3 | Studies on sustainable features of vernacular architecture in different regions across the world:A comprehensive synthesis and evaluation显示文摘Due to the increasing pressure brought by recent global environmental problems,building designers are embracing regionalism and the knowledge of traditional structures,arguing that these structures are energy efficient and highly sustainable.We observe clear evidence of the increasing interest in vernacular architecture among the research community.This study therefore aims to clarify the contents and issues raised in the studies on vernacular architecture and the knowledge and recommendations that can be derived from them.A database of the research is established by collecting many studies from primary sources.Obtained data is carefully refined and categorized into a table where synthesized information is introduced.The results of this study show an uneven geographic and climatic distribution of the studies;the trend in selecting research objectives and research objects;the choice of research methods with a clear shift towards quantitative research methods,and the generic findings from the database of the research.These results can support diverse inquiries about vernacular architecture across the world and be used as a resource or an orientation to support numerous subsequent studies. | Anh Tuan Nguyen Nguyen Song Ha Truong David Rockwood Anh Dung Tran Le | 2019 | Frontiers of Architectural Research2019，8，4： | 6 |
| 4 | 动脉瘤性蛛网膜下腔出血患者的重症监护处理:神经危重症监护学会多学科共识会议的推荐意见显示文摘蛛网膜下腔出血(subarachnoidhemorrhage,SAH)是一种可对中枢神经系统造成毁灭性打击并对其他多个器官产生显著影响的急性脑血管病。SAH患者被常规收入重症监护病房并由多学科团队进行治疗。由于高质量研究证据的缺乏,使得治疗方法各异,可供选择的指导意见不多。现有的指南主要强调危险因素、预防、自然史以及再出血的预防,很少涉及SAH患者的重症监护问题。美国神经危重症监护学会组织了一次国际性多学科共识会议来探讨SAH的重症监护处理。根据发表的文章和研究领域,此次会议召集了来自欧洲和北美地区的神经重症监护科、神经外科、神经内科、介入神经放射科和神经麻醉科方面的专家。根据临床经验和制定实践指南方面的经验,选择4名经验丰富的神经重症监护专家组成评判委员会。应用推荐分级的评估、制定与评价(GradesofRecommendationsAssessment,DevelopmentandEvaluation,GRADE)系统进行文献回顾,结合参会者的经验、评判委员会的审评以及文献讨论产生推荐意见。应用GRADE系统制定推荐意见,其制定原则不仅强调研究资料的质量,而且还重视利弊权衡与实践转化。对SAH患者日常处理过程中面临的所有问题均提供指导和推荐意见,即使缺乏高质量的证据。 | Michael N. Diringer Thomas P. Bleck J. Claude Hemphill David Menon Lori Shutter Paul Vespa Nicolas Bruder E. Sander Connolly Jr Giuseppe Citerio Daryl Gress Daniel Hanggi Brian L. Hoh Giuseppe Lanzino Peter Le Roux Alejandro Rabinstein, Erich Schmut zhard Nino Stocchetti Jose I. Suarez Miriam Tresgiari Ming-Yuan Tseng Mervyn D. I. Vergouwen Stefan Wolf Gregory Zip fel 田飞(译) 宿 英英(译) | 2013 | 国际脑血管病杂志2013，21，5： | 5 |
| 5 | Embedding CoS2 nanoparticles in N-doped carbon nanotube hollow frameworks for enhanced lithium storage properties显示文摘 | Jintao Zhang Le Yu Xiong Wen (David) Lou | 2017 | Nano Research2017，10，12： | 5 |
| 6 | Intraocular complications of IFN-α and ribavirin therapy in patients with chronic viral hepatitis C显示文摘We report a panel of severe inflammatory and vascular intraocular disorders occurring during interferon-alpha (IFN-α) treatment in eight hepatitis C virus (HCV)-infected patients. These events include three cases of Vogt-Koyanagi-Harada like (VKH) disease (an association of panuveitis, retinal detachment, ear and meningeal detachment and skin and hair changes), two cases of central retinal vein occlusion, one case of central retinal artery occlusion, one case of severe hypertensive retinopathy and one case of bilateral ischemic optic neuropathy with severe visual impairment. Rare as they are, such severe ophthalmological complications require a close follow-up of HCV-infected patients under IFN-α treatment with ophthalmological monitoring if any ocular manifestation occurs. | Damien Sène Valérie Touitou Bahram Bodaghi David Saadoun Gabriel Perlemuter Nathalie Cassoux Jean-Charles Piette Phuc Le Hoang Patrice Cacoub | 2007 | World Journal of Gastroenterology2007，13，22： | 5 |
| 7 | Comparison of two remote sensing models for estimating evapotranspiration: algorithm evaluation and application in seasonally arid ecosystems in South Africa显示文摘Remote sensing tools are becoming increasingly important for providing spatial information on water use by different ecosystems. Despite significant advances in remote sensing based evapotranspiration(ET) models in recent years, important information gaps still exist on the accuracy of the models particularly in arid and semi-arid environments. In this study, we evaluated the Penman-Monteith based MOD16 and the modified Priestley-Taylor(PT-JPL) models at the daily time step against three measured ET datasets. We used data from two summer and one winter rainfall sites in South Africa. One site was dominated by native broad leaf and the other by fine leafed deciduous savanna tree species and C4 grasses. The third site was in the winter rainfall Cape region and had shrubby fynbos vegetation. Actual ET was measured using open-path eddy covariance systems at the summer rainfall sites while a surface energy balance system utilizing the large aperture boundary layer scintillometer was used in the Cape. Model performance varied between sites and between years with the worst estimates(R2<0.50 and RMSE>0.80 mm/d) observed during years with prolonged mid-summer dry spells in the summer rainfall areas. Sensitivity tests on MOD16 showed that the leaf area index, surface conductance and radiation budget parameters had the largest effect on simulated ET. MOD16 ET predictions were improved by:(1) reformulating the emissivity expressions in the net radiation equation;(2) incorporating representative surface conductance values;and(3) including a soil moisture stress function in the transpiration sub-model. Implementing these changes increased the accuracy of MOD16 daily ET predictions at all sites. However, similar adjustments to the PT-JPL model yielded minimal improvements. We conclude that the MOD16 ET model has the potential to accurately predict water use in arid environments provided soil water stress and accurate biome-specific parameters are incorporated. | Sebinasi DZIKITI Nebo Z JOVANOVIC Richard DH BUGAN Abel RAMOELO Nobuhle P MAJOZI Alecia NICKLESS Moses A CHO David C LE MAITRE Zanele NTSHIDI Harrison H PIENAAR | 2019 | Journal of Arid Land2019，11，4： | 4 |
| 8 | Metabolic syndrome and non-alcoholic fatty liver disease in liver surgery: The new scourges?显示文摘The aim of this topic highlight is to review relevant evidence regarding the influence of the metabolic syndrome(MS) and its associated liver manifestation, non-alcoholic fatty liver disease(NAFLD), on the development of liver cancer as well as their impact on the results of major liver surgery. MS and NAFLD, whose incidences are significantly increasing in Western countries, are leading to a changing profile of the patients undergoing liver surgery. A MEDLINE search was performed for relevant articles using the key words 'metabolic syndrome', 'liver resection', 'liver transplantation', 'non alcoholic fatty liver disease', 'non-alcoholic steatohepatitis' and 'liver cancer'. On one hand, the MS favors the development of primary liver malignancies(hepatocellular carcinoma and cholangiocarcinoma)either through NAFLD liver parenchymal alterations(steatosis, steatohepatitis, fibrosis) or in the absence of significant underlying liver parenchyma changes. Also, the existence of NAFLD may have a specific impact on colorectal liver metastases recurrence. On the other hand, the postoperative period following partial liver resection and liver transplantation is at increased risk of both postoperative complications and mortality. These deleterious effects seem to be related to the existence of liver specific complications but also higher cardio-vascular sensitivity in a setting of MS/NAFLD. Finally, the long-term prognosis after curative surgery joins that of patients operated on with other types of underlying liver diseases. An increased rate of patients with MS/NAFLD referred to hepatobiliary units has to be expected. The higher operative risk observed in this subset of patients will require specific improvements in their perioperative management. | Francois Cauchy David Fuks Alban Zarzavadjian Le Bian Jacques Belghiti Renato Costi | 2014 | World Journal of Hepatology2014，6，5： | 4 |
| 9 | p53 isoform △113p53/△133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage显示文摘在 DNA 双海滨的 p53 的禁止的角色裂缝(DSB ) 修理对它的压制肿瘤的性质似乎矛盾。p53 isoform Δ 113p53/Δ 133p53 是反对 p53 apoptotic 的 p53 目标基因活动。然而,它在 DNA 损坏修理的功能的信息正在缺乏。这里,我们报导那 Δ 113p53 表示被 γ 强烈导致; -irradiation, 然而并非由紫外照耀或热电震疗法。惊人地, Δ 113p53 支持 DNA DSB 修理小径包括相应再结合,非相应的结束加入并且单个海滨的退火。学习 Δ 的生物意义;在支持 DNA DSB 修理的 113p53,我们产生了 zebrafish Δ 113p53 经由抄写的 M/M 异种像使活跃之物的受动器核酸酶技术并且发现异种对 γ 更敏感;照耀。人的 ortholog, Δ 133p53,被 γ 仅仅也导致;照耀和功能修理支持 DNA DSB。Δ 133p53-knockdown 房间响应 γ 在以后的阶段在 G2 阶段被逮捕;照耀由于 unrepaired DNA DSB 的高水平,它最后导致了房间老朽。而且, Δ 113p53/Δ 133p53 经由 upregulating 支持 DNA DSB 修理由到在他们的倡导者的 p53 应答的元素的一种新奇类型的绑定的修理基因 rad51, lig4 和 rad52 的抄写。我们的结果表明那 Δ 113p53/Δ 133p53 是为由阻止 apoptosis 并且支持 DNA DSB 修理禁止房间老朽的 DNA 损坏应力的一个进化地保存的支持幸存的因素。我们的数据也建议 Δ 的正式就职;在正常房间或纸巾的 133p53 表示为癌症病人提供一个重要忍耐标记给放射疗法。 | Lu Gong Hongjian Gong Xiao Pan Changqing Chang Zhao Ou Shengfan Ye Le Yin Lina Yang Ting Tao Zhenhai Zhang Cong Liu David P Lane Jinrong Peng Jun Chen | 2015 | Cell Research2015，25，3： | 4 |
| 10 | Clinical End Points in Coronary Stent Trials: A Case for Standardized Definitions显示文摘 | Donald E. Cutlip Stephan Windecker Roxana Mehran Ashley Boam David J. Cohen Gerrit-Anne van Es P Gabriel Steg Marie-angèle Morel Laura Mauri Pascal Vranckx Eugene McFadden Alexandra Lansky Martial Hamon Mitchell W. Krucoff Patrick W. Serruys | 2007 | Circulation2007，，17： | 4 |
| 11 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 12 | Saccharomyces boulardii Does Not Prevent Relapse of Crohn’s Disease显示文摘 | Arnaud Bourreille Guillaume Cadiot Gérard Le Dreau David Laharie Laurent Beaugerie Jean–Louis Dupas Philippe Marteau Patrick Rampal Dominique Moyse Ashraf Saleh Marie–Emmanuelle Le Guern Jean–Paul Galmiche | 2013 | Clinical Gastroenterology and Hepatology2013，，8： | 3 |
| 13 | Diuretic and antioxidant activities of the aqueous extract of leaves of Cassia occidentalis(Linn.) in rats显示文摘Objective: To assess the putative diuretic and antioxidant properties of Cassia occidentalis(C. occidentalis) leaves' aqueous extract. Methods: Adult rats were administered with C. occidentalis leaves aqueous extract acutely(24-h) and subchronically(7 d), at doses 80, 160, 240, 320, and 400 mg/kg(per os). Negative control group received only an equivalent volume of distilled water, while the two positive control groups received the diuretic drugs furosemide(20 mg/kg, i.p.) and hydrochlorothiazide(HCTZ, 20 mg/kg, i.p.). Urinary elimination of electrolytes in response to treatments was evaluated, together with changes in concentrations of creatinine, urea, aldosterone, glucose, and albumin in urine and plasma. Various urinary indicators of kidney function and plasmatic markers of oxidative stress were also assessed. Results: The acute administration of C. occidentalis increased the urinary excretion of 107.58% at the higher dose tested, compared to negative control. The reference drugs furosemide and HCTZ induced increases of 84.27 % and 48.05 %, respectively. Acutely, the extract induced Na+ and Cl- elimination, whereas subchronically an increase in K+ elimination was also observed. The extract also improved the kidney function indexes and oxidative stress markers. These effects were dose-dependent and comparable with positive control observations. Conclusions: Our i ndings strongly suggest that C. occidentalis aqueous extract has diuretic and antioxidant activities, and deserves further studies considering the potential for the treatment of hypertension. | Théophile Dimo Fidèle Ntchapda Joseph Barama David Romain Kemeta Azambou Paul Faustin Seke Etet | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，9： | 2 |
| 14 | Haplorchis pumilio and H. taichui in Vietnam discriminated using ITS-2 DNA sequence data from adults and larvae显示文摘 | Kim Van Van Anders Dalsgaard David Blair Thanh Hoa Le | 2009 | Experimental Parasitology2009，，2： | 2 |
| 15 | Cell:癌基因“遗传平衡”或会影响患者对癌症疗法的反应显示文摘进行癌症疗法的选择越来越需要确定肿瘤细胞中是否含有一些特殊突变的癌基因会驱动癌细胞异常生长。并且确定是否癌细胞会对特殊药物耐受或敏感.近日来自加州大学旧金山分校的研究人员就通过研究发现。以常见的癌基因KRAs突变为例。患者对疗法的反应往往会随着肿瘤的不断进化而发生改变。相关研究刊登于国际杂志Cell上。 | Michael R. Burgess Eugene Hwang Rana Mroue Craig M. Bielski Anica M. Wandler Benjamin J. Huang Ari J. Firestone Amy Young Jennifer A. Lacap Lisa Crocker Saurabh Asthana Elizabeth M. Davis Jin Xu Keiko Akagi Michelle M. Le Beau Qing Li Benjamin Haley David Stokoe Deepak Sampath Barry S. Taylor Marie Evangelista Kevin Shannon | 2017 | 现代生物医学进展2017，17，18： | 2 |
| 16 | Insulin resistance–associated hepatic iron overload显示文摘 | Michel-Henry Mendler Bruno Turlin Romain Moirand Anne-Marie Jouanolle Thierry Sapey Dominique Guyader Jean-Yves le Gall Pierre Brissot Véronique David Yves Deugnier | 1999 | Gastroenterology1999，，5： | 2 |
| 17 | The Metallic Nature of Epitaxial Silicene Monolayers on Ag(111)显示文摘 | Neil W. Johnson Patrick Vogt Andrea Resta Paola De Padova Israel Perez David Muir Ernst Z. Kurmaev Guy Le Lay Alexander Moewes | 2014 | Adv. Funct. Mater2014，，： | 2 |
| 18 | On Locating Malicious Code in Piggybacked Android Apps显示文摘为在机器人生态系统检测恶意的包裹设计有效途径和工具,研究人员们逐渐地被要求有恶意软件的深理解。因此有需要提供一个框架因为把的恶意软件和定位恶意的节目在应用软件代码以内碎裂以便造恶意的样品的全面数据集。向探讨这需要,我们在一条基于工具的途径把 HookRanker 称为的这个工作求婚,它基于恶意软件行为代码被触发的路提供潜在地恶意的包裹的评价的表。与 piggybacked 应用软件的一张地面真相的实验,我们能自动地为如此的包裹与 83.6% 的 accuracy@5 从 piggybacked 机器人应用软件定位恶意的包裹那为如此的包裹通过方法祈祷和 82.2% 的 accuracy@5 被触发那独立地被触发。 | Li Li Daoyuan Li Tegawende F. Bissyande Jacques Klein Haipeng Cai David Lo Yves Le Traon | 2017 | Journal of Computer Science & Technology2017，32，6： | 2 |
| 19 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet . 2013 (9867)2013，，9867： | 2 |
| 20 | Design and optimization of a torque controller for a switched reluctance motor drive for electric vehicles by simulation 显示文摘 | David Cajander Hoang Le Huy | 2006 | Mathematics and Computers in Simulation2006，71，4： | 1 |
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