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| 1 | 96-Week Treatment of Tenofovir Amibufenamide and Tenofovir Disoproxil Fumarate in Chronic Hepatitis B Patients显示文摘Background and Aims:Tenofovir amibufenamide(TMF)is a novel phosphoramidated prodrug of tenofovir with nonin-ferior efficacy and better bone and renal safety to tenofovir disoproxil fumarate(TDF)in 48 weeks of treatment.Here,we update 96-week comparison results.Methods:Patients with chronic hepatitis B were assigned(2:1)to receive either 25 mg TMF or 300 mg TDF with matching placebo for 96 weeks.The virological suppression was defined as HBV DNA levels<20 IU/mL at week 96.Safety was evaluated thoroughly with focusing on bone,renal,and metabolic pa-rameters.Results:Virological suppression rates at week 96 were similar between TMF and TDF group in both HBeAg-positive and HBeAg-negative populations.Noninferior efficacy was maintained in the pooled population,while it was first achieved in patients with HBV DNA≥7 or 8 log10 IU/mL at baseline.Non-indexed estimated glomerular filtration rate for renal safety assessment was adopted,while a smaller decline of which was seen in the TMF group than in the TDF group(p=0.01).For bone mineral density,patients receiv-ing TMF displayed significantly lower reduction levels in the densities of spine,hip,and femur neck at week 96 than those receiving TDF.In addition,the lipid parameters were stable after week 48 in all groups while weight change still showed the opposite trend.Conclusions:TMF maintained similar efficacy at week 96 compared with TDF with continued superior bone and renal safety profiles(NCT03903796). | Zhihong Liu Qinglong Jin Yuexin Zhang Guozhong Gong Guicheng Wu Lvfeng Yao Xiaofeng Wen Zhiliang Gao Yan Huang Daokun Yang Enqiang Chen Qing Mao Shide Lin Jia Shang Huanyu Gong Lihua Zhong Huafa Yin Fengmei Wang Peng Hu Qiong Wu Chao Pan Wen Jia Chuan Li Chang’an Sun Junqi Niu Jinlin Hou TMF Study Group | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 3 |
| 2 | Wireless Sensor Network for Continuous Monitoring Water Quality in Aquaculture Farm显示文摘 | Ma Daokun Ding Qisheng Li Daoliang | 2010 | Sensor Letters2010，18，1： | 1 |
| 3 | A remote wireless system for water quality online monitoring in intensive fish culture显示文摘 | Xiuna Zhu Daoliang Li Dongxian He Jianqin Wang Daokun Ma Feifei Li | 2009 | Computers and Electronics in Agriculture2009，，： | 1 |
| 4 | How does cancer cell metabolism affect tumor migration and invasion?显示文摘 | Tianyu Han De Kang Daokun Ji Xiaoyu Wang Weihua Zhan Minggui Fu Hong-Bo Xin Jian-Bin Wang | 2013 | Cell Adhesion & Migration2013，，5： | 1 |
| 5 | Three-dimensional numerical modeling of a four-pin probe for soil water content 显示文摘 | M a Daokun Sun Yurui Wang M aohua | 2006 | Australian Journal of Soil Research2006，44，2： | 1 |
| 6 | Three-dimensional numerical modeling of a four-pin probe for soil water content显示文摘 | Ma Daokun Sun Yurui Wang Maohua | 2006 | Australian Journal of Soil Research2006，44，2： | 1 |
| 7 | Residual Strength Study for Damaged Hull and Risk Analysis and Formal Safety Assessment显示文摘Residual strength assessment and prediction has been introduced in the project studies, including the determination of risk failure scenario, the change law of structural capacity and load effects in the damage of ship structure, the models for structural response and ultimate strength analysis, and dynamical model of reliability assessment. In addition, the project has improved the calculation method of ship ultimate load -bearing capacity, and studied the change law, assessment criteria of residual strength, and the method of predicting lifetime for aging ships. The valuable conclusions have been obtained by a large number of engineering calculations. The project and its extended results can provide theoretical foundation and background condition to make risk rule and modem design system, and can implement risk analysis and formal safety assessment for the marine world. The results will improve design quality and shipping safety of ship and offshore and enhanced their society and economic benefits. | GuoChangjie LiJiangjun Zhang Daokun ZhouBinghuan(Dalian University of Technology, Dalian 116024) | 2002 | Science Foundation in China2002，10，1： | 1 |
| 8 | Evaluation of a combined penetrometer for simultaneous measurement of penetration resistance and soil water content显示文摘 | Sun Yurui Peter Schulze Lammers Ma Daokun | 2004 | Journal of Plant Nutrition and Soil Science2004，167，6： | 1 |
| 9 | A 3D-printed molybdenum-containing scaffold exerts dual pro-osteogenic and anti-osteoclastogenic effects to facilitate alveolar bone repair显示文摘The positive regulation of bone-forming osteoblast activity and the negative feedback regulation of osteoclastic activity are equally important in strategies to achieve successful alveolar bone regeneration. Here, a molybdenum(Mo)-containing bioactive glass ceramic scaffold with solid-strut-packed structures(Mo-scaffold) was printed, and its ability to regulate pro-osteogenic and antiosteoclastogenic cellular responses was evaluated in vitro and in vivo. We found that extracts derived from Mo-scaffold(Moextracts) strongly stimulated osteogenic differentiation of bone marrow mesenchymal stem cells and inhibited differentiation of osteoclast progenitors. The identified comodulatory effect was further demonstrated to arise from Mo ions in the Mo-extract,wherein Mo ions suppressed osteoclastic differentiation by scavenging reactive oxygen species(ROS) and inhibiting mitochondrial biogenesis in osteoclasts. Consistent with the in vitro findings, the Mo-scaffold was found to significantly promote osteoblastmediated bone formation and inhibit osteoclast-mediated bone resorption throughout the bone healing process, leading to enhanced bone regeneration. In combination with our previous finding that Mo ions participate in material-mediated immunomodulation, this study offers the new insight that Mo ions facilitate bone repair by comodulating the balance between bone formation and resorption. Our findings suggest that Mo ions are multifunctional cellular modulators that can potentially be used in biomaterial design and bone tissue engineering. | Beimin Tian Xuan Li Jiujiu Zhang Meng Zhang Dian Gan Daokun Deng Lijuan Sun Xiaotao He Chengtie Wu Faming Chen | 2022 | International Journal of Oral Science2022，14，4： | 1 |
| 10 | Evaluation of a combined penetrometer for simultaneous measurement of penetration resistance and soil water content 显示文摘 | Sun Yurui Lammers P S Ma Daokun | 2004 | Plant Nutr Soil Sci2004，167，： | 1 |
| 11 | On-the-go measurement of soil water content and mechanical resistance by a combined horizontal penetrometer 显示文摘 | Sun Yurui Ma Daokun Schulze Lammers | 2006 | Soil & Tillage Research2006，86，： | 1 |
| 12 | Wireless sensor network for continuous monitoring water quality in aquaculture farm显示文摘 | Daokun Ma Qisheng Ding Daoliang Li | 2010 | SensorLetters2010，，8： | 1 |
| 13 | Essence,Value and Development of the Military Judicial System显示文摘It was generally agreed that the military judicial system is a kind of military system rather than a justice system. It must effectively meet the practical needs of military operation,and of course,emphasize the promotion and maintenance of combat effectiveness.However,after the world war II,the military justice became more similar to the judicial system,more specifically,the military justice tended to be independent from the military power,and became more and more civilian and neutral. According to the Constitution of PRC,the military judicial system is a part of the national justice system. The military judicial system must first satisfy the requirement of the national justice system,and meet the needs of the reality of the military activities,realizing the coordinated unification of military system and national system. | Zhu Daokun | 2017 | 学术界2017，，10： | 0 |
| 14 | Pivotal Social Organization:Institutional Logic and Practical Approach显示文摘The social organization is the periodic product of the change of social management mode before and after the reform and opening-up. Under the background of governance theory,the status of social organizations must be further enhanced. To realize the modernization of the national governance system, it is necessary to further develop and improve social organizations to meet the needs of The Times when traditional social management changes to modern social governance. The generation of pivotal social organizations should aim at improving the governance of social organizations. The key lies in the implementation of the concept of'separation of politics and society'. The construction of pivotal social organization should become the representative of social interests in function,break away from the color of'official office'in main body, and strengthen the cultivation, service and supervision of social organization in behavior. | Zhu Daokun | 2018 | 学术界2018，，10： | 0 |
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