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| 1 | Circulating tumor cells:biology and clinical significance显示文摘Circulating tumor cells(CTCs)are tumor cells that have sloughed off the primary tumor and extravasate into and circulate in the blood.Understanding of the metastatic cascade of CTCs has tremendous potential for the identification of targets against cancer metastasis.Detecting these very rare CTCs among the massive blood cells is challenging.However,emerging technologies for CTCs detection have profoundly contributed to deepening investigation into the biology of CTCs and have facilitated their clinical application.Current technologies for the detection of CTCs are summarized herein,together with their advantages and disadvantages.The detection of CTCs is usually dependent on molecular markers,with the epithelial cell adhesion molecule being the most widely used,although molecular markers vary between different types of cancer.Properties associated with epithelial-tomesenchymal transition and stemness have been identified in CTCs,indicating their increased metastatic capacity.Only a small proportion of CTCs can survive and eventually initiate metastases,suggesting that an interaction and modulation between CTCs and the hostile blood microenvironment is essential for CTC metastasis.Single-cell sequencing of CTCs has been extensively investigated,and has enabled researchers to reveal the genome and transcriptome of CTCs.Herein,we also review the clinical applications of CTCs,especially for monitoring response to cancer treatment and in evaluating prognosis.Hence,CTCs have and will continue to contribute to providing significant insights into metastatic processes and will open new avenues for useful clinical applications. | Danfeng Lin Lesang Shen Meng Luo Kun Zhang Jinfan Li Qi Yang Fangfang Zhu Dan Zhou Shu Zheng Yiding Chen Jiaojiao Zhou | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 8 |
| 2 | Identifying the molecular basis of Jinhong tablets against chronic superficial gastritis via chemical profile identification and symptom-guided network pharmacology analysis显示文摘Chronic superficial gastritis(CSG)is a common disease of the digestive system that possesses a serious pathogenesis.Jinhong tablet(JHT),a traditional Chinese medicine(TCM)prescription,exerts therapeutic effects against CSG.However,the molecular basis of its therapeutic effect has not been clarified.Herein,we employed ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry(UPLC-Q/TOF-MS)based chemical profile identification to determine the chemical components in JHT.Further,we applied network pharmacology to illustrate its molecular mechanisms.A total of 96 chemical constituents were identified in JHT,31 of which were confirmed using reference standards.Based on the bioinformatics analysis using the symptom-guided pharmacological networks of“chi,”“blood,”“pain,”and“inflammation,”and target screening through the interaction probabilities between compounds and targets,matrix metalloproteinase 2(MMP2),dopamine d2 receptor(DRD2),and Aldo-keto reductase family 1 member B1(AKR1B1)were identified as key targets in the therapeutic effect exhibited by JHT against CSG.Moreover,according to the inhibitory activities presented in the literature and binding mode analysis,the structural types of alkaloids,flavonoids,organic acids,including chlorogenic acid(10),caffeic acid(13),(-)-corydalmine(33),(-)-isocorypalmine(36),isochlorogenic acid C(38),isochlorogenic acid A(41),quercetin-3-O-a-L-rhamnoside(42),isochlorogenic acid B(47),quercetin(63),and kaempferol(70)tended to show remarkable activities against CSG.Owing to the above findings,we systematically identified the chemical components of JHT and revealed its molecular mechanisms based on the symptoms associated with CSG. | Danfeng Shi Lingxian Liu Haibo Li Dabo Pan Xiaojun Yao Wei Xiao Xinsheng Yao Yang Yu | 2022 | Journal of Pharmaceutical Analysis2022，12，1： | 6 |
| 3 | Discovery of the ancient Ordovician oil-bearing karst cave in Liuhuanggou,North Tarim Basin,and its significance显示文摘A typical ancient karst cave is found in the Yijianfang Formation of Ordovician at Liuhuanggou,North Tarim Basin.With an entrance of 4.8 m wide and 20 m high,the Liuhuanggou ancient karst cave extends to NW 315° and has been filled by sediments,which can be classified into three types according to their nature and origin:clastic sediments(gravels),chemical sediments(palaeotravertine),and mixed sediments.Among them,the Paleotravertine and gravels are most common.The palaeotravertine is laminated type and yellowish brown or black in color due to oil inside.When saturated with oil,the palaeotravertine is black.Under microscope,oil mainly accumulates in the cracks between calcite crystals.The filling period of the Liuhuanggou karst cave can be divided into three stages:mixed filling,chemical filling,and clastic(palaeotravertine breccia) filling.Numerous fractures are distributed on one side of the karst cave.The fractures can be as wide as 40 cm and over 40 m long.Fractures of different periods and sizes constitute a fracture network and are all filled with calcite veins.Oil can be found inside the fractures.In the chemical fillings,sulfur is also found,which can indicate the magma influence on karst caves.The existence of sulfur also confirms that the Liuhunggou karst cave was formed in ancient times rather than recently or nowadays.Different from normal sedimentary limestone,the ancient Liuhuanggou karst cave has a distinct isotope fractionation and the depletion of heavy carbon and oxygen isotope.Controlled by the northwest oriented vertical strike-slip shear fault,the karst cave is actually a dissolved vertical fault belt. | ZHONG JianHua MAO Cui LI Yong LI Yang YUAN XiangChun NIU YongBin CHEN Xin HuANG ZhiJuan SHAO ZhuFu WANG PeiJun LI Jia ZHANG DanFeng | 2012 | Science China Earth Sciences2012，55，9： | 4 |
| 4 | A polypropylene melt-blown strategy for the facile and efficient membrane separation of oil-water mixtures显示文摘Porous materials with selective wettability and permeability have significant importance in oil-water separation,but complex fabrication processes are typically required to obtain the desired structures with suitable surface chemistry.In this work,an industrial melt-blown strategy that utilized commercially available polypropylene(PP)was used for the large-scale fabrication of superhydrophobic/superoleophilic membranes with staggered fabric structures.These membranes could readily separate different oils including pump oil and crude oil from various aqueous solutions such as strongly acidic,alkaline,and saline media.In addition,the separation efficiencies of these membranes exceeded 99%,and they could remain functional even after exposure to corrosive media.We anticipate that this work will further the design of membranes and enhance their applicability in oil-water separation,and provide researchers and engineers with a more effective tool for performing challenging separations and mitigating pollution. | Zhenqiang Zhang Danfeng Yu Xiubin Xu Huayi Li Taoyan Mao Cheng Zheng Jianjia Huang Hui Yang Zihan Niu Xu Wu | 2021 | Chinese Journal of Chemical Engineering2021，34，1： | 3 |
| 5 | A novel integrated non-targeted metabolomic analysis reveals significant metabolite variations between different lettuce (Lactuca sativa. L) varieties显示文摘Lettuce is an important leafy vegetable that represents a significant dietary source of antioxidants and bioactive compounds.However,the levels of metabolites in different lettuce cultivars are poorly characterized.In this study,we used combined GC×GC-TOF/MS and UPLC-IMS-QTOF/MS to detect and relatively quantify metabolites in 30 lettuce cultivars representing large genetic diversity.Comparison with online databases,the published literature,standards as well using collision cross-section values enabled putative identification of 171 metabolites.Sixteen of these 171 metabolites(including phenolic acid derivatives,glycosylated flavonoids,and one iridoid)were present at significantly different levels in leaf and head type lettuces,which suggested the significant metabolomic variations between the leaf and head types of lettuce are related to secondary metabolism.A combination of the results and metabolic network analysis techniques suggested that leaf and head type lettuces contain not only different levels of metabolites but also have significant variations in the corresponding associated metabolic networks.The novel lettuce metabolite library and novel non-targeted metabolomics strategy devised in this study could be used to further characterize metabolic variations between lettuce cultivars or other plants.Moreover,the findings of this study provide important insight into metabolic adaptations due to natural and human selection,which could stimulate further research to potentially improve lettuce quality,yield,and nutritional value. | Xiao Yang Shiwei Wei Bin Liu Doudou Guo Bangxiao Zheng Lei Feng Yumin Liu Francisco A.Tomás-Barberán Lijun Luo Danfeng Huang | 2018 | Horticulture Research2018，5，1： | 3 |
| 6 | A model to determine the lake nutrient standards for drinking water sources in Yunnan-Guizhou Plateau Ecoregion, China显示文摘Lake eutrophication (LE) has become an increasingly severe environmental problem recently. However, there has been no nutrient standard established for LE control in many developing countries such as China. This study proposes a structural equation model to assist in the establishment of a lake nutrient standard for drinking water sources in Yunnan-Guizhou Plateau Ecoregion (Yungui Ecoregion), China. The modeling results indicate that the most predictive indicator for designated use-attainment is total phosphorus (TP) (total effect =-0.43), and chlorophyll a (Chl-a) is recommended as the second important indicator (total effect =-0.41). The model is further used for estimating the probability of use-attainment associated with lake water as a drinking water source and various levels of candidate criteria (based on the reference conditions and the current environmental quality standards for surface water). It is found that these candidate criteria cannot satisfy the designated 100% use-attainment. To achieve the short-term target (85% attainment of the designated use), TP and Chl-a values ought to be less than 0.02 mg/L and 1.4 μg/L, respectively. When used as a long-term target (90% or greater attainment of the designated use), the TP and Chl-a values are suggested to be less than 0.018 mg/L and 1 μg/L, respectively. | Danfeng Ji Beidou Xi Jing Su Shouliang Huo Li He Hongliang Liu Queping Yang | 2013 | Journal of Environmental Sciences2013，25，9： | 2 |
| 7 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 8 | Competitive biosorption of Acid Blue 25 and Acid Red 337 onto unmodified and CD- AB-modified biomass of Aspergillus oryzae 显示文摘 | Yang Yuyi Jin Danfeng Wang Guan | 2011 | Bioresource Technology2011，102，16： | 1 |
| 9 | Trust-Compensation-Based Access Control Model for Web Services显示文摘For most current Web Service access control methods,Web Service providers create a series of access control rules based on specified attributes.Only by meeting all the rules can a subject obtain the access to necessary operations and resources.However,because of the dynamic and open traits of Web Services,it is difficult for Web Service providers to work out an access control policy with moderate intensity and to realize a satisfactory balance between protecting the security of resources and maintaining the service reachable rate.To provide a solution to the above problem,this paper proposed a trust compensation access control method based on the Attribute-Based Access Control model.Our main contributions include a formal description of the access control method,a method to calculate the attribute trust degree based on time decay,and the trust compensation value of the attribute trust degree,as well as a new Service Oriented Architecture(SOA) architecture and its procedures based on a detailed trust compensation access control method. | Yan Danfeng Sun Jing Zhang Liying Yang Fangchun | 2012 | China Communications2012，9，12： | 1 |
| 10 | Tumor extracellular vesicles mediate anti-PD-L1 therapyresistance by decoying anti-PD-L1显示文摘PD-L1+tumor-derived extracellular vesicles(TEVs)cause systemic immunosuppression and possibly resistance to anti-PD-L1 antibody(αPD-L1)blockade.However,whether and how PD-L1+TEVs mediateαPD-L1 therapy resistance is unknown.Here,we show that PD-L1+TEVs substantially decoyαPD-L1 and that TEV-boundαPD-L1 is more rapidly cleared by macrophages,causing insufficient blockade of tumor PD-L1 and subsequentαPD-L1 therapy resistance.Inhibition of endogenous production of TEVs by Rab27a or Coro1a knockout reversesαPD-L1 therapy resistance.Either an increasedαPD-L1 dose or macrophage depletion mediated by the clinical drug pexidartinib abolishesαPD-L1 therapy resistance.Moreover,in the treatment cycle with the same total treatment dose ofαPD-L1,high-dose and low-frequency treatment had better antitumor effects than low-dose and highfrequency treatment,induced stronger antitumor immune memory,and eliminatedαPD-L1 therapy resistance.Notably,in humanized immune system mice with human xenograft tumors,both increasedαPD-L1 dose and high-dose and low-frequency treatment enhanced the antitumor effects ofαPD-L1.Furthermore,increased doses ofαPD-L1 andαPD-1 had comparable antitumor effects,butαPD-L1 amplified fewer PD-1+Treg cells,which are responsible for tumor hyperprogression.Altogether,our results reveal a TEV-mediated mechanism ofαPD-L1-specific therapy resistance,thus providing promising strategies to improveαPD-L1 efficacy. | Jiming Chen Jie Yang Wenhui Wang Danfeng Guo Chengyan Zhang Shibo Wang Xinliang Lu Xiaofang Huang Pingli Wang Gensheng Zhang Jing Zhang Jianli Wang Zhijian Cai | 2022 | Cellular & Molecular Immunology2022，19，11： | 1 |
| 11 | Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: the role of particle size, shape and composition 显示文摘 | Hui Yang Chao Liu Danfeng Yang Huashan Zhang Zhuge Xi | 2009 | Journal of applied Toxicology2009，29，1： | 1 |
| 12 | TMTP1, a novel tumor-homing peptide specifically tar- geting metastasis显示文摘 | Yang Wanhua Luo Danfeng Wang Shixuan | 2008 | Clinical Cancer Research2008，14，17： | 1 |
| 13 | Distribution of Organic Pesticide HCH in Jiaozhou Bay显示文摘According to the investigated data of Jiaozhou Bay in April,August,September and October of 1989,distribution,source and seasonal change of HCH in Jiaozhou Bay were analyzed. Results showed that HCH content changed during 0. 012 7-0. 069 8 μg /L in Jiaozhou Bay and was very low. Seen from HCH content,water in Jiaozhou Bay was cleaner,and HCH did not have seasonal change. Horizontal distribution of HCH showed that HCH was directly input into offshore water only by surface runoff,and there was no river input. HCH was area source and was from land. In Jiaozhou Bay,the maximum HCH was gradually becoming smaller,and input manner also changed. HCH migration changed from river input to river and surface runoff input to final surface runoff input. | Yang Dongfang Song Wenpeng Xu Zijun Geng Xiao Yang Danfeng | 2014 | Meteorological and Environmental Research2014，5，4： | 1 |
| 14 | Discovery of a mammalian FASN inhibitor against xenografts of non-small cell lung cancer and melanoma显示文摘Dear Editor,Cancer cells need to reprogram fatty acid(FA)metabolism to promote cell growth and survival through exogenous lipid uptake and FA biosynthesis catalyzed by the multidomain containing mammalian FA synthase(FASN).1,2 The bidirectional relationships of oncogenic signaling and de novo lipogenesis(DNL)suggest that FASN is a druggable target in many cancers. | Danfeng Cao Jie Yang Youchao Deng Meng Su Yeji Wang Xueqiong Feng Yi Xiong Enhe Bai Yanwen Duan Yong Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 1 |
| 15 | Electromagnetic characteristics and microwave absorption properties of carbon-encapsulated cobalt nanoparticles in 2–18-GHz frequency range显示文摘 | Danfeng Zhang Fangxing Xu Jin Lin Zhenda Yang Min Zhang | 2014 | Carbon2014，，： | 1 |
| 16 | Growth and electrical properties of large size Pb(Inl/2 Nb1/2 ) O3-Pb ( Mg1/3 Nb2/3 ) O3-PbTiO3 crystals pre- pared by the vertical Bridgman technique显示文摘 | XU Guisheng CHEN Kai YANG Danfeng | 2007 | Applied Physics Letters2007，90，03： | 1 |
| 17 | An Early Stage Detecting Method against SYN Flooding Attacks显示文摘Existing detection methods against SYN flooding attacks are effective only at the later stages when attacking signatures are obvious.In this paper an early stage detecting method(ESDM) is proposed.The ESDM is a simple but effective method to detect SYN flooding attacks at the early stage.In the ESDM the SYN traffic is forecasted by autoregressive integrated moving average model, and non-parametric cumulative sum algorithm is used to find the SYN flooding attacks according to the forecasted traffic.Trace-driven simulations show that ESDM is accurate and efficient to detect the SYN flooding attacks. | Sun Qibo Wang Shangguang Yan Danfeng Yang Fangchun | 2009 | China Communications2009，6，4： | 1 |
| 18 | Icariin from epimedium brevicornum maxim promotes the biosynthesis of estrogen by aromatase( CYP19 ) 显示文摘 | Yang Lijaan Lu Danfeng Guo Jiajia | 2013 | J Ethnopharmaco12013，145，3： | 1 |
| 19 | The regulatory roles of DDIT4 in TDCIPP-induced autophagy and apoptosis in PC12 cells显示文摘Tris(1,3-dichloro-2-propyl) phosphate(TDCIPP) is a commonly used organophosphatebased flame retardant and can bio-accumulate in human tissues and organs. As its structure is similar to that of neurotoxic organophosphate pesticides, the neurotoxicity of TDCIPP has raised widespread concerns. TDCIPP can increase neuronal apoptosis and induce autophagy.However, its regulatory mechanism remains unclear. In this study, we found that the expression upregulation of the DNA Damage-Inducible Transcript 4(DDIT4) protein, which might play essential roles in TDCIPP-induced neuronal autophagy and apoptosis, was observed in TDCIPP-treated differentiated rat PC12 cells. Furthermore, we determined the protective effect of the DDIT4 suppression on the autophagy and apoptosis induced by TDCIPP using Western blot(WB) and Flow cytometry(FACS) analysis. We observed that TDCIPP treatment increased the DDIT4, the autophagy marker Beclin-1, and the microtubule-associated protein light chain 3-II(LC_(3)II) expressions and decreased the mTOR phosphorylation levels. Conversely, the suppression of DDIT4 expression increased the p-mTOR expression and decreased cell autophagy and apoptosis. Collectively, our results revealed the function of DDIT4 in cell death mechanisms triggered by TDCIPP through the m TOR signaling axis in differentiated PC12 cells. Thus, this study provided vital evidence necessary to explain the mechanism of TDCIPP-induced neurotoxicity in differentiated PC12 cells. | Li Li Lingyi Xi JinWu Zunquan Zhao Youliang Chen Weili Liu Zhihui Pan Mingzhu Liu Danfeng Yang Zhaoli Chen Yanjun Fang | 2023 | Journal of Environmental Sciences2023，，3： | 0 |
| 20 | The growth status of relaxor-based ferroelectric crystals and their development trends显示文摘Our progress in the growth of ternary system Pb(In_(1/2)Nb_(1/2))O_(3)–Pb(Mg_(1/3)Nb_(2/3))O_(3)–PbTiO_(3)(PIMNT)crystals and reviews on the possible developing trends in the piezoelectric crystals are presented.Large PIMNT crystals with 3 inches in diameter have been grown by using a modified Bridgman method.Meanwhile,Mn-doped PIMNT crystals have also been obtained.PIMNT crystals exhibit Curie temperature Tc190C,rhombohedral–tetragonal phase transition temperature Trt>100℃ and coercive field Ec5:0–7.0 kV/cm on(001)cuts.Meanwhile,higher piezoelectric constant d_(32)-1500–2200 pC/N,d_(15)4000–6000 pC/N and coercive field E_(c)-7:0–9.0 kV/cm have been achieved on(110)cuts.The development trends of relaxor-based ferroelectric crystals are suggested to grow novel crystals with high rhombohedral–tetragonal phase transition temperature T_(rt)>150-160℃ and/or high coercive field Ec and mechanical quality factor Q_(m),to promote growth efficiency of PIMNT crystals and to create new growth methods fitting for the growth of metastable or instable crystals. | Guisheng Xu Danfeng Yang Jinfeng Liu Ying Liu Xiaxia Chen | 2014 | Journal of Advanced Dielectrics2014，4，1： | 0 |
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