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| 1 | Circulating tumor cells:biology and clinical significance显示文摘Circulating tumor cells(CTCs)are tumor cells that have sloughed off the primary tumor and extravasate into and circulate in the blood.Understanding of the metastatic cascade of CTCs has tremendous potential for the identification of targets against cancer metastasis.Detecting these very rare CTCs among the massive blood cells is challenging.However,emerging technologies for CTCs detection have profoundly contributed to deepening investigation into the biology of CTCs and have facilitated their clinical application.Current technologies for the detection of CTCs are summarized herein,together with their advantages and disadvantages.The detection of CTCs is usually dependent on molecular markers,with the epithelial cell adhesion molecule being the most widely used,although molecular markers vary between different types of cancer.Properties associated with epithelial-tomesenchymal transition and stemness have been identified in CTCs,indicating their increased metastatic capacity.Only a small proportion of CTCs can survive and eventually initiate metastases,suggesting that an interaction and modulation between CTCs and the hostile blood microenvironment is essential for CTC metastasis.Single-cell sequencing of CTCs has been extensively investigated,and has enabled researchers to reveal the genome and transcriptome of CTCs.Herein,we also review the clinical applications of CTCs,especially for monitoring response to cancer treatment and in evaluating prognosis.Hence,CTCs have and will continue to contribute to providing significant insights into metastatic processes and will open new avenues for useful clinical applications. | Danfeng Lin Lesang Shen Meng Luo Kun Zhang Jinfan Li Qi Yang Fangfang Zhu Dan Zhou Shu Zheng Yiding Chen Jiaojiao Zhou | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 8 |
| 2 | Construction of heparin-based hydrogel incorporated with Cu_(5.4)O ultrasmall nanozymes for wound healing and inflammation inhibition显示文摘Excessive production of inflammatory chemokines and reactive oxygen species(ROS)can cause a feedback cycle of inflammation response that has a negative effect on cutaneous wound healing.The use of wound-dressing materials that simultaneously absorb chemokines and scavenge ROS constitutes a novel‘weeding and uprooting’treatment strategy for inflammatory conditions.In the present study,a composite hydrogel comprising an amine-functionalized star-shaped polyethylene glycol(starPEG)and heparin for chemokine sequestration as well as Cu_(5.4)O ultrasmall nanozymes for ROS scavenging(Cu_(5.4)O@Hep-PEG)was developed.The material effectively adsorbs the inflammatory chemokines monocyte chemoattractant protein-1 and interleukin-8,decreasing the migratory activity of macrophages and neutrophils.Furthermore,it scavenges the ROS in wound fluids to mitigate oxidative stress,and the sustained release of Cu_(5.4)O promotes angiogenesis.In acute wounds and impaired-healing wounds(diabetic wounds),Cu_(5.4)O@Hep-PEG hydrogels outperform the standard-of-care product Promogram®in terms of inflammation reduction,increased epidermis regeneration,vascularization,and wound closure. | Yuan Peng Danfeng He Xin Ge Yifei Lu Yuanhao Chai Yixin Zhang Zhengwei Mao Gaoxing Luo Jun Deng Yan Zhang | 2021 | Bioactive Materials2021，6，10： | 7 |
| 3 | Catalytic pyrolysis of Pubescens to phenols over Ni/C catalyst显示文摘The pyrolysis of Pubescens over Ni/C catalyst was studied at 350°C in H2 flow.The presence of Ni/C catalyst efficiently improved the degradation of raw materials,and produced bio-oil with high content of phenols but low contents of acetic acid,furfural and water.In the reaction,Ni/C catalyst plays the role of catalytic decomposition and catalytic hydrogenation.The existence of the carbon carrier favors the formation of active Ni in small sizes with more defects,which results in high catalytic activity of Ni in biomass decomposition and selective production of phenols. | LUO Jia LI Jie SHEN DanFeng HE Ling TONG DongMei HU ChangWei | 2010 | Science China Chemistry2010，53，7： | 4 |
| 4 | A novel integrated non-targeted metabolomic analysis reveals significant metabolite variations between different lettuce (Lactuca sativa. L) varieties显示文摘Lettuce is an important leafy vegetable that represents a significant dietary source of antioxidants and bioactive compounds.However,the levels of metabolites in different lettuce cultivars are poorly characterized.In this study,we used combined GC×GC-TOF/MS and UPLC-IMS-QTOF/MS to detect and relatively quantify metabolites in 30 lettuce cultivars representing large genetic diversity.Comparison with online databases,the published literature,standards as well using collision cross-section values enabled putative identification of 171 metabolites.Sixteen of these 171 metabolites(including phenolic acid derivatives,glycosylated flavonoids,and one iridoid)were present at significantly different levels in leaf and head type lettuces,which suggested the significant metabolomic variations between the leaf and head types of lettuce are related to secondary metabolism.A combination of the results and metabolic network analysis techniques suggested that leaf and head type lettuces contain not only different levels of metabolites but also have significant variations in the corresponding associated metabolic networks.The novel lettuce metabolite library and novel non-targeted metabolomics strategy devised in this study could be used to further characterize metabolic variations between lettuce cultivars or other plants.Moreover,the findings of this study provide important insight into metabolic adaptations due to natural and human selection,which could stimulate further research to potentially improve lettuce quality,yield,and nutritional value. | Xiao Yang Shiwei Wei Bin Liu Doudou Guo Bangxiao Zheng Lei Feng Yumin Liu Francisco A.Tomás-Barberán Lijun Luo Danfeng Huang | 2018 | Horticulture Research2018，5，1： | 3 |
| 5 | TMTP1, a novel tumor-homing peptide specifically tar- geting metastasis显示文摘 | Yang Wanhua Luo Danfeng Wang Shixuan | 2008 | Clinical Cancer Research2008，14，17： | 1 |
| 6 | Identification of two potential glycogen synthase kinase 3β inhibitors for the treatment of osteosarcoma显示文摘Osteosarcoma 是在与高死亡率世界范围的青少年之中的最普通的主要恶意的骨头肿瘤。肝糖 synthase kinase (GSK3 ) 3 是 serine/threonine kinase 并且在 osteosarcoma 被看作一个验证目标治疗。因此, GSK3 禁止者的学习是在 anti-osteosarcoma 药开发的最流行的领域之一。这里,生物信息学的工具被用来从锌药数据库屏蔽 GSK3 的新奇有效禁止者。分子的停靠、分子的动态模拟, MM/GBSA,和精力分解分析被执行识别禁止者。最后, ZINC08383479 和 ZINC08441251 作为潜在的 GSK3 禁止者被选择。这二个禁止者被 GSK3 kinase 抑制试金在 vitro 评估。房间增长的抑制在 vitro 在 osteosarcoma 房间线 U2OS 和 MG63 被测试。结果显示出那 ZINC08383479, ZINC08441251 对 GSK3 举办了高抑制活动。我们发现 CHIR99021 (一个已知的 GSK3 禁止者) , ZINC08383479,和 ZINC08441251 在 U2OS 房间和 MG63 房间举办了重要抑制活动。这些调查结果可以为 osteosarcoma 为更多的有势力 GSK3 禁止者和治疗学的目标的设计提供新想法。 | Kaimin Lu Xin Wang Yuyu Chen Danfeng Liang Hao Luo Li Long Zongyue Hu Jinku Bao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，5： | 0 |
| 7 | Improved suspension quality and liquid level stability in stirred tanks with Rotor-Stator agitator based on CFD simulation显示文摘The solid-liquid mixing is an important operation unit in the preparation of composites by stirring casting.High quality composite materials need good homogeneity and stable liquid level.In this work,the performances of the Rotor-Stator agitator for solid suspension in stirred tank were investigated through CFD modeling,including the homogeneity,power consumption and liquid level stability.The Eulerian-Eulerian(E-E)multiphase model and the RNG k-εturbulence model were adopted for modeling the multiphase flow and the turbulence effects,respectively.The effect of various important parameters such as stirring speed,particle size,solid loading and the use of baffles were examined.Adding a stator structure with array holes outside the rotor can optimize the flow pattern,thereby improving the mixing uniformity and liquid level stability.The homogeneity and liquid level stability attained by the Rotor-Stator agitator were better than those for the A200(an axial-flow agitator)and the Rushton(a radial-flow agitator). | Cuicui Yin Jiazhen He Yongnan Xiong Zhibo Zhang Xing Luo Yao Shu Danfeng Long Kaihong Zheng | 2023 | Particuology2023，，11： | 0 |
| 8 | Anthrazoline Photocatalyst for Promoting Esterification and Etherification Reactions via Photoredox/Nickel Dual Catalysis显示文摘Here,we demonstrate a readily prepared anthrazoline photocatalyst,which can effectively promote C—O bond formation reactions with the aid of Ni(II)complex.This methodology enables the esterification(36 examples)and etherification(8 examples)with a broad range of scope,allowing aryl and alkyl halides coupled with diverse carboxylic acids/alcohols.Our metal-free photocatalysts have a potential broad application,may serve as an alternative to some iridium and ruthenium based photocatalysts,and are of potential importance to the pharmaceutical industry. | Xiaolin Zhu Qiujin Fan Wei Luo Danfeng Wang Yihui Jia Heyang Li Zhen Wang Qi Xiao Xiaoming He | 2023 | Chinese Journal of Chemistry2023，41，4： | 0 |
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