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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Fibrin D-dimer and coro-nary heart disease:prospective study and meta-analysis显示文摘 | Danesh J Whincup P Walker M | 2001 | Circu-lation2001，103，： | 1 |
| 3 | Chlamydia pnemoniae IgG titres and coronary heart disease:prospective study and meta-analysis显示文摘 | Danesh J Whincup P Walker M | 2000 | BMJ2000，321，： | 1 |
| 4 | Soluble adhesion molecules and prediction of coronary heart disease:a prospective study and meta-analysis显示文摘 | Malik I Danesh J Whincup P | 2001 | Lancet2001，358，： | 1 |
| 5 | Association of fibrino- gen, C - reactive protein, albumin, or leukocyte count with coronary heart disease: meta - analyses of prospec- tive studies 显示文摘 | Danesh J Collins R Appleby P | 1998 | JAMA1998，279，18： | 1 |
| 6 | Prospective study of potentially virulent strains of Helicobacter pylori and coronary heart disease in middle-aged men 显示文摘 | Whineup P Danesh J Walker M | 2000 | Circulation2000，101，： | 1 |
| 7 | Association offibrinogen,C-reactive protein,albumin,or leukocyte count with coronary artery disease显示文摘 | Collins R Appleby P | 1998 | J Am Med Assoc1998，279，： | 1 |
| 8 | Low grade inflammation and coronary heart disease: prospective study and updated meta -analysis显示文摘 | Whincup P Walker M | 2000 | BMJ2000，321，： | 1 |
| 9 | Fibrin D-dimer and coronny heart disease:prospective study and meta-analysis显示文摘 | Danesh J Whincup P Walker M | 2001 | Cieculation2001，103，： | 1 |
| 10 | Association of fibrinogen,Creactive protein,allburnin,or leukocyte count with coronary heart disease显示文摘 | Danesh J Collis R Appleby P | 1998 | JAMA1998，279，： | 1 |
| 11 | association of fibrinogen,C-reactive protein,albumin,or leukocyte count with coronary heart disease显示文摘 | Collins R Appleby P | 1998 | JAMA1998，279，： | 1 |
| 12 | Association of fibrinogen,C-reactive protein,albumin,or leukocyte count with coronary heart disease:meta-analyses of prospective studies显示文摘 | Danesh J Collins R Appleby P | 1998 | JAMA1998，279，18： | 1 |
| 13 | Low grade inflammation and coronary heart disease:prospective study and updated meta-analyses显示文摘 | Danesh J Whincup P Walker M | 2000 | BMJ2000，321，7255： | 1 |
| 14 | fibrin D-dimer and coronary heart disease:prospective study and mete analysis:Circulation显示文摘 | Danesh J Whincup P WalkerM | 2001 | 103:2323-23272001，103，： | 1 |
| 15 | Low grade inflammationandcoronary heartdisease:perspective study updated meal - analyses显示文摘 | Danesh J Whincup P Walker M | 2000 | BMJ2000，321，： | 1 |
| 16 | Low grade inflammation and coronary heart disease:prospective study and updated meta-analyses显示文摘 | Danesh J Whincup P Walker M | 2000 | BMJ2000，321，7255： | 1 |
| 17 | Low grade inflammation and coronary heart disease: prospective study and updated meta-analysis显示文摘 | Danesh J Whincup P Walker M | 2000 | BMJ2000，321，： | 1 |
| 18 | SHG and AFM study of PECVD a-Si∶H films显示文摘 | Alexandrova S Danesh P Maslyanitsyn I A | 2002 | 69(1):391-3942002，69，1： | 1 |
| 19 | Fibrin D-dimer and coronary heart disease:prospective study and metaanalysis 显示文摘 | Danesh J Whincup P Walker M | 2001 | Circulation2001，103，19： | 1 |
| 20 | Low grade inflammation and coronary heart disease:prospective study and updated meta-analysis显示文摘 | Whincup P Walker M | 2000 | BMJ2000，321，： | 1 |
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