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| 1 | The favorable impact of PIK3CA mutations on survival: an analysis of 2587 patients with breast cancer显示文摘The phosphatidylinositol-3 kinase(PI3K) pathway regulates a number of cellular processes, including cell survival, cell growth, and cell cycle progression. Consequently, this pathway is commonly deregulated in cancer. In particular, mutations in the gene PIK3CA that encodes the p110α catalytic subunit of the PI3K enzymes result in cell proliferation and resistance to apoptosis in vitro and induce breast tumors in transgenic mice. These data underscore the role of this pathway during oncogenesis. Thus, an ongoing, large-scale effort is underway to develop clinically active drugs that target elements of the PI3K pathway. However, conflicting data suggest that gain-of-function PIK3CA mutations may be associated with either a favorable or a poor clinical outcome, compared with the wild-type PIK3CA gene. In the current study, we performed a systematic review of breast cancer clinical studies. Upon evaluation of 2587 breast cancer cases from 12 independent studies, we showed that patients with tumors harboring a PIK3CA mutation have a better clinical outcome than those with a wild-type PIK3CA gene. Importantly, this improved prognosis may pertain only to patients with mutations in the kinase domain of p110α and to postmenopausal women with estrogen receptor-positive breast cancer. We propose three potential explanations for this paradoxical observation. First, PIK3CA mutations may interfere with the metastasis process or may induce senescence, which results in a better outcome for patients with mutated tumors. Secondly, we speculate that PIK3CA mutations may increase early tumor diagnosis by modification of the actin cytoskeleton in tumor cells. Lastly, we propose that PIK3CA mutations may be a favorable predictive factor for response to hormonal therapy, giving a therapeutic advantage to these patients. Ultimately, an improved understanding of the clinical impact of PIK3CA mutations is critical for the development of optimally personalized therapeutics against breast cancer and other solid tumors. This effort will be important to prevent or explain therapeutic failures and select patients who are most likely to respond to new therapies that inhibit the PI3K pathway. | Amaury G. Dumont Sarah N.Dumont Jonathan C. Trent | 2012 | Chinese Journal of Cancer2012，31，7： | 5 |
| 2 | Bilateral versus unilateral cryptorchidism in nonobstructive azoospermia:testicular sperm extraction outcomes显示文摘Cryptorchidism is one of the most frequent causes of nonobstructive azoospermia(NOA)in adulthood.Although it is well known that spermatogenesis is more impaired in bilateral than in unilateral cryptorchidism,previous studies have only described small cohorts or inhomogeneous population.Consequently,we analyzed a cohort of 225 men with only a history of cryptorchidism as sole etiopathogenetic factor for NOA,and compared testicular sperm extraction(TESE)outcomes between men with bilateral versus unilateral cryptorchidism.Our results show no difference in follicle-stimulating hormone(FSH)levels and testicular volumes between men with a history of bilateral cryptorchidism compared to unilateral cryptorchidism(median:21.3 IU I^-1 vs 19.3 IU I^-1,P=0.306;and 7.2 ml vs 7.9 ml,P=0.543,respectively).In addition,sperm retrieval rates were similar(66.2%vs 60.0%,P=0.353).Using multivariate analysis,we have found that only a low inhibin B level(above the assay's detection limit)was positively associated with successful sperm retrieval(P<0.05).Regarding intracytoplasmic sperm injection outcomes,we found that cumulative pregnancy rate and live birth rate per cycle were not statistically different between the two groups(17.4%vs 27.8%,P=0.070;and 16.1%vs 26.4%,P=0.067,respectively).Unexpectedly,there was no significant difference in hormonal profiles(FSH,luteinizing hormone[LH],testosterone,and inhibin B levels)and TESE outcomes between unilateral versus bilateral cryptorchidism.This suggests that a history of unilateral cryptorchidism could reflect a bilateral testicular impairment.Interestingly,inhibin B level might be a predictor of successful TESE. | Anne-Laure Barbotin Anais Dauvergne Agathe Dumont Nassima Ramdane Valerie Mitchell Jean-Marc Rigot Florence Boitrelle Geoffroy Robin | 2019 | Asian Journal of Andrology2019，21，5： | 4 |
| 3 | On the relationship between microstructure, strength and toughness in AA7050 aluminum alloy显示文摘 | D. Dumont A. Deschamps Y. Brechet | 2003 | Materials Science & Engineering A2003，，1： | 3 |
| 4 | Monolithic crystalline silicon solar cells with SiN_x layers doped with Tb^(3+) and Yb^(3+) rare-earth ions显示文摘In this study, we propose the fabrication of monolithic crystalline silicon solar cells with Tb^(3+) and Yb^(3+)-doped silicon nitride(SiN_x) layers by low-cost screen-printing methods. The performances of c-Si solar cells can be enhanced by rare-earth ions doped SiN_x layers via the mechanism of spectrum conversion.These SiN_x doped and codoped thin films were deposited by reactive magnetron co-sputtering and integrated as the antireflection coating layers in c-Si solar cells. The characterizations of SiN_x, SiN_x:Tb^(3+) tand SiN_x:Tb^(3+)-Yb^(3+) thin films were conducted by means of photoluminescence, Rutherford backscattering spectroscopy, Ellipsometry spectroscopy and Fourier transform infrared measurements. Their composition and refractive index was optimized to obtain good anti-reflection coating layer for c-Si solar cells.Transmission electron microscopy performs the uniform coatings on the textured emitter of c-Si solar cells. After the metallization process, we demonstrate monolithic c-Si solar cells with spectrum conversion layers, which lead to a relative increase by 1.34% in the conversion efficiency. | Ing-Song Yu Shao-Chun Wu Lucile Dumont Julien Cardin Christophe Labbé Fabrice Gourbilleau | 2019 | Journal of Rare Earths2019，37，5： | 3 |
| 5 | Global Wheat Head Detection 2021:An Improved Dataset for Benchmarking Wheat Head Detection Methods显示文摘The Global Wheat Head Detection(GWHD)dataset was created in 2020 and has assembled 193,634 labelled wheat heads from 4700 RGB images acquired from various acquisition platforms and 7 countries/institutions.With an associated competition hosted in Kaggle,GWHD_2020 has successfully attracted attention from both the computer vision and agricultural science communities.From this first experience,a few avenues for improvements have been identified regarding data size,head diversity,and label reliability.To address these issues,the 2020 dataset has been reexamined,relabeled,and complemented by adding 1722 images from 5 additional countries,allowing for 81,553 additional wheat heads.We now release in 2021 a new version of the Global Wheat Head Detection dataset,which is bigger,more diverse,and less noisy than the GWHD_2020 version. | Etienne David Mario Serouart Daniel Smith Simon Madec Kaaviya Velumani Shouyang Liu Xu Wang Francisco Pinto Shahameh Shafiee Izzat SATahir Hisashi Tsujimoto Shuhei Nasuda Bangyou Zheng Norbert Kirchgessner Helge Aasen Andreas Hund Pouria Sadhegi-Tehran Koichi Nagasawa Goro Ishikawa Sébastien Dandrifosse Alexis Carlier Benjamin Dumont Benoit Mercatoris Byron Evers Ken Kuroki Haozhou Wang Masanori Ishii Minhajul ABadhon Curtis Pozniak David Shaner LeBauer Morten Lillemo Jesse Poland Scott Chapman Benoit de Solan Frédéric Baret Ian Stavness Wei Guo | 2021 | Plant Phenomics2021，3，1： | 2 |
| 6 | Growth kinetics rather than stress accelerate telomere shortening in cultures of human diploid fibroblasts in oxidative stressinduced premature senescence 显示文摘 | Dumont P Royer V Pascal T | 2001 | FEBS Lett2001，502，3： | 2 |
| 7 | Toluene degradation by a water/silicone oil mixture for the design of two phase partitioning bioreactors显示文摘Toluene degradation performances were studied in a 10 L Two-Phase Partitioning Bioreactor(TPPB).The liquid phase consisted of a mixture of water and PDMS 50(Poly Di Methyl Siloxane,i.e.silicone oil,viscosity of 46 m Pa·s) in the volume ratio of 75%/25%.Two series of experiments were carried out:in the first,the reactor was sequentially supplied with toluene whereas in the second,toluene was continuously supplied.Activated sludge from the wastewater treatment plant of Beaurade(Rennes,France) was used at an initial concentration of 0.5 dry mass g·(mixture L)^(-1).The elimination capacity(EC) was investigated as well as the change in biomass concentration over time.Toluene biodegradation was very ef ficient(removal ef ficiency,RE=100%) for toluene flows ranging from 0.2 to 1.2 ml·h^(-1),corresponding to elimination capacities of up to 104 g·m^(-3)·h^(-1).For a toluene flow of 1.2 ml·h^(-1),the biomass concentration measured at the end of the experiment was 4.7 dry mass g·(mixture L)^(-1).The oxygen concentration in the liquid phase was clearly not a limiting factor in these operating conditions.Based on these results,an extrapolation leading to the design of a large-scale pilot TPPB can now be considered to study toluene degradation performances in industrial conditions. | Maxime Guillerm Annabelle Couvert Abdeltif Amrane Edith Norrant Audrey Breton éric Dumont | 2017 | Chinese Journal of Chemical Engineering2017，25，10： | 2 |
| 8 | Is There a Possibility of a Cure in Patients With Colorectal Peritoneal Carcinomatosis Amenable to Complete Cytoreductive Surgery and Intraperitoneal Chemotherapy?显示文摘 | Diane Goéré David Malka Dimitri Tzanis Vinicius Gava Valérie Boige Clarisse Eveno Léon Maggiori Frédéric Dumont Michel Ducreux Dominique Elias | 2013 | Annals of Surgery2013，，6： | 2 |
| 9 | Diurnal and nocturnal blood pressure drops in patients with focal ischemic glaucoma 显示文摘 | Bechetoille A Dumont HB | 1994 | Graefes Arch Clin Exp Ophthalmol1994，232，： | 2 |
| 10 | Biogeography of rotifers显示文摘 | Henri J. Dumont | | Hydrobiologia0，，： | 2 |
| 11 | Preferential activation of capecitabine in tumor following oral administration to colorectal cancer patients显示文摘 | Schuller J Cassidy J Dumont E | 2000 | Cancer Chemother Pharmacol2000，45，： | 2 |
| 12 | Prise en charge chirurgicale de la pancréatite chronique显示文摘 | Jean-Marc Regimbeau Frédéric Dumont Thierry Yzet Denis Chatelain éric Bartoli Franck Brazier Olivier Bréhant Jean-Louis Dupas Fran?ois Mauvais Richard Delcenserie | 2007 | Gastroenterologie Clinique et Biologique2007，，8： | 2 |
| 13 | Definition of Patients Presenting a High Risk of Developing Peritoneal Carcinomatosis After Curative Surgery for Colorectal Cancer: A Systematic Review显示文摘 | Charles Honoré Diane Goéré Amine Souadka Frédéric Dumont Dominique Elias | 2013 | Annals of Surgical Oncology2013，，1： | 2 |
| 14 | Chronic Subdural Hematoma: A Sentinel Health Event显示文摘 | Travis M. Dumont Anand I. Rughani Tara Goeckes Bruce I. Tranmer | 2012 | World Neurosurgery2012，，： | 2 |
| 15 | The wide spectrum of multidrug resistance 3 deficiency: From neonatal cholestasis to cirrhosis of adulthood显示文摘 | Emmanuel Jacquemin J. Marleen L. De Vree Danièle Cresteil Etienne M. Sokal Ekkehard Sturm Micheline Dumont George L. Scheffer Marianne Paul Martin Burdelski Piter J. Bosma Olivier Bernard Michelle Hadchouel Ronald P.J. Oude Elferink | 2001 | Gastroenterology2001，，6： | 2 |
| 16 | 用心脏磁共振成像解释肥厚型心肌病的心电图异常显示文摘Aims: To clarify the mechanisms of electrocardiographic abnormalities in hypertrophic cardiomyopathy, 102 patients were examined with cardiac magnetic resonance. Distribution and magnitude of hypertrophy and late-enhancement were correlated with electrocardiographic abnormalities. Methods and results: Abnormal Q waves were associated with greater upper anterior septal thickness(22±7 mm vs. 18±5 mm, P=0.001) and increased ratios of upper anterior septum to mean inferolateral(P=0.01), anterolateral(P=0.002), apical(P=0.001), and right ventricular(P=0.001) wall thickness. There was no relation between abnormal Q waves and late-enhancement, except for Q waves ≥40 ms(P=0.02). Conduction disturbances and absent septal Q waves were associated with late-enhancement(89 vs. 45%, P=0.01 and 75 vs. 39%, P=0.002, respectively). The depth of negative T waves was related to an increased ratio of the mean thickness between apical and basal level(P=0.01), and to the presence of apical late-enhancement(P=0.03). Conclusion: Abnormal Q waves reflect the interrelation between upper anterior septal thickness and other regions of the left and right ventricles, and wider Q waves are associated with late-enhancement. Conduction disturbances and absent septal Q waves are associated with late-enhancement. The depth of negative T waves is related to craniocaudal asymmetry and apical late-enhancement. | Dumont C.A. Monserrat L. Soler R. 刘少伟 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，，12： | 2 |
| 17 | Tie receptors:new modulators of angiogenic and lymphangiogenic responses显示文摘 | Jones N Iljin K Dumont DJ | 2001 | Nat Rev Mol Cell Biol2001，2，： | 1 |
| 18 | Pharmacological modulation of insulin resistance and hyperinsulinemia in polycystic ovary syndrome显示文摘 | Verma S Mather K Dumont AS | 1998 | The Endocrinologist1998，8，6： | 1 |
| 19 | Grain boundary versus transgranular ductile failure显示文摘 | Pardoen T Dumont D Brechet Y Deschamps A | | J Mech Phys Solids0，51，： | 1 |
| 20 | activates Bak and causes disruption of a Bak-Mcll complex 显示文摘 | Leu J I Dumont P Mitochondrial p53 Hafey M | 2004 | Nat Cell Biol2004，6，5： | 1 |
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