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| 1 | Prognostic factors of refractory NSCLC patients receiving anlotinib hydrochloride as the third-or further-line treatment显示文摘Objective:Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor,fibroblast growth factor receptor,platelet-derived growth factor receptor,c-Kit,and c-MET;therefore,it exhibits both antitumor and anti-angiogenetic activities.A phase III trial has shown that anlotinib improved progression-free survival(PFS)and overall survival(OS)in patients with advanced non-small cell lung cancer(NSCLC),who presented with progressive disease or intolerance after standard chemotherapy.This study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the treatment.Methods:Data were collected from March 2015 to January 2017 from a randomized,double-blind,placebo-controlled,multicenter,phase III trial of anlotinib(ALTER0303).A total of 437 patients were enrolled and randomly allocated(2:1)to the anlotinib and placebo groups.Kaplan–Meier analysis and log-rank test were performed to compare PFS and OS.Cox proportional hazards model was adopted for multivariate prognostic analysis.Results:Multivariate analysis indicated that high post-therapeutic peripheral blood granulocyte/lymphocyte ratio and elevated alkaline phosphatase levels were independent risk factors for PFS.Meanwhile,elevated thyroid-stimulating hormone,blood glucose,and triglyceride levels;hypertension;and hand–foot syndrome were independent protective factors of PFS.High posttherapeutic peripheral blood granulocyte/lymphocyte ratio,an Eastern Cooperative Oncology Group(ECOG)score≥2,and the sum of the maximal target lesion length at baseline were independent risk factors of OS,and hypertriglyceridemia was an independent protective factor of OS.Conclusions:This study preliminarily explored the possible factors that affected PFS and OS after anlotinib treatment in patients with advanced refractory NSCLC,and the baseline characteristics of the therapeutically dominant populations were then identified. | Jing Wang Yizhuo Zhao Qiming Wang Li Zhang Jianhua Shi Zhehai Wang Ying Cheng Jianxing He Yuankai Shi Hao Yu Yang Zhao Weiqiang Chen Yi Luo Xiuwen Wang Kejun Nan Faguang Jin Jian Dong Baolan Li Zhujun Liu Baohui Han Kai Li | 2018 | Cancer Biology & Medicine2018，15，4： | 46 |
| 2 | Formation and evolution mechanisms of large-clusters during rapid solidification process of liquid metal Al显示文摘A molecular dynamics simulation study has been performed for the formation and evolution characteristics of nano-clusters in a large-scale system consisting of 400000 atoms of liquid metal Al. The center-atom method combined with pair-bond analysis technique and cluster-type index method (CTIM) has been applied here to describe the structural configurations of various basic clusters. It is demonstrated that both the 1551 bond-type and the icosahedral cluster (12 0 12 0) constructed by 1551 bond-types are dominant among all the bond-types and cluster-types, respectively, in the system and play a critical role in the microstructure transitions of liquid metal Al. The nano-clusters (containing up to 150 atoms) are formed by the combination of some middle and small clusters with distinctly different sizes, through mutual competition by unceasing annex and evolution in a seesaw manner (in turn of obtaining and losing),which do not occur as the multi-shell structures accumulated with an atom as the center and the surrounding atoms are arranged according to a certain rule. This is the essential distinction of nano-cluster in liquid metal from those obtained by gaseous deposition, ionic spray methods, and so on. Though the nano-clusters differ from each other in shape and size, all of them possess protruding corners that could become the starting points of various dendrite structures in the solidification processes of liquid metals. | LIU Rangsu, DONG Kejun, LIU Fengxiang, ZHENG Caixing, LIU Hairong & LI Jiyong Department of Applied Physics, Hunan University, Changsha 410082, China College of Materials Science and Engineering, Hunan University, Changsha 410082, China College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China | 2005 | Science China(Physics,Mechanics & Astronomy)2005，48，1： | 7 |
| 3 | Nanostructured transition metal nitride composites as energy storage material显示文摘There are growing demands for the next generation lithium ion batteries with high energy density as well as high power performance for renewable energy storage and electric vehicles application.Recently,nanoscale materials with outstanding energy storage capability have received considerable attention due to their unique effect caused by the reduced dimensions.This review describes some recent developments of our group in research of transition metal nitride nanocomposites in application of energy storage,especially for lithium ion battery and supercapacitor.The strategies of mixed conduction(electron and ion) network with a favorable charge transportation interface in the design of the nanocomposites for such devices are highlighted. | YUE YanHua HAN PengXian DONG ShanMu ZHANG KeJun ZHANG ChuanJian SHANG ChaoQun CUI-GuangLei | 2012 | Chinese Science Bulletin2012，57，32： | 3 |
| 4 | Simulation study on the formation and transition properties of cluster structures in liquid metals during rapid cooling processes显示文摘 | Caixing Zheng Rangsu Liu Kejun Dong Ping Peng Hairong Liu Zhongyu Xu Xiaoyong Lu | 2002 | Science in China Series A: Mathematics2002，，2： | 1 |
| 5 | Pressure-induced robust emission in a zero-dimensional hybrid metal halide (C_(9)NH_(20))_(6)Pb_(3)Br_(12)显示文摘Zero-dimensional(0D)hybrid metal halides are under intensive investigation owing to their unique physical properties,such as the broadband emission from highly localized excitons that is promising for white-emitting lighting.However,fundamental understanding of emission variations and structure–property relationships is still limited.Here,by using pressure processing,we obtain robust exciton emission in 0D(C_(9)NH_(20))_(6)Pb_(3)Br_(12) at room temperature that can survive to 80 GPa,the recorded highest value among all the hybrid metal halides.In situ experimental characterization and first-principles calculations reveal that the pressure-induced emission is mainly caused by the largely suppressed phonon-assisted nonradiative pathway.Lattice compression leads to phonon hardening,which considerably weakens the exciton–phonon interaction and thus enhances the emission.The robust emission is attributed to the unique structure of separated spring-like[Pb_(3)Br_(12)]^(6−)trimers,which leads to the outstanding stability of the optically active inorganic units.Our findings not only reveal abnormally robust emission in a 0D metal halide,but also provide new insight into the design and optimization of local structures of trimers and oligomers in lowdimensional hybrid materials. | Mengting Chen Songhao Guo Kejun Bu Sujin Lee Hui Luo Yiming Wang Bingyan Liu Zhipeng Yan Hongliang Dong Wenge Yang Biwu Ma Xujie Lü | 2021 | Matter and Radiation at Extremes2021，6，5： | 1 |
| 6 | Experimental and numerical study of a gas cyclone with a central filter显示文摘This paper studies a novel gas cyclone with a cylindrical fiter face installed in the center from the vortex finder to the bottom hopper.The experimental results show that this composite cyclone has a higher collection fficiency and a lower pressure drop than the original cyclone.The mechanisms for the improvement are analyzed by both physical experiments and numerical simulations.By measuring dust samples collected at different places it is revealed that the center filter can prevent fine particles from entering the inner vortex and escaping,which accounts for the increase of the collection eficiency.In addition,the flow field of the composite cyclone is simulated by computational fluid dynamics and compared with that of the original cyclone.The analysis shows that with the filter layer installed,the swirling flow disappears in the vortex finder,which decreases the kinetic energy dissipation and hence lowers the pressure drop. | Zihui Zhang Sijie Dong Kejun Dong Li'an Hou Wenzheng Wang Yi Wei Bo Wang | 2022 | Particuology2022，20，4： | 1 |
| 7 | Circulating microRNA expressions in colorectal cancer as predictors of response to chemotherapy显示文摘 | Jian Zhang KeJun Zhang MeiSheng Bi XueLong Jiao DianLiang Zhang Qian Dong | 2014 | Anti-Cancer Drugs2014，，3： | 1 |
| 8 | ∑HfF_5^- current monitoring with off-axis Faraday cup in AMS measurement of ^(182)Hf at CIAE显示文摘In order to reduce the systematic uncertainties caused by the sequential injection in AMS measurement of ^(182)Hf,a technique for instantaneous monitoring of off-axis∑HfF_5^- current was developed in the AMS laboratory at China Institute of Atomic Energy(CIAE).The stability and reliability of this method have been experimentally verified.As a result,the accuracy for AMS measurement of^(182)Hf was significantly improved. | LI Zhenyu HE Ming DONG Kejun LI Chaoli HE Guozhu HE Xianwen ZHANG Wei HU Hao ZHENG Guowen LI Heng WU Shaoyong JIANG Shan | 2012 | Nuclear Science and Techniques2012，23，4： | 1 |
| 9 | Locked nucleic acids based DNA circuits with ultra-low leakage显示文摘DNA circuits based on toehold-mediated DNA strand displacement reaction are powerful tools owing to their programmability and predictability.However,performance and practical application of the circuits are greatly restricted by leakage,which refers to the fact that there is no input(invading strand)in the circuit,and the output signal is still generated.Herein,we constructed locked nucleic acids-based DNA circuits with ultra-low leakage.High binding affinity of LNA(locked nucleic acid)-DNA/LNA suppressed the leakage by inhibiting the breathing effect.Based on the strategy,we have built various low-leakage DNA circuits,including translator circuit,catalytic hairpin assembly(CHA)circuit,entropy-driven circuit(EDC),and seesaw circuit.More importantly,our strategy would not affect the desired main reactions:The output signal remained above 85%for all tested circuits,and the signalto-noise ratios were elevated to 148.8-fold at the most.We believe our strategy will greatly promote the development and application of DNA circuits-based DNA nanotechnology. | Hao Hu Liquan Liu Lei Zhang Wei Zhang Kejun Dong Bei Yan Yaoqin Mu Mengdi Shi Longjie Li Xianjin Xiao | 2023 | Nano Research2023，16，1： | 0 |
| 10 | A new method for evaluating the quality of single sperm by detecting reactive oxygen species显示文摘Sperm damage caused by reactive oxygen species(ROS) is one of the main causes of male infertility.Therefore, the level of ROS in sperm is an important indicator for the diagnosis and prognosis of male infertility. Herein, we constructed a single sperm ROS detection method(SSRDM) with an optical microprobe fabricated via focused ion beam process. The micro-probe is used to separately excite fluorescence in the sperm and the area around the sperm after ROS staining, and the difference in fluorescence values can reflect the level of ROS in the sperm. We collected 102 semen samples and 72 of them were divided into asthenozoospermia and non-asthenozoospermia groups. SSRDM and flow cytometry were used to detect the ROS levels of the two groups. The results of SSRDM showed that the ROS levels of asthenozoospermia group were higher than that of non-asthenozoospermia group(P = 0.002), while the results of flow cytometry indicated no difference(P = 0.152). In terms of ROS levels, compared with flow cytometry, SSRDM has a stronger ability to distinguish between those two groups, providing a reliable basis for assessment of sperm quality. Another 30 semen samples were used to investigate temperature and temporal variability of SSRDM to ensure the stability and accuracy of this method. Overall, we have developed a method that can quantitatively detect fluorescent substances in sperm at the single-cell level supplying evidence for diagnosis and prognosis of male infertility. | Hao Hu Bei Yan Wei Zhang Wenbo Yan Liquan Liu Xiaofeng Tang Kejun Dong Longjie Li Xianjin Xiao Chengliang Xiong | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
| 11 | The initial exploration for ^(26)Al chronology in deep-sea ferromanganese crust显示文摘Background The deep-sea ferromanganese crust(DSFC)is a natural archive for recording the history of the Earth’s evolution,as one of the most common authigenic assemblages in marine sediments.Although the depositional age dating using meteoric ^(10)Be has been successfully used in the study on the chronology of DSFC,the research on ^(26)Al has not seen relevant reports in this aspect due to the influence of factors such as measurement sensitivity and ^(26)Al in situ production.Method The first exploration for ^(26)Al chronology in DSFC was carried out by using accelerator mass spectrometry(AMS)measurements of ^(10)Be and ^(26)Al,and the comparison of relationship between isotopic ratios and concentrations of Al and Be.Results The growth rates of G.R=(1.44±0.09)mm/Ma,(3.58±0.29)mm/Ma,(1.52±0.10)mm/Ma and(2.93±0.14)mm/Ma are derived using ^(10)Be/^(9)Be,^(26)Al/^(27)Al ratios,^(10)Be and ^(26)Al concentrations,respectively.Conclusion The ^(26)Al chronological methods have been explored based on a DSFC sample and encouraging results were obtained.The results are preliminary and insufficient;some information is still needed to explain the difference between ^(26)Al and ^(10)Be chronology. | Kejun Dong Ying Hu Lifeng Cui Jiaqi Zhang Sheng Xu Hongtao Shen | 2023 | Radiation Detection Technology and Methods2023，7，2： | 0 |
| 12 | Measurement of the natural ^(36)Cl and ^(236)U in uranium mineral with accelerator mass spectrometry显示文摘The concentration of the natural ultra-trace radionuclides CI and U in the uranium depended on the neutron flux.In this article,a method for measuring 36C1 and 236U in the same uranium mineral with accelerator mass spectrometry was developed in China Institute of Atomic Energy,providing a protocol of the potential application of 236U in uranium mining,environmental,and geological research.The two samples were from Guangxi and Shanxi province,China,and their ratios 36Cl/C1 and 236U/238U were measured.More experimental data conduced to understand the natural nuclides in the uranium mineral.We plan to conduct more efforts on the research. | WANG Xianggao JIANG Shan HE Ming DONG Kejun GUAN Yongjing | 2013 | Nuclear Science and Techniques2013，24，2： | 0 |
| 13 | Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO显示文摘The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main detector.Some of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator detectors.In this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/g.With ten years of data acquisition,approximately 60,000 signal and 30,000 background events are expected.This large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation framework.IfDelta m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith angle.Moreover,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment. | Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera Daojin Hong YuenKeung Hor Shaojing Hou Yee Hsiung Bei-Zhen Hu Hang Hu Jianrun Hu Jun Hu Shouyang Hu Tao Hu Zhuojun Hu Chunhao Huang Guihong Huang Hanxiong Huang Qinhua Huang Wenhao Huang Xingtao Huang Yongbo Huang Jiaqi Hui Wenju Huo Cédric Huss Safeer Hussain Antonio Insolia Ara Ioannisian Daniel Ioannisyan Roberto Isocrate Kuo-Lun Jen Xiaolu Ji Xingzhao Ji Huihui Jia Junji Jia Siyu Jian Di Jiang Xiaoshan Jiang Ruyi Jin Xiaoping Jing Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Kampmann Li Kang Michael Karagounis Narine Kazarian Amir Khan Waseem Khan Khanchai Khosonthongkee Patrick Kinz Denis Korablev Konstantin Kouzakov Alexey Krasnoperov Svetlana Krokhaleva Zinovy Krumshteyn Andre Kruth Nikolay Kutovskiy Pasi Kuusiniemi Tobias Lachenmaier Cecilia Landini Sébastien Leblanc Frederic Lefevre Liping Lei Ruiting Lei Rupert Leitner Jason Leung Demin Li Fei Li Fule Li Haitao Li Huiling Li Jiaqi Li Jin Li Kaijie Li Mengzhao Li Nan Li Nan Li Qingjiang Li Ruhui Li Shanfeng Li Shuaijie Li Tao Li Weidong Li Weiguo Li Xiaomei Li Xiaonan Li Xinglong Li Yi Li Yufeng Li Zhibing Li Ziyuan Li Hao Liang Hao Liang Jingjing Liang Jiajun Liao Daniel Liebau Ayut Limphirat Sukit Limpijumnong Guey-Lin Lin Shengxin Lin Tao Lin Jiajie Ling Ivano Lippi Fang Liu Haidong Liu Hongbang Liu Hongjuan Liu Hongtao Liu Hu Liu Hui Liu Jianglai Liu Jinchang Liu Min Liu Qian Liu Qin Liu Runxuan Liu Shuangyu Liu Shubin Liu Shulin Liu Xiaowei Liu Yan Liu Alexey Lokhov Paolo Lombardi Claudio Lombardo Kai Loo Chuan Lu Haoqi Lu Jingbin Lu Junguang Lu Shuxiang Lu Xiaoxu Lu Bayarto Lubsandorzhiev Sultim Lubsandorzhiev Livia Ludhova Fengjiao Luo Guang Luo Pengwei Luo Shu Luo Wuming Luo Vladimir Lyashuk Qiumei Ma Si Ma Xiaoyan Ma Xubo Ma Jihane Maalmi Yury Malyshkin Fabio Mantovani Francesco Manzali Xin Mao Yajun Mao Stefano MMari Filippo Marini Sadia Marium Cristina Martellini Gisele Martin-Chassard Agnese Martini Davit Mayilyan Axel Müller Ints Mednieks Yue Meng Anselmo Meregaglia Emanuela Meroni David Meyhöfer Mauro Mezzetto Jonathan Miller Lino Miramonti Salvatore Monforte Paolo Montini Michele Montuschi Nikolay Morozov Pavithra Muralidharan Massimiliano Nastasi Dmitry VNaumov Elena Naumova Igor Nemchenok Alexey Nikolaev Feipeng Ning Zhe Ning Hiroshi Nunokawa Lothar Oberauer Juan Pedro Ochoa-Ricoux Alexander Olshevskiy Domizia Orestano Fausto Ortica Hsiao-Ru Pan Alessandro Paoloni Nina Parkalian Sergio Parmeggiano Teerapat Payupol Yatian Pei Nicomede Pelliccia Anguo Peng Haiping Peng Frédéric Perrot Pierre-Alexandre Petitjean Fabrizio Petrucci Luis Felipe Piñeres Rico Oliver Pilarczyk Artyom Popov Pascal Poussot Wathan Pratumwan Ezio Previtali Fazhi Qi Ming Qi Sen Qian Xiaohui Qian Hao Qiao Zhonghua Qin Shoukang Qiu Muhammad Rajput Gioacchino Ranucci Neill Raper Alessandra Re Henning Rebber Abdel Rebii Bin Ren Jie Ren Taras Rezinko Barbara Ricci Markus Robens Mathieu Roche Narongkiat Rodphai Aldo Romani Bedřich Roskovec Christian Roth Xiangdong Ruan Xichao Ruan Saroj Rujirawat Arseniy Rybnikov Andrey Sadovsky Paolo Saggese Giuseppe Salamanna Simone Sanfilippo Anut Sangka Nuanwan Sanguansak Utane Sawangwit Julia Sawatzki Fatma Sawy Michaela Schever Jacky Schuler Cédric Schwab Konstantin Schweizer Dmitry Selivanov Alexandr Selyunin Andrea Serafini Giulio Settanta Mariangela Settimo Muhammad Shahzad Vladislav Sharov Gang Shi Jingyan Shi Yongjiu Shi Vitaly Shutov Andrey Sidorenkov FedorŠimkovic Chiara Sirignano Jaruchit Siripak Monica Sisti Maciej Slupecki Mikhail Smirnov Oleg Smirnov Thiago Sogo-Bezerra Julanan Songwadhana Boonrucksar Soonthornthum Albert Sotnikov Ondrej Sramek Warintorn Sreethawong Achim Stahl Luca Stanco Konstantin Stankevich DušanŠtefánik Hans Steiger Jochen Steinmann Tobias Sterr Matthias Raphael Stock Virginia Strati Alexander Studenikin Gongxing Sun Shifeng Sun Xilei Sun Yongjie Sun Yongzhao Sun Narumon Suwonjandee Michal Szelezniak Jian Tang Qiang Tang Quan Tang Xiao Tang Alexander Tietzsch Igor Tkachev Tomas Tmej Konstantin Treskov Andrea Triossi Giancarlo Troni Wladyslaw Trzaska Cristina Tuve Stefan van Waasen Johannes van den Boom Guillaume Vanroyen Nikolaos Vassilopoulos Vadim Vedin Giuseppe Verde Maxim Vialkov Benoit Viaud Cristina Volpe Vit Vorobel Lucia Votano Pablo Walker Caishen Wang Chung-Hsiang Wang En Wang Guoli Wang Jian Wang Jun Wang Kunyu Wang Lu Wang Meifen Wang Meng Wang Ruiguang Wang Siguang Wang Wei Wang Wenshuai Wang Xi Wang Xiangyue Wang Yangfu Wang Yaoguang Wang Yi Wang Yifang Wang Yuanqing Wang Yuman Wang Zhe Wang Zheng Wang Zhimin Wang Zongyi Wang Apimook Watcharangkool Lianghong Wei Wei Wei Yadong Wei Liangjian Wen Christopher Wiebusch Steven Chan-Fai Wong Bjoern Wonsak Diru Wu Fangliang Wu Qun Wu Wenjie Wu Zhi Wu Michael Wurm Jacques Wurtz Christian Wysotzki Yufei Xi Dongmei Xia Yuguang Xie Zhangquan Xie Zhizhong Xing Benda Xu Donglian Xu Fanrong Xu Jilei Xu Jing Xu Meihang Xu Yin Xu Yu Xu Baojun Yan Xiongbo Yan Yupeng Yan Anbo Yang Changgen Yang Huan Yang Jie Yang Lei Yang Xiaoyu Yang Yifan Yang Haifeng Yao Zafar Yasin Jiaxuan Ye Mei Ye Ugur Yegin Frédéric Yermia Peihuai Yi Xiangwei Yin Zhengyun You Boxiang Yu Chiye Yu Chunxu Yu Hongzhao Yu Miao Yu Xianghui Yu Zeyuan Yu Chengzhuo Yuan Ying Yuan Zhenxiong Yuan Ziyi Yuan Baobiao Yue Noman Zafar Andre Zambanini Pan Zeng Shan Zeng Tingxuan Zeng Yuda Zeng Liang Zhan Feiyang Zhang Guoqing Zhang Haiqiong Zhang Honghao Zhang Jiawen Zhang Jie Zhang Jingbo Zhang Peng Zhang Qingmin Zhang Shiqi Zhang Tao Zhang Xiaomei Zhang Xuantong Zhang Yan Zhang Yinhong Zhang Yiyu Zhang Yongpeng Zhang Yuanyuan Zhang Yumei Zhang Zhenyu Zhang Zhijian Zhang Fengyi Zhao Jie Zhao Rong Zhao Shujun Zhao Tianchi Zhao Dongqin Zheng Hua Zheng Minshan Zheng Yangheng Zheng Weirong Zhong Jing Zhou Li Zhou Nan Zhou Shun Zhou Xiang Zhou Jiang Zhu Kejun Zhu Honglin Zhuang Liang Zong Jiaheng Zou | 2021 | Chinese Physics C2021，45，2： | 0 |
| 14 | Thermodynamics-guided two-way interlocking DNA cascade system for universal multiplexed mutation detection显示文摘Detection of point mutations in driver genes is of great significance for the early diagnosis,treatment,and prognostic evaluation of cancer.However,current detection methods do not offer versatility,specificity,and rapid performance simultaneously.Thus,multiple mutation detection processes are necessary,which results in long processing times and high costs.In this study,we developed a thermodynamics-guided two-way interlocking DNA cascade system for universal multiplexed mutation detection(TTI-CS).This strategy is based on the DNA probe,which changes the thermodynamic balance of the DNA cascade by the designed bubble structure,thereby achieving a good distinction between mutant and wild-type DNA.The designed method greatly shortens the detection time through two-way intrusion.In addition,this method only changes two inexpensive trigger and bridge sequences,which replace the specific and expensive nucleic acid probes used in analyses based on traditional DNA probe methods,thereby enabling multiple detections.We performed the detection of synthetic single-stranded DNA for the five mutation points and successfully detected in endometrial cancer specimens.The detection limit of this method is0.1%,which better meets the needs of clinical low-abundance multiple mutation detection.Overall,TTI-CS is currently one of the best methods for detecting multiple mutation detections. | Wei Zhang Liquan Liu Yangwei Liao Wan Shu Xiaofeng Tang Kejun Dong Zhihao Ming Xianjin Xiao Hongbo Wang | 2022 | Chinese Chemical Letters2022，33，1： | 0 |
| 15 | Effects of co-exposure to lead and manganese on learning and memory deficits显示文摘Lead(Pb) and manganese(Mn) are common neurotoxins. However, individuals are subject to co-exposures in real life, and it is therefore important to study these metals in combination. Weaning Sprague-Dawley rats were given ad libitum access to drinking water solutions containing Pb(100 mg/L), Mn(2.5 mg/m L) or a mixture, and each treatment had its own minocycline(50 mg/(kg·day)) supplement group. The results showed a significant difference in spatial memory and induction levels of hippocampal long-term potentiation(LTP) in all exposure groups when compared with controls. The combined-exposure group exhibited the most pronounced effect when compared with each of the single-metal exposure groups.Microglia displayed activation at day 3 after exposure alone or in combination, while astrocytes showed activation at day 5, accompanied by decreased expression levels of GLAST,GLT-1, and GS. Furthermore, the levels of glutamate in the synaptic cleft increased significantly. When microglial activation was inhibited by minocycline, the activation of astrocytes and the expression of GLAST, GLT-1, and GS were both reversed. In addition, upon minocycline treatment, hippocampal LTP impairment and cognitive injury were significantly alleviated in each of the exposure groups. These results suggest that combined exposure to Pb and Mn can cause greater effects on cognition and synaptic plasticity when compared to single-metal exposure groups. The reason may involve abnormal activation of microglia leading to excessive regulation of astrocytes, resulting in glutamate reuptake dysfunction in astrocytes and leading to perturbed cognition and synaptic plasticity. | Ruili Guan Tao Wang Xiaoru Dong Kejun Du Juan Li Fang Zhao Jie Xu Bin Li Gang Zheng Xuefeng Shen Baohua Cao Jing Wang Michael Aschner Mingchao Liu Rui Chen | 2022 | Journal of Environmental Sciences2022，34，11： | 0 |
| 16 | Comparison of prevention and treatment of portal vein thrombosis between proximal splenic vein ligation followed by postoperative transcatheter anticoagulant therapy and systemic anticoagulant therapy in patients with cirrhotic portal hypertension显示文摘Aims:Splenectomy combined with pericardial devascularization is one of the important methods to treat hypersplenism,gastrointestinal bleeding,and other complications caused by liver cirrhosis;however,it is accompanied by a high risk of portal vein thrombosis(PVT).This study aimed to explore the preventive and therapeutic effects of proximal splenic vein ligation(PSVL)with postoperative transcatheter anticoagulant therapy(TCAT)on PVT.Methods:This study retrospectively selected 143 patients with liver cirrhosis and portal hypertension,who received splenectomy combined with pericardial devascularization from June 30,2018 to June 30,2021.According to computed tomography photography,within 1 week before the operation,the patients were divided into a prevention group(without preoperative PVT,n=112)and a treatment group(preoperative PVT,n=31).Then,each group was subdivided based on the treatment and prevention measures into PSVL+TCAT(n=70)and systemic anticoagulant therapy(SAT)subgroups(n=73).The preventive and therapeutic effects of PSVL followed by TCAT on PVT were analyzed.Results:The operation time in the PSVL+TCAT subgroups was longer than that in the SAT subgroups(185±76 min vs.161±55 min;p<0.01).There was no difference between the two subgroups in terms of operative bleeding(345±82 mL vs.336±65 mL;p>0.50).There was no operative death,and all patients recovered uneventfully.In the prevention group,procedure-related complications occurred in two patients in the PSVL+TCAT subgroup(3.7%[2/54]),including one patient with slight pancreatitis and one patient with chylous leakage,owing to mobilization of the pancreas.The PVT incidence in the prevention group was significantly different between the two subgroups at postoperative 7th day,3rd month,and 6th month(PSVL+TCAT:0%,11.1%,and 5.6%vs.SAT:39.7%,31.0%,and 20.7%,respectively;all p<0.05).In the treatment group,the thrombus regression rate at postoperative 7th day and disappearance rates at the 3rd month and the 6th month of the PSVL+TCAT subgroup were significantly higher than those in the SAT subgroup after anticoagulant and thrombolysis therapy(PSVL+TCAT:75.0%,68.8%,and 87.5%vs.SAT:20.0%,26.7%,and 40.0%;all p<0.05).Conclusions:PSVL+TCAT reduces the risk of PVT after splenectomy and is safe and effective in treating PVT during surgery for portal hypertension. | Yang Bu Kejun Liu Mingguo Tian Baoding Li Liyun Wang Dong Jia Yong Yang Junhao Liu | 2023 | Portal Hypertension & Cirrhosis2023，2，3： | 0 |
| 17 | Progress in XCAMS at Tianjin University显示文摘Background A compact ^(14)C AMS system extended for ^(10)Be and ^(26)Al(XCAMS)was installed at Tianjin University in Octo-ber 2017.As an initial testing result,a detection limit of 4.4×10^(−16) for ^(14)C/^(12)C,3.8×10^(−15) for ^(10)Be/^(9)Be and 6.9×10^(−15) for ^(26)Al/^(27)Al was achieved,respectively.Method The system was gradually smoothed and optimized based on a series of standard,blank and real samples measurement.Results The detection limit was down to 4.0×10^(−16) for ^(14)C/^(12)C,2.2×10^(−15) for ^(10)Be/^(9)Be and 5.6×10^(−15) for ^(26)Al/^(27)Al,respectively.More than one thousand samples of ^(14)C,^(10)Be and ^(26)Al have been successfully measured and analyzed.Conclusion The cosmogenic multi-nuclide of ^(14)C,^(10)Be and ^(26)Al AMS has been available for studies in archaeology,Earth science and environmental science,and some significant jobs still need to be carried out in the near future. | Kejun Dong Yunchao Lang Sheng Xu | 2019 | Radiation Detection Technology and Methods2019，3，4： | 0 |
| 18 | DNA origami-based nano-hunter enriches low-abundance point mutations by targeting wild-type gene segments显示文摘Point mutations can be used as biomarkers to perform diagnosis for diseases. In this study, a nanorobot for low-abundance point mutation enrichment was constructed using DNA origami. The novel design achieved limits of detection of 0.1% and 1% for synthesized DNA samples and clinical gene samples, respectively. Resettability was a key property of this method, which also involved a simpler process, lower cost and shorter detection duration than traditional enrichment methods. This novel DNA nanorobot may enable the detection of tumor markers, potentially facilitating early cancer diagnosis. | Longjie Li Kejun Dong Xinyu Wang Meizhou Zhang Jun Li Andreas KNussler Xianjin Xiao Hongbo Wang Yuzhou Wu | 2022 | Chinese Chemical Letters2022，33，4： | 0 |
| 19 | Effect of packing method on packing formation and the correlation between packing density and interparticle force显示文摘The packing of cohesive particles is of paramount importance in many industries because the packing structure is closely related to process performance.A general relation between packing density and interparticle force was previously proposed based on packing structures formed without dynamic fluid flows.Its universality is examined here in two different packings,formed in settling and defluidization of static and dynamic fluids,respectively.First,it is shown that the packings of the same particles formed by two different methods have different structures because of different impact-induced pressures.Nevertheless,a one-to-one relationship between packing density and structural properties still holds regardless of the different packing methods,and the force distribution in those packings obeys similar rules.Finally,the packing densities obtained by the different methods are demonstrated to be universally correlated with the ratio of the interparticle force to the effective gravity.These findings indicate that different phenomena of particulate systems at a macro-or meso-scale may share similar microscopic origins,with the interparticle force playing a crucial role. | Yongli Wu Qinfu Hou Kejun Dong Aibing Yu | 2020 | Particuology2020，18，1： | 0 |
| 20 | The new AMS facility at Tianjin University显示文摘Introduction Accelerator mass spectrometry(AMS)has been used for the analysis of a lot nuclides in many scientific fields and is one of the most optimal methods to determine very low concentrations of long-lived nuclides.The XCAMS system is an extension of the Compact ^(14)C Accelerator Mass Spectrometer for ^(10)Be and ^(26)Al.A description of the first Chinese XCAMS system and initial performance of three nuclides of ^(14)C,^(10)Be,and ^(26)Al,respectively,will be reported.Experimental procedures Solid sample material(graphite,Al_(2)O_(3),and BeO)is loaded into cathode holders for AMS analysis.The negatively charged ions(C−,Al−,and BeO−)are extracted and accelerated to the terminal,broken-up,and some orbital electrons stripped off to form positively charged atomic ions,and accelerated further.In the post-acceleration region,the magnetic and electrostatic devices act on momentum and energy analysis,respectively.A multi-anode detector is used for the identification and detection of relevant isotopes and isobars.System performance The test criteria of three rare isotopes each were set for beam current intensity,measurement precision,and machine background.The corresponding material and cathode holder were,respectively,used for ^(14)C,^(10)Be,and ^(26)Al test.Several batches of real sample have already been analyzed by the new AMS system based on the acceptance test results.In addition,several secondary standards were measured to check the stability of the system.Conclusion The new XCAMS facility has been installed successfully,and the latest performance also showed that the machine is reliable enough,in general.Both the hardware components and software system were in good condition for accurate and precise data analysis in the near future. | Kejun Dong Yunchao Lang Nan Hu Jun Zhong Sheng Xu Thilo-Michael Hauser Ross Gan | 2018 | Radiation Detection Technology and Methods2018，2，1： | 0 |
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