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| 1 | Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases显示文摘Matrix metalloproteinases(MMPs) are members of the neutral proteinase family. They were previously thought to be anti-fibrotic because of their ability to degrade and remodel of extracellular matrix. However, recent studies have shown that MMPs are implicated in initiation and progression of kidney fibrosis through tubular cell epithelial–mesenchymal transition(EMT) as well as activation of resident fibroblasts, endothelial-mesenchymal transition(Endo MT) and pericyte-myofibroblast transdifferentiation. Interstitial macrophage infiltration has also been shown to correlate with the severity of kidney fibrosis in various chronic kidney diseases. MMPs secreted by macrophages, especially MMP-9, hasbeen shown by us to be profibrotic by induction of tubular cells EMT. EMT is mainly induced by transforming growth factor-β(TGF-β). However, MMP-9 was found by us and others to be up-regulated by TGF-β1 in kidney tubular epithelial cells and secreted by activated macrophages, resulting in EMT and ultimately kidney fibrosis. Therefore, MMP-9 may serve as a potential therapeutic target to prevent kidney fibrosis in chronic kidney disease. This review, by a particular focus on EMT, seeks to provide a comprehensive understanding of MMPs, especially MMP-9, in kidney fibrosis. | Hong Zhao Yanting Dong Xinrui Tian Thian Kui Tan Zhuola Liu Ye Zhao Yun Zhang David CH Harris Guoping Zheng | 2013 | World Journal of Nephrology2013，2，3： | 21 |
| 2 | Recombinant CC16 protein inhibits the production of pro-inflammatory cytokines via NF-KB and p38 MAPK pathways in LPS-activated RAW264,7 macrophages显示文摘积累的证据显示克莱拉房间 protein-16 (CC16 ) 有反煽动性的功能,尽管深奥分子的小径完全没被阐明。这里,我们评估了效果肿瘤坏死因素 alpha (TNF-) 的表示上的 recombinant 老鼠 CC16 (rCC16 ) , interleukin-6 (IL-6 ) ,和在 lipopolysaccharide (LPS ) 的 IL-8 刺激了老鼠巨噬细胞(RAW264.7 房间) 并且探索了内在的分子的机制。rCC16 在两个禁止了导致 LPS 的 TNF- , IL-6,和 IL-8 表示,这被发现送信人 ribonucleicacid (mRNA ) 水平和蛋白质以一种集中依赖者方式铺平,由即时反向的 transcriptase 聚合酶链反应和连接酶的 immunosorbent 试金示威了。如此的镇压效果被 transcriptional 活动和原子因素(NF ) 的脱氧核糖核酸酸绑定活动的抑制伴随 -B 然而并非使活跃之物蛋白质(AP )-1。西方的污点分析进一步表明 rCC16 禁止了原子 NF-B 和 NF-B 禁止的蛋白质 IB,和 p38 的 cytosolic NF-B, phosphorylation 和减小的减小的增加激活 mitogen 的蛋白质 kinase (MAPK ) 依赖者由在它的 p65 子单元的 Ser276 的 phosphorylation 的 NF-B 激活。而且, rCC16 被发现没另外在c6月N终端 kinase ,c6月,或c-Jun.的原子 translocation 的 phosphorylation 上有效果,TNF-的减小, IL-6 ,并且 IL-8 被颠倒内长的uteroglobin有约束力的蛋白质的水平什么时候被 RNA 干扰在 对待rCC16 、 对待LPS 的 RAW264.7 房间减少。我们的数据建议 rCC16 由在 RAW264.7 房间使 NF-B 和 p38 MAPK 然而并非 AP-1 失去活性压制调停 LPS 的煽动性的调停人 TNF- , IL-6,和 IL-8 生产。 | Min Pang Yangyang Yuan Dong Wang Ting Li Dan Wang Xiaohong Shi Min Guo Chunfang Wang Xinri Zhang Guoping Zheng Baofeng Yu Hailong Wang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 14 |
| 3 | Reversible 3D optical data storage and information encryption in photo-modulated transparent glass medium显示文摘Transparent glass has been identified as a vital medium for three-dimensional(3D)optical information storage and multi-level encryption.However,it has remained a challenge for directly writing 3D patterning inside a transparent glass using semiconductor blue laser instead of high-cost femtosecond laser.Here,we demonstrate that rare earth ions doped transparent glass can be used as 3D optical information storage and data encryption medium based on their reversible transmittance and photoluminescence manipulation.The color of tungsten phosphate glass doped with rare earth ions change reversibly from light yellow to blue upon alternating 473 nm laser illumination and temperature stimulation,resulting in the reversible luminescence modulation.The information data could be repeatedly written and erased in arbitrary 3D space of transparent glass,not only showing the ability of the excellent reproducibility and storage capacity,but also opening opportunities in information security.The present work expands the application fields of luminescent glass,and it is conducive to develop a novel 3D data storage and information encryption media. | Zhen Hu Xiongjian Huang Zhengwen Yang Jianbei Qiu Zhiguo Song Junying Zhang Guoping Dong | 2021 | Light(Science & Applications)2021，10，8： | 6 |
| 4 | Cloning and characterization of three cheB genes in Leptospira interrogans显示文摘活动性和趋化性系统为 leptospires 的毒力是批评的。有在 leptospires 定位的通常认为的趋化性相当或相同的事物的多重拷贝大染色体。从螺旋体 interrogans 紧张 Lai 的 CheB1 和 CheB3 被预言有一个全球象 CheB 一样领域,但是 CheB2 被预言仅仅有一个 C 终端受动器领域。以便验证三通常认为的 cheB 基因的功能,他们被克隆进 pQE31 向量然后分别地,在野类型的 Escherichia coli 紧张 RP437 和 cheB 有缺陷者紧张 RP4972 表示了。聚集的试金的结果和 CheB1 的预言的第三的结构和 L 的 CheB3。interrogans 紧张 Lai 建议一个 N 终端规章的领域的缺席可以是原因之一让 CheB2 的失败补充 E。coli cheB 异种。而且, CheB2 在 leptospires 的相互作用网络完全连接到 CheR1 和 CheR3。一起拿,这些结果显示 CheB2 不能独自工作,并且在某些生理的条件下面,工作可以要求 CheB3 和 CheR1。趋化性基因相当或相同的事物的多重拷贝的存在建议了那 L。interrogans 紧张 Lai 可能有一条更复杂的化学感应的小径。 | Ke Dong Qingtian Li Chang Liu Yunyi Zhang Guoping Zhao Xiaokui Guo | 2010 | Acta Biochimica et Biophysica Sinica2010，42，3： | 5 |
| 5 | Subtyping of type A influenza by sequencing the variable regions of HA gene specifically amplified with RT-PCR显示文摘The outbreak of a novel influenza A(H1N1) virus across the globe poses a threat to human health.It is of paramount importance to develop a rapid,reliable and inexpensive diagnostic procedure.Based on the bioinformatic information from public database,primers specific for influenza A virus surface protein haemagglutinin(HA) of several subtypes(including H1,H2,H3,H5,H7 and H9) were designed.Primer-specific PCR products were subjected to sequencing for accurately distinguishing H1 and H3 subtypes from others.This sequencing-based detection method will not only be applied to rapid detection and simultaneous subtype identification of new influenza A virus H1N1,but also provide the strategies to monitor other new types ofinfluenza virus with explosive potential. | YAN An DING GuoHui ZHOU ZhenFeng DONG Hui ZHANG YaKun ZHU Lei HE YunGang ZHANG GuoQing LI YiXue SUN Bing HUANG Zhong LAN Ke JIN Li WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang DAI JianXin GUO YaJun WANG Hao CHE XiaoYan WU Fan YUAN ZhenGan ZHANG Xi CAO ZhiWei ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi ZHAO GuoPing JIN WeiRong XIONG Hui | 2009 | Chinese Science Bulletin2009，54，13： | 3 |
| 6 | Structure modeling and spatial epitope analysis for HA protein of the novel H1N1 influenza virus显示文摘In recent months,a novel influenza virus H1N1 broke out around the world.With bioinformatics technology,the 3D structure of HA protein was obtained,and the epitope residues were predicted with the method developed in our group for this novel flu virus.58 amino acids were identified as potential epitope residues,the majority of which clustered at the surface of the globular head of HA protein.Although it is located at the similar position,the epitope of HA protein for the novel H1N1 flu virus has obvious differences in the electrostatic potential compared to that of HA proteins from previous flu viruses. | WU Di XU TianLei SUN Jing DAI JianXin DING GuoHui HE YunGang ZHOU ZhengFeng XIONG Hui DONG Hui JIN WeiRong BIAN Chao JIN Li WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang WANG Hao CHE XiaoYan HUANG Zhong LAN Ke SUN Bing WU Fan YUAN ZhenAn ZHANG Xi ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi GUO YaJun ZHAO GuoPing LI YiXue CAO ZhiWei | 2009 | Chinese Science Bulletin2009，54，13： | 2 |
| 7 | The mobilization of rat’s mesenchymal stem cells into peripheral blood by LiCL and its potency differentiation显示文摘Mesenchymal stem cells (MSCs) are multipotent cells, which can differentiate into different tissues. It is still controversial whether MSCs can be isolated from adult peripheral blood (PB) under normal conditions and whether they can be mobilized in a way similar to that of hematopoietic stem cells (HSCs). In this study, rat MSCs circulating in the PB under normal conditions can be isolated and cultured, and MSCs from PB and BM can be mobilized by LiCL. The mobilized MSCs can be induced to differentiate into neuron by such factors as β-mercaptoethanol and supernatants of nerve cell cultures. The present study provides a broader perspective on the repair of neural trauma. | DENG dun ZOU ZhongMin ZHOU TaoLi AI GuoPing WANG JunPing DONG ShiWu SU YongPing | 2008 | Chinese Science Bulletin2008，53，17： | 2 |
| 8 | SarA influences the sporulation and secondary metabolism in Streptomyces coelicolor M145显示文摘细丝状的细菌 Streptomyces 展览包含词法区别和第二等的新陈代谢的一个复杂生命周期。通常认为的膜蛋白质基因 sarA (sco4069 ) ,孢子形成和抗菌素生产联系了基因 A,部分在 Streptomyces coelicolor M145 被描绘。基因产品不描绘了功能的领域并且高度在 Streptomyces 被保存。与野类型的 M145 相比, sarA 异种加速了孢子形成并且戏剧性地减少了 actinorhodin 和 undecylprodigiosin 的生产。反向的抄写聚合酶链反应分析证明 SarA 由控制许多 actII-orf4 和红 Z 送信人 RNA 影响了抗菌素生产。 | Xijun Ou Bo Zhang Lin Zhang Kai Dong Chun Liu Guoping Zhao Xiaoming Ding | 2008 | Acta Biochimica et Biophysica Sinica2008，40，10： | 2 |
| 9 | Fracture identification and evaluation using conventional logs in tight sandstones:A case study in the Ordos Basin,China显示文摘Fractures are of great significance to tight oil and gas development.Fracture identification using conventional well logs is a feasible way to locate the underground fractures in tight sandstones.However,there are three problems affecting its interpretation accuracy and practical application,namely weak well log responses of fractures,a lack of specific logs for fracture prediction,and relative change omission in log responses.To overcome these problems and improve fracture identification accuracy,a fracture indicating parameter(FIP)method composed of a comprehensive index method(CIM)and a comprehensive fractal method(CFM)is introduced.The CIM tries to handle the first problem by amplifying log responses of fractures.The CFM addresses the third one using fractal dimensions.The flexible weight parameters corresponding to logs in the CIM and CFM make the interpretation possible for wells lacking specific logs.The reconstructed logs in the CIM and CFM try to solve the second problem.It is noted that the FIP method can calculate the probability of fracture development at a certain depth,but cannot show the fracture development degree of a new well compared with other wells.In this study,a formation fracture intensity(FFI)method is also introduced to further evaluate fracture development combined with production data.To test the validity of the FIP and FFI methods,fracture identification experiments are implemented in a tight reservoir in the Ordos Basin.The results are consistent with the data of rock core observation and production,indicating the proposed methods are effective for fracture identification and evaluation. | Shaoqun Dong Lianbo Zeng Wenya Lyu Dongling Xia Guoping Liu Yue Wu Xiangyi Du | 2020 | Energy Geoscience2020，1，3： | 2 |
| 10 | Microstructure and electrical properties of Sc 2 O 3 -doped ZnO–Bi 2 O 3 -based varistor ceramics显示文摘 | Dong Xu Xiaonong Cheng Guoping Zhao Juan Yang Liyi Shi | 2010 | Ceramics International2010，，3： | 1 |
| 11 | Raman scattering studies of the Ge-In sulfide glasses显示文摘 | TAO Haizheng MAO Shun DONG Guoping | 2006 | Solid State Commun2006，137，8： | 1 |
| 12 | Reduction of Patulin in Apple Cider by UV Radiation显示文摘 | Dong Qingfang Manns David C Feng Guoping Yue Tianli Churey John J Worobo Randy W | 2010 | Journal of Food Protection2010，，1： | 1 |
| 13 | Learning with progressivetransductive support vector machine显示文摘 | YISONG C GUOPING W DONG S | 2003 | Pattern Recognition Let-ter2003，24，12： | 1 |
| 14 | Learning with progressive transductive support vector machine显示文摘 | Yisong C Guoping W Dong Shihai | 2003 | Pattern Recognition Letters2003，24，12： | 1 |
| 15 | Fabrication and optical properties of Y2O3∶ Eu3+ nanofibers prepared by electrospinning显示文摘 | DONG Guoping CHI Yingzhi XIAO Xiudi | 2009 | Optics Express2009，17，22： | 1 |
| 16 | Synthesis of K 2 SiF 6: Mn 4+ Phosphor from SiO 2 Powders via Redox Reaction in HF / KMnO 4 Solution and Their Application in Warm‐White LED显示文摘 | Chenxing Liao Renping Cao Zhijun Ma Yang Li Guoping Dong Kaniyarakkal N. Sharafudeen Jianrong Qiu | 2013 | J. Am. Ceram. Soc2013，，11： | 1 |
| 17 | A Tomato MADS-Box Transcription Factor, SlMADS1, Acts as a Negative Regulator of Fruit Ripening1[W]显示文摘 | Tingting Dong Zongli Hu Lei Deng Yi Wang Mingku Zhu Jianling Zhang Guoping Chen | 2013 | PLANT PHYSIOLOGY2013，，2： | 1 |
| 18 | Experimental realization of nonadiabatic geometric gates with a superconducting Xmon qubit显示文摘Geometric phases are only dependent on evolution paths but independent of evolution details so that they possess some intrinsic noise-resilience features. Based on different geometric phases, various quantum gates have been proposed, such as nonadiabatic geometric gates based on nonadiabatic Abelian geometric phases and nonadiabatic holonomic gates based on nonadiabatic nonAbelian geometric phases. Up to now, nonadiabatic holonomic one-qubit gates have been experimentally demonstrated with superconducting transmons, where the three lowest levels are all utilized in operation. However, the second excited state of transmons has a relatively short coherence time, which results in a decreased fidelity of quantum gates. Here, we experimentally realize Abelian-geometric-phase-based nonadiabatic geometric one-qubit gates with a superconducting Xmon qubit. The realization is performed on the two lowest levels of an Xmon qubit and thus avoids the influence from the short coherence time of the second excited state. The experimental result indicates that the average fidelities of single-qubit gates can be up to 99.6% and 99.7% characterized by quantum process tomography and randomized benchmarking. | PeiZi Zhao ZhangJingZi Dong ZhenXing Zhang GuoPing Guo DianMin Tong Yi Yin | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，5： | 1 |
| 19 | Study on the structure dependent ultrafast third-order optical nonlinearity of GeS2- InzS3 chalcogenide glasses 显示文摘 | DONG Guoping TAO Haizheng CHU Saisai | 2007 | Opt Commun2007，270，2： | 1 |
| 20 | Root excretion and plant tolerance to cadmium toxicity: a review显示文摘 | DONG Jing MAO Weihua ZHANG Guoping | 2007 | Plant Soil and Environment2007，53，5： | 1 |
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