|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Practice guidelines for the pathological diagnosis of primary liver cancer: 2015 update显示文摘In 2010, a panel of Chinese pathologists reported the first expert consensus for the pathological diagnosis of primary liver cancers to address the many contradictions and inconsistencies in the pathological characteristics and diagnostic criteria for PLC. Since then considerable clinicopathological studies have been conducted globally, prompting us to update the practice guidelines for the pathological diagnosis of PLC. In April 18, 2014, a Guideline Committee consisting of 40 specialists from seven Chinese Societies(including Chinese Society of Liver Cancer, Chinese Anti-Cancer Association; Liver Cancer Study Group, Chinese Society of Hepatology, Chinese Medical Association; Chinese Society of Pathology, Chinese Anti-Cancer Association; Digestive Disease Group, Chinese Society of Pathology, Chinese Medical Association; Chinese Society of Surgery, Chinese Medical Association; Chinese Society of Clinical Oncology, Chinese Anti-Cancer Association; Pathological Group of Hepatobiliary Tumor and Liver Transplantation, Chinese Society of Pathology, Chinese Medical Association) was created for the formulation of the first guidelines for the standardization of the pathological diagnosis of PLC, mainly focusing on the following topics: gross specimen sampling, concepts and diagnostic criteria of small hepatocellular carcinoma(SHCC), microvascular invasion(MVI), satellite nodules,and immunohistochemical and molecular diagnosis. The present updated guidelines are reflective of current clinicopathological studies, and include a novel 7-point baseline sampling protocol, which stipulate that at least four tissue specimens should be sampled at the junction of the tumor and adjacent liver tissues in a 1:1 ratio at the 12, 3, 6 and 9 o'clock reference positions. For the purposes of molecular pathological examination, at least one specimen should be sampled at the intratumoral zone, but more specimens should be sampled for tumors harboring different textures or colors. Specimens should be sampled at both adjacent and distant peritumoral liver tissues or the tumor margin in order to observe MVI, satellite nodules and dysplastic foci/nodules distributed throughout the background liver tissues. Complete sampling of whole SHCC ≤ 3 cm should be performed to assess its biological behavior, and in clinical practice, therapeutic borders should be also preserved, even in SHCC. The diagnostic criteria of MVI and satellite nodules, immunohistochemical panels, as well as molecular diagnostic principles, such as clonal typing, for recurrent HCC and multinodule HCC were also proposed and recommended. The standardized process of pathological examination is aimed at ensuring the accuracy of pathological PLC diagnoses as well as providing a valuable frame of reference for the clinical assessment of tumor invasive potential, the risk of postoperative recurrence, long-term survival, and the development of individualized treatment regimens. The updated guidelines could ensure the accuracy of pathological diagnoses of PLC, and provide a valuable frame of reference for its clinical assessment. | Wen-Ming Cong Hong Bu Jie Chen Hui Dong Yu-Yao Zhu Long-Hai Feng Jun Chen 无 | 2016 | World Journal of Gastroenterology2016，22，42： | 81 |
| 3 | Clinical characteristics, diagnosis and management of respiratory distress syndrome in full-term neonates显示文摘然而,背景呼吸悲痛症候群(RDS ) 是新生的呼吸失败和新生的死亡的最普通的原因之一它的临床的特征与早熟的 RDS,和这些特征很不同很好没迄今为止被记录。这研究是在完整术语的出生不满一月的婴儿调查致病,临床的特征和 RDS 的管理策略,与开发为改进在有 RDS.Methods 的完整术语的出生不满一月的婴儿的结果的一个工作协议的目的有 RDS 的 125 个完整术语的婴儿的一个总数在这研究被注册。他们的临床并且实验室数据为分析 125 个案例包括了的完整术语的新生的 RDS.Results (1 ) 的特征被收集 94 男性和 31 个女婴儿,阴道交货在 45 种情况中发生在 80 种情况和剖腹产中。(2 ) RDS 的发作时间是(3.11 牧潯敶吗? | LIU Jing SHI Yun DONG Jian-ying ZHENG Tian LI Jing-ya LU Li-li LIU Jing-jing LIANG Jing ZHANG Hao FENG Zhi-chun | 2010 | Chinese Medical Journal2010，，19： | 79 |
| 4 | New eolian red clay sequence on the western Chinese Loess Plateau linked to onset of Asian desertification about 25 Ma ago显示文摘The expansion of inland Asia deserts has considerably influenced the environmental, social and economic activities in Asia. Aridification of inland Asia, especially timing of the initiation of Asian desertification, is a contentious topic in paleoclimatology. Late Cenozoic eolian loess-red clay sequences on the Chinese Loess Plateau, which possess abundant paleoclimatic and paleo-environmental information, can be regarded as an indicator of inland Asia desertification. Here we present a detailed magnetostratigraphic investigation of a new red clay sequence about 654 m in Zhuanglang located at the western Chinese Loess Plateau. Sedimentological, geochemical, mineralogical, and quartz morphological lines of evidence show that the red clay is of eolian origin. Magnetostratigraphic correlations indicate that this core sequence spans from 25.6 to 4.8 Ma, and typical eolian red clay appears as early as 25 Ma. This extends the lower limit of the red clay on the Chinese Loess Plateau from the previously thought early Miocene back into the late Oligocene. This new red clay record further implies that the inland Asia desertification was initiated at least by the late Oligocene. This sequence provides a unique high-resolution geological record for understanding the inland Asia desertification process since the late Oligocene. | QIANG XiaoKe AN ZhiSheng SONG YouGui CHANG Hong SUN YouBin LIU WeiGuo AO Hong DONG JiBao FU ChaoFeng WU Feng LU FengYan CAI YanJun ZHOU WeiJian CAO JunJi XU XinWen AI Li | 2011 | Science China Earth Sciences2011，54，1： | 73 |
| 5 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 6 | Efficacy and safety of bevacizumab plus chemotherapy in Chinese patients with metastatic colorectal cancer:a randomized phase Ⅲ ARTIST trial显示文摘The efficacy and safety of bevacizumab with modified irinotecan,leucovorin bolus,and 5-fluorouracil intravenous infusion(mIFL) in the first-line treatment of metastatic colorectal cancer(mCRC) has not been well evaluated in randomized clinical trials in Chinese patients.We conducted a phrase Ⅲ trial in which patients with previously untreated mCRC were randomized 2:1 to the mIFL [irinotecan(125 mg/m2),leucovorin(20 mg/m2) bolus,and 5-fluorouracil intravenous infusion(500 mg/m2) weekly for four weeks every six weeks] plus bevacizumab(5 mg/kg every two weeks) group and the mIFL group,respectively.Co-primary objectives were progression-free survival(PFS) and 6-month PFS rate.In total,214 patients were enrolled.Our results showed that addition of bevacizumab to mIFL significantly improved median PFS(4.2 months in the mIFL group vs.8.3 months in the bevacizumab plus mIFL group,P < 0.001),6-month PFS rate(25.0% vs.62.6%,P < 0.001),median overall survival(13.4 months vs.18.7 months,P = 0.014),and response rate(17% vs.35%,P = 0.013).Grades 3 and 4 adverse events included diarrhea(21% in the mIFL group and 26% in the bevacizumab plus mIFL group) and neutropenia(19% in the mIFL group and 33% in the bevacizumab plus mIFL group).No wound-healing complications or congestive heart failure occurred.Our results suggested that bevacizumab plus mIFL is effective and well tolerated as first-line treatment for Chinese patients with mCRC.Clinical benefit and safety profiles were consistent with those observed in pivotal phase Ⅲ trials with mainly Caucasian patients. | Zhong-Zhen Guan Jian-Ming Xu Rong-Cheng Luo Feng-Yi Feng Li-Wei Wang Lin Shen Shi-Ying Yu Yi Ba Jun Liang Dong Wang Shu-Kui Qin Jie-Jun Wang Jing He Chuan Qi Rui-Hua Xu | 2011 | Chinese Journal of Cancer2011，30，10： | 48 |
| 7 | Chinese deserts and sand fields in Last Glacial Maximum and Holocene Optimum显示文摘The Last Glacial Maximum (LGM, c. 26-16 ka) and the Holocene Optimum (HO, c. 9-5 ka) were characterized by cold-dry and warm-wet climates respectively in the recently geological Earth. How Chinese deserts and sand fields responded to these distinctive climatic changes is still not clear, however. To reconstruct environments of the deserts and sand fields during the LGM and HO is helpful to understand the forcing mechanisms of environment change in this arid region, and to test paleoclimatic modeling results. Through our long-term field and laboratory investigations, 400 optically stimulated luminescence (OSL) ages and more than 100 depositional records in the Chinese deserts and sand fields were obtained; on the basis of these data, we reconstruct spatial distributions of the deserts and sand fields during the LGM and HO. Our results show that the sand fields of Mu Us, Hunshandake, Horqin and Hulun Buir in northern and northeastern China had expanded 25%, 37%, 38% and 270%, respectively, during the LGM; the sand fields of Gonghe in the northeastern Qinghai-Tibetan Plateau had expanded 20%, and the deserts of Badain Jaran, Tengger in central northern China had expanded 39% and 29% separately during the LGM; the deserts of Taklimakan, Gurbantünggüt and Kumtag in northwestern China had expanded 10%-20% respectively, compared to their modern areas. On the other hand, all of the sand fields were nearly completely covered by vegetation during the HO; the deserts in northwestern and central northern China were reduced by around 5%-20% in area during this time. Lakes in this arid region were probably expanded during the HO but this conclusion needs more investigation. Compared with the geological distributions of deserts and sand fields, human activity has clearly changed (expanded) the area of active sand dunes at the present time. Our observations show that environmental conditions of Chinese deserts and sand fields are controlled by regional climate together with human activity. | LU HuaYu YI ShuangWen XU ZhiWei ZHOU YaLi ZENG Lin ZHU FangYing FENG Han DONG LiNa ZHUO HaiXin YU KaiFeng MASON Joseph WANG XiaoYong CHEN YingYong LU Qi WU Bo DONG ZhiBao QU JianJun WANG XunMing GUO ZhengTang | 2013 | Chinese Science Bulletin2013，58，23： | 40 |
| 8 | Ultrafast epitaxial growth of metre-sized single-crystal graphene on industrial Cu foil显示文摘A foundation of the modern technology that uses single-crystal silicon has been the growth of highquality single-crystal Si ingots with diameters up to 12 inches or larger. For many applications of graphene, large-area high-quality(ideally of single-crystal) material will be enabling. Since the first growth on copper foil a decade ago, inch-sized single-crystal graphene has been achieved. We present here the growth, in 20 min, of a graphene film of(5 ×50) cm^2 dimension with >99% ultra-highly oriented grains.This growth was achieved by:(1) synthesis of metre-sized single-crystal Cu(1 1 1) foil as substrate;(2)epitaxial growth of graphene islands on the Cu(1 1 1) surface;(3) seamless merging of such graphene islands into a graphene film with high single crystallinity and(4) the ultrafast growth of graphene film.These achievements were realized by a temperature-gradient-driven annealing technique to produce single-crystal Cu(1 1 1) from industrial polycrystalline Cu foil and the marvellous effects of a continuous oxygen supply from an adjacent oxide. The as-synthesized graphene film, with very few misoriented grains(if any), has a mobility up to ~23,000 cm^2 V^(-1)s^(-1)at 4 K and room temperature sheet resistance of ~230 Ω/□. It is very likely that this approach can be scaled up to achieve exceptionally large and high-quality graphene films with single crystallinity, and thus realize various industrial-level applications at a low cost. | Xiaozhi Xu Zhihong Zhang Jichen Dong Ding Yi Jingjing Niu Muhong Wu Li Lin Rongkang Yin Mingqiang Li Jingyuan Zhou Shaoxin Wang Junliang Sun Xiaojie Duan Peng Gao Ying Jiang Xiaosong Wu Hailin Peng Rodney S. Ruoff Zhongfan Liu Dapeng Yu Enge Wang Feng Ding Kaihui Liu | 2017 | Science Bulletin2017，62，15： | 40 |
| 9 | Influence of ambulance use on early reperfusion therapies for acute myocardial infarction显示文摘背景救护车使用帮助尖锐心肌的梗塞(AMI ) 的权威的处理。这研究的目的是在北京与 AMI 为病人在早灌注治疗的管理上评估救护车使用的效果, China.Methods 数据有希望地与圣举起心肌的梗塞( STEMI )从 498 个病人被收集在 12 小时症状发作以内被同意到 19 所医院进入在11月1,2005日和2006年12月31日之间的北京。基线特征和救护车用户和非救护车用户的起始的管理仅仅是 compared.Results 186 (37.3%) 病人们把一辆救护车用作交通到医院。平均,救护车用户更老并且在表示上的相对更高的风险比非救护车用户。在为病人和医院特征的调整以后,救护车使用与更大的早灌注率被联系,主要因为主要经皮的冠的干预的更大的发生。另外,救护车用户有显著地更短的中部的 door-to-balloon (120 与 145 相比纪录, P < 0.001 ) 并且症状 onset-to-balloon (223 与 300 相比纪录, P < 0.001 ) 时间比非救护车 users.Conclusions 救护车是由在北京的 AMI 病人的 underused。救护车使用可以导致早灌注治疗的更多的经常、更快的收据。新公共健康策略应该被开发由 AMI 病人便于救护车的增加的使用。 | SONG Li HU Da-yi YAN Hong-bing YANG Jin-gang SUN Yi-hong LI Chao LIU Shu-shan WU Dong FENG Qi | 2008 | Chinese Medical Journal2008，，9： | 31 |
| 10 | Recent progress in medium-Mn steels made with new designing strategies, a review显示文摘After summarizing the relevant researches on the medium Mn steels in references, two new targets on the tensile properties have been defined. One is that both transformation-induced(TRIP) and twinninginduced plasticity(TWIP) could be realized for the steel with a relatively low Mn content, which exhibits the similar tensile properties to the classical TWIP steels with higher Mn content. The other is to achieve ultrahigh ultimate tensile strength(>1.5 GPa) without sacrificing formability. To achieve these goals,new designing strategies was put forward for compositions and the processing route. In particular, warm rolling was employed instead of the usual hot/cold rolling process because the former can produce a mixture of retained austenite grains with different morphologies and sizes via the partial recrystallization. Consequently, the retained austenite grains have a wide range of mechanic stability so that they can transform to martensite gradually during deformation, leading to enhanced TRIP effect and then improved mechanic properties. Finally, it is succeeded in manufacturing these targeted medium Mn steels in laboratory, some of them even exhibit better tensile properties than our expectation. | Bin Hu Haiwen Luo Feng Yang Han Dong | 2017 | Journal of Materials Science & Technology2017，33，12： | 31 |
| 11 | An Investigation of Oxidative DNA Damage in Pharmacy Technicians Exposed to Antineoplastic Drugs in Two Chinese Hospitals Using The Urinary 8-OHdG Assay显示文摘Objective To investigate oxidative DNA damage in pharmacy technicians preparing antineoplastic drugs at the PIVAS (Pharmacy Intravenous Admixture Service) in two Chinese hospitals.Methods Urinary 8-OHdG served as a biomarker.5-Fluorouracil (5-FU) concentrations in air,masks and gloves were determined.The spill exposure of each PIVAS technician to antineoplastic drugs was investigated.Eighty subjects were divided into exposed group I,II,and control group I,II.Results 5-FU concentration ratios for gloves and masks in exposed group I were significantly higher than those in exposed group II (P<0.05 or P<0.01).The average urinary 8-OHdG concentrations in exposed group I,control group I,exposed group II,and control group II were 14.69±0.93,10.68±1.07,10.57±0.55,and 11.96±0.73 ng/mg Cr,respectively.Urinary 8-OHdG concentration in exposed group I was significantly higher than that in control group I or that in exposed group II (P<0.01).There was a significant correlation between urinary 8-OHdG concentrations and spill frequencies per technician (P<0.01).Conclusion There was detectable oxidative DNA damage in PIVAS technicians exposed to antineoplastic drugs.This oxidative DNA damage may be associated with their spill exposure experience and contamination of their personal protective equipment. | HUANG Yu Wen JIAN Le ZHANG Mei Bian ZHOU Quan YAN Xiao Feng HUA Xu Dong ZHOU Ying HE Ji Liang | 2012 | Biomedical and Environmental Sciences2012，25，1： | 30 |
| 12 | Spatial patterns of ecological carrying capacity supply-demand balance in China at county level显示文摘一个平衡生态的带的能力和它的理解是重要的为人的类型完成持续开发。这里,生态的带的能力的概念被用于测量在人和自然之间的相关性。在供应和需求之间的瓷器生态的平衡成为了一颗全球担心并且广泛地被辩论。在这研究,生态的脚印方法被用来生态的带分析瓷器的供应要求平衡能力。第一,生态的供应和需求平衡计算、评估,并且第二,生态的带能力索引(ECCI ) 在 2007 为中国的每个县被导出,并且最后,这份报纸系统地评估了中国的生态的带能力供应要求平衡。结果证明生态的赤字看起来是在在县规模的 2007 中国的生态的带的能力供应要求平衡的主要特征。一般来说,超过五分之四张中国人口在不到三分之一个个陆地区域和超过三分之二个陆地区域被集中被不到五分之一个张人口住在。生态的带能力要求供应的空间分发被失衡从到富裕的重要过载从对中国的西北的部分东南。它看起来在在被候鸟吸引并且有通常更高的人口密度的沿海的区域定位的区域更主导。与在中国的快速的发展和都市化趋势一起,在这些区域的生态的赤字将变得更严重。 | LIU Dong FENG Zhiming YANG Yanzhao YOU Zhen | 2011 | Journal of Geographical Sciences2011，21，5： | 27 |
| 13 | Relationship between Cognition Function and Hippocampus Structure after Long-term Microwave Exposure显示文摘Objective To analyze the effects of long-term microwave exposure on hippocampal structure and function in the rat.Methods Experiments were performed on 184 male Wistar rats(three exposure groups and a sham group).Microwaves were applied daily for 6 min over 1 month at average power densities of 2.5,5,and 10 mW/cm2.Learning and memory abilities were assessed by Morris water maze.High performance liquid chromatography was used to detect neurotransmitter concentrations in the hippocampus.Hippocampal structures were observed by histopathological analysis.Results Following long-term microwave exposure there was a significant decrease in learning and memory activity in the 7 d,14 d,and 1 m in all three microwave exposure groups.Neurotransmitter concentrations of four amino acids(glutamate,aspartic acid,glycine,and gamma-aminobutyric acid) in hippocampus were increased in the 2.5 and 5 mW/cm2 groups and decreased in the 10 mW/cm2 group.There was evidence of neuronal degeneration and enlarged perivascular spaces in the hippocampus in the microwave exposure groups.Further,mitochondria became swollen and cristae were disordered.The rough endoplasmic reticulum exhibited sacculated distension and there was a decrease in the quantity of synaptic vesicles.Conclusion These data suggest that the hippocampus can be injured by long-term microwave exposure,which might result in impairment of cognitive function due to neurotransmitter disruption. | ZHAO Li PENG Rui Yun WANG Shui Ming WANG Li Feng GAO Ya Bing DONG Ji LI Xiang SU Zhen Tao | 2012 | Biomedical and Environmental Sciences2012，25，2： | 27 |
| 14 | Implementation of Envelope Analysis on a Wireless Condition Monitoring System for Bearing Fault Diagnosis显示文摘Envelope analysis is an effective method for characterizing impulsive vibrations in wired condition monitoring(CM)systems. This paper depicts the implementation of envelope analysis on a wireless sensor node for obtaining a more convenient and reliable CM system. To maintain CM performances under the constraints of resources available in the cost effective Zigbee based wireless sensor network(WSN), a low cost cortex-M4 F microcontroller is employed as the core processor to implement the envelope analysis algorithm on the sensor node. The on-chip 12 bit analog-to-digital converter(ADC) working at 10 k Hz sampling rate is adopted to acquire vibration signals measured by a wide frequency band piezoelectric accelerometer. The data processing flow inside the processor is optimized to satisfy the large memory usage in implementing fast Fourier transform(FFT) and Hilbert transform(HT). Thus, the envelope spectrum can be computed from a data frame of 2048 points to achieve a frequency resolution acceptable for identifying the characteristic frequencies of different bearing faults. Experimental evaluation results show that the embedded envelope analysis algorithm can successfully diagnose the simulated bearing faults and the data transmission throughput can be reduced by at least 95% per frame compared with that of the raw data, allowing a large number of sensor nodes to be deployed in the network for real time monitoring. | Guo-Jin Feng James Gu Dong Zhen Mustafa Aliwan Feng-Shou Gu Andrew D.Ball | 2015 | International Journal of Automation and computing2015，12，1： | 28 |
| 15 | Angiotensin-converting enzyme 2 activation protects against pulmonary arterial hypertension through improving early endothelial function and mediating cytokines levels显示文摘 | LI Gang XU Yu-lin LING Feng LIU Ai-jun WANG Dong WANG Qiang LIU Ying-long | 2012 | Chinese Medical Journal2012，，8： | 24 |
| 16 | Hydrogen peroxide-induced changes in intracellular pH of guard cells precede stomatal closure显示文摘Epidermal bioassay demonstrated that benzylamine, a membrane-permeable weak base, can mimick hydrogen peroxide (H2O2) to induce stomatal closure, and butyric acid, a membrane-permeable weak acid, can partly abolish the H2O2-induced stomatal closure. Confocal pH mapping with the probe 5-(and-6)- carboxy seminaphthorhodafluor- 1 - acetoxymethylester (SNARF-1-AM) revealed that H2O2 leads to rapid changes in cytoplasmic and vacuolar pH in guard cells of Viola faba L, i. e. alkalinization of cytoplasmic areas occur red in parallel with a decrease of the vacuolar pH, and that butyric acid pretreatment can abolish alkalinization of cytoplasmic areas and acidification of vacuolar areas of guard cells challenged with H2O2. These results imply that the alkalinization of cytoplasm via efflux of cytosol protons into the vacuole in guard cells challenged with H2O2 is important at an early stage in the signal cascade leading to stomatal closure. | ZHANG XIAO, FA CAI DONG, JUN FENG GAO, CHUN PENG SONG (Department of Biology, Henan University, Kaifeng 475001, China) (College of Life Sciences, Northwest Sci-Tech University of Agriculture and Forestry, Yangling 712100, China) | 2001 | Cell Research2001，11，1： | 24 |
| 17 | Oxidative Damage to DNA and Its Relationship With Diabetic Complications显示文摘Objective To detect the oxidative DNA damage in diabetic patients and to investigate the relationship of oxidative DNA damage with diabetes and diabetic nephropathy. Methods Single cell gel electrophoresis(SCGE) was used to detect the DNA strand breaks in peripheral blood lymphocytes,and oxidative DNA damage product and serum 8-OHdG were determined by a competitive ELISA in 47 cases,including 25 patients without diabetic complications,22 patients with diabetic nephropathy and 25 normal control subjects. Results Diabetic patients showed greater oxidative damage to DNA. The percentage of comet cells and the length of DNA migration(comet tail length) of peripheral blood lymphocytes were significantly increased in patients with diabetes,and significantly higher in patients with diabetic nephropathy than in diabetic patients without vascular complications(P<0.05). There was a significant increase in serum 8-OHdG in diabetic patients compared with normal subjects(P<0.05). Moreover,serum 8-OHdG was much higher in patients with diabetic nephropathy than in diabetic patients without vascular complications(P<0.05). Conclusion There is severe oxidative DNA damage in diabetic patients. Enhanced oxidative stress may be associated with diabetes,especially in patients with diabetic nephropathy. | HONG-ZHI PAN DONG CHANG LEI-GUANG FENG FENG-JUAN XU HONG-YU KUANG MING-JUN LU | 2007 | Biomedical and Environmental Sciences2007，20，2： | 23 |
| 18 | Metabolic profiling analysis of a D-galactosamine/lipopolysaccharide- induced mouse model of fulminant hepatic failure显示文摘 | Feng, B Wu, SM Lv, S Liu, F Chen, HS Yan, XZ Li, Y Dong, FT Wei, L | 2007 | 中国生物学文摘2007，21，11： | 23 |
| 19 | Spinal surgeons' learning curve for lumbar microendoscopic discectomy: a prospective study of our first 50 and latest 10 cases显示文摘背景 Microendoscopic discectomy ( MED )是为腰部的圆盘形成疝从外科允许快速的恢复的最低限度地侵略的操作,但是因为大多数外科医生避免它 curve.We 在针的 surgeons'learning curve.Methods 的阶段评估了腰部的 MED 的有效性和安全的长学习,在很少医院里代替了传统的开的外科从2002年6月接待 MED 到2003年2月的五十个病人各被划分成十的按年代先后的组: A-E.The 控制组 F 是十 | RONG Li-min XIE Pei-gen SHI De-hai DONG Jian-wen LIU Bin FENG Feng CAI Dao-zhang | 2008 | Chinese Medical Journal2008，，21： | 23 |
| 20 | Hepatic resection: an analysis of the impact of operative and perioperative factors on morbidity and mortality rates in 2008 consecutive hepatectomy cases显示文摘背景 Hepatectomy 是一种标准肝的外科的技术。hepatectomy 的安全在外科的技术与改进一致被改进了。分析的这研究起作用并且与 hepatectomy.Methods 联系的 pedoperative 因素经历了在 1986 年 1 月和 2005 年 12 月之间的连续 hepatectomies 的 2008 个病人的一个总数回顾地被调查。诊断基于病理学的调查结果被做。分别地,恶意的结果和良性的肝疾病要求切除术的条件占了 58.5% 和 41.2% 。主要的肝癌症说明了 76.1% 恶意的肿瘤,当 hilar cholangiocarcinomas 占了 6.7% 时。Hemangiomas (41.7%) 和 hepatolithiasis (29.6%) 良性的条件是最普通的。微波同轴的凝结在 236 个我们的肝切除术案例中被使用。全面手术后的复杂并发症率是 14.44% ,哪个 12.54% 切除术为主要的肝癌症被执行, 16.40% 为第二等的肝癌症,并且 16.32% 为 hepatolithiasis。全面医院死亡是 0.55% ,并且那为恶意的肝疾病是 0.51% 。高死亡(2.53%) 为 hilar cholangiocarcinomas (在 79 种情况中的二死亡) 与广泛的肝切除术被联系。微波同轴的凝结前切除术,分级的孩子呸,操作时间,停留的手术后的长度,和外科手术前的浆液白朊铺平是病态的独立预言者。血损失,分级的孩子呸,操作时间和外科手术前的浆液白朊水平是死亡的独立预言者。结论 Hepatectomy 能与低病态和死亡安全地被执行,如果它与最佳的 perioperative 管理和创新外科的技术被执行。 | HUANG Zhi-qiang XU Li-ning YANG Tao ZHANG Wen-zhi HUANG Xiao-qiang CAI Shou-wang ZHANG Ai-qun FENG Yu-quan ZHOU Ning-xin DONG Jia-hong | 2009 | Chinese Medical Journal2009，，19： | 23 |
您所在的机构暂未开通此部分的功能，请联系管理员