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| 1 | Management of adults with coarctation of aorta显示文摘Coarctation of the aorta(CoA)is a relatively common congenital cardiac defect often causing few symptoms and therefore can be challenging to diagnose.The hallmark finding on physical examination is upper extremity hypertension,and for this reason,CoA should be considered in any young hypertensive patient,justifying measurement of lower extremity blood pressure at least once in these individuals.The presence of a significant pressure gradient between the arms and legs is highly suggestive of the diagnosis.Early diagnosis and treatment are important as long-term data consistently demonstrate that patients with CoA have a reduced life expectancy and increased risk of cardiovascular complications.Surgical repair has traditionally been the mainstay of therapy for correction,although advances in endovascular technology with covered stents or stent grafts permit nonsurgical approaches for the management of older children and adults with native CoA and complications.Persistent hypertension and vascular dysfunction can lead to an increased risk of coronary disease,which,remains the greatest cause of long-term mortality.Thus,blood pressure control and periodic reassessment with transthoracic echocardiography and threedimensional imaging(computed tomography or cardiac magnetic resonance)for should be performed regularly as cardiovascular complications may occur decades after the intervention. | Pradyumna Agasthi Sai Harika Pujari Andrew Tseng Joseph N Graziano Francois Marcotte David Majdalany Farouk Mookadam Donald J Hagler Reza Arsanjani | 2020 | World Journal of Cardiology2020，12，5： | 8 |
| 2 | Clinical application of concentrated bone marrow aspirate in orthopaedics:A systematic review显示文摘AIM To examine the evidence behind the use of concentrated bone marrow aspirate(c BMA) in cartilage, bone, and tendon repair; establish proof of concept for the use of cB MA in these biologic environments; and provide the level and quality of evidence substantiating the use of cB MA in the clinical setting.METHODS We conducted a systematic review according to PRISMA guidelines. EMBASE, MEDLINE, and Web of Knowledge databases were screened for the use of cB MA in the repair of cartilage, bone, and tendon repair. We extracted data on tissue type, cB MA preparation, cB MA concentration, study methods, outcomes, and level of evidence and reported the results in tables and text.RESULTS A total of 36 studies met inclusion/exclusion criteria and were included in this review. Thirty-one of 36(86%) studies reported the method of centrifugation and preparation of cB MA with 15(42%) studies reporting either a cell concentration or an increase from baseline. Variation of c BMA application was seen amongst the studies evaluated. Twenty-one of 36(58%) were level of evidence Ⅳ, 12/36(33%) were level of evidence Ⅲ, and 3/36(8%) were level of evidence Ⅱ. Studies evaluated full thickness chondral lesions(7 studies), osteochondral lesions(10 studies), osteoarthritis(5 studies), nonunion or fracture(9 studies), or tendon injuries(5 studies). Significant clinical improvement with the presence of hyaline-like values and lower incidence of fibrocartilage on T2 mapping was found in patients receiving cB MA in the treatment of cartilaginous lesions. Bone consolidation and time to bone union was improved in patients receiving cB MA. Enhanced healingrates, improved quality of the repair surface on ultrasound and magnetic resonance imaging, and a decreased risk of re-rupture was demonstrated in patients receiving cB MA as an adjunctive treatment in tendon repair. CONCLUSION The current literature demonstrates the potential benefits of utilizing c BMA for the repair of cartilaginous lesions, bony defects, and tendon injuries in the clinical setting. This study also demonstrates discrepancies between the literature with regards to various methods of centrifugation, variable cell count concentrations, and lack of standardized outcome measures. Future studies should attempt to examine the integral factors necessary for tissue regeneration and renewal including stem cells, growth factors and a biologic scaffold. | Arianna L Gianakos Li Sun Jay N Patel Donald M Adams Frank A Liporace | 2017 | World Journal of Orthopedics2017，8，6： | 5 |
| 3 | Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Joseph P Costantino Takamaru Ashikaga Donald L Weaver Eleftherios P Mamounas Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Norman Wolmark | 2010 | Lancet Oncology2010，，10： | 3 |
| 4 | Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity显示文摘 | Matthew N Meriggioli Donald B Sanders | 2009 | Lancet Neurology2009，，5： | 2 |
| 5 | Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Takamaru Ashikaga Donald L Weaver Barbara J Miller Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Denise M Mammolito David R McCready Eleftherios P Mamo | 2007 | Lancet Oncology2007，，10： | 2 |
| 6 | Randomized, Placebo-Controlled, Clinical Trial of Donepezil in Vascular Dementia: Differential Effects by Hippocampal Size显示文摘 | Gustavo C. Román Stephen Salloway Sandra E. Black Donald R. Royall Charles DeCarli Michael W. Weiner Margaret Moline Dinesh Kumar Rachel Schindler Holly Posner | 2010 | Stroke2010，，6： | 2 |
| 7 | Adipocyte iron regulates adiponectin and insulin sensitivity显示文摘 | Gabrielsen J Scott Gao Yan Simcox Judith A Huang Jingyu Thorup David Jones Deborah Cooksey Robert C Gabrielsen David Adams Ted D Hunt Steven C Hopkins Paul N Cefalu William T McClain Donald A | 2012 | EN2012，，10： | 2 |
| 8 | Models of an annual plant population with a seed bank显示文摘 | Mac Donald N Watkinson A R | 1981 | Journal of Theoretical Biology1981，93，： | 1 |
| 9 | Current control of VSI-PWM inverters显示文摘 | Brod David M Donald W N | 1985 | IEEE Transactions on Industry Applications1985，21，3： | 1 |
| 10 | A ubiquitin-10 promoter-based vector set for fluorescent protein tagging facili- tates temporal stability and native protein distribution in transient and stable expression studies显示文摘 | GREFEN C DONALD N HASHIMOTO K | 2010 | Plant Journal2010，64，2： | 1 |
| 11 | The capsaicinoid: their separation, synthesis and mutagenicith 显示文摘 | Peter M G Donald L N Pam J R | 1988 | J Org Chem1988，53，5： | 1 |
| 12 | Accruals and the Prediction of Future Cash Flows 显示文摘 | MARY E B DONALD P C KAREN K N | 2001 | The Accounting Re- view2001，76，1： | 1 |
| 13 | Innate immtme control of pulmonary dendritic cell tracking 显示文摘 | Donald N C Kim B | 2007 | Proc Am Thorac Soc2007，4，3： | 1 |
| 14 | Titanium dioxide photocatalysis显示文摘 | Akira Fujishima Tata N Rao Donald A Tryk | 2000 | Journal of Photochemistry and Photobiology C: Photochemistry Reviews2000，1，： | 1 |
| 15 | Stationary frame current regulation of PWM inverters with zero steady- state error显示文摘 | Zmood Daniel N Donald G H | 2003 | IEEE Transactions on Power Electronics2003，18，3： | 1 |
| 16 | Efficient operation of surface-mounted PM synchronous motors 显示文摘 | COLBY R S DONALD W N | 1987 | IEEE Transactions on Industry Applications1987，23，6： | 1 |
| 17 | Hydraulic Performance of a Steep Single Layer Riprap Drainage Channel显示文摘 | ROBERT N E DONALD D G | 2008 | Journal of Hydraulic Engineering2008，134，11： | 1 |
| 18 | PTEN methylation is associated ith advanced stage and microsatallite instability in endometrial carcinoma显示文摘 | Salvesen HB Mac Donald N Ryan A | 2001 | Int J Cancer2001，1，1： | 1 |
| 19 | Vector Fidelity of Land Multicomponent Measurements in the Context of the Earth-Sensor System:Misconceptions and Implications显示文摘 | Donald N B Alexander S C John M N GX Technology | 2005 | SEG/Houston 2005 Annual Meeting2005，，： | 1 |
| 20 | Starburst Dendrimers: Molecular-Level Control of Size, Shape, Surface Chemistry, Topology, and Flexibility from Atoms to Macroscopic Matter显示文摘 | Donald A T Adel M N William A G | 1990 | Angewandte Chemie International Edition in English1990，29，2： | 1 |
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