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| 1 | Effect of serum γ-glutamyltranferase and albumin levels on the response to cardiac resynchronization therapy in the elderly显示文摘Background Several liver function tests have been identified as predictors of hospitalization for heart failure(HF) and death in patients with chronic HF. The relationship between serum γ-glutamyltranferase(GGT) and albumin(SA) levels with the response to cardiac resynchronization therapy(CRT) has not been reliably determined. The aim of the study was to evaluate the impact of liver function tests on the results of CRT in the elderly. Methods Baseline GGT and SA were assessed before CRT device implantation in the elderly(> 70-year-old) patients. The endpoints were:(1) CRT response defined as > 5% left ventricular ejection fraction improvement and no hospitalization for HF or cardiovascular death;(2) hospitalizations;and(3) mortality. Results Eighty of 138(58%) included patients were responders at nine months. Compared to responders, the SA levels were not significantly different(35.1 ± 5.4 vs. 33.6 ± 5.5 g/L, P = 0.103);but the GGT levels, higher(81.6 ± 69.3 vs. 54.7 ± 49.6 U/L, P = 0.013) in non-responders to CRT. GGT level was independently associated with non-response to CRT(P < 0.001, OR = 0.17;95% CI: 0.08–0.38, P < 0.001). GGT cut-off value ≥ 55 U/L was highly predictive of non-response [AUC = 0.65, 64% Sensitivity, 69% Specificity(95% CI: 0.56–0.74)]. GGT ≥ 55 U/L was also associated with higher risk of hospitalization for atrial fibrillation(AF)(95% vs. 83%, P = 0.024). Both SA and GGT had no impact on overall(P = 0.220, P = 0.723) mortality. Conclusions Higher level of GGT is an independent predictor of non-response to CRT in patients over age 70 years and is associated with higher risk of hospitalization for AF. Baseline serum levels of albumin and GGT and have no impact on mortality in elderly patients undergoing CRT. | Maciej Kubala Alexis Hermida Otilia Buiciuc Pierre-Marc Lallemand Geneviève Bertaina Frédéric Anselme Didier Klug Momar Diouf Jean-Sylvain Hermida | 2020 | Journal of Geriatric Cardiology2020，17，6： | 3 |
| 2 | Ultrasonographic diagnosis of hepatic fibrosis or cirrhosis显示文摘 | Christophe Aubé Frédéric Oberti Nouri Korali Marc-Antoine Namour Didier Loisel Jean-Yves Tanguy Emmanuelle Valsesia Christophe Pilette Marie Christine Rousselet Pierre Bedossa Hervé Rifflet Moussa Y Ma?ga Dominique Penneau-Fontbonne Christine Caron Paul C | 1999 | Journal of Hepatology1999，，3： | 2 |
| 3 | Solid propulsion for space applications: An updated roadmap显示文摘 | Jean-Francois Guery I-Shih Chang Toru Shimada Marilyn Glick Didier Boury Eric Robert John Napior Robert Wardle Christian Pérut Max Calabro Robert Glick Hiroto Habu Nobuhiro Sekino Gilles Vigier Bruno d’Andrea | 2009 | Acta Astronautica2009，，1： | 2 |
| 4 | Cloning and analysis of structural genes from Streptomyces pristinaesplralis encoding enzymes involved in the conversion of pristinamycin Ⅱs to pristinamycin ⅡA (PⅡA);PⅡA synthase and NADH: riboflavin 5'-phosphate oxidoreductase 显示文摘 | Blenc V Lagneaux D Didier P | 1995 | J Bacteriol1995，18，199： | 1 |
| 5 | Fabrication of porous polysaccharide-based scaffolds using a combined freeze-drying/cross-linking process显示文摘 | Aude Autissier Catherine Le Visage Cécile Pouzet Frédéric Chaubet Didier Letourneur | 2010 | Acta Biomaterialia2010，，9： | 1 |
| 6 | Viruses and thyroidi- tis: an update显示文摘 | Rachel D Didier H | 2009 | Virology Journal2009，6，5： | 1 |
| 7 | Hydrogen Storage in Semiclath- rate Hydrates of Tetrabutyl Ammonium Chloride and Tetra- butyl Phosphonium Bromide 显示文摘 | JOHNNY D DIDIER D | 2010 | Chem Eng2010，，55： | 1 |
| 8 | Performance ofhelical computed tomography in unselected outpatients withsuspected pulmonary embolism 显示文摘 | Perrier A Howarth N Didier D | 2001 | Ann Int Med2001，335，2： | 1 |
| 9 | MERIS in-flight spectral calibration in 05 absorption using surface pressure retrieval显示文摘 | Didier R Richard S Philippe D | 2003 | SPIE2003，4891，： | 1 |
| 10 | Morphologic and fimctional evaluation of congenital heart disease by magnetic resonance imaging显示文摘 | Didier D Ratib O Beghetti M | 1999 | J Magn Reson Imaging1999，10，： | 1 |
| 11 | Early EUS of the bile duct before endoscopic sphincterotomy for acute biliary pancreatitis显示文摘 | Frédéric Prat Jo?l Edery Bruno Meduri Renaud Chiche Charles Ayoun Michel Bodart Didier Grange Fran?oise Loison Pierre Nedelec Mohamed Sa?d Sbai-Idrissi Alain Valverde Bertrand Vergeau | 2001 | Gastrointestinal Endoscopy2001，，6： | 1 |
| 12 | Early tracheotomy versus prolonged endotracheal intubation in unselected severely ill ICU patients显示文摘 | Fran?ois Blot Thomas Similowski Jean-Louis Trouillet Patrick Chardon Jean-Michel Korach Marie-Alyette Costa Didier Journois Guillaume Thiéry Muriel Fartoukh Isabelle Pipien Nicolas Bruder David Orlikowski Frédéric Tankere Isabelle Durand-Zaleski Christian | 2008 | Intensive Care Medicine2008，，10： | 1 |
| 13 | Construction of a set Gateway-based destination vectors for high-throughput cloning and expression screening in Escherichia coli显示文摘 | Didier B Bénédicte D B Dino M | 2005 | Analy Biochem2005，343，2： | 1 |
| 14 | CMOS long linear array for space application显示文摘 | LEPAGEA G DIDIER D DIELSA W | 2006 | SPIE2006，6068，： | 1 |
| 15 | Solid propulsion for space applications: An updated roadmap显示文摘 | Jean-Francois Guery I-Shih Chang Toru Shimada Marilyn Glick Didier Boury Eric Robert John Napior Robert Wardle Christian Pérut Max Calabro Robert Glick Hiroto Habu Nobuhiro Sekino Gilles Vigier Bruno d’Andrea | 2009 | Acta Astronautica2009，，1： | 1 |
| 16 | Stellate ganglion drives sympathetic regulation of cochlear blood now 显示文摘 | Laurikainen EA Kim D Didier A | 1993 | Hear Res1993，64，2： | 1 |
| 17 | Liver Retransplantation: A Model for Determining Long-Term Survival显示文摘 | Marcelo M. Linhares Daniel Azoulay Délcio Matos Adauto Castelo-Filho Tarcísio Trivi?o Alberto Goldenberg Denis Castaing René Adam Valerie Délvart Phillipe Ichai Fauze Saliba Antoine Lemoine Didier Samuel Henry Bismuth | 2006 | Transplantation2006，，7： | 1 |
| 18 | Gold nanoparticles:assembly,supramolecular chemistry,quantum-size-related properties,and applications toward biology,catalysis,and nanotechnology显示文摘 | Christine D M Didier A | 2004 | Chem Rev2004，104，1： | 1 |
| 19 | Polycystic Ovary Syndrome: a multidisciplinary challenge 显示文摘 | Benoit S Didier D Robert L | 1996 | The Endocrinologist1996，6，1： | 1 |
| 20 | Lignin depolymerization in hydrogen-donor solvents显示文摘 | Edwin D Marieke K Didier P | 1999 | Holzforschung1999，53，6： | 1 |
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