|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Phylogenetic and genetic characterization of a 2017 clinical isolate of H7N9 virus in Guangzhou,China during the fifth epidemic wave显示文摘Pathogenic H7N9 influenza viruses continue to pose a public health concern. The H7N9 virus has caused five outbreak waves of human infections in China since 2013. In the present study, a novel H7N9 strain(A/Guangdong/8 H324/2017) was isolated from a female patient with severe respiratory illness during the fifth wave of the 2017 H7N9 epidemic. Phylogenetic analysis showed that the H7N9 viruses collected during the fifth wave belong to two different lineages: the Pearl River Delta lineage and the Yangtze River Delta lineage. The novel isolate is closely related to the Pearl River Delta H7N9 viruses, which were isolated from patients in Guangdong Province. The novel H7N9 isolate has an insertion of three basic amino acids in the cleavage site of hemagglutinin(HA), which may enhance virulence in poultry. The 2017 isolate also possesses an R292 K substitution in the neuraminidase(NA)protein, which confers oseltamivir resistance. This study highlights the pandemic potential of the novel H7N9 virus in mammals;thus, future characterization and surveillance is warranted. | Yongqiang Deng Chunlin Li Jianfeng Han Yingfen Wen Jian Wang Wenxing Hong Xiaofeng Li Zhongyu Liu Qing Ye Jing Li Changshuai Zhou Lei Yu Chengfeng Qin Fuchun Zhang Tao Jiang | 2017 | Science China(Life Sciences)2017，60，12： | 9 |
| 2 | Analysis of vegetation changes and dominant factors on the Qinghai-Tibet Plateau, China显示文摘This research was undertaken to clarify the characteristics of vegetation change and its main influencing factors on the Qinghai-Tibet Plateau. Using the greenness rate of change(GRC) and correlation factors, we analyzed the trend of vegetation change and its dominant factors from 2000 to 2015. The results indicate that the vegetation tended to improve from 2000 to 2015 on the Qinghai-Tibet Plateau, with the improved area accounting for 39.93% of the total; and the degraded area accounting for 19.32%. The areas of degraded vegetation are mainly concentrated in the low-relief and intermediate-relief mountains of the high-altitude and extremely high-altitude areas on the Qinghai-Tibet Plateau, as the vegetation characteristics are impacted by the terrain. Temperature and precipitation have obvious response mechanisms to vegetation growth, but the effects of precipitation and temperature on vegetation degradation are not significant over a short time frame. Overgrazing and population growth are the dominant factors of vegetation degradation on the Qinghai-Tibet Plateau. | HongWei Wang Yuan Qi ChunLin Huang XiaoYing Li XiaoHong Deng JinLong Zhang | 2019 | Research in Cold and Arid Regions2019，11，2： | 5 |
| 3 | A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice,rabbits and NHPs显示文摘The emergence of SARS-CoV-2 variants and potentially other highly pathogenic sarbecoviruses in the future highlights the need for pan-sarbecovirus vaccines.Here,we discovered a new STING agonist,CF501,and found that CF501-adjuvanted RBD-FC vaccine(CF501/RBD-FC)elicited significantly stronger neutralizing antibody(nAb)and T cell responses than Alum-and cGAMP-adjuvanted RBD-FC in mice.Vaccination of rabbits and rhesus macaques(nonhuman primates,NHPs)with CF501/RBD-FC elicited exceptionally potent nAb responses against SARS-CoV-2 and its nine variants and 41 S-mutants,SARS-CoV and bat SARSr-CoVs.CF501/RBD-FC-immunized hACE2-transgenic mice were almost completely protected against SARS-CoV-2 challenge,even 6 months after the initial immunization.NHPs immunized with a single dose of CF501/RBD-FC produced high titers of nAbs.The immunized macaques also exhibited durable humoral and cellular immune responses and showed remarkably reduced viral load in the upper and lower airways upon SARS-CoV-2 challenge even at 108 days post the final immunization.Thus,CF501/RBD-Fc can be further developed as a novel pan-sarbecovirus vaccine to combat current and future outbreaks of sarbecovirus diseases. | Zezhong Liu Jie Zhou Wei Xu Wei Deng Yanqun Wang Meiyu Wang Qian Wang Ming Hsieh Jingming Dong Xinling Wang Weijin Huang Lixiao Xing Miaoling He Chunlin Tao Youhua Xie Yilong Zhang Youchun Wang Jincun Zhao Zhenghong Yuan Chuan Qin Shibo Jiang Lu Lu | 2022 | Cell Research2022，32，3： | 5 |
| 4 | Multi-ingredients determination and fingerprint analysis of leaves from Ilex latifolia using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry显示文摘 | Chunlin Fan Jiewei Deng Yunyun Yang Junshan Liu Ying Wang Xiaoqi Zhang Kuokchiu Fai Qingwen Zhang Wencai Ye | 2013 | Journal of Pharmaceutical and Biomedical Analysis2013，，： | 1 |
| 5 | Preparation of Functionalized Graphene Nano-platelets and Use for Adsorption of Pb2+ from Solution显示文摘Functionalized graphene nano-platelets(FGN) were obtained via treating graphene nanoplatelets(GN) with HNO_3, and served as adsorbent for the removal of Pb^(2+) from solutions. We investigated the FGN adsorption capacity for Pb^(2+) at different initial concentrations, varying pH, contact time and temperature. The characterization results of scanning electron microscopy(SEM), thermal analysis(TG/DTG), Fourier transform infrared spectroscopy(FT-IR) and Brunauer-Emmett-Teller(BET) method indicated that FGN layers were thin and possess large specific area with oxygen-containing functional groups grafted onto their surface. Meanwhile, the determined equilibrium adsorption capacity of FGN for Pb^(2+) was 57.765 mg/g and adsorption isotherms well confirmed to Langmuir isotherms models. The results reveals that the FGN has better effect of water treatment. | 盛智博 曹明莉 HONG Yin WANG Shengniang FAN Zhihong XIONG Jianbo YANG Haicheng DENG Chunlin | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，6： | 1 |
| 6 | Meromorphic Function Sharing Sets with Its Difference Operator or Shifts显示文摘Let f be a nonconstant meromorphic function, c ∈ C, and let ■be a meromorphic function. If f(z) and P(z, f(z)) share the sets {a(z),-a(z)},{0} CM almost and share {∞} IM almost, where P(z, f(z)) is defined as(1.1), then f(z) ≡±P(z, f(z)) or f(z)P(z, f(z)) ≡±a^2(z). This extends the results due to Chen and Chen(2013), Liu(2009) and Yi(1987). | Bingmao DENG Chunlin LEI Mingliang FANG | 2019 | Chinese Annals of Mathematics,Series B2019，40，3： | 1 |
| 7 | Identification and determination of the major constituents in Deng's herbal tea granules by rapid resolution liquid chromatography coupled with mass spectrometry显示文摘 | Deng Jiewei Fan Chunlin Yang Yunyun | 2011 | Journal of Pharmaceutical and Biomedical Analysis2011，56，5： | 1 |
| 8 | Effect of Mn doping on the dielectric properties of BaZr0.2Ti0.8O3 ceramics显示文摘 | Wei Cai Chunlin Fu Jiacheng Gao Xiaoling Deng | 2010 | Journal of Materials Science: Materials in Electronics2010，，4： | 1 |
| 9 | Dissolution and mineralization behaviors of HA coatings显示文摘 | Qiyi Zhang Jiyong Chen Jiaming Feng Yang Cao Chunlin Deng Xingdong Zhang | 2003 | Biomaterials2003，，26： | 1 |
| 10 | Biomass increment and mortality losses in tropical secondary forests of Hainan, China显示文摘Secondary forests, created after heavy logging,are an important part of China's forests. We investigated forest biomass and its accumulation rate in 38 plots in a tropical secondary forest on Hainan Island. These secondary forests are moderate carbon sinks, averaging1.96–2.17 t C ha-1 a-1. Biomass increment is largely by medium-sized(10–35 m) trees. Tree mortality accounts for almost 30% of the biomass and plays a negligible role in biomass accumulation estimates. Mortality rate is highly dependent on tree size. For small trees and seedlings, it is related to competition due to elevated irradiance after logging. Regarding prospective biomass and rates of accumulation, recovery is not as rapid as in secondary forests of cleared land. Therefore, tropical forests are susceptible to logging operations and need careful forest management. | Junfu Zhao Chunsheng He Chunlin Qi Xu Wang Haiyan Deng Chunxin Wang Haiwei Liu Lianyan Yang Zhenghong Tan | 2019 | Journal of Forestry Research2019，30，2： | 1 |
| 11 | Degradable nanocatalyst enables antitumor/antibacterial therapy and promotion of wound healing for diabetes via self-enhanced cascading reaction显示文摘Diabetic patients often have problems such as residual tumor and wound infection after tumor resection,causing severe clinical problems.It is urgent to develop effective therapies to reach oncotherapy/antiinfection/promotion of wound healing combined treatment.Herein,we propose CS/MnO_(2)-GO_x (CMGO_x)nanocatalysts for the specific catalytic generation of ~·OH to inhibit tumors and bacteria in a hyperglycemic environment.The good biocompatible chitosan (CS),as a carrier for the catalyst,exhibits excellent antibacterial effect as well as promotes wound healing.Glucose oxidase (GO_x) is loaded on the surface of CS nanoparticles to generate H_(2)O_(2) and gluconic acid by consuming glucose (starvation therapy,ST) and O_(2).The MnO_(2) depletes glutathione (GSH) to produce Mn^(2+),amplifying oxidative stress and further promoting the activity of Mn^(2+)-mediated Fenton-like reaction to produce~·OH (chemodynamic therapy,CDT)in weak acidic environment.Moreover,the produced gluconic acid lowers the p H of the environment,enhancing chemodynamic therapy (ECDT).The tumor cells and bacteria are efficiently eliminated by the synergistic effect of ST and ECDT.The MnO_(2) nanoparticles at neutral environment decomposes H_(2)O_(2) into O_(2),which cooperate with CS to promote healing.The self-enhanced cascade reaction of CMGO_x in situ exhibits excellent effects of antitumor/antibacterial therapy and promotion of wound healing,offering a promising integrated treatment for diabetic patients after tumor surgical resection. | Xiang Wang Cheng Ding Ziwen Zhang Chunlin Li Dongmiao Cao Linjing Zhao Guoying Deng Yu Luo Chunping Yuan Jie Lu Xijian Liu | 2023 | Chinese Chemical Letters2023，34，7： | 0 |
| 12 | Regio-selective chlorination of vinca alkaloids catalyzed by Lewis acid显示文摘Novel C-17-chloro-substituted derivative of vinorelbine or vinflunine has been regio-selectively synthesized via the chlorination reaction in the presence of Lewis acid.The catalyst Cp2TiCl2 plays a key role in the chlorination reaction. | FANG LiSong ZHANG Qiao DENG ChunLin LEI XinSheng LIN GuoQiang | 2011 | Science China Chemistry2011，54，7： | 0 |
| 13 | Effect of Hydroxyapatite Coating Surface Morphology on Adsorption Behavior of Differently Charged Proteins显示文摘The morphology of bone repair materials,such as particle size and roughness of the materials surface,can affect the adsorption of protein molecules.The effects of surface morphology on the absorption of proteins with different charges were studied.Submicron and nano hydroxyapatite(HA)powders prepared by the chemical precipitation method were coated on the surface of a gold sheet by electrophoretic deposition.Various hydroxyapatite coating morphologies were obtained by controlling the powder particle size and the deposition time.The coating surface morphology was analyzed by Atomic Force Microscopy(AFM),and the adsorption behavior of differently charged proteins on the surface was dynamically monitored by Quartz Crystal Microbalance with Dissipation(QCM-D).The adsorption dependence of two proteins with different charges upon hydroxyapatite coating surface morphology was investigated.Results show that coating surfaces with smaller deposited particle sizes are favorable for the adsorption of negatively-charged bovine albumin,while with larger deposited particles facilitate the adsorption of positively-charged lysozyme.This may be because that the negatively-charged hydroxyapatite coating exhibits stronger electrostatic effect as the increase in the coating particle size,which facilitates the adsorption of positively-charged proteins and hinders the adsorption of negatively-charged proteins.Increasing coating surface roughness facilitates protein adsorption,though the particle size exhibits a dominant influence.These results are significant for selective adsorption of proteins on material surfaces. | Zhihuan He Shili Sun Chunlin Deng | 2020 | Journal of Bionic Engineering2020，17，2： | 0 |
| 14 | The electronic structure and optical properties of Ca_(3)(Mn_(1-x)Ti_(x))_(2)O_(7) from first-principle calculations显示文摘The electronic structure and optical properties of Ca_(3)(Mn_(1-x)Ti_(x))_(2)O_(7)(x¼0,1/8,2/8,3/8,4/8)were studied by first-principle calculations within the generalized gradient approximation approaches(GGA).The lattice constants of Ca_(3)(Mn_(1-x)Ti_(x))_(2)O_(7) increase with the increase of Ti^(4+)content caused by the substitution of Ti^(4+)with larger ionic radius for Mn^(4+).Ca_(3)(Mn_(1-x)Ti_(x))_(2)O_(7) is a direct band gap semiconductor,and the band gap(Eg)increases with the increase of Ti^(4+)content.From the density of states,the introduction of Ti-3d states can weaken the effects of Mn-3d states on the bottom of conduction band and has little influence on O-2p states on the top of valence band.The introduction of nonmagnetic Ti^(4+)ions can weaken the magnetism of Ca_(3)(Mn_(1-x)Ti_(x))_(2)O_(7).According to the Mulliken population analysis,it is found that the introduction of Ti^(4+)enhances the electronic accepting capacity of oxygen ions and enhances the electronic losing capacity of manganese ions.The bond strength of Ti–O covalent bond is stronger than that of Mn–O covalent bond.Furthermore,the optical properties of Ca_(3)(Mn_(1-x)Ti_(x))_(2)O_(7) was calculated.As Ti^(4+)content increases,the absorption edge of Ca_(3)(Mn_(1-x)Ti_(x))_(2)O_(7) has a blue shift,the static refractive index n0 decreases,the static dielectric constant'1(0)decreases,the position of loss peak moves to higher energy. | Fengqi Wang Wei Cai Chunlin Fu Rongli Gao Gang Chen Xiaoling Deng Zhenhua Wang Chaoyang Zhang | 2019 | Journal of Advanced Dielectrics2019，9，1： | 0 |
| 15 | Synthesis and Evaluation of the Analogues of Penicillide against Cholesterol Ester Transfer Protein显示文摘与在 C-3 和 C-9 位置的修正,一系列 penicillide 类似物作为潜在的 cholesteryl 酉旨转移被综合蛋白质(CETP ) 禁止者。在提供的 vitro 抑制试金初步 penicillide 的一些珍贵结构活动关系信息。 | Qiao Zhang Chunlin Deng Lisong Fang Wenwei Xu Qun Zhao Jiange Zhang Yiping Wang Xinsheng Lei | 2013 | Chinese Journal of Chemistry2013，31，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员