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| 1 | Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures显示文摘 | Bin-Kuan Chou Prashant Mali Xiaosong Huang Zhaohui Ye Sarah N Dowey Linda MS Resar Chunlin Zou Alex Zhang Jay Tong Linzhao Cheng | 2011 | Cell Research2011，21，3： | 38 |
| 2 | Development of a Chinese land data assimilation system:its progress and prospects显示文摘陆地数据吸收的目的是为改进陆地表面状态的评价把多来源观察合成陆地表面模型的动力学。我们为中国的陆地领土开发了一个陆地数据吸收系统。在这个系统,普通陆地模型和简单生物圈,模型 2 被用来模仿陆地表面过程。当转移的观察操作员为预言建模进估计的亮度温度,融化并且结冰的土壤,雪,湖,和植被的放射的转移模型被使用。一个 Monte-Carlo 顺序的过滤器,整体 Kalman 过滤器,作为数据吸收方法被实现集成当模特儿并且观察。系统能够遥远地吸收被动微波察觉到的数据象特殊传感器微波成像器那样(SSM 我) , TRMM 微波成像器(TMI ) ,和先进微波扫描辐射计为曙光女神(AMSRE ) 提高了并且在土壤和雪的 situmeasurements 常规。与 0.25 度的一个空间决定和一个小时的时间的分辨率,为土壤潮湿,土壤温度,雪和冻结的土壤的空间与时间地一致的吸收数据集被生产了。这篇论文介绍在数据吸收算法,陆地表面水文学变量的陆地表面建模微波遥感,和大气的强迫的数据的准备上做的中国陆地数据吸收系统和进步的开发。为未来开发开发陆地数据吸收系统和观点的不同特征和挑战也被讨论。 | Li Xin Huang Chunlin Che Tao Jin Rui Wang Shugong Wang Jiemin Gao Feng Zhang Shuwen Qiu Chongjian Wang Chenghai | 2007 | Progress in Natural Science:Materials International2007，17，8： | 30 |
| 3 | High-resolution geochemistry records of climate changes since late-glacial from Dajiuhu peat in Shennongjia Mountains,Central China显示文摘A peat core with depths of 297 cm was obtained from the Dajiuhu Basin(31°29′27″N,109°59′45″E,1760 m)in Hubei Province,Central China.10 AMS ages provide a time control and reveal that this core spans the past about 16.0 kaBP(calibrated age)(1 4C age:13.3 kaBP).Multi-proxy indexes analysis of geochemistry shows the following character of climate and environmental changes since about 16 kaBP:(1) The climate during the late-glacial period was cold and wet as a whole,but fluctuated continually.11.4- 12.6 cal.kaBP,12.6-15.2 cal.kaBP and 15.2-16 kaBP were corresponding respectively to the Younger Drays,Bφlling-Allerφd Warm Period and the Oldest Drays.(2)Inheriting the some climate characteristics of the late-glacial,the climate during the early-Holocene was wet and temperature increased gradually,during which an obvious dry event around 10.6 cal.kaB appeared.(3)The climate during the mid-Holocene was genarally warm and wet.During 9.2-7.5 kaBP,temperature increased gradually, precipitation was less comparatively and the 8.2 kaBP cold event which might be representative in the globe was reflected markedly.Then,multi-proxy records were relatively stable during 6.7-4.2 kaBP, which shows the best water and thermal condition in the Holocene Optimum.(4)Around 4.2 kaBP,the climate and environment transform from warm and wet to cool and dry,which may result in the collapse of the Neolithic Culture and midwifery the civilization of Xia Dynasty in this region.After 0.9 kaBP,the climate turned cool and wet.Climate and environmental changes archived in Dajiuhu peat respond to the global changes since the late-glacial period and can be contrasted to the changes recorded in other high-resolution archives from the East Asia Monsoon region,which take on the variety model that the monsoon strengthened abruptly after the late-glacial,was strong during the early Holocene,subse- quently declined and became weak after the middle Holocene with dry climate.According to our analysis,the driving mechanism should be the response of solar radiation changes in the East Asia Monsoon region at middle latitudes. | MA ChunMei ZHU Cheng ZHENG ChaoGui WU ChunLin GUAN Yong ZHAO ZhiPing HUANG LinYan HUANG Run | 2008 | Chinese Science Bulletin2008，53，S1： | 19 |
| 4 | Multifunctional barium titanate ceramics via chemical modification tuning phase structure显示文摘Global environmental concerns on the toxicity of lead-based piezoelectrics impel the great mass fervor on investigations of lead-free alternatives.Barium titanate(BaTiO3,BT)ceramics,the first discovered perovskite ferroelectrics,were widely employed to fabricate dielectric capacitors from 1950s.Since a piezoelectric breakthrough was achieved via chemical modification,intensive researches have been performed embracing lead-free BT-based piezoelectrics and their extensional functionalities.In this review,we encompass the stateof-the-art progress on chemical modification tuning phase structure toward advanced electrical properties in BT-based ceramics.Generally,modulated regularity of cations substitution on phase transition is summarized and clarified.Then,we highlight the common methodologies of phase structure(phase boundary,relaxor phase,room-temperature phase transition,etc.)design for optimizing piezoelectricity,electrostrictive strain,electrocaloric,dielectric energy storage or permittivity performances,and cover the noticeable developments and relevant physical mechanisms.Finally,perspectives and challenges on future research issues are featured.This review proposes to exert the significant guidance and service for material design of BT-based and other lead-free perovskite materials with superior functionalities. | Chunlin Zhao Yanli Huang Jiagang Wu | 2020 | InfoMat2020，2，6： | 9 |
| 5 | Toward automatic estimation of urban green volume using airborne LiDAR data and high resolution Remote Sensing images显示文摘城市的绿体积是为分析城市的植被结构,生态的评估,和绿经济的评价的重要指示物。这份报纸为城市的绿体积联合的自动化评价建议一个基于目标的方法三维(3D ) 从在空中的轻察觉的信息并且变化(激光雷达) 从高分辨率的数据和植被信息遥远地通过 Lujiazui 区域的案例研究察觉到图象,上海,中国。在空中的在红外线附近的相片被用于识别城市的植被分发的高分辨率。在空中的激光雷达数据提议提取单个树并且测量树的属性的可能性,例如树高度和王冠直径。在这研究,单个树和草地作为城市的植被的独立对象被识别,并且城市的绿卷作为二宽广部分的和被计算:单个树体积和草地体积。方法由后面的步骤组成:产生并且过滤规范的数字表面模型( nDSM ),定位本地最大值点,分割植被,提取基于规范的差别植被索引( NDVI )的城市的植被的 nDSM 单个树王冠和草地反对,并且计算每个植被目标的城市的绿体积。结果在 Lujiazui 区域显示出数量和城市的绿体积的分发特征,并且为城市的绿计划和管理提供珍贵参数。激光雷达数据和图象数据的综合申请介绍一个有效方法估计城市的绿体积,这也从这份报纸被结束[出版摘要] | Yan HUANG Bailang YU Jianhua ZHOU Chunlin HU Wenqi TAN Zhiming HU Jianping WU | 2013 | Frontiers of Earth Science2013，7，1： | 6 |
| 6 | Analysis of vegetation changes and dominant factors on the Qinghai-Tibet Plateau, China显示文摘This research was undertaken to clarify the characteristics of vegetation change and its main influencing factors on the Qinghai-Tibet Plateau. Using the greenness rate of change(GRC) and correlation factors, we analyzed the trend of vegetation change and its dominant factors from 2000 to 2015. The results indicate that the vegetation tended to improve from 2000 to 2015 on the Qinghai-Tibet Plateau, with the improved area accounting for 39.93% of the total; and the degraded area accounting for 19.32%. The areas of degraded vegetation are mainly concentrated in the low-relief and intermediate-relief mountains of the high-altitude and extremely high-altitude areas on the Qinghai-Tibet Plateau, as the vegetation characteristics are impacted by the terrain. Temperature and precipitation have obvious response mechanisms to vegetation growth, but the effects of precipitation and temperature on vegetation degradation are not significant over a short time frame. Overgrazing and population growth are the dominant factors of vegetation degradation on the Qinghai-Tibet Plateau. | HongWei Wang Yuan Qi ChunLin Huang XiaoYing Li XiaoHong Deng JinLong Zhang | 2019 | Research in Cold and Arid Regions2019，11，2： | 5 |
| 7 | A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice,rabbits and NHPs显示文摘The emergence of SARS-CoV-2 variants and potentially other highly pathogenic sarbecoviruses in the future highlights the need for pan-sarbecovirus vaccines.Here,we discovered a new STING agonist,CF501,and found that CF501-adjuvanted RBD-FC vaccine(CF501/RBD-FC)elicited significantly stronger neutralizing antibody(nAb)and T cell responses than Alum-and cGAMP-adjuvanted RBD-FC in mice.Vaccination of rabbits and rhesus macaques(nonhuman primates,NHPs)with CF501/RBD-FC elicited exceptionally potent nAb responses against SARS-CoV-2 and its nine variants and 41 S-mutants,SARS-CoV and bat SARSr-CoVs.CF501/RBD-FC-immunized hACE2-transgenic mice were almost completely protected against SARS-CoV-2 challenge,even 6 months after the initial immunization.NHPs immunized with a single dose of CF501/RBD-FC produced high titers of nAbs.The immunized macaques also exhibited durable humoral and cellular immune responses and showed remarkably reduced viral load in the upper and lower airways upon SARS-CoV-2 challenge even at 108 days post the final immunization.Thus,CF501/RBD-Fc can be further developed as a novel pan-sarbecovirus vaccine to combat current and future outbreaks of sarbecovirus diseases. | Zezhong Liu Jie Zhou Wei Xu Wei Deng Yanqun Wang Meiyu Wang Qian Wang Ming Hsieh Jingming Dong Xinling Wang Weijin Huang Lixiao Xing Miaoling He Chunlin Tao Youhua Xie Yilong Zhang Youchun Wang Jincun Zhao Zhenghong Yuan Chuan Qin Shibo Jiang Lu Lu | 2022 | Cell Research2022，32，3： | 5 |
| 8 | Gut microbiota contributes to the development of endometrial glands in gilts during the ovary-dependent period显示文摘Background:The hyper-prolificacy Meishan gilts achieved a superior endometrial gland development(EGD)than white crossbred gilts during the ovary-independent period(before 60 d of age).Then,the EGD continues under the management of ovary-derived steroid hormones that regulated by gut microbiota(after 60 d of age).However,whether Meishan gilts’superiority in EGD lasting to the ovary-dependent period(after 60 d of age)and the role of gut microbiota in this period both remain unclear.Methods:Meishan gilts and Landrace x Yorkshire(LxY)gilts were raised under the same housing and feeding conditions until sexual maturity and then we compared their EGD and gut microbiota.Meanwhile,we transplanted fecal microbiota from Meishan gilts to L×Y gilts to explore the role of gut microbiota in EGD.We sampled plasma every 3 weeks and collected the uterus,ovary,liver,and rectal feces after the sacrifice.We then determined the hormone concentrations and expressions of the EGD-related genes.We also profiled the gut microbiota using 16S rDNA sequencing and metabolites of plasma and liver tissue using untargeted metabolomics.Finally,the correlation analysis and significant test was conducted between FMT-shifted gut microbes and EGD-related indices.Results:Meishan gilts have larger endometrial gland area(P<0.001),longer uterine horn length(P<0.01)but lighter uterine horn weight(P<0.05),a distinctive gut microbiota compared with L×Y gilts.Fecal microbiota transplantation(FMT)increased endometrial gland area(P<0.01).FMT markedly shifted the metabolite profiles of both liver and plasma,and these differential metabolites enriched in steroid hormone biosynthesis pathway.FMT increased estradiol and insulin-like growth factor 1 but decreased progesterone dynamically.FMT also increased the expression of the EGD-related genes estrogen receptor 1 gene,epithelial cadherin,and forkhead box protein A2.There is a significant correlation between FMT-shifted gut microbes and EGD-related indices.Conclusion:Sexually matured Meishan gilts achieved a superior EGD than LxY gilts.Meanwhile,gut microbiota contribute to the EGD potentially via regulating of steroid hormones during the ovary-dependent period. | Baoyang Xu Wenxia Qin Yiqin Yan Yimei Tang Shuyi Zhou Juncheng Huang Chunlin Xie Libao Ma Xianghua Yan | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 4 |
| 9 | Characterizing the induction of diabetes in juvenile cynomolgus monkeys with different doses of streptozotocin显示文摘Juvenile(2-3 years old) cynomolgus monkeys are frequently used as recipients in non-human primate islet transplantation studies.The aim of this study was to examine the effects of different doses of streptozotocin(STZ),and find the optimal dose for inducing diabetes in these monkeys.Fifteen juvenile(2-3 years old) cynomolgus monkeys were separated into three groups and administered with different doses of STZ(100,68 or 60 mg kg-1).Basal and glucose-stimulated blood glucose,insulin,and C-peptide levels,as well as body weights were monitored.Hepatic and renal function tests and pancreatic immunohistochemistry were performed before and after STZ treatment.Monkeys treated with both 100 and 68 mg kg-1 of STZ exhibited continuous hyperglycemia,which coincided with a nearly complete loss of islet--cells.Two monkeys received 60 mg kg-1 of STZ,but only one became completely diabetic.During the first week following STZ treatment,hepatic and renal function slightly increased in these three groups.However,24 hours post-STZ,serum total bile acid levels were significantly increased in monkeys treated with 100 mg kg-1 than those treated with 68 mg kg-1 of STZ(P<0.05).These data suggest that 100 mg kg-1 and 68 mg kg-1 of STZ can safely induce diabetes in cynomolgus monkeys aged 2-3 years,but 68 mg kg-1 of STZ,rather than 100 mg kg-1 of STZ,may be more appropriate for inducing diabetes in these monkeys.Furthermore,body surface area,rather than body weight,was a more reliable determinant of dosage,where 700 mg m-2 of STZ should be the lower limit for inducing diabetes in juvenile monkeys. | ZOU ChunLin WANG JiaYin WANG ShuYan HUANG Fen REN ZhenHua CHEN ZhiGuo ZHANG YU | 2012 | Science China(Life Sciences)2012，55，3： | 3 |
| 10 | A prototype RF power source for CSNS/RCS显示文摘A prototype RF power source has been built to supply high RF power to a ferrite-loaded cavity, which is a part of R&D of the Rapid Cycling Synchrotron of China Spallation Neutron Source (CSNS/RCS). A direct fast RF feedback amplifier, a 4:1 impedance transformer and auto tuning grid were locally located to compensate the heavy beam loading of CSNS/RCS. Design and commissioning of the RF power source is discussed here, also with some advice on system improvement. | WeiLing Huang (1) Hong Sun (1) HaiQi Zhao (2) Yu Liu (2) YanDong Li (2) ZhiGuang Qiao (2) Xiao Li (1) ChunLin Zhang (1) | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S2： | 3 |
| 11 | MIMO RADAR IMAGING MODEL AND ALGORITHM显示文摘Based on the array architecture of multiple transmitting/receiving antennas, Multi-Input Multi-Output (MIMO) radar provides a new mechanism for radar imaging technology. In order to explore the processing approach to this imaging mechanism, the two dimensional (2D) imaging model of MIMO radar is established first, and the spatial sampling ability is analyzed from the concept of spatial convolution of the antenna elements. The target spatial spectral filling format of MIMO radar with monochromatic transmitting signal is described. High-resolution imaging capability of MIMO radar is analyzed according to spatial spectral coverage and the corresponding imaging algorithm is presented. Finally, field imaging experiment is used to demonstrate the superior imaging performance of MIMO radar. | Wang Huaijun Lei Wentai Huang Chunlin Su Yi | 2009 | Journal of Electronics(China)2009，26，5： | 2 |
| 12 | Efficacy of Chaihu Jisang decoction on post-infection cough and its effect on cough reflex sensitivity显示文摘OBJECTIVE:To investigate the efficacy of Chaihu Ji Sang Decoction(CJSD),(a modification of Xiao Chaihu Tang(Minor Decoction of Bupleurum) was evaluated in patients with post-infection cough(PIC).Its effect on cough reflex sensitivity(CRS) was also described.METHODS:One hundred and eighteen patients with PIC were enrolled and randomly divided into an experimental group and control group(54 patients in each group).The experimental group was given CJSD orally,and the control group was given cetirizine hydrochloride for 7 d.Cough symptom scores and TCM symptom scores were compared before and after treatment.Efficacy,cough onset time,recurrence,and adverse drug reactions were additionally evaluated.Finally,CRS was evaluated before and after treatment of PIC patients in the experimental group.RESULTS:Fifty-two patients in the experimental group and fifty control patients completed the study.Cough symptom scores and the TCM symptom scores of the two groups were significantly improved after treatment,however cough symptoms in the experimental group 1(0,2) were significantly lower than the control group 2(1,2) after treatment(P < 0.05).Similarly,TCM symptom scores 4(0,7) in the experimental group were significantly lower than the control group 6(3,12)(P < 0.01).Overall,the effective rate of the experimental treatment(84.60%) was significantly higher than that of the control treatment(68.00%)(P < 0.01).The onset time of efficacy of the experimental treatment was one day faster than the control treatment [2(2,3) d vs 3(2,3) d,P < 0.01].The relapse rate in the experimental group(9.09%) was lower than that of the control group(29.41%)(P < 0.05).39 PIC patients in the experimental group completed a capsaicin cough challenge test before treatment.The lgC2 and lg C5 of the experimental group prior to treatment was 1.19(0.59,1.49) and 1.80(1.49,2.10),respectively.The lgC2,lg C5 of the healthy control group was 1.49(0.89,2.40) and 2.70(2.40,3.00),respectively.The differences in lgC2 and lg C5 between experimental group and healthy groups were significant at this time point(both P < 0.01).After treatment,34 patients in the experimental group received re-examination.lg C5 increased from 1.80(1.49,2.10) to 2.10(1.49,3.00).CRS after treatment/re-examination was significantly lower than those of baseline in the experimental group(P < 0.05).CONCLUSION:CJSD could effectively improve the clinical symptoms of PIC patients,with demonstrable low recurrence and safety.CJSD also significantly decreased the CRS in patients with PIC. | Hong Minli Huang Baopei Hong Chunlin Chen Huinuan Chen Wenxi Liu Chaohui Li Xinjian Li Candong | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 2 |
| 13 | Towards Wide-Open, Adaptable DCF Implementation for Dynamic Networks显示文摘This work proposes a Field Programmable Gate Array (FPGA)-oriented architecture for the IEEE 802. 11 Distributed Coordination Function (DCF) transceiver. We describe the functional blocks carrying out the Carrier Sense Multiple Accesses with Collision Avoidance (CSMA/CA), develop the interfaces to the application layer and the physical layer, and implement it on FPGA devices by utilizing Very-high-speed-integrated-circuit Hardware Description Language (VHDL). The novelty of our proposal is twofold. Firstly, all MAC parameters (i.e., Max/Min Contention Window, Data Unit Length, Fragmentation Threshold, Retry Limit, etc.) can be directly accessed and programmed from the application layer interface, which is necessary to achieve better network performance in dynamic environments. Secondly, the character based on FPGA makes the proposal more flexible and risk-reduced for the development of DCF-based wireless networks, such as MANETs and software-defined-radio-based cognitive ad hoc networks. | Wang Shan Abdelhakim Hafid Zhao Haitao Huang Shengchun Xieng Chunlin Wei Jibo | 2012 | China Communications2012，9，7： | 2 |
| 14 | Fusion of polarimetric and texture information for urban building ex- traction from fully polarimetric SAR imagery显示文摘 | Zhai Wei Shen Huanfeng Huang Chunlin | 2016 | Re- mote Sensing Letters2016，7，1： | 1 |
| 15 | Simultaneous estimation of surface soil moisture and soil properties with a dual ensemble Kalman smoother显示文摘In this paper, a new state-parameter estimation approach is presented based on the dual ensemble Kalman smoother(DEn KS) and simple biosphere model(Si B2) to sequentially estimate both the soil properties and soil moisture profile by assimilating surface soil moisture observations. The Arou observation station, located in the upper reaches of the Heihe River in northwestern China, was selected to test the proposed method. Three numeric experiments were designed and performed to analyze the influence of uncertainties in model parameters, atmospheric forcing, and the model's physical mechanics on soil moisture estimates. Several assimilation schemes based on the ensemble Kalman filter(En KF), ensemble Kalman smoother(En KS), and dual En KF(DEn KF) were also compared in this study. The results demonstrate that soil moisture and soil properties can be simultaneously estimated by state-parameter estimation methods, which can provide more accurate estimation of soil moisture than traditional filter methods such as En KF and En KS. The estimation accuracy of the model parameters decreased with increasing error sources. DEn KS outperformed DEn KF in estimating soil moisture in most cases, especially where few observations were available. This study demonstrates that the DEn KS approach is a useful and practical way to improve soil moisture estimation. | CHU Nan HUANG ChunLin LI Xin DU PeiJun | 2015 | Science China Earth Sciences2015，58，12： | 1 |
| 16 | Recent advances in bacterial cellulose显示文摘 | Huang Yang Zhu Chunlin Yang Jiazhi | 2014 | Cellulose2014，21，1： | 1 |
| 17 | Experiments of one-di- mensional soil moisture assimilation system based on Ensemble Kalman Filter显示文摘 | Huang Chunlin Li Xin Lu Ling | | 0，，03： | 1 |
| 18 | Retrieving soil temperature profile by as- similating MODIS LST products with Ensemble Kalman Filter显示文摘 | Huang Chunlin Li Xin | | 0，，04： | 1 |
| 19 | Intrinsically zincophobic protective layer for dendrite-free zinc metal anode显示文摘Aqueous zinc anodes have attracted the attention of many researchers owing to their high safety,low cost,and high theoretical specific capacity.However,its practical application is severely limited by the dendrite growth on zinc anode.Herein,we develop an intrinsically zincophobic barium-titanate protective layer with a porous structure to suppress the zinc dendrite formation by homogenizing the ion distribution on the anode surface,increasing the nucleation sites,and limiting the irregular zinc growth.Based on these synergistic effects,the coated zinc anode can exhibit long cycle life(840 h at 0.5 mA/cm^(2) for 0.5 mAh/cm^(2))and low voltage hysteresis(36 mV).This work can provide a feasible direction for the design of intrinsically zincophobic coating materials to uniformize the zinc stripping and plating. | Chunlin Xie Qi Zhang Zefang Yang Huimin Ji Yihu Li Huanhuan Li Liang Fu Dan Huang Yougen Tang Haiyan Wang | 2022 | Chinese Chemical Letters2022，33，5： | 1 |
| 20 | A decision support system for irrigation water allocation along the middle reaches of the Heihe River Basin,Northwest China显示文摘 | Ge Yingchun Li Xin Huang Chunlin | 2013 | Environmental Modelling&Software2013，47，： | 1 |
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