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| 1 | Relationship between serum cytokine levels and histopathological changes of liver in patients with hepatitis B显示文摘AIM: To investigate whether there was a relationship between the liver functions and fibrosis scores of hepatitis B patients and their TNF-α, IFN-γ, IL-4, and TGF-β1 serum levels based on the studies of liver biopsies. METHODS: Thirty patients with chronic hepatitis B (CHB)receiving no treatment and 30 healthy individuals with negative hepatitis serology and normal values of liver biochemistry were studied. After serum samples of the patients were collected, liver needle biopsy was performed on each patient. Cytokine levels were studied by ELISA.The biopsy materials were scored based on Knodell's histological activity index.RESULTS: In comparison of cytokine levels between CHB patients and control group, TNF-α, IL-4, and TGF-β1 levels of the patients were higher in CHB patients than in the controls, while IFN-γ level was lower in the patients than in the controls. There were significant differences between the groups in TNF-α, IL-4, TGF-β1, and IFN-γ (P<0.005,0.03, 0.002, 0.0001, respectively). There was a negativecorrelation between TGF-β1 and IL-4 and IFN-γ (P<0.05),TNF-α and the other cytokines and IFN-γ and IL-4 were not correlated (P>0.05). TGF-β1 was correlated with fibrosis (P<0.05). Liver necroinflammatory activity and fibrosis and TNF-α, IL-4, and IFN-γ were not correlated (P>0.05).CONCLUSION: In the course of HBV infection and its chronic progress, cytokines play an important role. IL-4and IFN-γ are effective in the chronic progression, whileTGF-β1 is effective in the development of fibrosis. Serum cytokine levels may be effective tools in the estimation of chronic progression and fibrosis development. | Nusret Akpolat Seyfettin Yahsi Ahmet Godekmerdan Kutbettin Demirbag Mehmet Yalniz | 2005 | World Journal of Gastroenterology2005，11，21： | 46 |
| 2 | Protective Effect of Melatonin on Antioxidative System in Experimental Ischemia-reperfusion of Rat Small Intestine 显示文摘 | Ustundag B Kazez A Demirbag M | 2000 | Cell Physiol Biochem2000，10，4： | 1 |
| 3 | Association of seirum uricacid level and coro- nary blood flow 显示文摘 | Yildiz A Yilmaz R Demirbag R | 2007 | Coronary Artery Disease2007，18，： | 1 |
| 4 | Relation of serum uric acid levels with the presence and severity of angiographic coronary artery disease显示文摘 | Gur M Yilmaz R Demirbag R | 2008 | Angiology2008，59，2： | 1 |
| 5 | The inverse relationship between thoracic aortic intima media thickness and testosterone level 显示文摘 | DEMIRBAG R YILMAZ R ULUCAY A | 2005 | Endocr Res2005，31，4： | 1 |
| 6 | Paraoxonase and arylesterase activities in patients with cardiac syndrome X,and their relationship with oxidative stress markers 显示文摘 | Gur M Yildiz A Demirbag R | 2007 | Coronary Artery Disease2007，18，2： | 1 |
| 7 | The inverse relationship between thoracicaortic intima-media thickness and testosterone 显示文摘 | Demirbag R Yilmaz R UIucay A | 2005 | Endocr Res2005，31，4： | 1 |
| 8 | Relationship between DNA damage,total antioxidant capacity and coronary artery disease显示文摘 | Demirbag R Yilmaz R Kocyigit A | 2005 | Mutat Res2005，570，2： | 1 |
| 9 | Effects of testicular fixation on oxidative stress - related parameters in prepubertal rat testis 显示文摘 | Surer I Demirbag S Ozturk H | 2006 | Arch Androl2006，52，1： | 1 |
| 10 | leaching kinetics of malachite in ammonia solution 显示文摘 | KUNKUL M M KOCAKERIM S DEMIRBAG Y A | 1994 | International Journal of Mineral Processing1994，41，3： | 1 |
| 11 | Global Knowledge and R&D Foreign Direct Investment Flows:Recent Patterns in Asia Pacific,Europe,and North America显示文摘 | Huggins R DEmirbag M Ratcheva V I | | 0，，03： | 1 |
| 12 | Global knowledge and R&D foreign direct investment flows:recent patterns in Asia Pacific,Europe,and North America显示文摘 | HUGGINS R DEMIRBAG M RATCHEVA V I | | 0，，03： | 1 |
| 13 | The relationship between potency of oxidative stress and severity of dilated cardiomyopathy显示文摘 | Demirbag R Yilmaz R Erel O | 2005 | Can J Cardiol2005，21，10： | 1 |
| 14 | Effects of treadmill exercise test on oxidative/ antioxidative parameters and DNA damage显示文摘 | Demirbag R Yilmaz R Gu zel S | 2006 | Anadolu Kardiyol Derg2006，6，2： | 1 |
| 15 | Resources and equity owner- ship in UVs in Turkey显示文摘 | DEMIRBAG M WEIR D | 2006 | Thunderbird International Bus- iness Review2006，48，1： | 1 |
| 16 | Leaching kinetic of malachite in ammonia solution 显示文摘 | KUNKUL A KOCAKERIM M M YAPICI S DEMIRBAG A | 1994 | International Journal of Mineral Processing1994，41，34： | 1 |
| 17 | Factors affecting perceptions of the choice between acquisition and greenfield entry: The case of Western FDI in an emerging market显示文摘 | Mehmet Demirbag Ekrem Tatoglu Keith W. Glaister | 2008 | Management International Review2008，，1： | 1 |
| 18 | The protective effects of ozone therapy in a rat model of acetaminophen-induced liver injury显示文摘 | Husamettin Gul Bulent Uysal Erdinc Cakir Halil Yaman Enis Macit Ali Osman Yildirim Yusuf Emrah Eyi Umit Kaldirim Emin Oztas Emin Ozgur Akgul Tuncer Cayci Mehmet Ozler Turgut Topal Sukru Oter Ahmet Korkmaz Mehmet Toygar Suzi Demirbag | 2012 | Environmental Toxicology and Pharmacology2012，，1： | 1 |
| 19 | The inverse relationship between thoracic aortic intima media thickness and testosterone level显示文摘 | Demirbag R Yilmaz R Ulucay A Unlu D | 2005 | End Res2005，31，4： | 1 |
| 20 | The relationship between plasma C-reactive protein levels and presence and severity of coronary stenosis in patients with stable angina显示文摘 | Ulucay A Demirbag R Yilmaz R | 2007 | Angiology2007，58，： | 1 |
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