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| 1 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020，2，1： | 26 |
| 2 | Levels and trends of poly-and perfluoroalkyl substances in the Arctic environment-An update显示文摘Poly-and perfluoroalkyl substances(PFASs)are important environmental contaminants globally and in the early 2000s they were shown to be ubiquitous contaminants in Arctic wildlife.Previous reviews by Butt et al.and Letcher et al.have covered studies on levels and trends of PFASs in the Arctic that were available to 2009.The purpose of this review is to focus on more recent work,generally published between 2009 and 2018,with emphasis on PFASs of emerging concern such as perfluoroalkyl carboxylates(PFCAs)and short-chain perfluoroalkyl sulfonates(PFSAs)and their precursors.Atmospheric measurements over the period 2006e2014 have shown that fluorotelomer alcohols(FTOHs)as well as perfluorobutanoic acid(PFBA)and perfluoroctanoic acid(PFOA)are the most prominent PFASs in the arctic atmosphere,all with increasing concentrations at Alert although PFOA concentrations declined at the Zeppelin Station(Svalbard).Results from ice cores show generally increasing deposition of PFCAs on the Devon Ice cap in the Canadian arctic while declining fluxes were found in a glacier on Svalbard.An extensive dataset exists for long-term trends of long-chain PFCAs that have been reported in Arctic biota with some datasets including archived samples from the 1970s and 1980s.Trends in PFCAs over time vary among the same species across the North American Arctic,East and West Greenland,and Svalbard.Most long term time series show a decline from higher concentrations in the early 2000s.However there have been recent(post 2010)increasing trends of PFCAs in ringed seals in the Canadian Arctic,East Greenland polar bears and in arctic foxes in Svalbard.Annual biological sampling is helping to determine these relatively short term changes.Rising levels of some PFCAs have been explained by continued emissions of long-chain PFCAs and/or their precursors and inflows to the Arctic Ocean,especially from the North Atlantic.While the effectiveness of biological sampling for temporal trends in long-chain PFCAs and PFSAs has been demonstrated,this does not apply to the C4eC8ePFCAs,perfluorobutane sulfonamide(FBSA),or perfluorobutane sulfonate(PFBS)which are generally present at low concentrations in biota.In addition to air sampling,sampling abiotic media such as glacial cores,and annual sampling of lake waters and seawater would appear to be the best approaches for investigating trends in the less bioaccumulative PFASs. | Derek Muir Rossana Bossi Pernilla Carlsson Marlene Evans Amila De Silva Crispin Halsall Cassandra Rauert Dorte Herzke Hayley Hung Robert Letcher Frank Riget Anna Roos | 2019 | Emerging Contaminants2019，5，1： | 3 |
| 3 | 黄芪及其发酵产物对PM2.5肺损伤动态可视化微循环的影响显示文摘目的:探讨黄芪发酵产物拮抗PM2.5肺损伤的干预效果,为黄芪研究及其发酵产物的开发利用提供参考依据。方法:通过电感耦合等离子体发射光谱仪确定PM2.5重金属的主要成分。将36只Wistar大鼠随机分成空白对照组,染毒组,黄芪组,黄芪发酵产物低、中、高剂量组,根据文献采用气管滴注方法复制PM2.5肺损伤的动物模型,各组相应处理4周,最后1次滴注后,进行微循环动态可视化观察研究,并进行血气分析检测。录制直径在30~50μm的肺细静脉白细胞黏附动态视频,计算200μm长的肺细静脉内粘附白细胞数量。结果:本研究PM2.5的重金属成分以铁(Fe)、锌(Zn)、铬(Cr)为主。与空白对照组比较,染毒组肺组织白细胞聚集严重(P<0.01),PCO_(2)显著升高(P<0.05),PO_(2)和SO_(2)显著降低(P<0.05)。与染毒组比较,黄芪组及黄芪发酵产物中、高剂量组黏附于肺细静脉血管壁的白细胞数量显著减少(P<0.05),PCO_(2)显著降低(P<0.05),PO_(2)和SO_(2)显著升高(P<0.05)。结论:黄芪发酵产物能使PM2.5损伤的肺组织炎性程度降低,肺功能得到改善,对临床上呼吸系统疾病防治及其黄芪科学研究具有一定的启示作用。 | 刘必旺 赵换 马一方 张惠忠 燕小宁 栾智华 马艳苗 周文静 封雪 赵俊云 杨向竹 Baukje de Roos | 2021 | 中华中医药杂志2021，36，9： | 3 |
| 4 | Altered Myocardial Substrate Metabolism and Decreased Diastolic Function in Nonischemic Human Diabetic Cardiomyopathy显示文摘 | Luuk J. Rijzewijk Rutger W. van der Meer Hildo J. Lamb Hugo W.A.M. de Jong Mark Lubberink Johannes A. Romijn Jeroen J. Bax Albert de Roos Jos W. Twisk Robert J. Heine Adriaan A. Lammertsma Johannes W.A. Smit Michaela Diamant | 2009 | Journal of the American College of Cardiology2009，，16： | 2 |
| 5 | Reduction of Postoperative Ileus by Early Enteral Nutrition in Patients Undergoing Major Rectal Surgery: Prospective, Randomized, Controlled Trial显示文摘 | Petra G. Boelens Fanny F. B. M. Heesakkers Misha D. P. Luyer Kevin W. Y. van Barneveld Ignace H. J. T. de Hingh Grard A. P. Nieuwenhuijzen Arnout N. Roos Harm J. T. Rutten | 2014 | Annals of Surgery2014，，4： | 2 |
| 6 | A simple raster-based model for flood inundation simulation显示文摘 | P.D Bates A.P.J De Roo | 2000 | Journal of Hydrology2000，，1： | 2 |
| 7 | Real-Time Three-Dimensional Echocardiography: Segmental Analysis of the Right Ventricle in Patients with Repaired Tetralogy of Fallot显示文摘 | Annelies E. van der Hulst Arno A.W. Roest Eduard R. Holman Albert de Roos Nico A. Blom Jeroen J. Bax Victoria Delgado | 2011 | Journal of the American Society of Echocardiography2011，，11： | 2 |
| 8 | Regional assessment of soil erosion using the distributed model SEMMED and remotely sensed data显示文摘 | S.M. de Jong M.L. Paracchini F. Bertolo S. Folving J. Megier A.P.J. de Roo | 1999 | Catena1999，，3： | 2 |
| 9 | Long-chain n-3 polyunsaturated fatty acids:new insights into mechanisms relating to inflammation and coronary heart disease显示文摘 | de Roos B Mavrommatis Y Brouwer IA | 2009 | Br J Pharmacol2009，，2： | 1 |
| 10 | Soil erosion modeling using ANSWERS and geographical information system显示文摘 | Roo de A p J Hazelhoff L Burrough P A | 1980 | Earth Surface Processes and Landforms1980，14，： | 1 |
| 11 | Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death inpolyglutamine diseases显示文摘 | de Pril R Fischer D F Roos R A C | 2007 | Mol Cell Neurosci2007，34，： | 1 |
| 12 | Resistant starch has little effect on appetite, food intake and insulin secretion of healthy young men显示文摘 | de ROOS N HEIJNEN M L de GRAFF C | 1995 | European Journal of Clinical Nutrition1995，49，7： | 1 |
| 13 | Lack of vascular connexin 40 is associated with hypertension and irregular arteriolar vasomotion显示文摘 | de Wit C Roos E Bolz SS | 2003 | Physiol Genom2003，13，2： | 1 |
| 14 | Impact of the jobs-housing balance on urban commuting in Beijing in the transformation era显示文摘 | Zhao P Lti B De Roo G | 2011 | Journal of transport geography2011，19，1： | 1 |
| 15 | Chronic granulomatous disease caused by mutations other than the common GT deletion in NCF1, the gene encoding the p47phox component of the phagocyte NADPH oxidase 显示文摘 | Roos D de Boer M Yavuz KM | 2006 | Human Mutation2006，27，12： | 1 |
| 16 | Cell markers, cyto- kines, and immune parameters in cement mason apprentices 显示文摘 | Carlsten C De Roos AJ Kaufman JD | 2007 | Arthritis Rheum2007，57，1： | 1 |
| 17 | Replacement of dietarysaturated fatty acids by trans fatty acids lowers serum HDL cholesteroland impairs endothelial function in healthy men and women显示文摘 | DE ROOS N M BOTS M L KATAN M B | 2001 | Arterioscler Thromb Vasc Biol2001，21，： | 1 |
| 18 | Progression of brain atrophy and cognitive decline in diabetes mellitus: a 3-year follow-up显示文摘 | Van Elderen S G De Roos A De Craen a J | 2010 | Neurology2010，75，11： | 1 |
| 19 | Factors affecting oocyte quality and quantity in commercial application of embryo technologies in the cattle breeding industry显示文摘 | MERTON J S DE ROOS A P W MULLAART E | | 0，，02： | 1 |
| 20 | Volatile anesthetics rapidly in- crease dendritic spine density in the rat medial prefrontal cortex dur- ing synaptogenesis 显示文摘 | Briner A De Roo M Dayer A | 2010 | Anesthesiology2010，112，3： | 1 |
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