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| 1 | 儿童期肥胖、成年期肥胖和心血管风险因子显示文摘过去30年,儿童超重或肥胖的发生率明显增加[1]。儿童期肥胖是死亡率增加的预测因子,这主要是由于儿童期肥胖可导致心血管疾病发生率增加。相关的预测研究提示"肥胖流行症"可能改变目前心血管疾病死亡率下降的趋势,使现今儿童的寿命缩短。 | Juonala M Magnussen CG Berenson GS Venn A Burns TL Sabin MA Srinivasan SR Daniels SR Davis PH Chen W Sun C Cheung M Viikari JS Dwyer T Raitakari OT 叶鹏 | 2012 | 中华高血压杂志2012，20，1： | 6 |
| 2 | Oedema and glial cell involvement in the aged mouse brain after permanent focal ischaemia显示文摘 | Fotheringham A P Davies C A Davies I | 2000 | Neuropathol Appl Neurobiol2000，26，5： | 4 |
| 3 | Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation显示文摘 | D.L Lacey E Timms H.-L Tan M.J Kelley C.R Dunstan T Burgess R Elliott A Colombero G Elliott S Scully H Hsu J Sullivan N Hawkins E Davy C Capparelli A Eli Y.-X Qian S Kaufman I Sarosi V Shalhoub G Senaldi J Guo J Delaney W.J Boyle | 1998 | Cell1998，，2： | 4 |
| 4 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 5 | Verification and sensitivity experiments for the WISP94 MM5 forecasts显示文摘 | MANNING K W DAVIS C A | 1997 | Wea Forecasting1997，12，： | 1 |
| 6 | Characterization of the behavior of rubber for engineering design purpose显示文摘 | De K D Thomas A G | 1994 | Rubber Chem Tech1994，67，4： | 1 |
| 7 | A new and highly efficient grubbs initiator for ring-opening metathesis polymerization显示文摘 | Robson D A Gibson V C Davies R G | 1999 | Macromolecules1999，32，19： | 1 |
| 8 | Bacterical inoculants for preservation oI alfalfa hay显示文摘 | Rotz C A Davis R G Buckmaster D R | 1988 | Journal of Production Agriculture1988，，1： | 1 |
| 9 | Electromagnetic determination of soil water content: measurement in coaxial transmission lines显示文摘 | Topp G C Davis J L Annan A P | 1980 | Water Resources Research1980，16，3： | 1 |
| 10 | Bioretention column studies of phosphorus removal from urban storm water runoff显示文摘 | Hsieh C H Davis A P Needleman B A | 2007 | Water Environ Res2007，79，2： | 1 |
| 11 | Two new mechanisims of macrolide resistace in clinical mains of Streptococcus pneumoniase from Eastern Europe and North America 显示文摘 | Tait-Kamradt A Davies T A ppebatun P C | 2000 | Antimitrob Agents Chemother2000，44，11： | 1 |
| 12 | The purification and characterization of extremely thermostable α-amylase from the hyperthmophilic archaebacterium Pyrococcus furiosus显示文摘 | Laderman K A Davis B R Krutzsch H C | 1993 | The Journal of Biological Chemistry1993，268，24： | 1 |
| 13 | 5-epi-deoxyrhamnojirimycin is a potent inhibitor of an α-L-rhamnosidase:5-epi-deoxymannojirimycin is not a potent inhibitor of an α-D-mannosidase显示文摘 | Davis B G Hull A Smith C | 1998 | Tetrahedron:Asymmetry1998，9，： | 1 |
| 14 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 15 | Sweet potato viru- ses:15 years of progress on understanding and managing complex diseases显示文摘 | Clark C A Davis J A Abad J A | 2012 | Plant Disease2012，96，： | 1 |
| 16 | 查看详情显示文摘 | Cole A C Jensen J L Ntai I Tran K L T Weaver K J Forbes D C Davis J H Jr | | 0，，： | 1 |
| 17 | A potential-vorticity diagnosis of the importance of initial structure and condensational heating in observed extra-tropical cyclogenesis显示文摘 | Davis C A | | 0，，： | 1 |
| 18 | Indication of the Maillard reaction during storage of protein isolates显示文摘 | Davies C G A Netto F M Glassenap N | | 0，，： | 1 |
| 19 | Robust regeneration of adult sensory axons in degenerating white matter of the adult rat spinal cord显示文摘 | Davies S J A Goucher D R Doller C | | 0，，14： | 1 |
| 20 | Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates显示文摘 | LEE R G WILLINGHAM M C DAVIS M A | 2000 | J Lipid Res2000，41，12： | 1 |
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