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| 1 | The roles of MAPKs in disease显示文摘印射响应许多 ligands 和房间刺激涉及大量的细胞的小径和功能的家族 ases transduce 信号。MAPK 的异常或不恰当的功能现在在从癌症到煽动性的疾病到肥胖和糖尿病的疾病被识别了。在许多房间类型, MAPK ERK1/2 被连接到细胞增殖。因为在地岬和 B-Raf 的变化,能激活 ERK1/2 串联,在许多人的肿瘤被发现, ERK1/2 被认为在一些癌症起一个作用。发信号的反常 ERK1/2 也在 polycystic 肾疾病被发现了,并且象 cardio-facio-cutaneous 症候群那样的严肃的发展混乱在 ERK1/2 串联的部件从变化产生。ERK1/2 在区分得好的房间是必要的并且在神经原并且在上皮的极性的维护被连接了到长期的 potentiation。另外, ERK1/2 为在胰腺的贝它房间的胰岛素基因抄写是重要的,它响应传播葡萄糖的增加生产胰岛素在有机体允许有效葡萄糖利用和存储。导致或镇压的营养素和荷尔蒙胰岛素分泌物以在贝它房间上反映能分泌的需求的一种方式激活或禁止 ERK1/2。在这和另外的规章的小径的骚乱可以导致对某些人的混乱的病原学的 ERK1/2 的贡献。 | Michael C Lawrence Arif Jivan Chunli Shao Lingling Duan Daryl Goad Elma Zaganjor Jihan Osborne Kathleen McGlynn Steve Stippec Svetlana Earnest Wei Chen Melanie H Cobb | 2008 | Cell Research2008，18，4： | 64 |
| 2 | Evacuated tube transport technologies (ET3)^(tm):a maximum value global transportation network for passengers and cargo显示文摘Evacuated Tube Transport Technologies(ET3) offers the potential for more than an order of magnitude improvement in transportation efficiency,speed,cost,and effectiveness.An ET3 network may be optimized to sustainably displace most global transportation by car,ship,truck,train,and jet aircraft.To do this,ET3 standards should adhere to certain key principals:maximum value through efficiency,reliability,and simplicity;equal consideration for passenger and cargo loads;optimum size;high speed/high frequency operation;demand oriented;random accessibility;scalability;high granularity;automated control;full speed passive switching;open standards of implementation;and maximum use of existing capacities,materials,and processes. | Daryl OSTER Masayuki KUMADA Yaoping ZHANG | 2011 | Journal of Modern Transportation2011，19，1： | 25 |
| 3 | 小麦谷蛋白聚合体粒度分布与面粉揉面特性关系的研究显示文摘选用在谷蛋白 Glu- 1和 Glu- 3的 5个位点 (除 Glu- A1位点外 )上均带有不同等位基因的小麦品种 Suneca和 Cook的杂交 F4 代群体中谷蛋白各亚基位点均为纯合基因的 60个系 ,测定基因型不同的系间谷蛋白聚合体粒度分布和面粉揉面特性的变异 ,研究小麦谷蛋白聚合体粒度分布与面粉揉面特性的关系。结果表明 ,不同的谷蛋白基因型 ,其谷蛋白聚合体粒度大小相对分布 (即 U PP% )和面团形成时间 (即揉面曲线图峰值的和面时间 ,PTM)均有显著差异。面粉的揉面曲线形状与其 U PP%值密切相关 ,U PP%与 PTM呈极显著正相关 ,与揉面曲线图峰高 ( PHM)呈显著负相关 ;与面粉蛋白质含量 ( FP% )相比 ,U PP%对 PTM和 PHM的影响更大些 。 | 赵惠贤 胡胜武 吉万全 薛秀庄 郭蔼光 Daryl Mares | 2001 | 中国农业科学2001，34，5： | 23 |
| 4 | Key vacuum technology issues to be solved in evacuated tube transportation显示文摘Evacuated tube transportation(ETT) will be one of the ultra-large-scale vacuum application areas.This paper lists some key vacuum technology issues in ETT:(1) how to construct ultra-large-scale vacuum chamber with lower cost and high reliability,(2) how to evacuate gas out of the ETT tube in short time,(3) how to release heat or reduce temperature in the vacuum tube,(4) how to avoid vacuum discharge,(5) how to make vehicles with airproof shells and life support system,and(6) how to detect leaks and find leak positions efficiently.At the same time,some solutions are proposed. | Yaoping ZHANG Daryl OSTER Masayuki KUMADA Jianye YU Shengshan LI | 2011 | Journal of Modern Transportation2011，19，2： | 13 |
| 5 | Update on the applications and limitations of alpha-fetoprotein for hepatocellular carcinoma显示文摘Alpha-fetoprotein(AFP)is an oncofetal glycoprotein that has been used as a tumor marker for hepatocellular carcinoma(HCC)in combination with ultrasound and other imaging modalities.Its utility is limited because of both low sensitivity and specificity,and discrepancies among the different methods of measurements.Moreover,its accuracy varies according to patient characteristics and the AFP cut-off values used.Combination of AFP with novel biomarkers such as AFP-L3,Golgi specific membrane protein(GP73)and des-gamma-carboxyprothrombin significantly improved its accuracy in detecting HCC.Increased AFP level could also signify severity of hepatic destruction and subsequent regeneration and is commonly observed in patients with acute and chronic liver conditions and cirrhosis.Hereditary and other non-hepatic disorders can also cause AFP elevation. | Hira Hanif Mukarram Jamat Ali Ammu T Susheela Iman Waheed Khan Maria Alejandra Luna-Cuadros Muzammil Muhammad Khan Daryl Tan-Yeung Lau | 2022 | World Journal of Gastroenterology2022，28，2： | 9 |
| 6 | Intrahepatic distribution of hepatitis B virus antigens in patients with and without hepatocellular carcinoma显示文摘AIM: To study the intrahepatic expression of hepatitis B surface antigen(HBs Ag) and hepatitis B core antigen(HBc Ag) in chronic hepatitis B patients with and without hepatocellular carcinoma. METHODS: A total of 33 chronic hepatitis B patients(mean age of 40.3 ± 2.5 years), comprising of 14 HBe Ag positive and 19 HBe Ag negative patients; and 13 patients with hepatitis B virus related hepatocellular carcinoma(mean age of 49.6 ± 4.7 years), were included in our study. Immunohistochemical staining for HBc Ag and HBs Ag was done using standard streptavidin-biotin-immunoperoxidase technique on paraffin-embedded liver biopsies. The HBc Agand HBs Ag staining distributions and patterns were described according to a modified classification system. RESULTS: Compared to the HBe Ag negative patients, the HBe Ag positive patients were younger, had higher mean HBV DNA and alanine transaminases levels. All the HBe Ag positive patients had intrahepatic HBc Ag staining; predominantly with 'diffuse' distribution(79%) and 'mixed cytoplasmic/nuclear ' pattern(79%). In comparison, only 5% of the HBe Ag-negative patients had intrahepatic HBc Ag staining. However, the intrahepatic HBs Ag staining has wider distribution among the HBe Ag negative patients, namely; majority of the HBe Ag negative cases had 'patchy' HBs Ag distribution compared to 'rare' distribution among the HBe Ag positive cases. All but one patient with HCC were HBe Ag negative with either undetectable HBV DNA or very low level of viremia. Intrahepatic HBc Ag and HBs Ag were seen in 13(100%) and 10(77%) of the HCC patients respectively. Interestingly, among the 9 HCC patients on anti-viral therapy with suppressed HBV DNA, HBc Ag and HBs Ag were detected in tumor tissues but not the adjacent liver in 4(44%) and 1(11%) patient respectively. CONCLUSION: Isolated intrahepatic HBc Ag and HBs Ag can be present in tumors of patients with suppressed HBV DNA on antiviral therapy; that may predispose them to cancer development. | Parham Safaie Mugilan Poongkunran Ping-Ping Kuang Asad Javaid Carl Jacobs Rebecca Pohlmann Imad Nasser Daryl TY Lau | 2016 | World Journal of Gastroenterology2016，22，12： | 5 |
| 7 | 动脉瘤性蛛网膜下腔出血患者的重症监护处理:神经危重症监护学会多学科共识会议的推荐意见显示文摘蛛网膜下腔出血(subarachnoidhemorrhage,SAH)是一种可对中枢神经系统造成毁灭性打击并对其他多个器官产生显著影响的急性脑血管病。SAH患者被常规收入重症监护病房并由多学科团队进行治疗。由于高质量研究证据的缺乏,使得治疗方法各异,可供选择的指导意见不多。现有的指南主要强调危险因素、预防、自然史以及再出血的预防,很少涉及SAH患者的重症监护问题。美国神经危重症监护学会组织了一次国际性多学科共识会议来探讨SAH的重症监护处理。根据发表的文章和研究领域,此次会议召集了来自欧洲和北美地区的神经重症监护科、神经外科、神经内科、介入神经放射科和神经麻醉科方面的专家。根据临床经验和制定实践指南方面的经验,选择4名经验丰富的神经重症监护专家组成评判委员会。应用推荐分级的评估、制定与评价(GradesofRecommendationsAssessment,DevelopmentandEvaluation,GRADE)系统进行文献回顾,结合参会者的经验、评判委员会的审评以及文献讨论产生推荐意见。应用GRADE系统制定推荐意见,其制定原则不仅强调研究资料的质量,而且还重视利弊权衡与实践转化。对SAH患者日常处理过程中面临的所有问题均提供指导和推荐意见,即使缺乏高质量的证据。 | Michael N. Diringer Thomas P. Bleck J. Claude Hemphill David Menon Lori Shutter Paul Vespa Nicolas Bruder E. Sander Connolly Jr Giuseppe Citerio Daryl Gress Daniel Hanggi Brian L. Hoh Giuseppe Lanzino Peter Le Roux Alejandro Rabinstein, Erich Schmut zhard Nino Stocchetti Jose I. Suarez Miriam Tresgiari Ming-Yuan Tseng Mervyn D. I. Vergouwen Stefan Wolf Gregory Zip fel 田飞(译) 宿 英英(译) | 2013 | 国际脑血管病杂志2013，21，5： | 5 |
| 8 | Cytogenetic and molecular aberrations of multiple myeloma patients: a single-center study in Singapore显示文摘 | LIM Alvin Soon Tiong LIM Tse Hui SEE Karen Hsu Shien NG Yit Jun TAN Yu Min CHO0 Natasha Swee Lian LIM Sherry Xin Er YEE Yenny LAU Lai Ching TIEN Sim Leng Kumar Sathish TAN Daryl Chen Lung | 2013 | Chinese Medical Journal2013，，10： | 4 |
| 9 | Optical disassembly of cellular clusters by tunable ‘tug-of-war’ tweezers显示文摘Bacterial biofilms underlie many persistent infections,posing major hurdles in antibiotic treatment.Here we design and demonstrate‘tug-of-war’optical tweezers that can facilitate the assessment of cell–cell adhesion—a key contributing factor to biofilm development,thanks to the combined actions of optical scattering and gradient forces.With a customized optical landscape distinct from that of conventional tweezers,not only can such‘tug-of-war’tweezers stably trap and stretch a rod-shaped bacterium in the observing plane,but,more importantly,they can also impose a tunable lateral force that pulls apart cellular clusters without any tethering or mechanical movement.As a proof of principle,we examined a Sinorhizobium meliloti strain that forms robust biofilms and found that the strength of intercellular adhesion depends on the growth medium.This technique may herald new photonic tools for optical manipulation and biofilm study,as well as other biological applications. | Anna S Bezryadina Daryl C Preece Joseph C Chen Zhigang Chen | 2016 | Light(Science & Applications)2016，5，1： | 4 |
| 10 | 建立初级卒中中心的修订和更新意见来自脑卒中联盟的总结声明显示文摘背景和目的自从2000年脑卒中联盟发布首份关于建立初级卒中中心的推荐意见以来,初级卒中中心的组建和认证工作已出现迅速发展。本文的目的在于修订和更新我们关于初级卒中中心的推荐意见以反映最新资料和经验。方法我们使用MEDLINE和PubMed数据库回顾了相关文献(2000年3月至2011年1月),主要针对急性卒中的诊断、治疗和护理。如果发现有效且相关,同样对原始文献、汇总分析和其他治疗指南进行回顾并纳入分析。标明证据等级以反映当前指南发展的实际情况。结果基于文献回顾以及针对初级卒中中心的经验,一些要素的重要性已得到进一步的加强,同时增加了几个新的领域。这些内容包括:(1)急诊卒中团队的重要性;(2)配备遥测监控的卒中单元的重要性;(3)MRj和弥散加权序列进行脑成像的实施;(4)用磁共振血管成像或CT血管成像对脑血管系统进行评价;(5)心脏影像学检查;(6)康复治疗的早期启动;(7)由独立机构进行的认证,包括实地考察和疾病评价指标。结论基于上述证据,初级卒中中心的某些要素对于改善急性卒中患者的诊治特别重要。其他要素则集中于脑、脑血管系统和心脏的影像学检查。这些新的要素也许能改善在初级卒中中心接受诊治的卒中患者的治疗和转归。 | Mark J. Alberts Richard E. Latchaw Andy Jagoda Lawrence R Wechsler Todd Crocco Mary G. George E.S. Connolly Barbara Mancini Stephen Prudhomme Daryl Gress Mary E. Jensen Robert Bass Robert Ruff Kathy Foell Rocco A. Armonda Marian Emr Margo Warren Jim Baranski Michael D. Walker 黄志超(译) 张霞(译) 尤寿江(译) 曹勇军(译) 刘春风(译) | 2012 | 国际脑血管病杂志2012，20，7： | 3 |
| 11 | A high-density microsatellite consensus map for bread wheat ( Triticum aestivum L.)显示文摘 | Daryl J. Somers Peter Isaac Keith Edwards | 2004 | Theoretical and Applied Genetics2004，，6： | 3 |
| 12 | 高纤维日粮饲喂妊娠母猪的效果显示文摘评注(闫之春,美国谷物协会):Reese博士的这篇综述,给我们指出了发现问题的新思路:尽管多年来对在母猪料中添加纤维素的研究已有很多,但是,按添加的时机/期长短、纤维素的种类、来源分类后,对母猪后续繁殖周期胎产活仔、窝均断奶活仔、泌乳期采食量、泌乳期失重的影响就不同了。尽管如此,在妊娠期母猪料中添加纤维素总体上仍然是有益的。 | Duane E.Reese Allen Prosch Daryl A.Travnicek Kent M.Eskridge 赵克斌(译者) 罗兰(译者) 闫之春(审校) | 2008 | 今日养猪业2008，，4： | 3 |
| 13 | Optical force-induced nonlinearity and self-guiding of light in human red blood cell suspensions显示文摘Osmotic conditions play an important role in the cell properties of human red blood cells(RBCs),which are crucial for the pathological analysis of some blood diseases such as malaria.Over the past decades,numerous efforts have mainly focused on the study of the RBC biomechanical properties that arise from the unique deformability of erythrocytes.Here,we demonstrate nonlinear optical effects from human RBCs suspended in different osmotic solutions.Specifically,we observe self-trapping and scattering-resistant nonlinear propagation of a laser beam through RBC suspensions under all three osmotic conditions,where the strength of the optical nonlinearity increases with osmotic pressure on the cells.This tunable nonlinearity is attributed to optical forces,particularly the forward-scattering and gradient forces.Interestingly,in aged blood samples(with lysed cells),a notably different nonlinear behavior is observed due to the presence of free hemoglobin.We use a theoretical model with an optical force-mediated nonlocal nonlinearity to explain the experimental observations.Our work on light self-guiding through scattering biosoft-matter may introduce new photonic tools for noninvasive biomedical imaging and medical diagnosis. | Rekha Gautam Yinxiao Xiang Josh Lamstein Yi Liang Anna Bezryadina Guo Liang Tobias Hansson Benjamin Wetzel Daryl Preece Adam White Matthew Silverman Susan Kazarian Jingjun Xu Roberto Morandotti Zhigang Chen | 2019 | Light(Science & Applications)2019，8，1： | 3 |
| 14 | Impacts of climate change on hydrology,water quality and crop productivity in the Ohio-Tennessee River Basin显示文摘Nonpoint source pollution from agriculture is the main source of nitrogen and phosphorus in the stream systems of the Corn Belt region in the Midwestern US.The eastern part of this region is comprised of the Ohio-Tennessee River Basin(OTRB),which is considered a key contributing area for water pollution and the Northern Gulf of Mexico hypoxic zone.A point of crucial importance in this basin is therefore how intensive corn-based cropping systems for food and fuel production can be sustainable and coexist with a healthy water environment,not only under existing climate but also under climate change conditions in the future.To address this issue,a OTRB integrated modeling system has been built with a greatly refined 12-digit subbasin structure based on the Soil and Water Assessment Tool(SWAT)water quality model,which is capable of estimating landscape and in-stream water and pollutant yields in response to a wide array of alternative cropping and/or management strategies and climatic conditions.The effects of three agricultural management scenarios on crop production and pollutant loads exported from the crop land of the OTRB to streams and rivers were evaluated:(1)expansion of continuous corn across the entire basin,(2)adoption of no-till on all corn and soybean fields in the region,(3)implementation of a winter cover crop within the baseline rotations.The effects of each management scenario were evaluated both for current climate and projected mid-century(2046-2065)climates from seven global circulation models(GCMs).In both present and future climates each management scenario resulted in reduced erosion and nutrient loadings to surface water bodies compared to the baseline agricultural management,with cover crops causing the highest water pollution reduction.Corn and soybean yields in the region were negligibly influenced from the agricultural management scenarios.On the other hand,both water quality and crop yield numbers under climate change deviated considerably for all seven GCMs compared to the baseline climate.Future climates from all GCMs led to decreased corn and soybean yields by up to 20%on a mean annual basis,while water quality alterations were either positive or negative depending on the GCM.The study highlights the loss of productivity in the eastern Corn Belt under climate change,the need to consider a range of GCMs when assessing impacts of climate change,and the value of SWAT as a tool to analyze the effects of climate change on parameters of interest at the basin scale. | Yiannis Panagopoulos Philip W.Gassman Raymond W.Arritt Daryl E.Herzmann Todd D.Campbell Adriana Valcu Manoj K.Jha Catherine L.Kling Raghavan Srinivasan Michael White Jeffrey G.Arnold | 2015 | International Journal of Agricultural and Biological Engineering2015，8，3： | 2 |
| 15 | Nitrite Regulates Hypoxic Vasodilation via Myoglobin-Dependent Nitric Oxide Generation显示文摘 | Matthias Totzeck Ulrike B. Hendgen-Cotta Peter Luedike Michael Berenbrink Johann P. Klare Heinz-Juergen Steinhoff Dominik Semmler Sruti Shiva Daryl Williams Anja Kipar Mark T. Gladwin Juergen Schrader Malte Kelm Andrew R. Cossins Tienush Rassaf | 2012 | Circulation2012，，3： | 2 |
| 16 | Optical tug-of-war tweezers:shaping light for dynamic control of bacterial cells(Invited Paper)显示文摘We design and demonstrate new types of optical tweezers with lateral pulling forces that allow full control of biological samples with complex geometric shapes.With appropriate beam shaping,the dual tug-of-war tweezers effectively hold and stretch elongated biological objects of different sizes,and the triangular tug-of-war tweezers with threefold rotational symmetry steadily hold asymmetric objects in the plane of observation and exert stretching forces along three directions.We successfully apply these tweezers to manipulate microparticles and bacterial cells in aqueous media. | Joshua Lamstein Anna Bezryadina Daryl Preece Joseph C. Chen Zhigang Chen | 2017 | Chinese Optics Letters2017，15，3： | 2 |
| 17 | Antibiotic resistance in Escherichia coli outpatient urinary isolates: final results from the North American Urinary Tract Infection Collaborative Alliance (NAUTICA)显示文摘 | George G. Zhanel Tamiko L. Hisanaga Nancy M. Laing Melanie R. DeCorby Kim A. Nichol Barb Weshnoweski Jack Johnson Ayman Noreddin Don E. Low James A. Karlowsky Daryl J. Hoban | 2006 | International Journal of Antimicrobial Agents2006，，6： | 2 |
| 18 | Hepatitis B virus reactivation in B-cell lymphoma patients treated with rituximab: Analysis from the Asia Lymphoma Study Group显示文摘 | Seok Jin Kim Chiun Hsu Yu-Qin Song Kevin Tay Xiao-Nan Hong Junning Cao Jin Seok Kim Hyeon Seok Eom Joon Hyeok Lee Jun Zhu Kian-Meng Chang Arry Harryanto Reksodiputro Daryl Tan Yeow Tee Goh Jejung Lee Tanin Intragumtornchai Wee-Joo Chng Ann-Lii Cheng Soon | 2013 | European Journal of Cancer2013，，： | 2 |
| 19 | 土壤侵蚀日发布系统显示文摘土壤侵蚀发布系统作为定量研究土壤侵蚀过程的重要工具,一直是土壤侵蚀学科的前沿领域,其对于估算土壤流失速度、评估水土保持措施效益具有重要的科学意义。然而,现有土壤侵蚀发布系统多仅依靠一年内降雨事件或利用多年平均降雨数据进行潜在土壤侵蚀程度估算,无法对一次平均水平的土壤侵蚀事件进行定量描述,更无法回答土壤侵蚀在何时何地发生,侵蚀动态如何变化,以及降雨、地形、土壤、作物管理方式和极端事件的时空变化对土壤侵蚀的影响。作为土壤侵蚀发布系统领域最新研究进展的土壤侵蚀日发布系统DEP(Daily Erosion Project),解决了以往土壤侵蚀发布系统中出现的上述问题。DEP基于侵蚀模型、地理信息、土地利用、植被变化等信息,逐日模拟降雨、径流、剥离、土壤流失等定量指标,结合第二代气象雷达云图生成土壤侵蚀分布图,实现以日为步长的土壤侵蚀发布,成为首个土壤侵蚀日发布系统,已在美国成功应用。本文详细介绍了土壤侵蚀日发布系统,并对实例进行了分析,探讨了该系统在我国土壤侵蚀发布研究与应用中的前景。 | 陈学文 Richard M.Cruse Brian K.Gelder Timothy J.Sklenar Daryl E.Herzmann David E.James 李浩 张兴义 | 2017 | 土壤与作物2017，6，4： | 2 |
| 20 | A high-density microsatellite consensus map for bread wheat (Triticum aestivum L.)显示文摘 | Daryl J. Somers Peter Isaac Keith Edwards | 2004 | Theoretical and Applied Genetics2004，，6： | 2 |
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