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| 1 | Restoration of electrical microenvironment enhances bone regeneration under diabetic conditions by modulating macrophage polarization显示文摘Macrophage-mediated inflammation compromises bone repair in diabetic patients.Electrical signaling cues are known to regulate macrophage functions.However,the biological effects of electrical microenvironment from charged biomaterials on the immune response for regulating osteogenesis under diabetic conditions remain to be elucidated.Herein the endogeneous electrical microenvironment of native bone tissue was recapitulated by fabricating a ferroelectric BaTiO_(3)/poly(vinylidene fluoridetrifluoroethylene)(BTO/P(VDF-TrFE))nanocomposite membrane.In vitro,the polarized BaTiO_(3)/poly(vinylidene fluoridetrifluoroethylene)(BTO/P(VDF-TrFE))nanocomposite membranes inhibited high glucose-induced M1-type inflammation,by effecting changes in cell morphology,M1 marker expression and pro-inflammatory cytokine secretion in macrophages.This led to enhanced osteogenic differentiation of human bone marrow mesenchymal stem cells(BM-MSCs).In vivo,the biomimetic electrical microenvironment recapitulated by the polarized nanocomposite membranes switched macrophage phenotype from the pro-inflammatory(M1)into the pro-healing(M2)phenotype,which in turn enhanced bone regeneration in rats with type 2 diabetes mellitus.Mechanistic studies revealed that the biomimetic electrical microenvironment attenuated pro-inflammatory M1 macrophage polarization under hyperglycemic conditions by suppressing expression of AKT2 and IRF5 within the PI3K-AKT signaling pathway,thereby inducing favorable osteo-immunomodulatory effects.Our study thus provides fundamental insights into the biological effects of restoring the electrical microenvironment conducive for osteogenesis under DM conditions,and offers an effective strategy to design functionalized biomaterials for bone regeneration therapy in diabetic patients. | Xiaohan Dai Boon Chin Heng Yunyang Bai Fuping You Xiaowen Sun Yiping Li Zhangui Tang Mingming Xu Xuehui Zhang Xuliang Deng | 2021 | Bioactive Materials2021，6，7： | 9 |
| 2 | Flooding attack and defence in Ad hoc networks显示文摘Mobile ad hoc networks are particularly vulnerable to denial of service (DOS) attacks launched through compromised nodes or intruders. In this paper, we present a new DOS attack and its defense in ad hoc networks. The new DOS attack,called Ad hoc Flooding Attack(AHFA), is that intruder broadcasts mass Route Request packets to exhaust the communication bandwidth and node resource so that the valid communication can not be kept. After analyzed Ad hoc Flooding Attack, we develop Flooding Attack Prevention (FAP), a generic defense against the Ad hoc Flooding Attack. When the intruder broadcasts exceeding packets of Route Request, the immediate neighbors of the intruder record the rate of Route Request. Once the threshold is exceeded, nodes deny any future request packets from the intruder. The results of our implementation show FAP can prevent the Ad hoc Flooding attack efficiently. | Yi Ping Hou Yafei Zhong Yiping Zhang Shiyong Dai Zhoulin | 2006 | Journal of Systems Engineering and Electronics2006，17，2： | 5 |
| 3 | Effects of Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) medicated serum on chemotactic migration of alveolar macrophages and inters regions macrophages in rats显示文摘OBJECTIVE: To observe the effects of serum containing Mahuang(Herba Ephedra Sinica) or Wuweizi(Fructus Schisandrae Chinensis) on the migration of alveolar macrophages(AM) and interstitial macrophages(IM) from normal rats, and to analyze and compare the mechanisms leading to cell migration differences.METHODS: Rats were randomly divided into three groups: Mahuang(Herba Ephedra Sinica), Wuweizi(Fructus Schisandrae Chinensis), and blank serum. After treatment with the herbs, serum was extracted from the rats. AM and IM were isolated from normal rats and cultured. The effects of Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) medicated serum on normal rat AM and IM chemotactic migration were determined by transwell assays. The CC chemokine receptor(CCR) 2, CCR5, voltage-gated Kvl. 3 K^+channel(Kv1. 3), and voltage-gated Kvl. 5 K^+channel(Kv1. 5) protein levels were analyzed by western blotting.RESULTS: The migration quantities of AM and IM in the Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) medicated serum groups were significantly higher than those in the blank serum group(P < 0.01). Compared with the Wuweizi(Fructus Schisandrae Chinensis) medicated serum group, the migration quantity of cultured rat AM in the Mahuang(Herba Ephedra Sinica) medicated serum group was significantly increased(P <0.01). Meanwhile, compared with the Mahuang(Herba Ephedra Sinica) medicated serum group, the migration quantity of cultured rat IM in the Wuweizi(Fructus Schisandrae Chinensis) medicated serum group was significantly increased(P < 0.01).CCR2, CCR5, Kv1. 3, and Kv1. 5 proteins were expressed on the AM cell surface, and showed significantly higher expression in the Mahuang(Herba Ephedra Sinica) medicated serum group compared with the Wuweizi(Fructus Schisandrae Chinensis)medicated serum group. In contrast, CCR5, Kv1.3,and Kv1.5 proteins were expressed on the IM cell surface, and showed significantly higher expression in the Wuweizi(Fructus Schisandrae Chinensis)medicated serum group compared with the Mahuang(Herba Ephedra Sinica) medicated serum group.CONCLUSION: Mahuang(Herba Ephedra Sinica)and Wuweizi(Fructus Schisandrae Chinensis) can promote AM and IM migration ability, with Mahuang(Herba Ephedra Sinica) targeting AM more apparently and Wuweizi(Fructus Schisandrae Chinensis) targeting IM more apparently. The mechanism may be that, by stimulating cells, Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) promote expression of CCR2 and CCR5 receptors on the AM and IM cell surface,which pass signals to Kvl.3 and Kvl.5 ion channels,leading to changes in the cytoskeleton, and ultimately promoting chemotactic cell migration. | Yuan Yiping Zhai Huaqiang Zhang Tian Guo Zhaojuan Kong Liting Jia Xiaoyu Wang Ningning Dai Ying Liu Guoxiu Wang Yanping | 2017 | Journal of Traditional Chinese Medicine2017，37，5： | 3 |
| 4 | Mineralogy and geochemistry of a superhigh-organic-sulfur coal, Yanshan Coalfield, Yunnan, China: Evidence for a volcanic ash component and influence by submarine exhalation显示文摘 | Shifeng Dai Deyi Ren Yiping Zhou Chen-Lin Chou Xibo Wang Lei Zhao Xingwei Zhu | 2008 | Chemical Geology2008，，1： | 3 |
| 5 | Geochemistry of trace elements in Chinese coals: A review of abundances, genetic types, impacts on human health, and industrial utilization显示文摘 | Shifeng Dai Deyi Ren Chen-Lin Chou Robert B. Finkelman Vladimir V. Seredin Yiping Zhou | 2011 | International Journal of Coal Geology2011，，： | 3 |
| 6 | Complementation analyses of Sinorhizobium meliloti nifA mutant with different originated nifA genes显示文摘推断的一个以前的工作 Enterobacter 下水道的 nifA 基因没恢复 Sinorhizobium meliloti nifA 的共生显型变异。在现在的学习, Bra-dyrhizobium 的 twonifA 基因日本嗯并且 Mesorhizobium huakuii 也没恢复 S 的共生显型。meliloti nifA 异种。在微数组试验的整个 genomic, 238 基因被发现是在 S 以后表示的差别。meliloti nifA 组成地在它的 nifAmutant 被表示了。相反,当表示 B.japonium 时,仅仅 20, 7 和 9 基因改变了他们的 transcriptional 层次, M。在 Sm nifA 异种的 huakuii 和 Enterobacter 下水道 nifA 基因独立。这些基因包括房子保留,精力和中央中间代谢被分类进几官能基,运输系统和共生。有趣地, nifHoperons,显示出的高表示面对任何一个 B 铺平的基因。japonium 或 M。huakuii NifA,它被随后的紫胶 Z 熔化实验证实。 | YAO Zhenhua TIAN Zhexian DAI Xiaomi BECKER Anke LI Jian YAN Haiqin XIAO Yan ZHU Jiabi YU Guanqiao RUVERG Silvia WANG Yiping ZOU Huasong | 2006 | Chinese Science Bulletin2006，51，22： | 2 |
| 7 | Woodland strawberry WRKY71 acts as a promoter of flowering via a transcriptional regulatory cascade显示文摘The WRKY proteins are a large family of transcription factors that play important roles in stress responses and plant development.However,the roles of most WRKYs in strawberry are not well known.In this study,FvWRKY71 was isolated from the woodland strawberry‘Ruegen’.FvWRKY71 was highly expressed in the shoot apex and red fruit.Subcellular localization analysis showed that FvWRKY71 was located in the nucleus.Transactivation analysis showed that FvWRKY71 presented transcriptional activation activity in yeast.Overexpression of FvWRKY71 in Arabidopsis and woodland strawberry revealed early flowering in the transgenic plants compared with the wild-type control.Gene expression analysis indicated that the transcript levels of the flowering time and development integrator genes AP1,LFY,FT,AGL42,FUL,FPF1,SEP1,SEP2,and SEP3 were increased in FvWRKY71-overexpressing Arabidopsis and strawberry plants compared with the wild-type controls,which may result in accelerated flowering in transgenic plants.Furthermore,FvWRKY71 was proven to directly bind to the W-boxes(TTGACT/C)of the FvFUL,FvSEP1,FvAGL42,FvLFY,and FvFPF1 promoters in vitro and in vivo.Taken together,our results reveal a transcriptional regulatory cascade of FvWRKY71 involved in promoting flowering in woodland strawberry. | Yingying Lei Yiping Sun BaotianWang Shuang Yu Hongyan Dai He Li Zhihong Zhang Junxiang Zhang | 2020 | Horticulture Research2020，7，1： | 2 |
| 8 | Oxidative coupling of cinnamic acid derivatives and their radical-scavenging activities显示文摘4-Hydroxycinnamic acid derivatives,including ferulic acid (FA) (1),sinapic acid (SA) (2) and caffeic acid (CA) (3),are widely distributed in the plant kingdom,and undergo oxidative cross-coupling leading to the corresponding dehydrodimers,trimers and even higher oligomers in plants. In order to evaluate the antioxidative ability of these 4-hydroxycinnamic acid derivatives and their oligomers,we synthesized 8-8'-bis-lactone-dimers (8-8'-DiFA (4),8-8'-DiSA (5) and 8-8'-DiCA (6)),as well as a new trimer (7),by the reaction of the corresponding monomers (1-3) with Ag2O in methanol,and assayed their free radical-scavenging activity by the reaction with 2,2-diphenyl-1-picrylhydrazyl radical (DPPH·). It was found that CA (3) and 8-8'-DiCA (6) bearing o-dihydroxyl groups exhibited significantly higher radical-scavenging activity than those bearing no such groups,and oxidative coupling of CA (3) resulted in remarkable enhancement in the activity. | JIN XiaoLing YANG RuTing SHANG YaJing DAI Fang QIAN YiPing CHENG LiXia ZHOU Bo LIU ZhongLi | 2010 | Chinese Science Bulletin2010，55，25： | 2 |
| 9 | Exergy analysis and optimization of a hydrogen production process by a solar-liquefied natural gas hybrid driven transcritical CO2 power cycle显示文摘 | SUN Zhixin WANG Jiangfeng DAI Yiping | 2012 | International Journal of Hydrogen Energy2012，37，18： | 1 |
| 10 | Geochemistry of trace elements in Chinese coals: A review of abundances, genetic types, impacts on human health, and industrial utilization显示文摘 | Shifeng Dai Deyi Ren Chen-Lin Chou Robert B. Finkelman Vladimir V. Seredin Yiping Zhou | 2011 | International Journal of Coal Geology2011，，： | 1 |
| 11 | Parametric optimization and comparative study of organic Rankine cycle (ORC) for low grade waste heat recovery 显示文摘 | Dai Yiping Wang Jiangfeng Gao Lin | 2009 | Energy Conversion and Management2009，50，3： | 1 |
| 12 | Exergy analyses and parametric optimizations for different cogeneration power plants in cement industry显示文摘 | WANG JIANGFENG DAI YIPING GAO LIN | 2009 | Applied Energy2009，86，： | 1 |
| 13 | Mineralogical and compositional characteristics of Late Permian coals from an area of high lung cancer rate in Xuan Wei, Yunnan, China: Occurrence and origin of quartz and chamosite显示文摘 | Shifeng Dai Linwei Tian Chen-Lin Chou Yiping Zhou Mingquan Zhang Lei Zhao Jumin Wang Zong Yang Hongzhi Cao Deyi Ren | 2008 | International Journal of Coal Geology2008，，4： | 1 |
| 14 | A new combined cooling, heating and power system driven by solar energy显示文摘 | Jiangfeng Wang Yiping Dai Lin Gao Shaolin Ma | 2009 | Renewable Energy2009，，12： | 1 |
| 15 | Parameter identification of interconnected power system frequency after trip-out of high voltage transmission line显示文摘精确建模和格子是的高电压(HV ) 的参数为系统频率的稳定性研究批评。在这篇论文,模拟当模特儿系统频率与传播在中国衬里的 HV 一个互连的力量系统被进行。基于使 HV 传播线的数据犯错记录,系统参数被使用基因算法(GA ) 识别。在模拟结果和记录数据之间的有利协议验证有效性系结模型和系统参数的精确性。这篇论文的结果能为 HV 力量格子的稳定性研究提供参考。 | Xuzhan ZHOU Yaohua TANG Shanshan LIU Mingkun WANG Yiping DAI | 2014 | Frontiers in Energy2014，8，3： | 1 |
| 16 | Exergy analyses and parametric optimizations for different cogeneration power plants in cement industry显示文摘 | Wang Jiangfeng Dai Yiping Gao Lin | 2009 | Applied Energy2009，86，： | 1 |
| 17 | Parametric opti-mization and comparative study of Organic Rankine Cy-cle (ORC)for low grade waste heat recovery 显示文摘 | Yiping Dai Jiangfeng Wang Lin Gao | 2009 | EnergyConversion and Management2009，50，3： | 1 |
| 18 | Origin of minerals and elements in the Late Permian coals, tonsteins, and host rocks of the Xinde Mine, Xuanwei, eastern Yunnan, China显示文摘 | Shifeng Dai Tian Li Vladimir V. Seredin Colin R. Ward James C. Hower Yiping Zhou Mingquan Zhang Xiaolin Song Weijiao Song Cunliang Zhao | 2014 | International Journal of Coal Geology2014，，： | 1 |
| 19 | Mineralogy and geochemistry of Late Permian coals from the Taoshuping Mine, Yunnan Province, China: Evidences for the sources of minerals显示文摘 | Xibo Wang Shifeng Dai Chen-lin Chou Mingquan Zhang Jumin Wang Xiaolin Song Wei Wang Yaofa Jiang Yiping Zhou Deyi Ren | 2012 | International Journal of Coal Geology2012，，： | 1 |
| 20 | ParametricOptimization and Comparative Study of Organic Rank-ine Cycle (ORC) for Low Grade Waste Heat Recovery 显示文摘 | DAI Yiping WANG Jiangfeng GAO Lin | 2009 | Energy Conversion and Management2009，50，3： | 1 |
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