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	题名	作者	年代	出处	被引量
1	S-DAPYs类似物的分子设计、合成及抑制HIV-1的活性研究显示文摘我们以已上市的etravirine和正在临床研究的VRX-480773两个逆转录酶抑制剂为模板,通过杂交这两个化合物的药效团,获得含酰胺片段的S—DAPYs类似物,该类似物对野生型HIV-1病毒株具有中等强度抑制活性.而Maurizio所发现的另一类无酰胺片段的S.DAPYs类似物却表现出优异的抑制活性.为了考察酰胺片段对S-DAPYs类似物抑制HIV-1活性的影响,本文合成了一系列无酰胺片段的S—DAPYs类似物.生物活性结果表明,3个化合物(6g、6m和6s)对野生型HIV-1具有中等强度抑制活性(EC50在6.5~15.4μmol/L范围内),弱于相应的具有酰胺片段的类似物.此外,分子模拟还揭示了酰胺片段可与K103形成至关重要的氢键作用,这为新型非核苷类逆转录酶抑制剂的设计奠定了理论基础.	万正勇陈芬儿 Erik De Clercq Dirk Daelemans Christophe Pannecouque	2015	中国科学:化学2015，45，9：	2
2	Prevalence of intra-abdominal hypertension in critically ill patients: a multicentre epidemiological study显示文摘	Manu L. N. G. Malbrain Davide Chiumello Paolo Pelosi Alexander Wilmer Nicola Brienza Vincenzo Malcangi David Bihari Richard Innes Jonathan Cohen Pierre Singer Andre Japiassu Elizabeth Kurtop Bart L. De Keulenaer Ronny Daelemans Monica Del Turco P. Cosimin	2004	Intensive Care Medicine2004，，5：	2
3	Structure-activity relationship study on anti-HiV 6-des fluoroquinolones显示文摘	Tabarrini O Massari S Daelemans D	2008	J Med Chem2008，51，17：	1
4	Kinetic and Molecular Analysis of Nuclear Export Factor CRM1 Association with Its Cargo in vivo 显示文摘	Daelemans D Costes SV Lockett S	2005	Mol Cell Biol2005，25，：	1
5	Prediction of severity of symptoms in iatrogenic ovarian hyperstimulatinon syndrome by follicle-stimulating hormone receptor Ser680Asn polymorphism显示文摘	Daelemans C Smits G De Maertelaer V	2004	J Clin Endocrinol Metab2004，89，12：	1
6	Pronostic value of a new scoring system for hospital mortality in acute renal failure显示文摘	IINS R L ELSEVIERS M DAELEMANS R	2000	Clin Nephrol2000，53，：	1
7	Virtual occlusion in planning orthognathic Surgical procedures显示文摘	Nadjmi N Mollemans W Daelemans A	2010	IntJ Oral Maxillofac Surg2010，，：	1
8	Reevaluation and modification of the Stuivenberg Hospital Acute Renal Failure (SHARF) scoring system for the prognosis of acute renal failure: an independent multicentre, prospective study显示文摘	Lins RL Elseviers MM Daelemans R	2004	Nephrol Dial Transplant2004，19，9：	1
9	Prognostic value of a new scoring system forhospital mortality in acute renal failure显示文摘	Lins RL Elseviers M Daelemans R	2000	Clin Nephrol2000，53，1：	1
10	Prognostic value of a new scoring system for hospital mortality in acute renal failure显示文摘	Lins RL Elserviers M Daelemans R	2000	Clin Nephrol2000，53，：	1
11	Igtree:Using trees for compression and classification in lazy learning algorithms显示文摘	Daelemans Walter Van Den Bosch Antal Weijters Ton	1997	Artificial Intelligence Review1997，11，：	1
12	Neutrophil adhesion molecules in chronic hemodialvsis patients显示文摘	Zachee P Daelemans R Pollaris P	1994	Nephron1994，68，2：	1
13	A synthetic HIV-1 Rev inhibitor interfering with the CRM1-mediated nuclear export显示文摘	Afonina E Nilsson J	2002	Proc Natl Acad Sci USA2002，99，14：	1
14	Prediction of se- verity of symptoms in iatrogenic ovarian hyperstimulation syndrome by follicle - stimulating hormone receptor Ser680Asn polymorphism 显示文摘	Daelemans C Smits G de Maertelaer V	2004	J Clin Endocrinol Metab2004，89，12：	1
15	Broadspectrum antiviral acitivity and mechanism of antiviral action of the fluoroquinolone derivative K-12 显示文摘	Wintvrouw M Daelemans D Pamnecouque C	2000	Antivir Chem Chemother2000，9，5：	1
16	Using rule induction techniques to model pronunciation variation in Dutch 显示文摘	Hoste V Daelemans W Gillis S	2004	Computer Speech and Language2004，18，1：	1
17	Prediction of severity of symptoms in iatrogenic ovarian hyperstimulation syndrome by follicle-stimulating hormone receptor Ser680Asn polymorphism显示文摘	DAELEMANS C SMITS G de MAERTELAER V		0，，12：	1
18	Nanofibre bridging as a toughening mechanism in carbon/epoxy composite laminates interleaved with electrospun polyamide nanofibrous veils显示文摘	Lode Daelemans Sam van der Heijden Ives De Baere	2015	Composites Science and Technology2015，117，：	1
19	Debio- 025 inhibits HIV-1 by interfering with an early event in the replication cycle显示文摘	Daelemans D Dumont J M Rosenwirth B	2010	Antiviral Res2010，85，2：	1
20	A synthetic HIV-I Rev inhibitor interfering with the CRM1-mediated nuclear export显示文摘	Daelemans D Afonia E Nilsson J		0，，：	1

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